approch to child with bleeding
TRANSCRIPT
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Approach To Child with
Bleeding Tendency
Halima Al.Dhali98181
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Case Scenario
Parents brought a 3 year old girl to emergency room with history of bruising on her lower limbs and chest for the last 4 days. The bruises were not painful but were increasing in number every day. No active bleeding seen. Child otherwise very active and playful.
What further history you would like to obtain from parents?What else you will be searching in your examination?What investigations you will order?
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History•Patient ID ,•PRESENTING
COMPLAINT – NATURE OF BLEED Onset – Acute
bleeds >> Acquired disorder– Bleeding since birth >> Congenital disorder Site – Superficial: skin, mucosa (nasal,gingival) >> Platelet – Deep: joint, muscle >> Coagulopathy
Other types of bleed – Hematemesis,Hematuria,
Hematochezia, Melena, epistaxis
Preceding/Precipitating event - Trauma, surgery, dental procedure
Duration and frequency – bleeding that stops and recur quickly → Coagulopathy
• Associated symptoms• nausea, vomiting, headache,
weakness• postural giddiness, pallor,
fatigue, chest pain,, palpitations, joint swelling
• Review of systemsPAST MEDICAL HISTORY• Previously Diagnosed
Bleeding disorder (eg Hemophilia, ITP)
• Liver disease• Renal disease• Malignancies(leukemia,
neuroblastoma)• Infections• Connective tissue disorders
AutoimmunePrevious admissions, surgeries and blood
transfusion
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HistoryPrenatal, perinatal and postnatal Hx Postcircumcision bleeding Birth cephalohematoma Umbilical stump bleeding or delayed stump separationNutritional Hx Protein malnutrition Vitamin C deficiency, or scurvy Vitamin K deficiency >>bacterial overgrowth, celiac disease,
chronic pancreatitis, inflammatory bowel disease.Developmental Hx gross motor (to corroborate the described mechanism of injury)
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History FAMILY HISTORY
• consanguinity >> autosomal recessive inherited bleeding disorder
• Known bleeding disorder or other heritable medical disorder that may predispose to bruising (eg, Ehlers-Danlos syndrome, osteogenesis imperfecta).
• Male relatives affected (Hemophilia, X-linked Recessive trait)
• Female relatives - Menstrual and Obstetric Hx• males and females affected >>an autosomal disorder
such as von Willebrand factor deficiency• autosomal dominant traits such as hereditary
hemorrhagic telangiectasia Social Hx
• child’s behavior and the family’s methods of discipline
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Examination General appearance: dysmorphisms , built. Vital signs Growth parameters: malnutrition General examination: hydration, pallor, jaundice,
lymphadenopathy Skin :Telangiectasia, Petechiae, Purpurae, Ecchymoses,
Hematoma (size, location, pattern) Mucosae : Nasal (Epistaxis), Gingival bleeding The musculoskeletal system : Intramuscular Bleed,
HemearthrosisJoint contractures ( chronic hemearthroses) , joint hypermobility, skin laxity and bony deformity
GI system: Hepatosplenomegaly
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petechiae Pinpoint flat round red spots under the
skin surface caused by intradermal hemorrhage (bleeding into the skin)
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Purpura
Purpura is purple-colored spots and patches that occur on the skin, and in mucus me
Group of adjoining petechiae
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Ecchymoses
Isolated lesion larger than petechiae ( larger than 1cm)
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Bleeding Disorder
CoagulationFactor
•Deficiency in coagulation Factor
Blood VesselsIntegrity
•Weak vessele•Inflammation
Platelet
disorder
•Decrease number•Abnormal function
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Platelet Its called thrombocyte from
megakaryocte Life span 8- 10 days One third of them sequestered in spleen production control by thromboprotein Normal Range150-400 X 109/L Less than 150X 109/L ,
thrombocytopenia.
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Causes of Thrombocytopenia
Decrease platelet
production
Increase platelet consump
tion
Splenic Sequestrat
ion
Dilution
-Bone marrow failure-Aplastic syndrome-cyanotic congenital heart D _Infection(HIV,CMV, Episten Barr viruse-Drug(heparin-Anti-biotic –quinidine)
-Idiopathic thrombocytopenic purpura (ITP)
-Neonatal alloimmune thrombocytopenia (NAIT)-SLE-Disseminated intravascular coagulation (DIC)-Sepsis
-Increase pooling in
spleen
Hypersplenism
InfectionInflammationCongestionRed cell disordersStorage diseases
-Massive Blood transfusion
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manifestations of thrombocytopenia Petechiae Bruises or purpura Bleeding of mucous membranes:
epistaxis, gingival bleeding Acute gastrointestinal bleeding Hematuria Acute CNS hemorrhage: the rarest but
MOST FEARED consequence of low platelets
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Degree of trauma and bleeding
Platelet Count Risk of bleeding Example
Less than 80×10^9 Primary hemostasis impaired
After Major trauma, Surgery
Less than 50×10^9 Spontaneous bleeding mostly in
Skin
Petechiae ,purpura
Less than 20×10^9 Noticeable hemorrhage
Seen in skin and mucosa
EpistaxisGingival bleeding
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Immune Thrombocytopenic (ITP)
isolated thrombocytopenia with normal bone marrow and in the absence of other causes of thrombocytopenia.
Usually follow an acute viral infection IgG,IgM that bind platelet membrane,
result in Fc receptor mediated splenic destruction
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signs, symptoms, and precipitating factors
Abrupt onset, Purpura Epistaxis Bruising tendency Gingival bleeding Recent live virus immunization Recent viral illness mainly after1-4 week Normal RBC,WBC count Sever type of thrombocytopenia Adenopathy or hepatosplenomegaly is unusual
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Diagnosis Usually based on clinical presentation Platelet Count low Atypical finding-Do Bone marrow
Examination( Increase megakaryocyte, Normal Erythroid,myloid element).
In ITP shows increased megakaryocytes and normal erythroid and amyloid elements.
(WBC,RBC,Hb) Normal Normal pt aptt time
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Our patient:Hb: 11g/dLWBC 5x109/L with normal differentialPlatelets 4 x109/LPT and APTT = normal
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Treatment Optimal treatment is Controversial 80% of children will have spontaneous
resolution(few weeks). child with mild
bleeding(bruising,petechia) no treatment required.
Severe and moderate bleeding with platelet count less 10,000mm
Treatment option
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Prednisone for 2 weeks IVIG for(1-2 Days)expensive,
Platelet transfusion: Actively bleeding patients with thrombocytopenia \central nervous system bleeding
Splenectomy (life threating condition/not responding to other medication)
Decrease clearance of sensitized platelet
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Coagulation Disorder Hemophilia
Von Willebrand Disease
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Hemophilia an inherited (genetic) disorder
blood doesn't clot normally because it lacks sufficient blood-clotting proteins (clotting factors).
you may bleed for a longer time after an injury than you would if your blood clotted normally.
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Types of hemophilia Types Hemophilia A Hemophilia
Binheritance X-linked X-linked
Factor Deficiency factor8 factor9
Bleeding site Muscle, joints ,surgical
Muscle, joints ,surgical
Prothrombin time Normal Normal
Activated partial thromboplastin time
prolong prolong
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Hemophilia A
Hemophilia B
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Clinical Manifestation Bleeding In soft Tissue ,GI ,Hip ,Joint,
elbow , and ankle Joint. Spontaneous joint bleeding occur when
child begin to walk Intracranial hemorrhage
uncommon(important cause of death) Petechiae usually do not occur in
patients with hemophilia
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Musculoskeletal (joints) - Tingling, cracking, warmth, pain, stiffness, refusal to use the joint (young children)
Central nervous system (CNS) - Headache, stiff neck, vomiting, lethargy, irritability, spinal cord syndromes
Gastrointestinal (GI) - Hematemesis, melena, frank red blood per rectum, abdominal pain
Genitourinary - Hematuria, renal colic, post-circumcision bleeding
Other - Epistaxis, oral mucosal hemorrhage, hemoptysis, dyspnea (hematoma leading to airway obstruction)
contusions, excessive bleeding with routine dental procedures
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Severity, Factor Activity, and Hemorrhage Type
Classification Factor Activity% Cause of hemorrhage
Mild 5-40% Major trauma, surgery
Moderate 1-5% Mild to moderate trauma
Severe Spontaneous
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Diagnosis
CBC(normal platelet count)
Coagulation Study:(aPTT) is prolonged,the bleeding time and prothrombin time are normal Factor 8,9 assay:levels are compared
with a normal pooled-plasma standard
Mixing study
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Mixing Study
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Management
Prevention of trauma is important Should avoid Aspirin and other NSAID Iv infusion whenever there is any bleeding
recombinant FVIII concentrate for haemophilia A recombinant FIX concentrate for haemophilia B
Highly purified, virally inactivated plasma-derived products should be used if recombinant products are unavailable
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Von Willebrand Disease VWF found in( Endothelia cell,
Megakaryocyte). Two Rules :Carrier Molecule for factor 8 Promote platelet Adhesion An Inherited bleeding disorder Women are worse affected than men 3types ( 1,2,3) Either Qualitative or Quantitative
Disorder
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Type1 Type2 Type3Quantitative partial Deficiency
70-80%-Mild clinical
symptoms-Autosomal
Dominant
Functional abnormality
15-20% -Mild-Moderate
-Autosomal Recessive/Dominan
t -4 subtypes
(2A ,2B,2M,2N)
Complete Deficiency
Most Sever Type -Autosomal
Recessive
-Similar to hemophilia A
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Manifestations Wide variation in Clinical Manifestation (even in the
same family).
Many children are asymptomatic .
Increased or easy bruising
Recurrent Epistaxis.
Post-operative bleeding( Tonsillectomy –dental Extraction )
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Laboratory finding Factor 8 levels are low. The APTT may be prolonged . VWF levels are low . Platelet count is normal (except in type
2B)
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Management DDAVP (Desmopressin Acetate) -synthetic form of vasopressinStimulate release of VWF from cells after 30min (for type1) . Purified plasma-derived
concentrates of vWF/FVIII are used for treatment of bleeds and for surgical prophylaxis when DDAVP is ineffective or contraindicated
Prophylactic (antifibronolytics ), before dental Extraction .
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A five-year-old child who is not clinically ill but presents with moderate mucocutaneous purpura in the wake of a viral infection
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A male infant who is starting to walk and presents with a painful swollen joint after a fall
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?