ANTIVIRAL DRUGS

GASCON, ANGELICA G.LARGADO, JESSICA C.LEUTERIO, RAMON E. SALINAS, KRIZZELLE ALLIZZA S.SUMELDAN, JODEN OLIVER

ZANAMIVIR

ZANAMIVIR

Generic Name:Zanamivir

Brand Name/S: :Relenza

Company:

GlaxoSmithKline

ZANAMIVIR

DESCRIPTION

ZANAMIVIRZanamivir is used in the treatment of the infection caused by the flu virus (influenza A and influenza B). This medicine may also be used to prevent and treat swine influenza A.DESCRIPTION

ZANAMIVIR

Zanamivir may reduce flu symptoms (weakness, headache, fever, cough, runny or stuffy nose, and sore throat) by 1 to 1.5 days.

DESCRIPTION

ZANAMIVIR

Zanamivir may not be for you if you are severely sick or have a breathing problem (e.g., asthma or chronic obstructive pulmonary disease). DESCRIPTION

ZANAMIVIR

PREPARATION

ZANAMIVIR

PREPARATION

Usual Adult Dose for Influenza•10 mg (2 inhalations) inhaled orally twice a day (12 hours apart) for 5days

ZANAMIVIR

PREPARATION

Usual Adult Dose for Influenza Prophylaxis•10 mg (2 inhalations) inhaled orally once a day

ZANAMIVIR

MECHANISM OF ACTION

ZANAMIVIR

MECHANISM OF ACTION

The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.

ZANAMIVIR

MECHANISM OF ACTION

By binding and inhibiting the neuraminidase protein, the drug renders the influenza virus unable to escape its host cell and infect others.

ZANAMIVIR

ZANAMIVIR

TARGET VIRUSES

ZANAMIVIR

TARGET VIRUSES

Influenza A Virus•causes influenza in birds and some mammals•cause severe disease both in domestic poultry and, rarely, in humans•transmitted from wild aquatic birds to domestic poultry

ZANAMIVIR

TARGET VIRUSES

Influenza B Virus•infect humans and seals giving them influenza•evolve slower than A viruses•mutates enough that lasting immunity is not possible

ZANAMIVIR

UPDATES

ZANAMIVIR

UPDATES

FDA: Termination of Declarations of Emergency Justifying Emergency Use Authorization (EUA) of Certain Antiviral Drugs - Zanamivir, Oseltamivir Phosphate, and Peramivir

ZANAMIVIR

UPDATES

ROCKVILLE, Md., June 23, 2010--The FDA has posted on its web site letters that announce the termination of  declarations for the emergency use antiviral drugs Zanamivir, Oseltamivir Phosphate, etc

ZANAMIVIR

UPDATES

The declarations described will terminate when the Public Health Emergency determination for 2009 H1N1 influenza expires on June 23, 2010.

FAMVIR

FAMVIRGENERIC NAME:

FAMCICLOVIRBRAND NAME/S:

U.S. :Famvir®

Canadian:Apo-

Famciclovir®CO FamciclovirFamvir®PMS FamciclovirSandoz-

Famciclovir 

FAMVIR

DESCRIPTION

FAMVIRFamvir (famciclovir) is an antiviral drug that slows the growth and spread of the herpes virus so that the body can fight off the infection.

DESCRIPTION

FAMVIRFamvir is used to treat infections caused by herpes viruses, including genital herpes, cold sores, and shingles.

DESCRIPTION

FAMVIRFAMVIR for Cold Sores are white, oval, film-coated tablets with "FV500" on one side.Each carton contains 3 tablets in a blister packwith 'FAMVIR famciclovir 500mg printed on the foil backing

DESCRIPTION

FAMVIR

PREPARATIONS

FAMVIRTablets: 125, 250, and 500 mg storage: famciclovir should be stored at room temperature, 15-30 C (59-86 F).

PREPARATIONS

FAMVIRDOSING: may be taken with or without food. The recommended doses are:•Recurrent genital herpes: 1,000 mg every 12 hours for one day.•Recurrent cold sores: 1,500 mg as a single dosePREPARATIONS

FAMVIR•Suppression of recurrent genital herpes: 250 mg twice daily.•Shingles: 500 mg every 8 hours for 7 days.•HIV-infected patients (cold sores or genital herpes): 500 mg twice daily for 7 days.

PREPARATIONS

FAMVIR

MECHANISM OF ACTION

FAMVIR

MECHANISM OF ACTION

Famciclovir undergoes rapid biotransformation to the active antiviral compound penciclovir, which has inhibitory activity against herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) and varicella zoster virus (VZV).

FAMVIR

MECHANISM OF ACTION

In cells infected with HSV-1, HSV-2 or VZV, viral thymidine kinase phosphorylates penciclovir to a monophosphate form that, in turn, is converted to penciclovir triphosphate by cellular kinases

FAMVIR

MECHANISM OF ACTION

In vitro studies demonstrate that penciclovir triphosphate inhibits HSV-2 DNA polymerase competitively with deoxyguanosine triphosphate. Consequently, herpes viral DNA synthesis and, therefore, replication are selectively inhibited.

FAMVIR

MECHANISM OF ACTION

Penciclovir triphosphate has an intracellular half-life of 10 hours in HSV-1-, 20 hours in HSV-2-and 7 hours in VZV-infected cells grown in culture. However, the clinical significance of the intracellular half-life is unknown.

FAMVIR

MECHANISM OF ACTION

FAMVIR

TARGET VIRUSES

FAMVIR

Herpes simplex virus 1 (HSV-1)-oral sores•causes sores around the mouth and lips •sometimes called fever blisters or cold sores.

TARGET VIRUSES

FAMVIRHerpes simplex virus 2 (HSV-2)•genital sores•sores around the genitals or rectum•Although HSV-2 sores may occur in other locations, these sores usually are found below the waist.

TARGET VIRUSES

FAMVIR

TARGET VIRUSES

FAMVIR

TARGET VIRUSES

FAMVIR

TARGET VIRUSES

FAMVIRVaricella Zoster Virus (VZV)•chickenpox virus•varicella virus•zoster virus• human herpes virus type 3 (HHV-3).

TARGET VIRUSES

FAMVIR•causes chickenpox and herpes zoster (shingles).•Chickenpox follows initial exposure to the virus and is typically relatively mild, and self-limiting with a characteristic exanthem, but can become disseminated.TARGET VIRUSES

FAMVIR

TARGET VIRUSES