antimicrobial surfaces
TRANSCRIPT
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About us Our experience in nanotechnology
Synthesis methods
Lab for synthesis & characterization
Projects
Publications
Participants
Antibacterial surfaces Conclusions
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A materials research group that belongs to the Faculty ofScience, Universidad Autnoma de San Luis Potos.
Our current research interests are in the field of
nanotechnology. These research interests have emerged
according to the projects we have been developing in this
field.
All these interests are related to the synthesis,characterization and applications of nanoparticles.
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-NPs antibacterial properties
- Cytotoxicology of NP`s
- Colloidal dispersions
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- - Dynamic of nanoparticles(Growth and forming studies)
- - Large scale productions
methods
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Formally we started our work in the area of
nanotechnology in 2004 exploring different
methods for the synthesis of metal nanoparticles.
In particular, this project was started at therequest of one of the largest mining companies in
Mexico. In the first stage we explored different
methods of synthesis at the laboratory for four
different materials, silver, gold, zinc oxide, andmagnesium hydroxide.
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Zn
ZnO or Zn(OH)2
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Titanium oxide(TiO2)
Silver
Gold
Copper
Platinum
Zinc oxide
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Alongside with the methods of synthesis for
nanoparticles we develop. We have
implemented a methodology for nanoparticle
characterization. This sounds like somethingobvious but it is necessary to have a
documented methodology for a long term
projects or when you develop methods for
others.
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300 350 400 450 500 550 600 650
-0.4
0.0
0.4
0.8
1.2
1.6
2.0
2.4 max433 nm
Absorbanc
e
Longitud de onda (nm)
H
L
N
P
G
I
K
M
O
12 horas
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Silver
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0 50 100 150 200 250 300
9
10
11
12
13
CDB
TGA
Temperatura (C)
Peso(%)
-10
-8
-6
-4
-2
0
2
4
6
8
10
Endo
Exo
Flujodecalor(mW)
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SEM
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During the course of nanotechnology-related
projects, we have built the necessary
infrastructure for the continuation of such
projects. We have also been expanding ourinfrastructure to solve problems related to
applications that we have been explored.
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We have designed andimplemented pilot plants to
produce NPs (silver and
TiO2:Ag
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Clinical and Laboratory Standards Institute (CLSI), M2-A9 and M7-A7, 2006NCCLS, Susceptibility Testing of Mycobacteria, Nocardiae and Other Aerobic Actinomycetes, M24-A,2003
National Committee for Clinical Laboratory Standar (NCCLS), M27-A, 1997
FACTOR CONDITIONMicroorganism Overnight culture
QuantificationSpectrometric, bacteria 620 nm
and fungus 530 nm, 0.5
McFarland
Culture media
Bacteria grown in Mueller
Hinton Broth and fungus grown
in RPMI
Endpoints
Determination of Minimum
Bactericidal Concentration
(MBC)
All experiments in triplicates
http://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.htmlhttp://www.accugenlabs.com/mic.html -
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b) 50 L Nanoparticle d)50 L microorganism
a) 50 L MH
BLACK
MICRODILUTION PLATE
3 4 5 6 7 9 10 11 12821
GREY
WHITE
BROWN
c)Dilutions
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MBC: Minimum Bactericidal Concentration test
MFC: Minimum Fungicidal Concentration test
PC
0.105 mg/ mL
0.21 mg/ mL
0.42 mg/ mL6.25 mg/ mL 12.5 mg/ mL
25 mg/ mL
MFCMBC
MBC and MFC are the lowest concentrtion of nanoparticles that kills 99.9% of the bacteria or fungi.
Clinical and Laboratory Standards Institute (CLSI), M2-A9 and M7-A7, 2006NCCLS, Susceptibility Testing of Mycobacteria, Nocardiae and Other Aerobic Actinomycetes, M24-A,2003National Committee for Clinical Laboratory Standar (NCCLS), M27-A, 1997
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S.aureusMRSAE.coliP.aeruginosaA.baumanii
M.smegmatisB.subtilisC.albicans
Minimum Bactericidal Concentration (MBC)
10m L
MBC
MIC
http://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.htmlhttp://www.accugenlabs.com/zone-of-inhibition-kirby-bauer.html -
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This is the disc diffusion method (ZOI,Kirby Bauer)Used to demonstrate activity / potency
of antimicrobials or antibiotics by
measuring the zone of inhibition against
specified microorganisms. The test is
applicable for materials treated with an
antimicrobial agent that leaches out of
the material.
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In these last years we have participated with
different companies trying to implement
applications based on nanotechnology
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Previousprojects
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Working with industries in applied research is
not easy
They have different rhythm of work
They do not want to deviate from the originalobjectives
They are not interested in publishing results
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Ceramics WC units, tiles and joint fillers for tiles
Plastics
Paints
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Synthesis methods for low cost materials
Scaling up
Aging/stabilization of nanoparticles
oxidation and/or fragmen
tation Environmental implications of nanoparticles
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Bio assays
Antimicrobial
Cytotoxicity
Antimicrobial mechanism ofnanoparticles (metallic)
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Biofilm inhibition
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The ceramic industry in Mexico is a very
important sector and is currently seeking for
innovative products.
Especially they are looking for ceramicsurfaces with different functionalities
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Sanitarios Lamosa
is a company dedicated to the design, manufacturingand commercialization of ceramic bathroom
fittings, oriented on the residential and institutional
use markets.
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Explorative project with a large Mexican paint
maker company:
Evaluating commercial additives
Adapting and validating microbiological assays
for paints
Testing inorganic additives (nanoparticles) Designing organic/inorganic additives
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Explorative project with a large Mexican paint
maker company:
Evaluating commercial additives Adapting and validating microbiological assays
for paints
Testing inorganic additives (nanoparticles) Designing organic/inorganic additives
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Sntesis de lasnanopartculas
Mtodo dereduccin
Caracterizacin
DRX, MET,DDL, UV-Vis Pruebas
Bactericidas
Mtodo demicrodilucin
en placa
Elaboracin delas pinturas
Conincorporacin de Nps
PruebasBactericidas
Protocolo delas placaspetrifilm 3M Pruebas
colorimtricas
Desviacindel color(Espacio decolorCIEL*a*b*)
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Pintura NanopartculasPintura conefecto
bacteriosttico
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a)
b)
c)
d)
e)
f)
Resultados de placa petrifilm de un muestreo sobre superficies: a), b), c), d) es el
recuento de bacterias; a) mesa y b) pared de cafetera, c) piso y d) lavabo de un
bao, e) y f) corresponde al recuento de hongos del piso y el lavabo
respectivamente.
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Resultados de concentracin inhibitoria mnima de nanopartculas de
compsitos TiO2@Ag.
Concentracin inhibitoria mnima (mg mL-1)Bacteria
Muestra
S. aureus (R) E. coli
Concentracin del
compsito
Concentracin de
Ag en el compsito
Concentracin del
compsito
Concentracin de
Ag en el compsito
1_1 ----* No ----* No
2_2 ----* No ----* NoNanopartculas de Ag No 16.67 No 13.02
M2_ 1, 10:1 333.33 129.10 33.10 354.17 166.15 35.16
MS_1@Ag 2, 10:1 375.00 136.93 28.12 395.83 173.59 29.68
M!, 25:1 250.00 0.0000 1.250 135.42 61.45 0.68
M2 2,2 5:1 270.00 122.90 1.080 208.33 64.55 0.83
M1 14 50:1 400.00 136.93 1.40 333.33 129.10 1.13
M 2 50:1 416.67 129.10 0.86 375.00 136.93 0.86
M 1 10:1 208.33
64.55 20.68 187.50
68.47 18.61M 2 10:1 229.17 51.03 19.25 187.50 68.47 15.75
M 14 25:1 291.67 102.06 1.46 166.67 64.55 0.83
M 2 25:1 291.67 102.06 1.46 270.83 122.90 1.35
M 14 50:1 416.67 129.10 1.42 458.33 102.06 1.56
M 2 50:1 416.67 129.10 1.29 458.33 102.06 1.42
datos para cada bacteria: CIM promedio del compsito (mg/mL) y la desviacin estndar (primeracolumna) y concentracin de Ag en el compsito (mg/mL) (segunda columna).
* En estas muestras no se encontr actividad bactericida a las concentraciones experimentadas.
Pruebas bactericidas sobre superficies de pintura
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Pruebas bactericidas sobre superficies de pintura
Muestra Efectividad (%)Pintura formulada (sin NP2) 64.48 7.61Pintura formulada (Sin Np2) 67.56 5.67
Pintura + Nanopartculas de Ag 66.02 2.66Pintura + M 1 10:1 93.44 1.72Pintura + M 125:1 99.11 0.84
n = 6
Resultados de pruebas bactericidas sobre superficies pintadas, utilizando
placas Petrifilm.
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ts
(4) Centro de Investigacin en Quimica Aplicada, Mxico
(5) Centro de Investigacin en Materiales Avanzados, S.C., Mxico
(6) SO.F.TER S.p.A., Italy
(7) Universidad Autnoma de San Luis Potosi, Mxico
(8) SO.VE.RE. S.p.A., Italy
(9) Owens Corning Mexico S.de R.L.de C.V., Mxico
(10) Owens Corning Fiberglas A.S. Ltda, Brazil
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Proceso de incorporacin de
nanopartculas en la matriz polimrica;
47.62 g/g (microgramos de
nanopartculas de plata por gramo de
poliestireno =0.0048% en peso
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Proceso de extrusin y peletizado del
nanocompsito; a) perfil de temperatura de
extrusin
Probetas de evaluacin para pruebas
mecnicas y antimicrobianas
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UFC %Inhibicin R Confiabilidad
OM07 (Testigo) 4.27E+06
OM08 6.67E+04 98.4% 1.81 0.02
BF09 9.33E+04 97.3% 1.58 0.01
BF10 3.33E+04 99.2% 2.11 0.01
BF11 0.00E+00 100% --- ---
R: Reduccin logartmica, UFC: Unidades Formadoras de Colonias
NOTA:
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We are still at the learning stage
Conventional Industries (cement, plastics, paints, textiles manufacturers)
are demanding application based in nanotechnology
In Mexico the nanotechnology is a field of opportunities