aortic bicuspid valve in flight crew: case-reports and aeromedical fitness
DESCRIPTION
Aortic Bicuspid Valve in Flight Crew: Case-Reports and Aeromedical Fitness. Med Maj DELRUE Centre for Aviation Medicine Brussels Belgium. Bicuspid Aortic Valve. Most common cardiac defect Not only the valve but the whole aortic root 1 to 2 % of the population Sex ratio 4 men/1 woman. - PowerPoint PPT PresentationTRANSCRIPT
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Aortic Bicuspid Valve in Flight Crew: Case-Reports and
Aeromedical Fitness
Med Maj DELRUE
Centre for Aviation Medicine
Brussels
Belgium
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Bicuspid Aortic Valve
• Most common cardiac defect
• Not only the valve but the whole aortic root
• 1 to 2 % of the population
• Sex ratio 4 men/1 woman
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Bicuspid Aortic Valve
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Tricuspid
Bicuspid
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Pathogenesis
• Defect fibrillin-1
• Hereditary? : autosomal dominant with reduce penetrance
• screening of first degree relatives
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Type of Bicuspid Aortic Valve
• Prof Sievers (Luebeck Germany)
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Type of Bicuspid Aortic Valve
• Prof Sievers (Luebeck Germany)
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Type 1 L/R
A B
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RISKS of Bicuspid Ao Valve
• Serious complications 33 %
• Responsible for more complications and death than all others cardiac malformations– Valvular stenosis– Regurgitation– Endocarditis– Dilation and dissection Aortic Root (X9)
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Associations
- 50 % of young people with normal bicuspid functioning valve have aortic dilation.
- coarctation of the aorta (50-80%)- septum anomalies- Coronary anomalies- More cerebral aneurysms ?
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Aortic Dilation and Bicuspid Aortic Valve
• Ascending Aorta :
D(mm) =31+0.16* age (years)
Aneurysm
40 mm 20-year-old
45 mm 40 year-old
50 mm 60 year-old
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Follow-up
• Annual transthoracic of transesophageal echocardiography (valve function)
• Annual MRI (or CT angiography/aortic protocol) if >40 mm or above age-related normal range
(6 months if rapid progression)
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Ct scan
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Surgery Repair
• No valvular indication
• a. max diam >= 50 mm
• b. rapid growth progession of >= 0.5 cm/year
• b. maximum aortic cross-sectional area/body height >= 10 cm2/m
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Surgery Repair
• If valvular indication
• Max diameter >=45 mm
• Max aortic cross-sectional area/body >= 8-9 cm2/m
• More Attention if pregnancy, sudden death or aortic dissection in 1st degree relative
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Screening
• Auscultation +- 60 % Aortic regurgitation
• 16% of severe not diagnostiqued
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Screening?
• 2278 asymptomatic competitive Italian athletes (Age 31+- 11 years) : echocardiography
• 58 (2,5%) BAV• Only 9 normal function• 45 Aortic regurgitation (14 mild, 25 moderate, 8
severe)• Stenosis 2• Aortic root > nl• 15 disqualified for sport
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Case Report 1
• Jan 2013 Military Pilot applicant Male 18 year• Sclerosis Aortic Valve• Aortic Bicuspid valve• Aortic Root dilatation 37 mm (nl 33.8 mm)
• Military Pilot Applicants : systematic echography• UNFIT
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• Classe 1 civilian ? EASA rules (European Aviation Safety Agency)
• May be assessed as fit if no other cardiac or aortic abnomaly
• Here : proposal FIT with annual cardiologic review
(outcome?) licensing autority
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Case Report 2
• Military ATC male 53 years• 2002 : aortic murmur detected
: echography : Bicuspid Valve + calcifications no dilation aorta + Aortic regurgitation ¼
• Follow up every year echography• 2011 : dyspnea (stairs) progression of sclerosis
valve (0.9 cm2) Aortic replacement Ross procedure (pulmonary autograft)
• 6 months unfit• FIT with Annual cardiologic review
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Case report 3
• 41 year old helicopter pilot Federal Police• 1990 : military heli applicants no echography• 2001 : Aortic murmur : echography Aortic
Bicuspid Valve + dilation Ao Root 41 mm• Aorta Regurgitation 2/4 • Fit with 6 months cardiologic review• 2005 Aortic Root : 46 mm CT scan• 2010 48.5 mm Classe 1 OML(multicrew) SIC
Cardiologic evaluation 6 months• 2011 51 mm unfit Classe 1
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Bentall
• video
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Read More
• Etz, Misfefd and al. Indication for Surgical Repair in Patients with Bicuspid Aortic Valve and Ascending Aortic Ectasia. Cardiol Res Pract 2012; 313879.
• Fedak, Verma and Al. Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve. Circulation 2002; 106: 900-904.