antigen processing
TRANSCRIPT
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DENDRITIC CELLS AND ANTIGEN PROCESSING
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epitope
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adherenceadherence
phagosomephagosome
phagolysosomephagolysosome
degradationdegradation
excretionexcretion
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α1 α2
α3 β2m
α1 β1
α2 β2
Endogenouspeptides
Exogenouspeptides
TcCD 8
Citotoxicity
ThCD 4
Humoral response
Cellular response
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Dendritic cell
AntIgen
B cell Macrophage
Helper T cellCD 4
EXOGENOUS ANTIGEN-PROCESSING CELLS
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The Origin of Dendritic Cells (DC)
Epidermal DCInterstitial DC
Only in mice
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DC
LT
LT
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Skin
1
2 3
Veiled cells
4
MHC II 5
Dendritic cell
6
Dendritic Cells
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IL-4, 5, 10IL-4, 5, 10
BB
BB BB
BB
1 DC >> 3,000 LT
TTTT
TT
TTTTTTTT
TT
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Dentritic Cells 1 and 2
IL-1, IL-4, IL-6
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Antigen
Dendriticcell
Beading of dendrites
Iccosomes
Antigen presentation by dendritic cells
Ag presentation
IL-1, IL-12
Th cellB cell
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RER
CITOPLASMA
Membranacelular
Procesamiento de Antígenos Exógenos
fagosoma
ESPACIO EXTRACELULAR
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mRNA
RER
MHC II
CITOPLASMA
Membranacelular
Procesamiento de Antígenos Exógenos
Agparcialmente
digerido(fagolisosoma)
Compartimientoendocitico
ESPACIO EXTRACELULAR
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Iicadenainvariante
RER
CITOPLASMA
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CITOPLASMA
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CLIP(class II-associated li peptide)
DM
CITOPLASMA
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RER
Agparcialmente
digerido
CITOPLASMA
Membranacelular
Procesamiento de Antígenos Exógenos
ESPACIO EXTRACELULAR
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RER
CITOPLASMA
Membrana celular
Procesamiento de Antígenos Exógenos
ESPACIO EXTRACELULAR
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RER
CITOPLASMA
Membranacelular
Expresión de Agunido a MHC II
Procesamiento de Antígenos Exógenos
ESPACIO EXTRACELULAR
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αα 11
αα 22
ββ11
ββ22
epitopo
MHC II
CPA(MØ , LB, DC)
Interacción MHC II-RCT y CD4
α β
δ γε ε
ζ ζ
CD4 CD4
Célula ThCD4+
CD3
RCT
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TAP-1 TAP-2
Calnexina
(chaperonina)
α1
α2
α3
β2m
Proteasoma
Ag Viral
Procesamiento de Ag Endógenos (1).
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proteasoma
U ubiquitina
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mRNA Viral
MHC ImRNA
MHC Icon epitopo
ComplejoPéptido-MHC I
U
Proteasoma
TAP
U U
Ubiquitina
U
U
U
Procesamiento de Ag Endógenos (2).
RER
Membranacelular ESPACIO
EXTRACELULAR
CITOPLASMA
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αα11 αα22
αα33
ββ2m2m
Célula nucleada
epitopo
α β
RCT
CD8 CD8
Célula TcCD8+
Interacción MHC I- RCT-CD8