are your medications on target? benefits of pgxone™...
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Benefits of PGxOne™ Plus
• Recommendations for drugs acrossmultiple therapeutic areas, includingcardiology, pain, psychiatry andoncology
• Life Time Utility
• Easy sample collection:buccal swab, mouth wash,saliva or blood.
• Clear, color-coded, concise reporting
T: 305-439-0085
240 Crandon Blvd. Ste. 230Key Biscayne, Florida 33149
Are Your Medications On Target?
Ask Your Physician About PGxOne™ Plus Testing.
A pharmacogenomics test that determine which medication is most compatible based
on a individual’s genetic makeup
Learn about PGxOneTM Plus testing www.gentoxmedicalservices.com
2016 Technology Innovation Award
2016 Trailblazer Award
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PGxOneTM Plus Report for Smith, JohnLaboratory Director: Dr. James Dermody CLIS ID: 0005783 CLIA ID: 31D2038676 Page 2 of 20
ActionDrug Impacted
Clinical InterpretationGene
GenotypePhenotypePatient Specific Genotype Results
and Comprehensive Drug Information for
Smith, John
ICD-9: 272.4 OTHER AND UNSPECIFIED HYPERLIPIDEMIA;276.7 HYPERPOTASSEMIA;410.10 ACUTE MYOCARDIAL INFARCTION OF OTHER
ANTERIOR WALL EPISODE OF CARE UNSPECIFIED;433.10 OCCLUSION AND STENOSIS OF CAROTID ARTERY WITHOUT CEREBRAL
INFARCTION;434.91 CEREBRAL ARTERY OCCLUSION UNSPECIFIED WITH CEREBRAL INFARCTION;790.29 OTHER ABNORMAL GLUCOSE
ActionDrug Impacted
Clinical InterpretationGene
GenotypePhenotype
Antiplatelets:
Clopidogrel (Plavix®)CONSIDER
ALTERNATIVES
CYP2C19*1/*2
Intermediate Metabolizer
Beta Blockers:
Metoprolol (Lopressor®)CONSIDER
ALTERNATIVES
(e.g., bisoprolol,
carvedilol)
OR
DECREASE DOSE
by 50% due to heart
failure caused by the
decreased drug
cardioselectivity
CYP2D6
*1/*4xN
Intermediate Metabolizer
Statins:Simvastatin (Zocor®)
CONSIDER
ALTERNATIVES
OR
DECREASE DOSE
to 40mg daily
SLCO1B1*1/*5
Intermediate Activity
Statins:Atorvastatin (Lipitor®),
Pitavastatin (Livalo®),
Pravastatin (Pravachol®),
Rosuvastatin (Crestor®)
DECREASE DOSESLCO1B1
*1/*5Intermediate Activity
Anticoagulants:
Phenprocoumon
(Marcoumar®)
INCREASE DOSECYP4F2
*1/*3Intermediate Metabolizer
Selective Serotonin
Reuptake Inhibitors
(SSRIs):Fluoxetine (Prozac®),
Fluvoxamine (Luvox®),
Paroxetine (Paxil®)
USE CAUTION
due to elevated risk for
drug overdose resulting
in adverse events and
drug interaction
CYP2D6*1/*4xN
Intermediate Metabolizer
Anticoagulants:
Rivaroxaban (Xarelto®)NORMAL RESPONSE
EXPECTED
CYP3A4*1A/*1A
Normal Metabolizer
50 GenesCoverage of ~200 Genetic VariantsOver 300 Commercial Drugss
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TRADITIONAL TREATMENT PERSONALIZED MEDICINE“One Size Fits All”
Same Prescription and Standard Dose for All“Pharmacogenomics”
Individualized Drug Therapy, a More Personalized Treatment
INCREASEDOSE
DECREASEDOSE
PROCEEDwith CAUTION
CONSIDERALTERNATIVE
NORMALRESPONSEEXPECTED
Disease Diagnosis
Patient Group
What is Pharmacogenomics Testing?
Analysis of gene variants that influence how a person responds to medications.
• Reduces the need for trial-and-errortreatment planning
• Maximizes drug efficacy whileminimizing adverse drug reactions
• Highly recommended for any patients takingmultiple medications
To view a PGxOne™ Plus sample report visit gentoxmedicalservices.com
PGxOneTM Plus is a clinical pharmacogenomics test that guides physicians’ treatment decisions based on a patient’s genetic profile.
Advanced molecular diagnostics company focused on precision medicine.
To learn more about product portfolio visit
www.gentoxmedicalservices.com
Cardiovascular Test PortfolioRisk Assessment, Disease Diagnosis and Treatment for Cardiovascular Diseases
PGxOne™ Plus Pharmacogenomics Testing to Predict a Patient’s Drug Response
Oncology Test PortfolioTumor Profiling to Guide Selection of Targeted Therapies
Gentox Medical Who We Are
• Predicts patient’s response to select the right drugs
• Improve quality of life
P Right Drug
P Right Dose
P Right Time
P Right Indication