antigen specificity

8/8/2019 antigen specificity

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OLVGCIL ^PINGJGNGVW

Dw

Zilhovi~m,^



Nblvilv~

GlvtbfynvgblNblvtgdyvgblIpgvbpiVwpi~D niaa ipgvbpiV niaa ipgvbpipotovbpiOlvgcil%pti~ilvglc niaa^gclgjgnolniNblnay~gbl



Glvtbfynvgbl

Olvgcil~ oti ~yd~vilni~!smgnm nol glfyni^pingjgn geeyli ti~pbl~i ,Vmg~ ptbni~~ g~ noaaifgeeyli cilgngvw smgnmnbl~g~v~ bj iaodbtovgbl bj olvgdbfw ptbfynvgblolf vmi fiziabpeilv bj niaa eifgovif geeylgvw,Olvgcilgngvwg~ vmi odgagvw vb nbedgli ~pingjgnoaawsgvm vmi jgloa ptbfynv~ bj vmi Xgeeyli ti~pbl~iU

~yd~volni~# vmov oti geeyli cilgn oti oasow~olvgcilgn dyv olvgcil~ oti lbv lini~~otgawgeeylbcilgn! ic;mopvil



,Nblvtgdyvgbl

,Jbtigclli~~,Ebainyait ~g{i,Nmiegnoa nbepb~gvgbl olfmivitbcilgngvw,Olvgcil ptbni~~glc olfpti~ilvglc



I}bcilby~ olvgcil~I}bcilby~ olvgcil~ oti olvgcil~ vmov mozi ilvitif

vmi dbfw jtbe vmi byv~gfi! jbt i}oepai dw glmoaovgbl!glci~vgbl

! bt glkinvgbl,

Ilfbcilby~ olvgcil~Ilfbcilby~ olvgcil~ oti olvgcil~ vmov mozi diil

cilitovif sgvmgl ptizgby~aw lbteoa niaa~ o~ o ti~yav bj lbteoa niaa eivodbag~e

! bt dinoy~i bj zgtoa btglvtoniaayaot donvitgoagljinvgbl

O yvbolvgcil~Ol oyvbolvgcil g~ y~yoaaw o lbteoa ptbvigl bt

nbepai} bj ptbvigl~ -olf ~beivgei~ FLO bt TLO' vmovg~ tinbclg{if dw vmi geeyli ~w~vie bj povgilv~~yjjitglc jtbe ~pingjgn oyvbgeeyli fg~io~i



IpgvbpiOl ipgvbpi ! oa~b hlbsl o~ olvgcilgn fiviteglolv ! g~vmi potv bj ol olvgcil vmov g~ tinbclg{if dw vmigeeyli ~w~vie ! ~pingjgnoaaw dw olvgdbfgi~ ! D niaa~ ! bt V niaa~ ,



Vmi ipgvbpi ~ oti vsb novicbtgi~,

nbljbteovgbloa ipgvbpi~ ,agliot ipgvbpi~ ,

Nbljbteovgbloa ipgvbpi~ oti glvitonv sgvm vitvgotw~vtynvyti bj vmi olvgcil

Agliot ipgvbpi~ glvitonv sgvm vmi potovbpi do~ifbl vmigt ptgeotw ~vtynvyti bj vmi olvgcil



Ionm D niaa olf V niaa g~~pingjgnjbt opotvgnyaotolvgcil ,

vmi D niaa tinipvbt -DNT ' jbt olvgcil olfvmi V niaa tinipvbt -VNT ' ti~pinvgziaw,



DNT~ olf VNT~ f gjjit gl;

vmigt ~vtynvyti8vmi cili~ vmov ilnbfi vmie8

vmi vwpi bj ipgvbpi vb smgnm vmiw dglf,



D N iaa~

DNT~ dglf ~baydai olvgcil~,Vmi dbylf olvgcil ebainyai~ oti ilcyajif glvbvmi D niaa dwtinipvbt%eifgovif ilfbnwvb~g~ ,Vmi olvgcil g~ fgci~vif glvb jtoceilv~smgnm oti vmil fg~paowif ov vmi niaa ~ytjonili~vaif gl~gfi o nao~~GGmg~vbnbepovgdgagvwebainyai ,Miapit V niaa~~pingjgn jbt vmg~ ~vtynvyti -g,i,! sgvmnbepaieilvotw VNT~' dglf vmi D niaa olf~intivi awepmbhgli~ vmov;



D%niaa Ipgvbpi~

^ pingjgn Ipgvbpi~ tinbclg{if d wvmi D%ni aatinipvbt otiabnovif bl vmi ~ytjoni bj vmi olvgcil,Miti EMN niaa~ lbv tiqygtif,Vmi nmiegnoa lovyti bj Oc g~ ptbvigl !pbaw ~onmotgfi!agpgf,



V Niaa~

Vmi ~ytjoni bj ionm V niaa oa~b fg~paow~vmby~olf~ bj gfilvgnoa Vni aatinipvbt~ -VNT

Vmi VNT -bj oapmo"divo V niaa~' dglf~ odgebainyaot nbepai} fg~paowif ov vmi ~ytjonibj ~be i bvmit ni aanoaaif ol olvgcil %

pti~ilvglc ni aa-OPN ',



V%Niaa Ipgvbpi~

^ pingjgnIpgvbpi~ tinbclg{if d wvmiV%ni aa tinipvbt oti bjvil abnovif gl vmi gllit!yli}pb~if ~gfi bj vmi olvgcil,olf dinbei onni~~gdai vb vmi V%niaa tinipvbt~ojvit ptbvibawvgn ptbni~~glc bj vmi olvgcil,Nmiegnoa lovyti bj Oc so~ eb~vaw ptbvigl~!dyv~bei agpgf~ olf cawnbagpgf~ pti~ilvif bl EMNebagnyai~,



potovbpi

Vmi potovbpi g~ vmi potv bj ol olvgdbfw smgnmtinbclg~i~ ol olvgcil ! vmi olvgcil%dglfglc ~gvi bj ololvgdbfw, Gv g~ o ~eoaa ticgbl -bj ?9 44 oeglb ongf~'bj vmi olvgdbfw#~ Jz ticgbl olf nblvogl~ potv~ bj vmiolvgdbfw#~ miozw olf agcmv nmogl~ ,

? , Jod ticgbl4, Jn ticgbl>,Miozw nmogl6, Agcmv nmoglsgvm bli zotgodai-ZA' olf bli nbl~volv -N A'fbeogl9, Jz ticgbl sgvm potovbpi

4, :,mglc ticgbl



O lyedit bj zonngli~ do~if bl D%niaa ipgvbpi~oti nyttilvaw ylfit naglgnoa pmo~i vtgoa~ ocogl~vzgty~i~ ! donvitgo olf nolnit , Vmi~i ipgvbpi~oti oa~b gepbtvolvIpgvbpi~ oti bjvil y~if gl ptbvibegn~ olf vmi~vyfw bj bvmit cili ptbfynv~,Y~glc tinbedglolv flo vinmlgqyi~ cilivgn~iqyilni~ nbfglc jbt ipgvbpi~ vmov otitinbclg{if dw nbeebl olvgdbfgi~ nol di jy~ifvb vmi cili,

^gclgjgnolni



Jbt gl~volni! gj o ptbvigl ~oepai g~ dbgaif!vtiovif sgvm divo%eitnopvbivmolba ! olf tyl gl^F^%POCI jbt vmi Si~vitl dabv! vmi ptbvigl~ otii~~ilvgoaawfilovytif olf vmitijbti nollbvo~~yei gv~ lovytoa vmtii%fgeil~gbloa

nbljbteovgbl,Vmitijbti! olvgdbfgi~ vmov tinbclg{i agliotipgvbpi gl~viof bj nbljbteovgbloa ipgvbpi otinmb~il jbt geeylbfivinvgbl,



Ol vgci l% pti~i l vg l c n iaa

Ol olvgcil %pti~ilvglc ni aa-OPN ' bt onni~~bt w ni aag~ oniaavmov fg~paow~ jbtigclolvgcil nbepai}sgvmEMN bl gv~ ~ytjoni,

V%niaa~eow tinbclg{i vmg~ nbepai} y~glc vmigtV%niaa tinipvbt-VNT', Vmi~i niaa~ptbni~~olvgcil~ olf pti~ilv vmie vb V niaa~,



OPN~ joaa glvb vsb novicbtgi~;ptbji~~gbloa btlbl% ptbji~~gbloa ,



P tbji~~gblo a OPN ~

Vmiti oti vmtii eogl vwpi~ bj ptbji~~gbloa olvgcil%pti~ilvglc niaa;Filftgvgn niaa~! smgnm mozi vmi dtbofi~v tolci bj olvgcil pti~ilvovgbl! olf oti ptbdodaw vmi eb~vgepbtvolv OPN,Eontbpmoci~ ! smgnm oti oa~b NF6( olf otivmitijbti oa~b ~y~nipvgdai vb gljinvgbl dwMGZ,D%niaa~! smgnm i}pti~~i~ -o~ D niaa tinipvbt' olf~intivi~ o ~pingjgn olvgdbfw! nol glvitloag{i vmiolvgcil smgnm dglf vb gv~ DNT olf pti~ilv gvglnbtpbtovif vb EMN GGebainyai! dyv oti glijjgngilvOPN jbt eb~v bvmit olvgcil~,



L bl %ptbji~~gblo aO lbl%ptbji~~gbloa OPN fbi~ lbv nbl~vgvyvgziaw

i}pti~~ vmi Eokbt mg~vbnbepovgdgagvw nbepai}!nao~~GG-EMN nao~~GG' ptbvigl~ tiqygtif jbtglvitonvgbl sgvm logzi V niaa~,Jgdtbdao~v~-~hgl'Vmwegn ipgvmiagoa niaa~Vmwtbgf ipgvmiagoa niaa~Cagoa niaa~-dtogl'Polntiovgn divo niaa~Zo~nyaotilfbvmiagoa niaa~



Nblnay~gbl

Olvgcil nblvogl~ ~pingjgn ~gvi~ jbt dglfglc vbvmi jbteglc ptbfynv~ dw

geeylbcilgngvw,vmi~i ~pingjgngvw g~ ~mbs~ vmilovyti bj vmi olvgcil,dw bd~itzglc vmi~i~pingjgngvw vmiti g~ o nmolni vb nyti vmifg~io~i dw ptbfynglc olvgdbfgi~ ~pingjgnoaaw

vb vmov olvgcil~,



TIJITILNI^ 8

? ,Tgnmotf,O!Vmbeo~,K!Dotdoto,b! nmo%>!olvgcil~ gl Hydw geeylbabcwifl 6!S,MJTIIEOL OLF NBEPOLW40008:>%= ?

4,Nmotai~,O!Poya Vtozit~!Eoth!nmo >%olvgcil tinbclgvgbl glGEEYLB

DGBABCW ifl :!Cotaolf ~ngilni!Liswbth!40098

?07%

??=

>,Eoai!Dtb~vbjj!Tbvm!Tbgvvnmo 3!olvgcil pti~ilvovgbl glGEEYLBABCWifl 3!Eb~dw!Liswbth!400:8 ? 69%? :4

6, N Z Tob!nmo 9%olvgcil~ glGEEYLBABCW

-Lotb~o pydag~mglc Mby~i!glfgo 40098:9%3?

9, Aigfglcit,P!Hiaao,O gfilvgjgnovgbl bj aylc nolnit sgvm mgcm ~il~gvgzgvwolf ~pingjgngvw dw dabbf vi~vglc! YH!40? 0! Jid,

antigen specificity

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