Assessment of natural compound influence on periodontal clinical status

and matrix metalloproteinases 2 ,8 and 9 (collagenase)

Yeh Feng-wei

International Cooperation of the association

• Universidad Caderal Herrera –CEU dentistry department • Taiwan sugar research institute

• Development center for biotechnology• ELITE Dentofacial Esthetic clinic

• Ventac Partners

First goal: make a connection to start the research • Periodontal issues is important on MMPs inhibition. • The applied bioscience division of Taiwan sugar research institute has

found a new natural compound which can inhibit MMPs in vitro.• And firstly we tend to have a MEMO for investigation with our

following partners;• University of Carderal Herrera-CEU• Taiwan sugar research institute• Development center for biotechnology• ELITE Dentofacial Esthetic clinic• Ventac Partners

Second goal:

• When we get the know how of new compound , we tend to start making all the proposals about investigation.

1. UCH-CEU responsible with clinical test and protocol management(sampling and analysis)

2. Department of Animal pharmacology ,Development center for biotechonoloogy Taiwan responsible for In vivo test and sampling( inhibition of MMP in animal test)

3. Ventac Partners responsible for fund collection and apply also finding other sponsors of the world.

4. Elite Dentofacial Esthetic clinic & their Cheng Gung national university (Taiwan) focus on clinical test and sampling of Asia model.

5. Taiwan sugar research institute responsible for compound amplification and preparation for cGMP management to ensure the compound can use in the medical test of the world.

Third goal: Stronger connection

• After all the partners finished the work of second goal , we will start to have more connection.• This goal is to focus on the application of fund , so we need to have a

contract with our all partners of this program to make a stronger connection.• This contract will including:• Every units’ rights and Responsibility • Data sharing• Business benefit

The Fourth goals: to start the investigation • Now , we start all the programs with every unit partner.• We have the same investigation data sharing• Taiwan sugar research institute responsible on Compound preparation

and amplification also assists with department of animal pharmacology of development center for biotechonology for doing the research of animal model test(in vivo).• ELITE DENTOFACIAL ESTHETIC CLINIC responsible for Asia clinical model

test in Taiwan with his investigation team.• UCH-CEU focus on European clinical model research.• Ventac partners focus on international patent and business negociation

The fifth goals: future wish

• The MMPs inhibitor can be used on different area about medical problems ex: severe inflammation and infection of trauma , Allegies and dental issues; dental adhesive restoration , endondontic surgery and periodontal treatment , even cosmetic application. • So if we have the patent of this compound , we can use it on different

researches about MMP inhibition.

Thank you for your patient