artemisina. malaria quinina cloroquina artemisina artemisina: nuevas armas contra la malaria
TRANSCRIPT
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Artemisina
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Malaria Quinina
H
O HH
N
N
MeO
Cloroquina
Artemisina
Artemisina: Nuevas armas contra la malaria
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GUERRA DEL VIETNAM (1955-1975)
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Artemisia annua Tu Youyou
Terapia combinada con artemisina (ACT)
Artemisina
Mefloquina
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Science, 2010, 330, 1355
Semisíntesis
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OZ439Roche-Medicines and Malaria Venture-Single dose-Low cost of goods-High oral bioavailability-phase IIIPNAS 2011, 108, 11, 4400
O
OOO N
O
Cl Cl
Cl
NHO
O
OH
H
OO
OMe
Artemether /Lumefantrina
Análogos
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Síntesis total
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Reacción de Shapiro
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Oxidación de Wacker-Tsuji
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Formación de oxígeno singlete