asian j. pharm. hea. sci. | oct - dec 2019 | vol-9 | issue-4 · figure 9: zero order absorption...
TRANSCRIPT
![Page 1: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/1.jpg)
![Page 2: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/2.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2153
![Page 3: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/3.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2154
Figure 2: Degradation pathway of diloxanidefuroate.
Figure 3: IRspectrum of intact diloxanidefuroate on K Br disc.
![Page 4: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/4.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2155
Figure 4: IR spectrum of diloxanidefuroate degradation production K Br disc.
1Figure 5: HNMR spectrum of intactdiloxanide furoatein (DMSO).
![Page 5: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/5.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2156
1Figure 6: HNMR spectrum of diloxanide furoate degradation productin (DMSO).
Figure 7: Mass spectrum of intact diloxanide furoate.
![Page 6: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/6.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2157
Figure 8: Mass spectrum of diloxanide furoate degradation product.
Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL).
![Page 7: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/7.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2158
Figure 10: Ratio spectra of diloxanidefuroateat various concentrations (2-30 µg/ml) using 15 µg/ml of degradation product as a divisor.
Figure 11: Mean centering of the ratio spectra of diloxanidefuroate at various concentrations (2-30 µg/ml) using 15 µg/ml of degradation product as a divisor.
![Page 8: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/8.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2159
Table 1 : Spectral and validation data for determination of diloxanidefuroate by the proposed methods:
* Peak area of diloxanidefuroate.
** Concentration of diloxanidefuroatein µg/ml.
***Average of three determinations of three concentration levels (5-15-25µg).
**** Relative standard deviation of nine determinations (tripled to determination of three concentrations).
![Page 9: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/9.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2160
Table 2 : Determination of diloxanidefuroatein laboratory prepared mixtures with its degradation product by the proposed methods:
![Page 10: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/10.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2161
Table 3 : Determination of diloxanidefuroate in Furamebe® tablets by the proposed methods and application of standard addition technique:
*Average of five determinations.** Average of three determinations.
Table 4 : Statistical comparison between the results obtained by the proposed methods and the reported methods for the determination of diloxanidefuroate [9]in pharmaceutical form:
*UV spectrophotometric method utilizing first derivative spectra at 270 nm. **The values in the parenthesis are tabulated values of t and F at (p= 0.05).
![Page 11: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/11.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2162
![Page 12: Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4 · Figure 9: Zero order absorption spectra of diloxanidefuroate (15ug/mL) and diloxanide degradation product(15 ug/mL)](https://reader033.vdocument.in/reader033/viewer/2022060802/6086c315c2176358ac04d6af/html5/thumbnails/12.jpg)
Asian J. Pharm. Hea. Sci. | Oct - Dec 2019 | Vol-9 | Issue-4
2163