asymmetric hydrogenation/asymmetric ... catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 oh oh 100 ref:...
TRANSCRIPT
![Page 1: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/1.jpg)
ASYMMETRIC HYDROGENATION/ASYMMETRIC TRANSFER HYDROGENATION OF KETONES, IMINES AND ALKENES THROUGH
NOYORI AND NOYORI TYPE CHIRAL RUTHENIUM CATALYSTS WITH REFERENCE TO PHARMA APPLICATIONS
Dr.Sambasiva R Poreddy ENANTIOTECH CATALYSTS PVT LTD
P.NO:22-B. Road No: 2 Venkataramana Colony, Vanasthalipuram Hyderabad-500070, India
E-mail: [email protected] Ph: +91-9849601776 www.enantiotechcatalysts.com
![Page 2: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/2.jpg)
PREPARATION OF CHIRAL BUILDING BLOCKS THROUGH
ASYMMETRIC HYDROGENATION/ASYMMETRIC TRANSFER HYDROGENATION
![Page 3: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/3.jpg)
![Page 4: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/4.jpg)
![Page 5: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/5.jpg)
![Page 6: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/6.jpg)
![Page 7: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/7.jpg)
![Page 8: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/8.jpg)
PHARMA APPLICATIONS
![Page 9: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/9.jpg)
PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF KETONES
![Page 10: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/10.jpg)
![Page 11: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/11.jpg)
![Page 12: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/12.jpg)
![Page 13: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/13.jpg)
![Page 14: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/14.jpg)
![Page 15: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/15.jpg)
![Page 16: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/16.jpg)
![Page 17: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/17.jpg)
![Page 18: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/18.jpg)
![Page 19: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/19.jpg)
![Page 20: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/20.jpg)
![Page 21: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/21.jpg)
![Page 22: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/22.jpg)
PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF IMINES
![Page 23: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/23.jpg)
![Page 24: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/24.jpg)
![Page 25: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/25.jpg)
![Page 26: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/26.jpg)
PREPARATION OF API’s /API INTERMEDIATES THROUGH ASYMMETRIC REDUCTION OF ALKENES
![Page 27: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/27.jpg)
![Page 28: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/28.jpg)
![Page 29: ASYMMETRIC HYDROGENATION/ASYMMETRIC ... Catalysts...5/2/1 3.1/2.6/1 3.1/2.6/1 5/2.4/1 OH OH 100 Ref: JOC 2002, Examples: OH Yield: 1000/0 OH Yield: 100% e e: 93% OH Yield: 1000/0 e](https://reader033.vdocument.in/reader033/viewer/2022051805/5ff9fda7e2a6f148d21d654e/html5/thumbnails/29.jpg)
THANK YOU