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Ascorbic Acid and Oxalate

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Copyright© 2019. Health Training Associates, LLC. All rights reserved.

(Advanced OAT Mastery Course Bonus Lecture)

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DisclaimerThe material contained within this document/presentation and subsequent support

documents for the Advanced OAT Mastery Course (AOAT) is not intended to replace the services and/or medical advice of a licensed health care practitioner, nor is it meant to encourage diagnosis and treatment of disease. It is for health education purposes only based on the clinical experiences of its authors. Health Training Associates, LLC., Kurt N.

Woeller, D.O., Tracy Tranchitella, N.D. or any of its associates and members do not accept legal responsibility for any problems arising from your personal experimentation with the health education information described herein. Any application of suggestions

set forth in the following portions of this document/presentation and other support documents of the AOAT (or other courses from Integrative Medicine Academy) is at the

reader/listener’s discretion and sole risk. As a health practitioner you are solely responsible for implementing treatment strategies for your patients or clients.

Implementation or experimentation with any supplements, herbs, dietary changes, medications, and/or lifestyle changes, etc., discussed in this course, including support

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herbs, dietary changes, etc. needs to be discussed with your (or your child’s) personal physician first.

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Ascorbic Acid and Oxalate

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Concentration Does Matter: The Beneficial and Potentially Harmful Effects of Ascorbate in Humans and Plants - Scientific Figure on ResearchGate. Available from:

https://www.researchgate.net/figure/The-different-redox-forms-and-the-degradation-of-Asc-MDA-is-formed-from-ascorbic-acid-by_fig1_320203929 [accessed 29 Dec, 2019]

L-Threonate is a metabolite of vitamin C that is currently being investigated for some

vitamin C-like properties as well as its ability to

greatly enhance mineral uptake.

L-Threonate

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“The breakdown of 60mg of (ascorbic acid) could potentially result in the formation of up to 30 mg oxalate per day.”

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…”follow-up of 11.3-11.7 years, 6,245 incident kidney stones were identified. After multivariable adjustments, total vitamin C intake

(1000mg/d) was not significantly associated with the risk of kidney stones among women but was among men.”

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February 2009. Volume 58, Issue 2, Pages 263–269

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“The rate limitation of intestinal ascorbic acid transport makes it unlikely that oral doses greater than 500mg/d will increase oxalic acid excretion and stone

risk proportionately, but intravenous administration bypasses this barrier.”

“In the setting of renal dysfunction, acute oxalate nephropathy has been reported after intravenous ascorbic acid administration.”

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“Much larger doses than this (500mg/d) have been administered therapeutically in recent years, but without any

information about the associated rate of oxalic acid excretion.”

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“We conclude that, when studied using correct procedures for sample handling, storage, and analysis, less than 0.5% of a very large

intravenous dose of ascorbic acid is recovered as urinary oxalic acid in people with normal renal function.”

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GlyoxylateGlycerate

Glycolatehydroxypyruvate

GRHPRGlyoxylate reductaseHydroxypyruvic reductaseType II Hyperoxaluria

GlycolateOxidase (GO)

B-6Glycine

LDHLactatedehydrogenase

Oxalate AscorbateArabinose

YeastFungi

AGTAlanineGlyoxylateAminoTransferaseType IHyperoxaluria

Ethylene glycol

Oxalate Metabolism

hydroxyproline

Protein,Gelatin

Protein

Collagen

Candidacollagenase

Isocitric acid lyase – candida and fungi

Glycolate

Fruits, Vegetables

13Oxalates diet

diet

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Destruction of Vitamin C by Free Copper Ions

Cu Cu Cu CuCu Cu Cu CuCu Cu

Ascorbate (Vitamin C)

Dehydroascorbate

Free copper and/or free iron (Fe) are powerful

oxidizing agents

oxalate

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Ceruloplasmin

Bound copper- not toxic

Excess free copper - very toxic

YOUR LOGO16https://www.slideserve.com/zbigniew/food-safety-toxicology-3

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+ copper

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“Fe and Cu could be promotor of calcium oxalate stone formation”

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“Evaluate vitamin C intake. Vitamin C can break down to form oxalates. However, in adults, the amount of oxalate formed did not increase until the amount exceeded 4 g

of vitamin C per day (26). A large study of more than 85,000 women found no relation between vitamin C intake and kidney stones (27). In addition, an evaluation of 100 children on the autistic spectrum at The Great Plains Laboratory revealed that there was nearly zero correlation between vitamin C and oxalates in the urine (Table 2). Megadoses (more than 100 mg/Kg body weight per day) of vitamin C were shown

to markedly reduce autistic symptoms in a double blind, placebo-controlled study (28) so any restriction of vitamin C needs to be carefully weighed against its

significant benefits.”

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Thank You

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Kurt N. Woeller, D.O.