asbmb your key to success in · your key to success in biochemistry and molecular biology an...
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Your KEY to Success in Biochemistry and Molecular Biology
an Society for Biochemistry and Molecular Biology is a nonprofitd educational organization, over 12,000 members strong, and
ward to supporting you in your professional and research goals!
Members receive the following benefits:
ine Access to all ASBMB Publications—all online content from nal of Biological Chemistry, Molecular & Cellular Proteomics, andnal of Lipid Research are available, including archived articles.
e Access to ASBMB Today—our member only magazine highlightst ASBMB events, critical research in the field, and profiles outstandingtors and dynamic students.
ing Opportunities—ASBMB offers you exclusive access to our onlineDirectory. Don’t miss our Annual Meeting or Special Symposia Series.
from the Bank of America “Bank at Work” Program—throughate program, receive discount loan rates, no fee mortgages and checking accounts.
on the Hill—Become part of the Local Advocates Network: w to contact your congressional representative and successfully increased funding for your research.
and Video Updates on Society News—Find out what is reallyin the research world with ASBMB Audiophiles, our podcast series
d to Journal and Society News. ASBMB online also includes a videoea where you can see prominent investigators discuss their research.w.asbmb.org/media for the interactive experience.
onal Development Resources—looking for a new position? g for an opening? Visit our job board at www.asbmb.org/jobs.
Join Now! www.asbmb.org
ASBMB
Cell Signaling
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Cell Signaling
4R-HNEAvanti Number 870607 4-Hydroxynonenal
(4-HNE or HNE) is an α,β-unsaturated hydroxyalkenal which is produced by lipid peroxidation in cells. 4-HNE
has been hypothesized by several researchers to play a key role in cell signal transduction, in a variety of pathways
from cell cycle events to cellular adhesion.
4R-HNE dimethylacetalAvanti Number 870608
The dimethylacetal derivative is a more stable form of 4-HNE which is good for long term storage of the
compound during use. It can be easily converted to 4-HNE in the presence of acid.
References:• Chen, C.H., Budas, G.R., Churchill, E.N., Disatnik, M.H., Hurley, T.D., Mochly-Rosen, D. (2008) Activation of aldehyde dehydrogenase-2 reduces ischemic damage to the heart. Science 321:1493-1495.• Awasthi, Y.C., Yang, Y., Tiwari, N.K., Patrick, B., Sharma, A., Li, J., Awasthi, S. (2004) Regulation of 4-hydroxynonenal-mediated signaling by glutathione S-transferases. Free Rad Biol Med. 37:607-19. • Sharma, R., Brown, D., Awasthi, S., Yang, Y., Sharma, A., Patrick, B., Saini, M.K., Singh, S.P., Zimniak, P., Singh, S.V., Awasthi, Y.C. (2004) Transfection with 4-hydroxynonenal-metabolizing glutathione S-transferase isozymes leads to phenotypic transformation and immortalization of adherent cells. Eur J Biochem. 271:1690-701. • Zarkovic, N. (2003) 4-Hydroxynonenal as a bioactive marker of pathophysiological processes. Mol. Aspects Med. 24:281-291.• Zarkovic K. (2003) 4-hydroxynonenal and neurodegenerative diseases. Mol. Aspects Med. 24:293-303. • Zarkovic, N., Zarkovic, K., Schaur, R.J., Stolc, S., Schlag, G., Redl, H., Waeg, G., Borovic, S., Loncaric, I., Juric, G., Hlavka, V. (1999) 4-Hydroxynon- enal as a second messenger of free radicals and growth modifying factor. Life Sci. 65:1901-1904. • Esterbauer, H., Schaur, R.J., Zollner, H. (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Rad Biol Med. 11:81-128.