applications in ophthalmology - optotune.com · compact phoropter-like module oct perimeter...
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Applications in Ophthalmology
July 2017
Dr. David Leuenberger, Business Development Manager
Bernstrasse 388 | CH-8953 Dietikon | SwitzerlandPhone +41 58 856 3011 | www.optotune.com | [email protected]
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1
Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
Progressive lens emulation fitting glass
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Optotune on a page
2
70 employees
25 sales partners in 30 countries
Founded 2008
Leader in tunable optics
HQ located in Zurich, Switzerland
Privately owned
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Focus tunable lenses
Optotune provides three core product lines
3
Laser speckle reducers Beam steering devices
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Expansion of product portfolio over the years
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Our vision: Enable optical innovations
5
Enables product innovation
• Compact & fast autofocus
• 3D laser processing
• Laser-based cinema
By delivering key components
• Tunable lenses
• Laser speckle reducers
• Beam steering devices
Based on platform technologies
• Membranes & liquids
• Electroactive polymers
• Reluctance force actuators
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Expertise in house from R&D to production
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Optotune’s market focus
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High-resolution, speckle-free projections
Ultra-compact solution with no mechanics
Low power consumption
Axial focusing over several 100um within milliseconds
Backward compatibility with several types of microscopes
Speckle-free laser illumination
Fast control of Z-axis
Compact, reliable design with less mechanics
Easy to integrate
Compensation of visual defects
Continuous adjustment in real-time
+/- 20 diopters spherical, +/- 10 diopters cylindrical
Focus within milliseconds
Working distances from infinity to 50mm
Maximal flexibility
What is your application?
Laser projection Laser processingMachine vision
MicroscopyMedical Custom design
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Key medical application
Microscopy OCT Handheld spectroscopy
Applications Confocal microscopy
2-Photon microscopy
Light-sheet microscopy
Eye OCT
Tissue OCT
Raman spectroscopy
Valueproposition
3D imaging
Fast tuning
Switch between retinaand cornea.
Higher lateral resolution
Increase signal strength faster, more accurate
measurement
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Key medical application
Endoscopy Ophthalmology Dental cameras
Applications Rigid endoscopy Subjective refractivemeasurement (Phoropter)
CAD/CAM systems
Valueproposition
Focus-on-demand
Auto-focus
Compact size (wearable)
Quicker measurement
Cost effective
Higher image quality (speckle-free)
Auto-focus
Image stabilization
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Optotune’s electrically focus tunable lenses
111111
EL-10-30-TC EL-10-30-C(i) EL-10-42-OF EL-16-40-TC-5D EL-16-40-TC-20D
Focal power range*
8 … 22 Dpt -1.5 … +3.5 Dpt -2 … +2 Dpt -2 … +3 Dpt -10 … +10 Dpt
Clear aperture 10mm 10mm 10mm 16mm 16mm
Outer diameter 30mm 30mm 42mm 40mm 40mm
Wavefront qualityRMS @525nm*****
<0.25 / 0.5 <0.15 / 0.25 <0.15 I: <0.15/ 0.5 II <0.25 / 0.5
I: <0.25 / 2.5 II: <0.5 / 2.5
Absolute focal power accuracy
<0.15 dpt < 0.1 dpt 0.008 dpt(temp. contr.)
< 0.1 dpt < 0.1 dpt
Built-in sensors None Temperature Temp./Optical feedback
Temp./Opticalfeedback
Temp./Opticalfeedback
Applications MVOCT
MVMicroscopy
Laser marking MV/MicroscopyOphthalmology
MV/MicroscopyOphthalmology
* Depends on selected optical fluid ** vertical / horizontal optical axis *** class I: high-mag, microscopyclass II: standard grade
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Focus tunable polymer lenses are reliable
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Test Test conditions Status
Mechanical cycling
40 million full-range cycles (0 to 300 mA rectangular, at 10 Hz) 5 billion sinusoidal cycles at resonant frequency
Passed
High temperature test
85±2°C; rel. hum. <6% for 168 hours, non-operational
Passed
Temperature cycling test
-40°C / +85°C for 30 min each, 3 min transition time, 100 cycles
Passed
Damp heat cycling test
25°C / 55°C at 90-100% relative humidity, 3 hour transition time, 24h per cycle (9h plus transition time each), 18 cycles
Passed
Shock test: 800g for 1ms duration, 5 pulses in each direction (30 pulses in total)
Passed
Solar radiation test:
1120 W per m2 (IEC 60068-2-5), 8 h irradiation & 16 h darkness, 10 cycles
Passed
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Optotune’s LSR is available in several standards
131313
LSR-5-17 LSR-5-17-E LSR-10-22 LSR-10-22-E
Aperture 5 mm 5 mm 10 mm 10 mm
Size (Ø or L x H) 17mm x 3.8mm 17mm x 3.8mm 22mm x 3.8mm 22mm x 3.8mm
Standard diffuser angles* 6°, 12°, 17°, 24° 6°, 12°, 17°, 24°
Resonant frequency 300 Hz 300 Hz 180 Hz 180 Hz
Oscillation amplitude 300 um 300 um 400 um 400 um
Electronics No Yes, not certified No Yes, not certified
* A variety of circular and elliptical diffusion angles available upon request
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New generation of ultra-thin steel LSRs
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Pico-projector
Cinema-projector
HUD(Planned)
Diffuser [mm] 6.5x4.7 18.5x18.5 53x23
Aperture [mm] 5.5x4 17x17 50x20
Size [mm] 7x14x2 39x39x5 40x70x5
Oscillation 1D 1D 2D
Amplitude [um] 500 1000 1000
Frequency [Hz] 400 130 >60
Status Alpha Series In Production Planned
• All-in-one platform for easy handling
• Can be designed more compact for OEMs
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Working Principle based on Membrane and Fluid
Membrane
Fluid
Lensshaper
Videos available on www.optotune.com
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-5
0
5
10
15
20
25
-300 -250 -200 -150 -100 -50 0 50 100 150 200 250 300
Op
tic
al
po
we
r [d
iop
ters
]
Current [mA]
EL-10-30-VIS-LD
EL-10-30-C-VIS-LD
EL-10-30-C-VIS-LD-MV (-150mm offset lens)
EL-10-42-OF (-150mm offset lens)
EL-16-40-TC-VIS-6D
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The focal power (D = 1/f ) of Optotune’s lenses is controlled by current
Note: This curve varies from lens to lens. However, it is reproducible once calibrated
LP
MV
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Currently three optical materials available
High refraction liquid
Medium refraction liquid
Low dispersion liquid
Refractive index (nD @ 589.3nm)
1.56 1.38 1.30
Abbe number V 32 70 100
Transmission range (>90%)
330 – 1600nm 350 – 1600nm 240 – 2200nm
Operating temperature range
-5° - 85°C -20° - 120°C -20° - 85°C
Toxicity None None None
Color stability (yellowing)
None None None
Monochromatic applications with
large tuning range
Polychromatic imaging, laser
processing
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Illumination systems based on
lasers or LEDs
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Membrane & Fluid is Transparent >90% from 240 – 2200nm
Lens schematic
18
0
10
20
30
40
50
60
70
80
90
100
200 400 600 800 1000 1200 1400 1600 1800 2000 2200 2400 2600
Tran
smis
sio
n [%
]
Wavelength [nm]
Lenses with LD material
Lenses with HR material
Transmission of the EL-10-30 assuming 100% transparent cover glasses.
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Response time of ~10ms
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Oscillation mode fast image stacking
Low-pass filtered:
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Tuning range and wavefront quality
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0.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
0.40
0.45
0.50
0.55
-5 0 5 10 15 20 25
RM
S w
ave
fro
nt
err
or
[λ]
Focal power [dpt]
EL-6-18-VIS-LD, Optical axishorizontal
EL-6-18-VIS-LD, Optical axisvertical
EL-10-30-C-VIS-LD,Optical axis horizontal
EL-10-30-C-VIS-LD,Optical axis vertical
EL-10-30-C-VIS-LD-LP,Optical axis horizontal
EL-10-30-C-VIS-LD-LP,Optical axis vertical
Gravity inducedcoma < 0.2
0.05 < 0.1
Measured at 525 nm and 80% of clear aperture, defocus, tilt & sphere excluded.
Precision optics quality can be achieved
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Polymer lenses can withstand high power!
• Only 0.1% absorption in VIS & NIR range
• The following tests were succesful with EL-10-42-OF (LD fluid, high-power coatings)
• Customized cover glasses are available
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Open loop operation with temp. calibration
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Command sent to lens driver
to set f=125mm
Lens calibration table and
temperature read by lens
driver
Lens calibration curve stored on
lens internal memory
Lens characterization
f vs T vs I
Temperature compensated
control current to adjust lens to f=125mm
“I need a lens with
f=125mm”
Set f=125mm in lens driver software
EL-10-30-C including NXP temperature sensor SE97B with internal
memory
f=125mm
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Optotune has developed a platform for 2D beam-steering
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0
10
20
30
40
50
60
0 2.5 5 7.5 10 12.5 15
Max o
ptical tilt (
°half a
ngle
)
Beam diameter (mm)
TP-12-16
MR-15-30
2D MEMS mirror
Galvo mirros
MR-7-10
MR-5-5
Unique in terms
of mirror size and tilt angle
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Optotune on-going beam-steering product development
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MR-15-30-(‘Scuti’)
MR-7-10-(‘Scutini’)
MR-5-5 (‘Mizar’)
Tunable prism (TP-12-16)
Primary mirror/aperture size [mm]
15 7 5 12
Mechanical tilt (° half angle)
25 4 16 20
Mech. Repeatability RMS typical
30-100 rad T.B.D 1.7 mrad Depends on actuator
Footprint 30x19 10x10x2.7 5x5x4 16x12
Position feedback yes yes yes N/A
Status Engineering samples available
Alpha proto Alpha proto Engineering samples available
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Trends:
• Combine different functionalities into one single compact instrument
- Precision Laser System with integrated 3D OCT
(e.g. AMO CATALYS® )
- Corneal topographer + OCT (e.g. Zeiss Atlas 9000)
- Corneal togographer + pupillometer
(e.g. TOPCON CA-200F Corneal Analyser)
- OCT + Fundus imaging by confocale laser scanning
+ eye tracking (Heidelberg Engineering)
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Trends
• Portable instruments
- Handheld refractometer by Adaptica
- Plus Optix Vision Screener
• More robust to transport, less calibration required no movable parts
• Multi-spectral devices requiring low dispersion optics (c.p. Optotune Abbe number of 100).
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Ophthalmology - How it works
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Application Optotune value proposition
IndirectOphthalmoscope
Change of magnification
Slit-lamp Autofocus of auxiliary camera
Phoropter Spherical lens+2 Stokes cylinder replaces lens wheels (compact)Fast tuning
Surgical microscope Autofocus/ superposition of real image and OCT display
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Ophthalmology - How it works
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Application Optotune value proposition
Fundus camera Autofocus
Wavefront Aberro-meter Autofocus
Perimeter Replace trial lens toadjust for eye correction
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Smaller, lighter, cheaper
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Mechanical
phoropter
Automatic
phoropter
Compact
phoropter
Phoropter
glasses
3.5 kg 600 g7 kg 200 g
DOMS PHOROSTAR 600
NIDEK RT-5100REICHERT ULTRAMATIC
A million lenses in one: Achieve +/-20 diopters with a single tunable lens
Trends
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Schematics of compact phoropter module
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Electrical
tunable
lens
2nd cylinder lens mounted on a rotationalactuator
1st cylinder lens mounted on a rotationalactuator
Casing
Front
plate
Phoropter
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Success stories - Adaptica
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Focusing on different focal planes within the eye
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Typical SD-OCT setup with added capability to switch between front and back plane of eye.
Spectral Domain
OCT configuration
OCT
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Extended scan-range
• Overcoming trade-off between lateral resolution and axial field of view.
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Trade-off between lateral resolution and axial field of view.
a) focusing optics with low NA, b) focusing optics with a high NA and c) sample focusing optics with a high NA and an extended axial
field of view due to an axial focus scan using the OptotuneEL-10-30-C
OCT
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New applications –Dynamic-focus SS-OCT
• Dynamic-focus SS-OCT system with a long axial imaging range
• Enhanced penetration depth and improved lateral resolution along the whole imaging depth
• High-resolution images of the human anterior eye chamber were demonstrated
• The developed system showed higher penetration depth than the commercial OCT systems
• Demonstrated, for the first time, the measurement of sulcus-to-sulcus distance in normal human eyes with OCT.
• The authors have a significant financial interest in Carl Zeiss Meditec, Inc. and Optovue
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J.P. Su et al, Journal of Biomedical Optics 126002-7 December 2015 • Vol. 20(12)
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Microscope-integrated intraoperative OCT
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Y. K. Tao et al., BIOMEDICAL OPTICS EXPRESS (2014), 5, (6), pp. 1877.
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Surgical guidance using iOCT feedback
• Optotune’s electrically tunable lens EL-10-30-NIR-LD allowed real-time adjustment of the OCT focal plane to maintain parfocalitywith the microscope view.
• Potential for iOCT-guided maneuvers and clinical decision-making in ophthalmic surgery
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
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Success stories - Perimeter
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ML-30-46:
• 28mm CA
• +/- 8dpt Tuning Range
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Agenda
• Company presentation
• Products & Technology
• Trends in Ophthalmology
• Applications in Ophthalmology
Compact Phoropter-like module
OCT
Perimeter
‘Fogging’ in auto refractometers
![Page 45: Applications in Ophthalmology - optotune.com · Compact Phoropter-like module OCT Perimeter ‘Fogging’ in auto refractometers Progressive lens emulation fitting glass. Optotune](https://reader031.vdocument.in/reader031/viewer/2022021902/5b92714209d3f2446f8bca28/html5/thumbnails/45.jpg)
‘Fogging’
• The Fogging allows the patient to view the target clearly and minimizes the interference with accommodation even in high astigmatism.
• The fast response from the Optotune EL is ideally suited to implement ‘fogging’.
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Typical fixation
target
NIDEK AR-1 AUTO REFRACTOMETER
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Optotune – 1 slide
Optotune AGBernstrasse 388CH-8953 DietikonSwitzerland
Phone: +41 58 856 3000 | Fax: +41 58 856 3001
www.optotune.com | [email protected]
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Lifetime test of EL-10-30
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Test Test conditions Status
Mechanical cycling
40 million full-range cycles (0 to 300 mA rectangular, at 10 Hz) 5 billion sinusoidal cycles at resonant frequency
Passed
High temperature test
85±2°C; rel. hum. <6% for 168 hours, non-operational
Passed
Temperature cycling test
-40°C / +85°C for 30 min each, 3 min transition time, 100 cycles
Passed
Damp heat cycling test
25°C / 55°C at 90-100% relative humidity, 3 hour transition time, 24h per cycle (9h plus transition time each), 18 cycles
Passed
Shock test: 800g for 1ms duration, 5 pulses in each direction (30 pulses in total)
Passed
Solar radiation test:
1120 W per m2 (IEC 60068-2-5), 8 h irradiation & 16 h darkness, 10 cycles
Passed