assessment of the toxicity of coal-fired power plant ......
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Assessment of the Toxicity of Coal-Fired Power Plant Emissions: Preliminary Results from the TERESA Study
Annette C. Rohr, Sc.D.Air Quality VArlington, VASeptember 19, 2005
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The Team
Harvard School of Public Health
Toxicology:• John Godleski• Beatriz Gonzalez-Flecha• Edgar Diaz• Meriam Lemos
Stack Sampling, Atmospheric Simulation/Characterization:• Petros Koutrakis • Steve Ferguson• Tarun Gupta• Choong-Min Kang• Joy Lawrence• Pablo Ruiz • Mike Wolfson
Supported in part by DOE-NETL(Cooperative Agreement DE-FC26-03NT41902)
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TERESA: Overview
TERESA: Toxicological Evaluation of Realistic Emissions of Source Aerosols
Approach:
• Evaluate toxicity of secondary particles from power plants, at power plants
• Expose rats to multiple simulated atmospheric conditions
• Examine mobile source emissions using same methods
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Study Schematic
Generating Unit
Control Devices
(e.g. ESP) Reaction
LabToxicology
Lab
Sampling Port
Primary emissions
Secondary particles
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Objectives
• Evaluate the relative toxicity of coal-fired power plant emissions, mobile source emissions, and ambient particles
• Assess the effect of atmospheric conditions on particle formation/toxicity• Oxidants (OH radicals) convert SO2 to sulfuric acid• NH3 neutralizes strong acidity• Secondary organic aerosol (α-pinene + ozone)
• Evaluate the impact of coal type and pollution control technologies on toxicity
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Why Is TERESA Important?
• Highly innovative and ground-breaking– First study to evaluate secondary particles at power
plants
• Previous studies have significant limitations:– Studies using collected primary coal fly ash– Inhalation exposure studies using emissions from
pilot combustors
• TERESA addresses these limitations
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Three Plants in Program
1. Upper Midwest: Powder River Basin coal, no SCR, no FGD. Fieldwork completed November 2004.
2. Southeast: Low sulfur (<1%) eastern bituminous coal, SCR, no FGD. Fieldwork nearing completion.
3. Midwest: Medium-to-high sulfur (>2-3%) eastern bituminous coal, SCR, FGD. Fieldwork in summer 2006.
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Field Operations at Plant 1
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Exposure Characterization
Parameter Medium and Method
Elements Teflon filter; XRF
Strong acidity Teflon filter; pH analysis
α-Pinene Tenax Tubes
Integrated
Ketones and aldehydes DNPH cartridges
PM2.5 mass 47 mm Teflon filter; gravimetric
Sulfate, nitrate, NH4, NH3, SO2, HNO3, HONO
Diffusion denuder + Teflon filter; ion chromatrography
47mm Quartz filter; TOR method
47mm teflon filter
R&P TEOM
CPC TSI 3022
UV absorbance method
Chemiluminescence method
Pulsed fluorescence method
Omega
EC/OC
SOA species (pinonic acid, pinic acid, etc.)
PM2.5 mass
Particle number
O3
NOX
SO2
RH and T
Continuous
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Toxicology Assessment
• Pulmonary function/breathing pattern• In vivo oxidative stress • Blood cytology (CBC/differential)• Bronchoalveolar lavage• Pulmonary histopathology• Blood chemistry • ECG monitoring (subset of
“susceptible” [MI – heart attack] animals)
Breathing Pattern
Electrocardiogram (ECG)
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Exposure Data, Plant 1, Fall 2004Values shown as mean (SD)
Round 1: October 4-7 (secondary + SOA)
Round 2: October 11-14 (secondary, neutralized
+ SOA)Round 3: November 3-5
(secondary only)
n=4 n=4 n=3Mass (µg/m3) 193 (73) 141 (16) 69 (10.4)
SO4 (µg/m3) 57.1 (24) 38.7 (11) 31.8 (1.3)
NO3 (µg/m3) 1 (0.4) 37.7 (6.2) 1.1 (1.2)
NH4+ (µg/m3) 3.1 (1.2) 14.7 (4.1) 3.3 (1.7)
Acidity (µg/m3 H2SO4) 49.1 (22.7) 1.6 (1.7) 22.5 (4)
SO2 (ppb) 17.5 (4.4) 16 (3) 9.3 (3.5)
HNO3 (ppb) 1.6 (0.3) 2.3 (0.6) 0.6 (0.1)
HONO (ppb) 11.2 (5.1) 7.8 (1.5) 5 (1)
NH3 (ppb) 20.8 (3.8) 16.1 (6.2) 9.9 (6.2)
Organic carbon (µg/m3) 130.7 (7.1) 100.6 (6.6) 54.9 (6.9)
Elemental carbon (µg/m3) 12.1 (9.4) 4.3 (0.7) 2.8 (1.6)
Formaldehyde (µg/m3) 16.1 (3.6) 18.1 (3.9) N/A
Acetaldehyde (µg/m3) 5.2 (1) 4.8 (0.6) N/A
Acetone (µg/m3) 15.5 (5.2) 13 (2.9) N/A
Pinene (µg/m3) 0.6 (0.1) 0.8 (0.3) N/A
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Plant 1: Respiratory Effects
0
50
100
150
200
250
300
350
PRIMARY SECONDARY SECONDARY +SOA
SECONDARY +NH3 + SOA
Freq
uenc
y (f
) CONTROLEXPOSED
0.00.20.40.60.81.01.21.41.61.8
PRIMARY SECONDARY SECONDARY +SOA
SECONDARY +NH3 + SOA
Penh
CONTROLEXPOSED
Respiratory Frequency:
Indicator of Airway Irritation
Enhanced Pause: Indicator of
Airway Restriction
20 15 20 60
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Plant 1: Oxidative Stress in Heart and Lung Tissue
Secondary + SOA(n=8 in each group)
Boston Particles(Gurgueira et al., 2002)(n=4-6 in each group)
0
10
20
30
40
50
60
HEART LUNG
CL
(cps
/cm
2 )
CONTROLEXPOSED
**
0
10
20
30
40
50
60
HEART LUNGC
L (c
ps/c
m2)
CONTROLEXPOSED
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Plant 1: Summary of Results
• No changes in breathing pattern or pulmonary function• No evidence of lung inflammation or injury• No changes in blood parameters• No evidence of oxidative stress in lung or heart tissue• No changes in lung tissue
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Plant 2: Respiratory Effects
SC - UNNEUTRALISED SULPHATEMI MODEL - ENHANCED PAUSE (Penh)
0.0
0.51.0
1.52.0
2.5
0:10
0:40
1:10
1:40
2:10
2:40
3:10
3:40
4:10
4:40
5:10
5:40
Time
Enha
nced
Pau
se
(Pen
h) ExposedSham
Secondary + SOA, MI Model
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Plant 2: Respiratory Effects
Scenario Respiratory Frequency
Tidal Volume
InspiratoryTime
Expiratory Time
Penh
Secondary, unneutralized + SOA #1
↑ ns ↓ p=0.003 NC…..ns NC ns ↓ ns
Secondary, unneutralized + SOA #2
↑ ns NC…..ns NC…..ns NC…..ns ↓ p=0.001
Secondary, unneutralized ↑ ns ↓ p=0.04 ↓ p=0.02 ↓ ns ↓ p=0.01
Secondary, unneutralized (MI model)
↑ p=0.024 NC…..ns NC…..ns ↓ p=0.005 ↑ p=0.03
Secondary, neutralized + SOA
↓ ns ↓ p=0.002 NC…..ns NC…..ns ↓ p=0.001
Primary particles ↓ ns ↓ p=0.001 NC…..ns NC…..ns ↓ p=0.003
Airway restriction: ↑ Penh, ↑ expiratory timeSensory irritation: ↓ frequencyPulmonary irritation: ↑ frequency, ↓ tidal volume, ↓ insp/exp time
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Plant 2: Summary
• Some biological effects observed: breathing pattern, oxidative stress
• Respiratory results don’t tell a clear story• Most effects with unneutralized scenarios
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Conclusions and Future Directions
• TERESA results to date suggest few/inconsistent effects of power plant emissions on laboratory rats
• But…we don’t have all the data yet• Awaiting ECG data from Plant 2 animals• Need to understand how exposures at Plants 1 and 2
differ• Plant 3 fieldwork next summer• Mobile source component to begin in 2007 (funded
through the Harvard/EPA PM Center)