arwa`s seminar on tocos
TRANSCRIPT
ARWA AHMED ALI
MENNA ALLAH
IBRAHIM TOCOTRIENOLS
VE:TOCOTRIENOL
AND ITS ISOMERS
WHAT ARE TOCOTRIENOLS • Among the VE compounds tocotrienol exist and possess a unique structure and properties as : antioxidants , anti cancerogenic agents ...etc ( will be discussed in brief) • Tocotrienols have isomers like alpha ,beta, gamma and delta they vary according to : • the strenghth of their properties • And methyl group subistitution on the cromanal ring at ortho or para or meta positions :• Gamma tocotrienol posseses a methyl group at the ortho position and its effective in antioxidation than the other isomers and tocopherols .
TOCOTRIENOL ISOMERS CHEMICAL STRUCTURE
THE BEST SOURCES OF TOCOTRIENOLS
OILY SOURCES FOR TOCOTRIENOLS
COCONUT O IL RED PALM OIL
R ICE-BRAN O IL PALM KERNEL O IL
RED PALM OIL
TOCOTRIENOLS BEST SOURCE•annato
TOCOTRIENOLS VERSUS TOCOPHEROLS• They differ in : • 1-chemical structure • 2-bioavailability• 3-digestion and absorbtion • 4-antioxidative effect
FIRSTLY: CHEMICAL STRUCTURE TOCOTRIENOL• vhave the Unsaturated
isoprenoid sidechain possesing double bonds
vTheir chemical structure make them more potent than tocopherols in several vitro systems
TOCOPHEROL
• vhave NO double bonds but saturated phytyl tail
Less potent than tocotrienols
COMPARISON
TOCOTRIENOL
• Chiral centers of tocotrienols prsesnt at c2 where isoprenoid chain binds
• Have 2 isomers however it can have 4 geometrical isomers cis/trans at 3' and 7' positions
TOCOPHEROL
• Have 3 chiral centers • Have 8 isomers
AS SHOWN HERE
ABOUT TOCOTRIENOL ISOMERS In cardio and
neuroprotection: Alpha and gamma are more potent
than others in rats and humans
anti cancer effect (esophagus and
prostate and colon cancers )in mouse and human cancer cells in vitro and
vivo
• Due to their ability to form reactive intermediates that combines DNA beside inhibiting the formation of mutagenic peroxynitriteand nitrosamines that can react with Dna biological molecules
**alpha tocotrienols have more molecular weight than gamma ,beta and delta
SECONDELY: DIGESTION AND ABSORBTION• vTocotrienols are poorer and more inferior with regard to tissue retention than alpha tocopherol •They are haif-life in camparison with tocopherols • vTocotrienols penetrate rapidly the skin cells
THIRDLY:ANTIOXIDATIVE EFFECT • vTocotrienols are much better in antioxidation than tocopherol especially alpha tocotrienol WHY? • vDue to its property that can counteract peroxyl and alkoxyl radicals generated during lipid peroxidation so it inhibits continuel hydrogen abstraction thus it inhibits chain propagation step • vThat’s why phospholipids and plasma lipoproteins are not oxidized maintaining good functioning membrane bilayer thanks to tocotrienols role
THIRDLY: BIOAVAILABILITY• Immediately afer oral ingestion tocotrienols are low in bioavailability that’s why its recommended to have a daily intake of its tablets or powder or the oils rich in tocotrienols
• Nearly this supplements can overcome • the following demerits of tocotrienols
DEMERITS •tocotrienols v poorly
assimilated by digestion
vPoorly distributed to tissues in blood
vAre rapidly metabolized and eleminated out of the body
Low bioavailability
TOCOTRIENOLS BENEFITS
BETTER ANTIOXIDATION• More uniform distribution in the membrane –lipid bilayer
Strong disordering of the membrane lipids .Chromanal ring interacts with lipid radicals and prevent continueal oxidationIts effect is in both vivo and vitro systems
PROTEIN OXIDATION•They inhibit oxidation of protein and according to various researches gamma tocotrienols gave better results so they are the strongest inhibitors in this oxidation
ADDITIONAL BENEFITS
•vReduces alzheimer`s risk by 55% •vDecrease DNA damage •vAnti cancerogenic properties
FUNCTIONING
HAVE THE ABILITY TO SCAVENGE VARIOUS BIOLOGICALLY RELEVANT FREE RADICALS
INHIBITINH FREE RADICALS
TOCOTRIENOL DIFFICIENCY
• it can results in antherosclerosis
Due to peroxidation of LDL cholesterol
RECOMMENDED DAILY DOSE •For men 120 mg/kg of body weight the excess dosage causes increasing in liver weights,women 130 mg/kg of body weight • Excess dosage causes reduction in
uterus and ovary weights
REFRENCE :
TOCOTRIENOL THANKS
YOU