Atherosclerosis

Definition

• Atheroma: an encysted tumour containing curdy matter = fibrofatty plaque

• Atherosclerosis: disease primarily of elastic arteries and large/medium sized muscular arteries. The basic lesion is atheroma, consisting of a raised focal plaque within the intima, having a core of lipid (mainly chol. & chol esters) and a covering fibrous cap

Pathogenesis

Aorta : fatty streaks

Aorta : mild, moderate, severe atherosclerosis

Coronary atherosclerosis with narrowing in proximal part