asd dr. h. sadeghian 1. asd ostium secondum: in the central portion of atrial septum in the position...
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ASDDr. H. Sadeghian
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1. ASD ostium secondum: in the central portion of
Atrial septum in the position of foramen ovalis
2. Sinus venosus: in the region of SVC, RA junction
or IVC RA junction
3. Unroofing coronary sinus: between ostium of CS
to RA and LA
septum primum and endocardial cushion defect
4. ASD ostium primum
Rudolph chapter 7
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Sinus venosus : 3 – 10%
ASD ostiom serondun: more common
F / M = 2/1
5% ASD + PS (valvuler)
Muller, chapter 22
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PVR abn
< 10% AsD ostium secondum
almost always ASD SV
Associates PVRAb
Braunwald
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Morphologic and Embriologic considerations
Septum primum grows from posterosuperior
side (SVC side) toward A-V junction where
endocardial cushion separotes Atria from
ventricles. The lower part of the septum
primum is completed by fusion with
endocardial cushion tissue.
Rudolph chapter 7
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Some fenestrations develop in midportion of
septum primum. Septum secrodum just
grows in the posterosuperior portion of IAS
(near SVC) but right to the septum primum.
It grows toward the AV junction and it partly
covers the central hole of septum prinum. It
has a semilunar edge which is concave
toward TV.
Rudolph chapter 7
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Ostium secondum defects
1. Large hole in septum primum or
2. Inadequite development of septum
secondum
Rudolph chapter 7
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1. Sinus venosus defects: septum primum
or secondum
2. Unroofing CS: the well between CS and
LA, may involved a portion of septum or
whole septum and are frequently
associated with LPSVC
Rudolph chapter 7
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LAP 1-2 mmHg >RAP
two ventricles fill with one pressure
so RV will be distended.
Rudolph chapter 7
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The degree of left to right
Shout depends on the
1- The size of the defect
2- Filling pressure of ventricles
Braunwald
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Infants
Large defects: QP/Qs > 2.5 : 1
Produce symptoms
Medium size defects: do not cause symptoms
during infancy and early childhood
Rudolph chapter 7
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ASD beyond infancy
The majority of children even those with large
defeats do not experience symptoms.
Unlike VSD most of them tend to be smaller with
growing, ASD usually grows in proportion to
heart size and there is evidence suggesting that
some defects may become larger as age increase.
Rudolph chapter 7
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40% ASDs in infants will close
spontonously
ASD < 3 mm in first 3 months always
close
ASD > 8 mm is unlikely to close
Muller, chapter 22
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Spontanous closure of ASD may occur
within the 1 year of life.
< 7 mm in neonatal period may reduce
in size and require no intervention
Braunwald
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Natural history of growth of ASD ostiun
secondum and implication
Heart 2002, 87, 256-9
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104 Patients
Exclusion criteria: multiple ASDs or
fenestrated 91 – 98
3 – 6 mm small ASD
6 – 12 moderate
12 large
65% patients size with ASD 30% > 50% increase in size
spontanous closure in 4 patients
12% 20 mm
Only factor associated with ASD growth was initial size
Heart 2002, 87, 256-9
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ASD growth was independent of age of
patients
Conclusion: 2/3 of ASDs growth with time
Heart 2002, 87, 256-9
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Defects < 6 mm
66% spontanous closure
Mean age of diagnosis: 4.5 years
F / M / 2.2/1
Heart 2002, 87, 256-9
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33% had small defects(34P)
FO
3p closed spontounsly
26% (27p) ASD
1 small mod
3 small large
1.6 mm/y size
Mean FO : 3.2 y
Heart 2002, 87, 256-9
Small ASD group
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40 p (38%)
FO 31% mod
3 small
8 large
1.6 mm/y mean FO: 3.3 y
Heart 2002, 87, 256-9
Mod ASD group
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30 p (29%) large
43% (45) FO : large
1.9 mm/y FO : 2.9 year
Heart 2002, 87, 256-9
Large ASD defeats
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66% ASD size
14% decrease
20% no change
Initial size, final size correlated
Heart 2002, 87, 256-9
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The main concerns in individuals
with ASD are
1. PV Resistance
2. Atrial arrhythmia
3. Cardiac failure
Rudolph chapter 7
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The association of PVD and ASD are infrequent
during childhood. Singificant PVD is unusual
before age of 25-30 years.
Beyond this age, PVD occurred in 5-10% ASDs and
is related to high altitude PVD f/M : 2 : 1
Altitude > 4000 ft PVD in earlier ages
Rudolph chapter 7
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PVR
PVR in ASD usually is normal ,
1 unit / m2
3 considerable
Rudolph chapter 7
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Atrial arrhythmia
Af , Flutter , PAT occurs commonly in older
patients. They are probably related to
large shunts.
< 20 y 1 - 2%
> 20 y 15 - 50%
Rudolph chapter 7
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Cardiac failure
>20 y , Right sided
Failure
Rudolph chapter 7
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ECG
SV defects: P ware 0
AV may be moderately prolonged with large defects
QRS Axis: RAD (90 to 180)
rsR or rSR , incomplete RBBB
R in right precordial 10 – 15 mm
> PVD
Rudolph chapter 7
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Negative P in Inferior leads
ASD SV below SVC
Braunwald
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Echo
1. RV Enlargement
2. QP/QS
3. PVR , SVR
4. PAP , TR , PAPm , d
5. RV function
Rudolph chapter 7
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Subcostal : bicaval
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Pressures
15 – 30 mmHg Pressure RV-PA
10 – 15 mmHg MPA , branches
Rudolph chapter 7
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30% of the patients have effort dyspnea
in third decade and more than 73%
by fifth decade
Braunwald
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SV arrhythmia and RSF 10%> 40y
Paradoxical embolic may occur
Braunwald
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1- Isenmenger
2- Prominent eustachien valve which leads IVC flow to ASD
3- ASD SV below IVC
Braunwald
Cyanosis
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Management
Large ASD
QP/Qs < 2 : 1
QP/QS < 1.5 : 1 Follow up
Rudolph chapter 7
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The presence of RSF + ASD > 5 mm with no sign of spontaneous closure
18 month 3/4 ASDs may close spontaneously
Muller and Hoffman
Indications for Intervention
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QP QS < 1.5 : don’t want
Closure except for paradoxical emboli
Braunwald
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Significant ASD : QP / QS > 1.5 : 1
Or RV volume overload intervention
P HTN : PAP > 2/3 systemic
Or
PVR > 2/3 SVR
1- QP / QS > 1.5 / 1
2- Challenge to O2 or No
3- Lung biopsy reversibility
ASD closure
Braunwald
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Stretch diameter < 41 mm
Adequate rim
Complications : embolization
thronbus formation < 1%
atrial perforation
Comparing surgery to device closure :
1- better preservation RV function
2- lower complication rate
Braunwald
Device closure
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- Sinus venosus
- Ostium primum
- Ostium serondum not suitable for device
closure
Mortality < 1%
Braunwald
Surgery
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ASD with P HTN
PVR > 8 – 12 unit / m2 : high mortality
PVR > 12 unit / m2 FO
PVR 4 – 8 unit / m2 mortality 10%
Rudolph chapter 7
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- Aspirin 6 mouths
- Prophylaxis of IE 6 mouths
Braunwald
After device closure
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1- ASD SV : Caval or PV stenosis
2- RV Failure
3- Atrial arrhythmia
Braunwald
Long surveillance
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< 10% ASD PHTN
PPHTN in association with ASD
> 50% patients > 45y AF
Muller, chapter 22
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Post op Atrial arrhythmia
Soon after surgery to later years 30 – 50%
incidence
PAT , AF and flutter but brady-tachy
arrhythmia pace
Transcatheter closure incidence arrhythmia?
Rudolph chapter 7
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AF 25% patients > 20 y
5% patients < 20 y
Late post operative arrhythmia :
2 - 9 % children
2 - 33% adults
Early after repair : 14% Atrial arrhthmia
espicially in SV defects
Muller
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Rim < 3m : deficient
Anteroinferior : mitral to ASD apical 4C
Antero superior : Aort
Postero superior :RUPV in Apical 4C back wall LA
Superior : SVC (90)
Postero inferior : IVC
Mathewson et al
JASE 2004
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