antidiarrhoeal drugs& laxatives
TRANSCRIPT
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Antidiarrheals and Laxatives
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Diarrhea
• Abnormal frequent passage of loose stools
or
• Abnormal passage of stools with increased frequency, fluidity, and weight, or with increased stool water excretion
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Diarrhea
Acute Diarrhea• Sudden onset in a previously healthy person
• Lasts from 3 days to 2 weeks
• Self-limiting
• Resolves without sequelae
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Diarrhea
Chronic Diarrhea
• Lasts for over 3 to 4 weeks
• Associated with recurring passage of diarrheal stools, fever, loss of appetite, nausea, vomiting, weight loss, and chronic weakness
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Causes of Diarrhea
Acute Diarrhea Chronic DiarrheaBacteria Tumors
Viral Diabetes
Drug-induced Addison’s diseasehyperthyroidism
Nutritional Irritable bowel syndrome
Protozoal
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Antidiarrheals: Mechanism of Action
Adsorbents• Coat the walls of the GI tract
• Bind to the causative bacteria or toxin, which are then eliminated through the stool
Examples: bismuth subsalicylate (Pepto-Bismol), kaolin-pectin, activated charcoal,
attapulgite (Kaopectate)
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Antidiarrheals: Mechanism of Action
Anticholinergics• Decrease intestinal muscle tone and peristalsis of GI tract
• Result: slowing the movement of fecal matter through the GI tract
Examples: belladonna alkaloids (Donnatal), atropine, hyoscyamine
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Antidiarrheals: Mechanism of Action
Intestinal Flora Modifiers• Bacterial cultures of Lactobacillus organisms
work by:– Supplying missing bacteria to the GI tract
– Suppressing the growth of diarrhea-causing bacteria
Examples: Lactobacillus acidophilus (Lactinex)
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Antidiarrheals: Mechanism of Action
Opiates• Decrease bowel motility and relieve rectal spasms
• Decrease transit time through the bowel, allowing more time for water and electrolytes to be absorbed
Examples: paregoric, opium tincture, codeine, loperamide, diphenoxylate
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Antidiarrheal Agents: Side Effects
Anticholinergics• Urinary retention, hesitancy, impotence
• Headache, dizziness, confusion, anxiety, drowsiness
• Dry skin, rash, flushing
• Blurred vision, photophobia, increased intraocular pressure
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Antidiarrheal Agents: Side Effects
Opiates• Drowsiness, sedation, dizziness, lethargy
• Nausea, vomiting, anorexia, constipation
• Respiratory depression
• Bradycardia, palpitations, hypotension
• Urinary retention
• Flushing, rash, urticaria
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Antidiarrheal Agents: Interactions
• Adsorbents decrease the absorption of many agents, including digoxin, clindamycin, quinidine, and hypoglycemic agents
• Adsorbents cause increased bleeding times when given with anticoagulants
• Antacids can decrease effects of anticholinergic antidiarrheal agents
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Antidiarrheal Agents: Nursing Implications
• Obtain thorough history of bowel patterns, general state of health, and recent history of illness or dietary changes, and assess for allergies.
• DO NOT give bismuth subsalicylate to children under age 16 or teenagers with chicken pox because of the risk of Reye’s syndrome.
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Antidiarrheal Agents: Nursing Implications
• Use adsorbents carefully in elderly patients or those with decreased bleeding time, clotting disorders, recent bowel surgery, or confusion.
• Anticholinergics should not be administered to patients with a history of glaucoma, BPH, urinary retention, recent bladder surgery, cardiac problems, or myasthenia gravis.
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Antidiarrheal Agents: Nursing Implications
• Teach patients to take medications exactly as prescribed and to be aware of their fluid intake and dietary changes.
• Assess fluid volume status; intake and output; and mucous membranes before, during, and after initiation of treatment.
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Antidiarrheal Agents: Nursing Implications
• Teach patients to notify their physician immediately if symptoms persist.
Monitor for therapeutic effect.
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LAXATIVES
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Constipation
• Abnormally infrequent and difficult passage of feces through the lower GI tract.
• Symptom, not a disease
• Disorder of movement through the colon and/or rectum
• Can be caused by a variety of diseases or drugs
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Causes of ConstipationMetabolic and endocrine disorders• Diabetes, hypothyroidism, pregnancy
Neurogenic• Autonomic neuropathy, multiple sclerosis, spinal cord
lesions, Parkinson’s disease, CVA
Adverse drug effects• Analgesics, anticholinergics, iron supplements, opiates,
aluminum antacids, calcium antacids
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Causes of Constipation
Lifestyle• Poor bowel movement habits: voluntary refusal to
defecate resulting in constipation
• Diet: poor fluid intake and/or low-residue (roughage) diet, or excessive consumption of dairy products
• Physical inactivity
• Psychological factors: stress, anxiety, hypochondria
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Laxatives:
Mechanisms of Action• Bulk-forming
• Emollient
• Hyperosmotic
• Saline
• Stimulant
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Laxatives: Mechanism of Action
Bulk-Forming• High fiber
• Absorbs water to increase bulk
• Distends bowel to initiate reflex bowel activity
Examples: psyllium (Metamucil), methylcellulose (Citrucel), polycarbophil
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Laxatives: Mechanism of Action
Emollient• Stool softeners and lubricants
• Promote more water and fat in the stools
• Lubricate the fecal material and intestinal walls
Examples: Stool softeners: docusate salts (Colace, Surfak)Lubricants: mineral oil
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Laxatives: Mechanism of Action
Hyperosmotic• Increase fecal water content
• Result: bowel distention, increased peristalsis, and evacuation
Examples: polyethylene glycol (GoLYTELY), sorbitol, glycerin, lactulose (Chronulac)
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Laxatives: Mechanism of Action
Saline• Increase osmotic pressure within the intestinal tract,
causing more water to enter the intestines
• Result: bowel distention, increased peristalsis, and evacuation
Examples: magnesium sulfate (Epsom salts)magnesium hydroxide (MOM),
magnesium citrate sodium phosphate (Fleet
Phospho-Soda)
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Laxatives: Mechanism of Action
Stimulant• Increases peristalsis via intestinal nerve stimulation
Examples: castor oil, senna, cascara, bisacodyl
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Laxatives: Therapeutic UsesLaxative Group UseBulk-forming Acute and chronic
constipation
Irritable bowel syndrome
Diverticulosis
Emollient Acute and chronicconstipation
Softening of fecal impaction
Facilitation of BMs inanorectal conditions
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Laxatives: Therapeutic UsesLaxative Group UseHyperosmotic Chronic constipation
Diagnostic and surgical preps
Saline Constipation
Diagnostic and surgical preps
Removal of helminths and parasites
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Laxatives: Therapeutic UsesLaxative Group UseStimulant Acute constipation
Diagnostic and surgicalbowel preps
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Laxatives: Therapeutic UsesLaxative Group Use
Bulk-forming Impaction and fluid overload
Emollient Skin rashes
Decreased absorption of vitamins
Hyperosmotic Abdominal bloating, rectal irritation
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Laxatives: Therapeutic UsesLaxative Group Use
Saline Magnesium toxicity (withrenal insufficiency),cramping, diarrhea,increased thirst
Stimulant Nutrient malabsorption, skin rashes, gastric irritation,
rectal irritation
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Laxatives: Side Effects
• All laxatives can cause electrolyte imbalances!!!
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Laxatives: Nursing Implications
• Obtain a thorough history of presenting symptoms, elimination patterns, and allergies.
• Assess fluid and electrolytes before initiating therapy.
• Patients should not take a laxative or cathartic if they are experiencing nausea, vomiting, and/or abdominal pain.
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Laxatives: Nursing Implications
• A healthy, high-fiber diet and increased fluid intake should be encouraged as an alternative to laxative use.
• Long-term use of laxatives often results in decreased bowel tone and may lead to dependency.
• All laxative tablets should be swallowed whole, not crushed or chewed, especially if enteric-coated.
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Laxatives: Nursing Implications
• Patients should take all laxative tablets with 6 to 8 ounces of water.
• Patients should take bulk-forming laxatives as directed by the manufacturer with at least 240 mL (8 ounces) of water.
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Laxatives: Nursing Implications
• Bisacodyl and cascara sagrada should be given with water due to interactions with milk, antacids, and H2 blockers.
• Patients should contact their physician if they experience severe abdominal pain, muscle weakness, cramps, and/or dizziness, which may indicate possible fluid or electrolyte loss.
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Laxatives: Nursing Implications
• Monitor for therapeutic effect.