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Argus Research Laboratories IncJPRIMEDICA 905 Sheehy Drive Building A Horsham PA 19044
Telephone (215) 443-8710 Telefax (215) 443-8587
October 2 1998
Annie Jarabek US EPA NCEA Mail Drop 52 3210 Highway 54 Catawba Bldg Durham (RTP) NC 27709
Telephone (919) 541-4114 or4847
RE Protocol1613-002- A Neurobehavioral Developmental Study of Ammonium Perchlorate Administered Orally in Drinking Water to Rats Sponsors Study Number 7757A210-1096-25F
Dear Ms Jarabek
We have addressed most of your questions in our previous fax Below is an update on the status of the remaining outstanding items for the above referenced study
1 All of the motor activity count data was reanalyzed by Dr Simon Mats our statistician at our sister laboratory in Worcester MA He can be reach at (508) 890-0908 for further clarification Counts for each time block for each treatment group for each male and each female on each testing days were combined When the first MANOVA was performed (APPENDIX 1) there was a significant effect for DAY (of testing) and BLOCK (5 minute intervals) but not for GROUP (dosage) or SEX (gender) Dr Mats then performed additional MANOVA and Univariate tests to probe for interactions (APPENDIX 2) These analysis indicated there was only a significant block by sex interaction on testing Day 22 If you look at the MAN OVA and Univariate analyses for testing DAY 14 there is only a significant effect for BLOCK and not for BLOCK x GROUP BLOCK x SEX nor BLOCK x GROUP x SEX
I spoke to Dr Mats regarding Dr Croftons concern that the total counts for Group V were 95 higher than Group I total counts on DAY 14 but the increase was not significant He indicated that the variation in the data sets probably was
middot~middot
Protocoll613-002 October 2 1998
Page2
the cause but this would be inappropriate analysis anyway because the data had already been analyzed by each time block and should not be collapsed
2 Historical control data for motor activity will be provided this week because we have two recently completed studies that need to be added to the historical control data (APPENDIX 3)
3 The F1 generation body weight data has been separated into pre-weaning and post-weaning graphs and error bars included (APPENDIX 4)
RGYgyb Enc
Sincerely
Raymond G York PhD DABT Associate Director of Research and Study Director
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APPENDIX 1 MOTOR ACTIVITY REANALYSIS -1
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bull 4
0 N II N N N N N M N N N N N N Ill ~ N N N N N N N N N N N If If II N N I( Ill N N N 8 J 3 3 3 3 4 4 4 4 4 4 4 5 5 5 5 5 5 5 s 5 s 6 G G amp 6 7 7 7 s 5 6 7 6 9 0 l 2 3 4 5 6 7 8 9 0 1 2 l 4 s 7 s 9 0 l 2 3 5 6 II 9 0 1 2
1Sl 0 2 S 44 41 37 Q 0 Sl 1 36 Zf 0 1 3 Z 56 30 40 64 1gt0 72 CS 52 21 49 SO 32 6 0 1 1 IS l 1 1 0 152 3 0 79 49 33 30 sa 30 0 2 2 44 25 0 l 2 0 1 l 2 52 67 64 SB SB 65 81 63 56 57 62 69 66 41 C7 53 10 1 153 1 o sa o 11 1 2G o o o o amp 1 o o 1 14 ss s s 29 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 54 JC 12 1 2 l l 1 0 l B SO 54 amp2 47 51 S2 58 67 59 66 69 15 52 71 57 64 2 58 48 27 0 0 0 lSS 1 0 iS 64 22 2 0 J 0 0 19 3 Z 3 3 l 4 1 3 4 SG S 71 0 6~ 68 21 1~ 1 o 0 0 1 11 1 l 7 8 1SG 0 l 74 1l as 76 75 sa Sl 2 0 7 0 4 1 1 0 0 o 0 71 ampl 71 CG 0 ampl 75 69 78 8A 18 3 76 70 75 48 7 7 157 3 o 75 49 26 48 51 4 0 0 o 1 ll 4 D l 0 l 0 1 64 54 2 60 BG 76 74 76 5 51 amp9 80 62 60 51 63 67 51gt 158 3 1 82 29 S7 1 17 0 l B 0 1 l 0 0 4 30 51 72 20 74 69 61 74 83 77 79 6 6 65 GS 74 65 S 81 73 37 42 1S9 2 l 65 10 13 Q 0 0 0 1 4 7 53 37 30 10 l 14 27 0 C2 66 58 63 69 63 41 26 amp1 29 17 1 6 0 1 0 B D 150 67 64 78 77 2l 24 0 0 7 1 0 5 2 0 0 0 ll J 49 5amp 55 6 72 76 62 57 55 7Z 1 1 ll l 6 G 1 161 2 0 59 4 45 67 48 12 1 0 l 0 3 1 0 l l 2 3 0 68 71 72 G1 61 S SO 8 Q 64 10 66 59 amp7 80 3 86 0 152 0 0 72 8G 6G 5 46 40 lG 0 0 2 0 0 0 1 0 0 3 9 62 67 S 79 74 77 70 83 90 84 4l 42 11 0 8 14 5 163 2 0 27 47 18 8 7~ 52 51 12 0 7 2 31 0 2 S 2 4 0 77 63 63 5 BJ 61 7S 74 0 74 62 81 29 9 0 3 1 1 164 0 1 0 15 59 14 S lS 59 0 0 o 2 2 28 72 63 69 75 15 SB 48 42 47 58 64 S SO S 74 73 69 72 1 57 32 7 165 2 18 4~ 2 51 0 15 a 1 1 0 3 2 0 8 4 a 0 5 2 70 63 66 54 61 62 SO 4 45 48 51 51 3S 0 1 0 3 2 1amp6 so o 93 so 14 o o 2 o so 36 2 1 o o 1 c o o o sa 60 10 71 57 66 s 73 12 sJ 53 28 9 o o 3 167 o z 38 22 o o a 1 o o o 2 o 1 o o o o 2 5~ ~ so 75 77 7o eG 57 14 3 o s 1 a o 1 43 1 168 Z2 2 55 45 44 23 18 S 3 39 38 51 56 29 Z8 49 2 0 1 0 52 5l 5 53 68 78 CS $7 73 69 64 77 77 SJ 51 4S 36 16 0 0 41 15 1 Q 0 0 0 D l 0 3 0 7 3 7 G1 38 ll 60 Sl 63 61 92 87 BC 55 3 65 57 58 24 11 1 S 1 0 110 2 4 ampG ss se s 2 1 8 o 1 13 o a 1s 9a 79 amp8 47 G7 84 60 66 68 74 bull~ ss 76 71 31 1 o 32 ss Gs a as 111 o 1 sG 41 29 l 1 2 10 o J 1 o 1 o 1 1 o a 12 so sa 84 s 57 G2 4 53 2laquo 10 c 2J o 1 o 1 2 172 s5 68 6 J 49 52 21 23 12 l 1 16 o a o o 1 21 S9 42 75 11 65 78 1 11 47 ampamp a 3o o s 10 o o o o 1 173 0 2 62 61 tO 17 4 S 0 B 1 29 B 5 4 2 D 21 JS l) 58 55 60 73 80 65 71 65 54 S 72 G6 34 C 0 2 0 0 174 3 0 69 37 14 32 ~ D 0 1 0 0 0 0 0 0 15 22 46 35 59 68 CS 75 72 83 56 6 36 9 2 1 0 0 0 0 1 11s o o B4 sz ~s 29 2s 41 s o co S 2s Jt 22 1 o 3 so 63 54 12 76 s sa ss samp Jl to 20 35 59 so 4 6 1
The 6AS Sys~am 0958 uesd~y Scp~embe 29 1998 8
G R )
0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
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o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
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0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
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GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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17 68 17 68
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-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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0 l 0
1 2 l
4 1 0
c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
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3 61 59 63
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0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
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50 D
SD 49 5
4
8 0 2
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27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
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61 53 uampe
3
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Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
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ampe 0 1
0 0 5
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27 0
17
D l l
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0
0 55
0 0 s
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7 50
0 0 l
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54 54
0 0 0
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0 u
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0 0 4
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
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(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
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11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
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SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
middot~middot
Protocoll613-002 October 2 1998
Page2
the cause but this would be inappropriate analysis anyway because the data had already been analyzed by each time block and should not be collapsed
2 Historical control data for motor activity will be provided this week because we have two recently completed studies that need to be added to the historical control data (APPENDIX 3)
3 The F1 generation body weight data has been separated into pre-weaning and post-weaning graphs and error bars included (APPENDIX 4)
RGYgyb Enc
Sincerely
Raymond G York PhD DABT Associate Director of Research and Study Director
~
APPENDIX 1 MOTOR ACTIVITY REANALYSIS -1
middot~
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1 F 1 102 45 sa 4 c 39 amps 33 z o 1 1 1 1 1 1 o o o o o l o a 1 6 e 26 35 ~s o 1 5 2 o 2 F 1 170amp 1 s 43 46 4~ 38 10 8 1 4 3 0 1 4 0 l 5 4 0 0 0 0 5 1G 42 13 34 22 Gll 55 GS SS 73 86 63 3 1 12~ 33 sa c2 zg s 3 5 e o 5 a 22 56 so 10 6 s6 cs 19 Jo e~ cJ 9 ampG 52 9 10 65 75 s cc 11 63 4 1 1731 3c 11 s o s 1 1 o o 1 o o 3 e o 2 3 1 s 78 e2 as eo eo 84 73 75 e3
P 1 1736 o o s o o o 1 1 3 2 1 o 8 4 l o 1 o c c o 1 1 o o o 2 10 9 c o o 3 z a56 F 1 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 C 9 0 0 0 3 G 12 6 0 Q 0 1 0 0 0 0 7 p 1 1750 2 5 0 0 7 19 27 16 G 5 3 5 2 4 3 2 2 1 11 59 59 77 72 SO 76 GO 36 53 45 4amp Sl 51 31 1 2 8 F 1 1757 3C 45 64 40 5 ll 1 0 1 2 0 2 2 1 8 4 7 2 20 2 23 9 0 0 0 0 0 1 l 0 0 2 0 0 9 r 1 17amp2 26 43 57 s1 4 3 zo 12 cs 22 C3 5 13 1 1 3 1 1 77 67 13 74 79 11 59 B1 go ao
1o v 1 1767 14 9 11 2amp 4 4 Lamp 8 a 1 15 6 3 15 1 so ss s amp3 amp3 60 12 st sc 41 59 12 ampa 11 F 1 1769 60 R2 90 74 8 6 45 61 70 90 59 85 amp7 l 45 77 83 64 SO 25 6 0 1 0 2 0 0 0 0 0 1 0 0 l 0 12 P 1 1110 cc 42 31 45 o 1 a 10 3 J o 1 1 s 2 2 o sa 31 12 3 o z 59 38 31 11 1 o 1 o o 13 r 1 1772 47 60 63 4S CS 33 8 1 1 2 l 4 4 ~ 3 J l S 35 19 24 3C 45 33 66 25 9 0 0 4 0 3 0 l 14 F 1 1717 70 60 30 65 67 38 57 58 SC Cl 25 41 9 0 3 0 0 CJ amp6 C3 6 3 16 20 l 2 6 0 0 D 1 2 D 15 F 1 11a1 42 26 o 4 1s 1s 3 10 5 J 8 s lo s 3 s l cJ 77 sa 29 91 11 o o z ~1 3 1 1 o 2 4 16 F 1 17RS 93 93 79 89 78 69 73 l 1 3 2 1 7 16 11 3 7 l 53 37 40 52 58 17 1 0 C 0 22 CS 72 70 35 60 17 F 1 1786 61 59 77 48 C4 6C 34 62 49 77 CC 29 70 C1 55 52 37 44 18 23 26 lC 5 1 26 41 D 44 24 0 0 l 1 0 0 18 F 1 1790 30 57 73 l9 31 0 25 71 85 68 6 SS C7 7 73 71 1 17 1 6C 7 0 4 53 l 33 23 3 24 3C 59 52 1 0 19 F 1 179amp 6 42 17 6 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 1 0 0 0 0 l 0 2 1 0 1 3 3 20 p 1 1796 1 S l 39 26 6 3 l 0 lC S 4 20 0 1 3 0 4 CS 43 9 27 60 0 3 0 0 0 4 2 0 0 0 1 21 F 2 1705 26 4C SO 39 54 17 ll 59 58 51 6 2 2 2 8 2 C 35 ampS GO 61 71 10 G GO 69 13 l 1 2 0 0 2 2 22 F 2 11os 11 o 22 12 o 1 J l c 2 2 3 a 1 o o J o 59 35 ss 10 55 so 45 15 sa 56 1 o o 1 o o o 23 F 2 1711 21 63 3pound 2 22 6 2 0 0 1 2 0 S 0 0 1 0 61 61 76 57 23 62 Ce G7 56 SS 53 GO 1 25 51 59 45 24 r 2 1112 12 1 o o 1 1 o o 2 o 1 o o o o 2 o 2 o o o o o 1 J o o o a o o o 1 1 25 F 2 1713 41 36 1G 0 28 22 33 1 6 4 1 10 2 5 1 G 12 0 0 0 1 l 0 0 0 2 0 1 0 3 0 0 1 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N H N N N N B 3 3 3 J 4 4 C 4 C 4 4 C 4 5 5 5 S S 5 5 5 S 5 6 6 6 6 6 6 6 6 7 7 7 a 6 7 a g o 1 2 a 4 s 6 1 a 9 o 1 2 l bull 5 6 1 s g o 1 l s 1 a 9 o 1 2
l 0 SS 3 9 14 0 0 0 0 5 0 1 5 0 C 0 3 0 4 61 62 60 65 41 CB 55 28 51 64 57 27 1 l 64 54 SC SO 2 65 25 2 0 0 0 0 0 2 0 25 34 63 51 14 38 32 0 0 64 62 GS G4 G1 73 53 C4 41 6 1 l 0 1 1 28 57 52 J SO 49 35 0 0 41 1C 2 0 0 6 5 19 36 20 SS 46 50 69 GO 71 76 71 74 62 68 53 51 53 25 2 0 o 0 0 4 76 56 33 21 32 19 64 16 0 0 0 C S2 70 48 7 lJ 23 0 70 l 70 67 80 73 C4 1B 1 36 55 GO G9 15 2 9 J 3 S 0 56 lO 22 0 27 36 28 3 0 0 0 ~4 0 0 0 2 0 0 6 S7 70 53 66 36 30 35 ll 0 0 0 0 1 2 2 1 0 6 o o 6 e o middoto o o o o o o 6 4 o o o o o ampl a ampl 33 1 o 2 o o 1 so 65 35 o 2 1 o 7 S 45 52 28 39 42 1B 4 l 15 Cl CO 0 0 2 0 0 0 3 65 72 75 66 67 71 S3 74 81 63 ll l 5 2 2 1 3 (l k 0 19 0 o o 0 0 0 o 2 0 0 0 0 0 0 0 0 0 67 59 S 63 70 S7 Cl 5 G7 49 SO 9 0 0 28 3 59 60 9 80 59 IS ll 6 0 0 l 0 1 C 1 0 27 6 1 S 59 34 55 66 63 ee 72 73 65 73 74 72 SG C2 60 Sl C9 69 59 54
10 55 GS 67 47 17 24 28 47 22 9 3 7 0 1 lamp 40 6l 66 59 G2 72 65 69 54 53 71 78 62 51 54 63 68 6S 66 19 S 11 2 89 Z3 57 23 o o o o o o 1 1 a o o o 1 o 55 79 62 68 55 59 53 5 5 o o 3 o 1 o o o 12 0 48 0 20 57 40 0 0 0 0 0 0 0 l 0 0 0 1 0 54 68 6~ 59 59 GO 54 C2 SS 61 6Q 46 0 64 S 30 16 0 1J o s 64 46 2e ~ o 29 6o Jo 2 s1 co 2s 2 o o o sa 60 amp1 sa cs 69 bulls s c6 Cl 6D sc co 3 5 o o c 14 18 G3 25 4~ 31 2 0 0 a 0 0 15 54 58 Cl SG 68 58 8 61 73 60 47 S 55 57 l CO 52 11 1C 4S 58 58 12 0 o 15 0 7G 64 33 56 64 1R C2 Sl 8 2 29 74 Jl 2 1 1 2 3 56 G3 61 54 72 56 60 C9 58 4~ 67 59 63 63 40 78 68 1 16 12 55 10 62 57 sa 12 1 o 22 o 2 o o 1 o o o 61 so 75 st 3 60 63 59 el ss ss s Gl ss eo 21 13 o 17 a sc 66 43 60 59 cc o o a o c 1 o 5 c 2 c 2 amp6 cc 52 6~ se 11 62 67 72 ~ c2 2s o s 23 59 18 a 11 32 43 o 20 o o 11 ampo 1 2e o o o 1s ss 66 81 4 10 a2 amp6 bulla 21 29 59 64 ss so JJ 6 31 61 19 11 tJ ce s 8s 1l o 1c bullbull o o o o o o o o o 1 58 55 74 amp1 48 ss c as 31 67 cz 29 a o 8 o s o 20 16 sa 46 55 24 lS 5 39 67 1S 0 1 2 0 0 0 1 3 64 51 54 65 SO S 61 GS 50 J6 64 54 36 0 l 32 58 52 33 21 o 73 ss 34 s3 c2 32 31 o o 29 42 9 53 19 o a J o 68 55 SR 53 6l 61 3 JS o o o 3 1 1 1 21 41 G 22 0 7B 41 66 39 52 22 46 SS 27 SO 61 54 2 0 1 7 0 0 68 65 88 72 7 G2 Bl 52 o 2 2 23 72 81 SO SS 2 4 23 0 52 4l ~3 l 0 l 5 3 1 4 13 51 29 1 0 3 0 0 4l l7 GJ 55 60 67 Samp 52 59 Sl 3cent 29 69 62 SO 49 4 19 24 0 6 10 C 0 0 l 2 2 0 0 0 1 0 0 amp 15 41 0 G4 72 76 ampB 77 6~ 0 69 6~ 73 2 5C JC 1 0 0 0 28 25 0 16 0 0 6 20 0 0 0 0 0 2 l 0 l 0 0 l 1 SB 5 67 70 3 57 1amp 0 3 1 53 71 59 S 21 1 2
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ll y 2 1760 74 59 14 l 0 1 2 lO 3 6 19 10 B 5 s 33 47 42 43 62 71 Gl l 1 l 3 2 0 1 J 3 0 1 33 F 2 1763 2 11 J2 55 ss 0 81 52 65 16 76 59 46 67 51 4 65 57 58 cs 17 53 so 65 0 a 35 s~ u 62 54 JB 34 y 3 1769 1 0 7 3 30 45 1 0 2 1 0 0 1 2 0 l 3 8 71 70 JS 27 D 0 0 3 0 0 0 0 0 0 1 0 J5 F 2 1771 38 12 11 14 l 3 l 7 5 5 3 6 8 12 8 2 z u lQ 11 s l 0 2 0 3 6 0 a 1 1 2 l l36 P a 111s zbull 37 39 sa 0 27 G7 co 1 0 1 l s J c l 5 2 0 16 35 3 0 0 0 0 1 l a 0 2 0 0 037 p 2 177 g 21 lJ 44 30 ss to 4 24 56 10 l 1 0 0 3 0 l 60 29 1 0 0 l 24 15 53 49 43 0 1 0 5 0 2JB F 2 11a2 79 sa 49 75 59 s1 19 c 0 1 67 38 82 71 S2 3B ZO 4 0 ) 4~ 55 43 53 61 57 6 5( 69 60 272 59 7531 F 2 1795 6 18 u 45 25 0 G Q s 0 l 2 2 0 l 1 4l 65 75 19 1 11 14 66 74 70 S2 70 70 18 0 2 140 P 2 1800 10 15 3 s 10 1 5 II 4 2 0 1 1 l 3 1 12 26 a7 24 eo 53 3o 4B 11 26 0 4 1 1 4 3 0 4Cl l 1703 26 2 1 1 2 0 3 1 1 l 1 1 1 3 l 2 1 3 39 14 30 72 40 64 4C 31 35 47 14 C3 1 1 1 2 042 F 3 1704 1 0 0 l 1 0 5 1 ~ 0 1 0 3 l 0 3 0 13 31 24 44 C4 29 C2 50 38 71 17 67 ampll 1 2 c 0 143 F J 1709 17 0 0 2 3 1 2 l l B 3 l 14 3 9 43 52 50 53 79 84 3 36 29 4 0 6 9 z 0 0 1U Y 3 1715 1 28 55 48 ~2 0 ll 58 5 20 53 10 6 s 0 5 3 1 13 60 so 46 67 67 36 63 29 14 sc 63 73 D 3
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1 42 2 l 4 3 1 2 2 1 l l 0 5 1 s 4 7 60 46 65 sa 31 amp2 ze 0 1 0 7 55 JO 1 0 1 0 0 30 1 59 5 0 0 0 4 7 0 6 0 1 0 3 2 0 1 1 1 75 74 69 91 75 69 65 52 2 6 0 s0 77 67 31 0 46 u 17 0 0 0 0 0 0 0 0 2 0 0 1 7 47 3C 75 1 71 42 46 77 71 51 67 l 72 39 1 0 0 0 0 032 0 63 77 13 0 0 0 1 l l l 2 0 0 6 5 53 s 67 e 88 11 at 11 5~ 0 11 0 0 0 57 fiB 67 ~ 2 31 5 55 35 31 11 1 0 1 8 1 4 0 25 56 38 45 52 20 1 59 7 72 72 59 55 70 62 76 48 58 73 62 5t 52 17 o 0 3~ 45 51 27 1fo 1 0 1 0 1 0 1 0 0 l 0 1 78 72 78 83 75 0 7amp t2 75 78 lt 65 2 1 1 29 51 511 IS lS 30 54 40 9 0 1 0 0 0 0 3 0 1 0 1 o 36 se 5s amp5 50 11 g cJ so s 11 0 0 22 6C lC 0
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25 u 56 7 15 40 cJ 2t 23 sa 0 3 0 1 0 3 1 59 52 51 62 4 73 72 68 Cl amp8 73 81 3 65 16 7 1 71 45 8 22 41 37 13 48
42 2 16 l 55 45 55 14 1 0 C2 67 t9 49 t7 43 CO tS 0 0 29 C5 cs 29 1 0 D 0 0
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0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 s C N H N N N N N N N N K N N N N N N N R N W N N N N N N B JU1 N N K N N N N N N 1 1 ~ 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 l l l 3 J J S X P liS 1 2 3 4 s G 1 a o 1 2 l 4 s 6 1 a o 1 2 J 4 s 6 1 8 g o 1 2 3 s 76 F ( 1774 17 13 25 20 l 1 (J 59 1 1 4 S 7 0 7 4 l 1 3 44 1 1 0 2 1 0 0 1 0 1 0 0 J 26 51 7 F 4 177G 6 4 25 5 1 10 10 36 41 29 28 27 1 47 5 D 0 l 31 0 12 l 0 4 I 38 37 65 60 6 (7 (7 54 44 27 7$ F 4 1783 10 28 4 49 43 46 27 1 l 1 4 1 2 4 3 0 4 l 7 32 17 2 11 35 69 1a 0 0 0 0 3 1 0 0 0 p 4 17a7 30 ll 11 l 2 16 0 1 3 19 0 1 3 1 l 32 (2 53 27 7 55 57 42 1 0 12 0 0 bull 3 ao v 1797 13 17 J o 4 24 sa 23 19 37 sz c 20 25 s o o J sg 6amp 47 61 l cJ 70 73 72 za 56 74 75 55 76 A1 v S 1710 46 10 75 73 84 54 53 76 3 2 40 89 38 3 63 76 37 5 38 32 14 17 3 18 1 0 0 5 0 1 0 0 2 D 2 82 F S 1720 6 6 1 0 1 0 3 2 D 0 2 1 13 2 4 1 0 0 JB 63 22 GO lO 91 95 IS 74 19 a1 0 Sl 85 52 2 5 83 F 5 1723 I 35 4~ 43 7 59 26 3 2 G 2 1 3 2 2 4 2 3 13 5 12 1 25 24 0 1 2 S 30 13 44 2 0 0 84 F 5 124 26 53 76 73 11 49 2 6 2 2 2 S 4 3 ~ 0 15 24 43 35 66 53 51 76 46 51 62 69 S 5( 76 70 ll 1 16 5 F 5 172 14 12 14 23 17 15 1 11 0 0 0 0 4 SC 59 2l 21 21 44 23 4 50 64 5 57 41 53 S 53 76 81 4G 50 2 ss F 5 1121 o o o o o a ca 22 6 2 3 2 3 2 3 a 2 57 19 2 s1 1 64 13 2 o o o a o 4 o o 87 F 5 1737 63 SO 1 0 1 1 2 6 5 13 15 0 2 7 0 l 0 D 80 24 41 0 0 2 0 0 0 1 I 0 S 2 0 0 0 SB F S 140 12 4 0 10 8 19 41 1 1 l 0 2 0 l 1 l 2 0 SO 57 34 43 24 7 0 0 2 0 1 D 0 2 D D 89 F 5 ~741 3 0 0 0 Q ~4 51 68 65 72 4Z 69 14 4 3 11 S 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 0 F 5 1743 32 53 4 0 39 74 52 CO 1 9 0 5 S G G S 4 G lJ 5a 55 31 72 42 5 6 30 72 ~3 37 CS 57 C6 12 2 91 F 5 14amp 31 42 25 19 38 lG 0 1 1 0 3 1 G 0 7 1 4 0 2a 39 5 Q 0 0 0 0 0 0 0 0 2 Q D 4 0 92 p 5 152 27 48 51 56 SG 1 4 50 51 54 1 0 6 46 48 4 50 27 55 60 57 58 e 80 71 Dl 4S 74 3 39 13 51 SG 72 Cl 93 F 5 166 12 16 30 55 13 2 27 15 4 4 1 2 2 S 2 l 2 2 54 66 61 7G 78 43 3 5 62 27 77 78 66 6 68 75 C4 94 V 5 1773 15 1 1 1 0 0 0 SD Jl 1 0 2 0 0 0 8 0 0 l 1 1 0 0 1 0 0 0 0 0 0 0 0 ~5 y s 177amp Jamp ampl ao amp9 7 o 7 2 2 11 40 56 a4 a1 co 1 53 o 2 sa so 44 Go 49 53 sa 54 7 11 26 2 a 13 1 9G F S 1784 17 42 ll 73 16 5 7 9 l 3 2 0 9 C 5 7 1amp 24 54 SS 70 55 5 55 63 71 70 SS 65 50 68 3 48 39 7 7 F 5 1788 0 S 0 0 0 2 1 1 15 44 58 S 0 1 0 0 2 0 1 0 1 D 0 0 0 0 D 10 30 14 0 0 0 0 0 ~8 F 5 178~ 2 64 31 amp4 bulle 1 22 61 69 10 20 21 76 44 20 c 84 12 rs 37 a o a 2 3 37 as as 11 a1 6 67 F 5 1793 15 l 0 I 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 36 51 3 1 12 0 4 a 0 1 0 0 0 4 34 51
100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
0
13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
l
19 2 2
1 1 0 so
lll K 1 1470 10 28 6 26 36 u u 30 4 1 2 1 4 1 4 l 2 2 112 M 1 1472 3 l3 34 34 1 0 0 4 0 1 1 2 0 1 J 20
2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
IC ts M M M M M K M M
1 2 1 2 z 2 2 2 a z
1412 Ull U18 1434 144G USl 14SS 1456 UampO 14l
9 l
45 37
7 u 53 16 IG so
l IS Z2 20
1 2 57 z
eo u
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
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Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
~
APPENDIX 1 MOTOR ACTIVITY REANALYSIS -1
middot~
The SAS SYII~ Oll 5I 111oaday Stlgttcmber 2 151 l
c
0 so II A
R If II N N II N N ll If N N ll raquo N N X raquo )l N N II If Ill w D lD z N N bull II N N II II N 1 1 1 l 1 1 1 1 l 1 2 2 l 2 2 2 2 2 2 2 3 3 l 3 3 3 s Xl X 1 2 3 c s I 9 0 1 2 3 bull s e 0 l 2 3 4 s 7 i Q 1 2 l 4 s 7
1 F 1 102 45 sa 4 c 39 amps 33 z o 1 1 1 1 1 1 o o o o o l o a 1 6 e 26 35 ~s o 1 5 2 o 2 F 1 170amp 1 s 43 46 4~ 38 10 8 1 4 3 0 1 4 0 l 5 4 0 0 0 0 5 1G 42 13 34 22 Gll 55 GS SS 73 86 63 3 1 12~ 33 sa c2 zg s 3 5 e o 5 a 22 56 so 10 6 s6 cs 19 Jo e~ cJ 9 ampG 52 9 10 65 75 s cc 11 63 4 1 1731 3c 11 s o s 1 1 o o 1 o o 3 e o 2 3 1 s 78 e2 as eo eo 84 73 75 e3
P 1 1736 o o s o o o 1 1 3 2 1 o 8 4 l o 1 o c c o 1 1 o o o 2 10 9 c o o 3 z a56 F 1 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 C 9 0 0 0 3 G 12 6 0 Q 0 1 0 0 0 0 7 p 1 1750 2 5 0 0 7 19 27 16 G 5 3 5 2 4 3 2 2 1 11 59 59 77 72 SO 76 GO 36 53 45 4amp Sl 51 31 1 2 8 F 1 1757 3C 45 64 40 5 ll 1 0 1 2 0 2 2 1 8 4 7 2 20 2 23 9 0 0 0 0 0 1 l 0 0 2 0 0 9 r 1 17amp2 26 43 57 s1 4 3 zo 12 cs 22 C3 5 13 1 1 3 1 1 77 67 13 74 79 11 59 B1 go ao
1o v 1 1767 14 9 11 2amp 4 4 Lamp 8 a 1 15 6 3 15 1 so ss s amp3 amp3 60 12 st sc 41 59 12 ampa 11 F 1 1769 60 R2 90 74 8 6 45 61 70 90 59 85 amp7 l 45 77 83 64 SO 25 6 0 1 0 2 0 0 0 0 0 1 0 0 l 0 12 P 1 1110 cc 42 31 45 o 1 a 10 3 J o 1 1 s 2 2 o sa 31 12 3 o z 59 38 31 11 1 o 1 o o 13 r 1 1772 47 60 63 4S CS 33 8 1 1 2 l 4 4 ~ 3 J l S 35 19 24 3C 45 33 66 25 9 0 0 4 0 3 0 l 14 F 1 1717 70 60 30 65 67 38 57 58 SC Cl 25 41 9 0 3 0 0 CJ amp6 C3 6 3 16 20 l 2 6 0 0 D 1 2 D 15 F 1 11a1 42 26 o 4 1s 1s 3 10 5 J 8 s lo s 3 s l cJ 77 sa 29 91 11 o o z ~1 3 1 1 o 2 4 16 F 1 17RS 93 93 79 89 78 69 73 l 1 3 2 1 7 16 11 3 7 l 53 37 40 52 58 17 1 0 C 0 22 CS 72 70 35 60 17 F 1 1786 61 59 77 48 C4 6C 34 62 49 77 CC 29 70 C1 55 52 37 44 18 23 26 lC 5 1 26 41 D 44 24 0 0 l 1 0 0 18 F 1 1790 30 57 73 l9 31 0 25 71 85 68 6 SS C7 7 73 71 1 17 1 6C 7 0 4 53 l 33 23 3 24 3C 59 52 1 0 19 F 1 179amp 6 42 17 6 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 1 0 0 0 0 l 0 2 1 0 1 3 3 20 p 1 1796 1 S l 39 26 6 3 l 0 lC S 4 20 0 1 3 0 4 CS 43 9 27 60 0 3 0 0 0 4 2 0 0 0 1 21 F 2 1705 26 4C SO 39 54 17 ll 59 58 51 6 2 2 2 8 2 C 35 ampS GO 61 71 10 G GO 69 13 l 1 2 0 0 2 2 22 F 2 11os 11 o 22 12 o 1 J l c 2 2 3 a 1 o o J o 59 35 ss 10 55 so 45 15 sa 56 1 o o 1 o o o 23 F 2 1711 21 63 3pound 2 22 6 2 0 0 1 2 0 S 0 0 1 0 61 61 76 57 23 62 Ce G7 56 SS 53 GO 1 25 51 59 45 24 r 2 1112 12 1 o o 1 1 o o 2 o 1 o o o o 2 o 2 o o o o o 1 J o o o a o o o 1 1 25 F 2 1713 41 36 1G 0 28 22 33 1 6 4 1 10 2 5 1 G 12 0 0 0 1 l 0 0 0 2 0 1 0 3 0 0 1 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N H N N N N B 3 3 3 J 4 4 C 4 C 4 4 C 4 5 5 5 S S 5 5 5 S 5 6 6 6 6 6 6 6 6 7 7 7 a 6 7 a g o 1 2 a 4 s 6 1 a 9 o 1 2 l bull 5 6 1 s g o 1 l s 1 a 9 o 1 2
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0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 s C N H N N N N N N N N K N N N N N N N R N W N N N N N N B JU1 N N K N N N N N N 1 1 ~ 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 l l l 3 J J S X P liS 1 2 3 4 s G 1 a o 1 2 l 4 s 6 1 a o 1 2 J 4 s 6 1 8 g o 1 2 3 s 76 F ( 1774 17 13 25 20 l 1 (J 59 1 1 4 S 7 0 7 4 l 1 3 44 1 1 0 2 1 0 0 1 0 1 0 0 J 26 51 7 F 4 177G 6 4 25 5 1 10 10 36 41 29 28 27 1 47 5 D 0 l 31 0 12 l 0 4 I 38 37 65 60 6 (7 (7 54 44 27 7$ F 4 1783 10 28 4 49 43 46 27 1 l 1 4 1 2 4 3 0 4 l 7 32 17 2 11 35 69 1a 0 0 0 0 3 1 0 0 0 p 4 17a7 30 ll 11 l 2 16 0 1 3 19 0 1 3 1 l 32 (2 53 27 7 55 57 42 1 0 12 0 0 bull 3 ao v 1797 13 17 J o 4 24 sa 23 19 37 sz c 20 25 s o o J sg 6amp 47 61 l cJ 70 73 72 za 56 74 75 55 76 A1 v S 1710 46 10 75 73 84 54 53 76 3 2 40 89 38 3 63 76 37 5 38 32 14 17 3 18 1 0 0 5 0 1 0 0 2 D 2 82 F S 1720 6 6 1 0 1 0 3 2 D 0 2 1 13 2 4 1 0 0 JB 63 22 GO lO 91 95 IS 74 19 a1 0 Sl 85 52 2 5 83 F 5 1723 I 35 4~ 43 7 59 26 3 2 G 2 1 3 2 2 4 2 3 13 5 12 1 25 24 0 1 2 S 30 13 44 2 0 0 84 F 5 124 26 53 76 73 11 49 2 6 2 2 2 S 4 3 ~ 0 15 24 43 35 66 53 51 76 46 51 62 69 S 5( 76 70 ll 1 16 5 F 5 172 14 12 14 23 17 15 1 11 0 0 0 0 4 SC 59 2l 21 21 44 23 4 50 64 5 57 41 53 S 53 76 81 4G 50 2 ss F 5 1121 o o o o o a ca 22 6 2 3 2 3 2 3 a 2 57 19 2 s1 1 64 13 2 o o o a o 4 o o 87 F 5 1737 63 SO 1 0 1 1 2 6 5 13 15 0 2 7 0 l 0 D 80 24 41 0 0 2 0 0 0 1 I 0 S 2 0 0 0 SB F S 140 12 4 0 10 8 19 41 1 1 l 0 2 0 l 1 l 2 0 SO 57 34 43 24 7 0 0 2 0 1 D 0 2 D D 89 F 5 ~741 3 0 0 0 Q ~4 51 68 65 72 4Z 69 14 4 3 11 S 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 0 F 5 1743 32 53 4 0 39 74 52 CO 1 9 0 5 S G G S 4 G lJ 5a 55 31 72 42 5 6 30 72 ~3 37 CS 57 C6 12 2 91 F 5 14amp 31 42 25 19 38 lG 0 1 1 0 3 1 G 0 7 1 4 0 2a 39 5 Q 0 0 0 0 0 0 0 0 2 Q D 4 0 92 p 5 152 27 48 51 56 SG 1 4 50 51 54 1 0 6 46 48 4 50 27 55 60 57 58 e 80 71 Dl 4S 74 3 39 13 51 SG 72 Cl 93 F 5 166 12 16 30 55 13 2 27 15 4 4 1 2 2 S 2 l 2 2 54 66 61 7G 78 43 3 5 62 27 77 78 66 6 68 75 C4 94 V 5 1773 15 1 1 1 0 0 0 SD Jl 1 0 2 0 0 0 8 0 0 l 1 1 0 0 1 0 0 0 0 0 0 0 0 ~5 y s 177amp Jamp ampl ao amp9 7 o 7 2 2 11 40 56 a4 a1 co 1 53 o 2 sa so 44 Go 49 53 sa 54 7 11 26 2 a 13 1 9G F S 1784 17 42 ll 73 16 5 7 9 l 3 2 0 9 C 5 7 1amp 24 54 SS 70 55 5 55 63 71 70 SS 65 50 68 3 48 39 7 7 F 5 1788 0 S 0 0 0 2 1 1 15 44 58 S 0 1 0 0 2 0 1 0 1 D 0 0 0 0 D 10 30 14 0 0 0 0 0 ~8 F 5 178~ 2 64 31 amp4 bulle 1 22 61 69 10 20 21 76 44 20 c 84 12 rs 37 a o a 2 3 37 as as 11 a1 6 67 F 5 1793 15 l 0 I 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 36 51 3 1 12 0 4 a 0 1 0 0 0 4 34 51
100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
0
13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
l
19 2 2
1 1 0 so
lll K 1 1470 10 28 6 26 36 u u 30 4 1 2 1 4 1 4 l 2 2 112 M 1 1472 3 l3 34 34 1 0 0 4 0 1 1 2 0 1 J 20
2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
IC ts M M M M M K M M
1 2 1 2 z 2 2 2 a z
1412 Ull U18 1434 144G USl 14SS 1456 UampO 14l
9 l
45 37
7 u 53 16 IG so
l IS Z2 20
1 2 57 z
eo u
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
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Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
middot~
The SAS SYII~ Oll 5I 111oaday Stlgttcmber 2 151 l
c
0 so II A
R If II N N II N N ll If N N ll raquo N N X raquo )l N N II If Ill w D lD z N N bull II N N II II N 1 1 1 l 1 1 1 1 l 1 2 2 l 2 2 2 2 2 2 2 3 3 l 3 3 3 s Xl X 1 2 3 c s I 9 0 1 2 3 bull s e 0 l 2 3 4 s 7 i Q 1 2 l 4 s 7
1 F 1 102 45 sa 4 c 39 amps 33 z o 1 1 1 1 1 1 o o o o o l o a 1 6 e 26 35 ~s o 1 5 2 o 2 F 1 170amp 1 s 43 46 4~ 38 10 8 1 4 3 0 1 4 0 l 5 4 0 0 0 0 5 1G 42 13 34 22 Gll 55 GS SS 73 86 63 3 1 12~ 33 sa c2 zg s 3 5 e o 5 a 22 56 so 10 6 s6 cs 19 Jo e~ cJ 9 ampG 52 9 10 65 75 s cc 11 63 4 1 1731 3c 11 s o s 1 1 o o 1 o o 3 e o 2 3 1 s 78 e2 as eo eo 84 73 75 e3
P 1 1736 o o s o o o 1 1 3 2 1 o 8 4 l o 1 o c c o 1 1 o o o 2 10 9 c o o 3 z a56 F 1 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 C 9 0 0 0 3 G 12 6 0 Q 0 1 0 0 0 0 7 p 1 1750 2 5 0 0 7 19 27 16 G 5 3 5 2 4 3 2 2 1 11 59 59 77 72 SO 76 GO 36 53 45 4amp Sl 51 31 1 2 8 F 1 1757 3C 45 64 40 5 ll 1 0 1 2 0 2 2 1 8 4 7 2 20 2 23 9 0 0 0 0 0 1 l 0 0 2 0 0 9 r 1 17amp2 26 43 57 s1 4 3 zo 12 cs 22 C3 5 13 1 1 3 1 1 77 67 13 74 79 11 59 B1 go ao
1o v 1 1767 14 9 11 2amp 4 4 Lamp 8 a 1 15 6 3 15 1 so ss s amp3 amp3 60 12 st sc 41 59 12 ampa 11 F 1 1769 60 R2 90 74 8 6 45 61 70 90 59 85 amp7 l 45 77 83 64 SO 25 6 0 1 0 2 0 0 0 0 0 1 0 0 l 0 12 P 1 1110 cc 42 31 45 o 1 a 10 3 J o 1 1 s 2 2 o sa 31 12 3 o z 59 38 31 11 1 o 1 o o 13 r 1 1772 47 60 63 4S CS 33 8 1 1 2 l 4 4 ~ 3 J l S 35 19 24 3C 45 33 66 25 9 0 0 4 0 3 0 l 14 F 1 1717 70 60 30 65 67 38 57 58 SC Cl 25 41 9 0 3 0 0 CJ amp6 C3 6 3 16 20 l 2 6 0 0 D 1 2 D 15 F 1 11a1 42 26 o 4 1s 1s 3 10 5 J 8 s lo s 3 s l cJ 77 sa 29 91 11 o o z ~1 3 1 1 o 2 4 16 F 1 17RS 93 93 79 89 78 69 73 l 1 3 2 1 7 16 11 3 7 l 53 37 40 52 58 17 1 0 C 0 22 CS 72 70 35 60 17 F 1 1786 61 59 77 48 C4 6C 34 62 49 77 CC 29 70 C1 55 52 37 44 18 23 26 lC 5 1 26 41 D 44 24 0 0 l 1 0 0 18 F 1 1790 30 57 73 l9 31 0 25 71 85 68 6 SS C7 7 73 71 1 17 1 6C 7 0 4 53 l 33 23 3 24 3C 59 52 1 0 19 F 1 179amp 6 42 17 6 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 1 0 0 0 0 l 0 2 1 0 1 3 3 20 p 1 1796 1 S l 39 26 6 3 l 0 lC S 4 20 0 1 3 0 4 CS 43 9 27 60 0 3 0 0 0 4 2 0 0 0 1 21 F 2 1705 26 4C SO 39 54 17 ll 59 58 51 6 2 2 2 8 2 C 35 ampS GO 61 71 10 G GO 69 13 l 1 2 0 0 2 2 22 F 2 11os 11 o 22 12 o 1 J l c 2 2 3 a 1 o o J o 59 35 ss 10 55 so 45 15 sa 56 1 o o 1 o o o 23 F 2 1711 21 63 3pound 2 22 6 2 0 0 1 2 0 S 0 0 1 0 61 61 76 57 23 62 Ce G7 56 SS 53 GO 1 25 51 59 45 24 r 2 1112 12 1 o o 1 1 o o 2 o 1 o o o o 2 o 2 o o o o o 1 J o o o a o o o 1 1 25 F 2 1713 41 36 1G 0 28 22 33 1 6 4 1 10 2 5 1 G 12 0 0 0 1 l 0 0 0 2 0 1 0 3 0 0 1 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N H N N N N B 3 3 3 J 4 4 C 4 C 4 4 C 4 5 5 5 S S 5 5 5 S 5 6 6 6 6 6 6 6 6 7 7 7 a 6 7 a g o 1 2 a 4 s 6 1 a 9 o 1 2 l bull 5 6 1 s g o 1 l s 1 a 9 o 1 2
l 0 SS 3 9 14 0 0 0 0 5 0 1 5 0 C 0 3 0 4 61 62 60 65 41 CB 55 28 51 64 57 27 1 l 64 54 SC SO 2 65 25 2 0 0 0 0 0 2 0 25 34 63 51 14 38 32 0 0 64 62 GS G4 G1 73 53 C4 41 6 1 l 0 1 1 28 57 52 J SO 49 35 0 0 41 1C 2 0 0 6 5 19 36 20 SS 46 50 69 GO 71 76 71 74 62 68 53 51 53 25 2 0 o 0 0 4 76 56 33 21 32 19 64 16 0 0 0 C S2 70 48 7 lJ 23 0 70 l 70 67 80 73 C4 1B 1 36 55 GO G9 15 2 9 J 3 S 0 56 lO 22 0 27 36 28 3 0 0 0 ~4 0 0 0 2 0 0 6 S7 70 53 66 36 30 35 ll 0 0 0 0 1 2 2 1 0 6 o o 6 e o middoto o o o o o o 6 4 o o o o o ampl a ampl 33 1 o 2 o o 1 so 65 35 o 2 1 o 7 S 45 52 28 39 42 1B 4 l 15 Cl CO 0 0 2 0 0 0 3 65 72 75 66 67 71 S3 74 81 63 ll l 5 2 2 1 3 (l k 0 19 0 o o 0 0 0 o 2 0 0 0 0 0 0 0 0 0 67 59 S 63 70 S7 Cl 5 G7 49 SO 9 0 0 28 3 59 60 9 80 59 IS ll 6 0 0 l 0 1 C 1 0 27 6 1 S 59 34 55 66 63 ee 72 73 65 73 74 72 SG C2 60 Sl C9 69 59 54
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16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 s C N H N N N N N N N N K N N N N N N N R N W N N N N N N B JU1 N N K N N N N N N 1 1 ~ 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 l l l 3 J J S X P liS 1 2 3 4 s G 1 a o 1 2 l 4 s 6 1 a o 1 2 J 4 s 6 1 8 g o 1 2 3 s 76 F ( 1774 17 13 25 20 l 1 (J 59 1 1 4 S 7 0 7 4 l 1 3 44 1 1 0 2 1 0 0 1 0 1 0 0 J 26 51 7 F 4 177G 6 4 25 5 1 10 10 36 41 29 28 27 1 47 5 D 0 l 31 0 12 l 0 4 I 38 37 65 60 6 (7 (7 54 44 27 7$ F 4 1783 10 28 4 49 43 46 27 1 l 1 4 1 2 4 3 0 4 l 7 32 17 2 11 35 69 1a 0 0 0 0 3 1 0 0 0 p 4 17a7 30 ll 11 l 2 16 0 1 3 19 0 1 3 1 l 32 (2 53 27 7 55 57 42 1 0 12 0 0 bull 3 ao v 1797 13 17 J o 4 24 sa 23 19 37 sz c 20 25 s o o J sg 6amp 47 61 l cJ 70 73 72 za 56 74 75 55 76 A1 v S 1710 46 10 75 73 84 54 53 76 3 2 40 89 38 3 63 76 37 5 38 32 14 17 3 18 1 0 0 5 0 1 0 0 2 D 2 82 F S 1720 6 6 1 0 1 0 3 2 D 0 2 1 13 2 4 1 0 0 JB 63 22 GO lO 91 95 IS 74 19 a1 0 Sl 85 52 2 5 83 F 5 1723 I 35 4~ 43 7 59 26 3 2 G 2 1 3 2 2 4 2 3 13 5 12 1 25 24 0 1 2 S 30 13 44 2 0 0 84 F 5 124 26 53 76 73 11 49 2 6 2 2 2 S 4 3 ~ 0 15 24 43 35 66 53 51 76 46 51 62 69 S 5( 76 70 ll 1 16 5 F 5 172 14 12 14 23 17 15 1 11 0 0 0 0 4 SC 59 2l 21 21 44 23 4 50 64 5 57 41 53 S 53 76 81 4G 50 2 ss F 5 1121 o o o o o a ca 22 6 2 3 2 3 2 3 a 2 57 19 2 s1 1 64 13 2 o o o a o 4 o o 87 F 5 1737 63 SO 1 0 1 1 2 6 5 13 15 0 2 7 0 l 0 D 80 24 41 0 0 2 0 0 0 1 I 0 S 2 0 0 0 SB F S 140 12 4 0 10 8 19 41 1 1 l 0 2 0 l 1 l 2 0 SO 57 34 43 24 7 0 0 2 0 1 D 0 2 D D 89 F 5 ~741 3 0 0 0 Q ~4 51 68 65 72 4Z 69 14 4 3 11 S 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 0 F 5 1743 32 53 4 0 39 74 52 CO 1 9 0 5 S G G S 4 G lJ 5a 55 31 72 42 5 6 30 72 ~3 37 CS 57 C6 12 2 91 F 5 14amp 31 42 25 19 38 lG 0 1 1 0 3 1 G 0 7 1 4 0 2a 39 5 Q 0 0 0 0 0 0 0 0 2 Q D 4 0 92 p 5 152 27 48 51 56 SG 1 4 50 51 54 1 0 6 46 48 4 50 27 55 60 57 58 e 80 71 Dl 4S 74 3 39 13 51 SG 72 Cl 93 F 5 166 12 16 30 55 13 2 27 15 4 4 1 2 2 S 2 l 2 2 54 66 61 7G 78 43 3 5 62 27 77 78 66 6 68 75 C4 94 V 5 1773 15 1 1 1 0 0 0 SD Jl 1 0 2 0 0 0 8 0 0 l 1 1 0 0 1 0 0 0 0 0 0 0 0 ~5 y s 177amp Jamp ampl ao amp9 7 o 7 2 2 11 40 56 a4 a1 co 1 53 o 2 sa so 44 Go 49 53 sa 54 7 11 26 2 a 13 1 9G F S 1784 17 42 ll 73 16 5 7 9 l 3 2 0 9 C 5 7 1amp 24 54 SS 70 55 5 55 63 71 70 SS 65 50 68 3 48 39 7 7 F 5 1788 0 S 0 0 0 2 1 1 15 44 58 S 0 1 0 0 2 0 1 0 1 D 0 0 0 0 D 10 30 14 0 0 0 0 0 ~8 F 5 178~ 2 64 31 amp4 bulle 1 22 61 69 10 20 21 76 44 20 c 84 12 rs 37 a o a 2 3 37 as as 11 a1 6 67 F 5 1793 15 l 0 I 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 36 51 3 1 12 0 4 a 0 1 0 0 0 4 34 51
100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
0
13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
l
19 2 2
1 1 0 so
lll K 1 1470 10 28 6 26 36 u u 30 4 1 2 1 4 1 4 l 2 2 112 M 1 1472 3 l3 34 34 1 0 0 4 0 1 1 2 0 1 J 20
2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
IC ts M M M M M K M M
1 2 1 2 z 2 2 2 a z
1412 Ull U18 1434 144G USl 14SS 1456 UampO 14l
9 l
45 37
7 u 53 16 IG so
l IS Z2 20
1 2 57 z
eo u
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
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Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
0 N )I )I w N N II N N bull as N 1C N N H If bull If If N N IJ N lit N at N 1C If N II N N N N II 3 3 3 J c 4 5 5 5 5 5 5 s s 5 6 6 6 6 5 7 7 7 4 c
s 7 0 1 2 3 5 6 7 a 9 5 0 1 2 3 4 5 7 8 0 1 2 3 4 5 6 7 a 9 0 1 2
2 1 1amp
bull 47 52 13 7 1 1 2 0 0 0 1 0 7 41 50 21 61 74 IS 74 72 84 16 88 87 78 13 0 0 32 732 ll 1
17 75 76 70 B 0 0 J 1 J z 10 0 1 5 l 8 57 51 0 14 BB 88 93 70 79 88 77 8 76 80 51 lC 1 0 5 28 0 55 37 l 0 0 0 0 1 0 1 0 0 4 1 0 0 1 0 74 6] 61 so co 36 36 1 2 0 0 U U 2C 47 7 1 1
1 42 2 l 4 3 1 2 2 1 l l 0 5 1 s 4 7 60 46 65 sa 31 amp2 ze 0 1 0 7 55 JO 1 0 1 0 0 30 1 59 5 0 0 0 4 7 0 6 0 1 0 3 2 0 1 1 1 75 74 69 91 75 69 65 52 2 6 0 s0 77 67 31 0 46 u 17 0 0 0 0 0 0 0 0 2 0 0 1 7 47 3C 75 1 71 42 46 77 71 51 67 l 72 39 1 0 0 0 0 032 0 63 77 13 0 0 0 1 l l l 2 0 0 6 5 53 s 67 e 88 11 at 11 5~ 0 11 0 0 0 57 fiB 67 ~ 2 31 5 55 35 31 11 1 0 1 8 1 4 0 25 56 38 45 52 20 1 59 7 72 72 59 55 70 62 76 48 58 73 62 5t 52 17 o 0 3~ 45 51 27 1fo 1 0 1 0 1 0 1 0 0 l 0 1 78 72 78 83 75 0 7amp t2 75 78 lt 65 2 1 1 29 51 511 IS lS 30 54 40 9 0 1 0 0 0 0 3 0 1 0 1 o 36 se 5s amp5 50 11 g cJ so s 11 0 0 22 6C lC 0
00 4736 65 68 28 4 0 1 2 0 1 5 0 0 5 1 0 o c1 s cs 7 Gs amp1 t6 57 54 s2 ca amp2 as 2s 1 0 0 37 3 15 30 0 0 0 0 0 0 11 211 35 022 29 e Sl 11 75 ea s 7t 73 75 43 1 1 G St 62 6amp tpound 18 0 38 72 ss u U Sl 32 53 n li amp6 13 20 l4 16 17 68 CC 56 6C 5C 1 ll ampC 66 70 tl ampJ 6C BO 80 69 64 56 a 51 2 3 3 47 co 26 4 19 1 0 3 2 l 0 0 1 l 3 0 58 74 56 65 60 60 ~5 53 1 o 25 12 5 se 41 s 11 0 to 20 as 55 u co 54 53 so 58 27 5 3 S5 59 36 2 1 0 0 56 65 CC Cl 77 75 67 75 63 77 6R Cl 74 7C 70 4 0 1 41 0 46 15 28 12 so 31 52 11 CS 41 41 25 56 JS 3 28 6 2 5 CO amp4 63 76 C4 7t 21 l 1 11 0 22 2 1 4 1 42 s 55 21 11 24 63 58 31 1 011 0 7 0 2 s 0 3 5$ 55 52 s c1 59 5 4 sa amp7 52 32 l 0 CD U tJ 2 75 25 2 1 0 3 0 3 3 3 Q 17 5 1t 0 l tB 49 79 70 Cl 7t 90 21 0 0 5 66 cs l 3 0 l 4
25 u 56 7 15 40 cJ 2t 23 sa 0 3 0 1 0 3 1 59 52 51 62 4 73 72 68 Cl amp8 73 81 3 65 16 7 1 71 45 8 22 41 37 13 48
42 2 16 l 55 45 55 14 1 0 C2 67 t9 49 t7 43 CO tS 0 0 29 C5 cs 29 1 0 D 0 0
46 6 74 11 l 1 119 0 1 1 2 3 1 4 10 12 5 44 pound0 ampI 60 71 C1 73 52 1l l 0 0 0 2 0 0 21 2 47 l 65 18 0 4 24 0 3 0 2 4 4 0 8 Jll 13 amp2 2 3 60 64 76 GZ 71 53 22 2 3 17 77 7t tl 24 5 48 0 U ~B 8 24 2 55 73 e J6 oa u 1s 0 1 2 0 0 3 68 65 CG Ct GS 7 SC 44 59 G7 70 55 t 0 0 10 3C 51 1 81 amp3 1e ss sa 76 65 se 73 amps amps 65 48 68 66 54 t2 33 75 so lB 58 71 sc 57 te 1 o 26 o o 50 Gl 51 17 40 2l 0 0 0 0 0 0 0 1 0 0 0 0 72 67 60 70 46 6J 62 67 55 C7 23 14 57 57 44 7 C3
The SJS Cet~ll 0958 Tue~dcy September as 18 l
G 1 A
0 s 0 )I )I )I N N N N Ill II N N II ) N N N N ll N J1 N II N N N Ill N I amp11 N N N N N )I N N 1 1 1 1 l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 ) J 3 3 l J
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lZG H 2 1418 45 22 42 Cl 4 70 74 C4 S 2 2 C 1 0 l 0 0 1 61 42 2 1 0 2 1 21 12 64 31 8 53 0 0 0 1 12 M 2 1434 3 20 58 amp 11 8 2 10 19 45 72 4C 8 3 4 1 8 0 7( JQ 59 63 5 3 1 2 4 4 Q 1 4 7 2 1 1 126 M 2 1446 7 1 3 1 e 45 31 l7 o 1 l 4 o ~ o o o 5 54 75 sa 65 6amp 50 54 s ss 56 48 cs 63 se 57 59 12 M 2 1453 1 29 15 7 16 4 40 4 8 1 7 C 2 1 6 6 5 3 54 49 47 18 45 0 0 0 9 36 62 32 CJ 9 l A 130 K 2 1455 63 S7 57 80 63 0 1 63 10 0 1 11 6 34 10 2 2 11 81 6G 5 9 91 86 8S g 83 2 92 87 57 a ec 131 K 2 1456 16 2 17 C 3 4 l 14 1 3 6 8 32 SO 28 6 24 SJ 2 20 11 7 4 1 0 3 C 0 0 S 1 10 0 4 132 N 2 1460 QG QO 77 65 2 6 0 3 0 0 1 1 7 4 lD C J ~ SO S~ 72 55 0 0 1 J a l 0 5 J 0 2 11 0 121 M 2 146J so 4amp 6 52 5e sa 21 3 56 7 G1 s 35 35 10 28 54 15 54 s 52 52 56 21 4o 15 1 3 1 s 1 Jo 6o J bull 134 K 2 146 S1 12 0 0 1 0 0 3 37 82 22 JJ ~5 12 5 12 2 2 81 45 GO 35 86 a1 47 23 0 J 5 a 1 0 0 l C 135 K ~ 1bull11 ~ 33 16 o 7 o o o 2 1 3 12 2 2 7 16 sa 73 67 sc 43 59 6 o 5 1 o ~ J s ~2 47 s1 51 41 135 M 2 145 52 66 48 BS B 5 77 26 0 J 16 30 1 2 1 l 0 1 91 81 59 61 Jl 3 a 0 0 0 13 Sl 12 1 2 1 0 13 M 2 1479 3 10 J 0 0 0 2 1 l 5 33 18 10 3 S 2 J 0 52 48 21 0 1 8 C2 0 0 10 3P 39 26 0 0 l 13a M 2 1CI2 15 4 0 2 2 0 12 4 36 1 S 0 7 0 0 0 l 69 87 70 3 5 D 7 2 12 29 57 74 amp5 SJ 0 51 24 13 K 2 1amp95 16 18 24 32 27 l 1 1 0 1 0 2 5 26 5 3 10 48 18 52 7 15 1 57 6 72 55 32 65 0 0 0 0 1 1 140 M 2 1500 43 41 5 55 ~3 0 6 21 46 3 18 46 0 1 23 48 3~ 15 32 78 66 71 69 55 65 73 5 2 3 4 0 10 5 7 41 141 N 3 1403 0 0 0 1 0 2 0 0 l 0 0 0 0 0 0 1 0 0 ~ 12 18 D 0 0 0 a 0 0 0 0 1 0 0 1 0 142 M 3 1404 4 19 1 4 0 1 0 0 1 0 1 2 0 2 1 11 14 63 73 C4 89 59 90 8 1 57 II 53 2 0 2 0 0 143 bull J 1co 21 2 o 27 44 52 4 10 5 3 13 2 s e o a 4 44 65 61 6J sa 63 57 11 2s 22 c 1 5 o s 12 144 M J 1415 G 10 62 2 21 11 S 5 1 2 0 5 8 0 1 24 27 2 10 43 S2 82 27 S 4 5 0 l 2 0 1 J 7 1 145 K J lClG 1 2 9 19 2 0 0 16 4 0 0 Q 0 0 0 0 0 0 C 1C 11 8 14 16 19 0 11 0 35 3 0 1 0 Q 0 1laquo6 M J 1417 36 o 5 21 so so 3 a 3 a s 5 1 11 2 2 4 ~ 45 o 61 11 3 1 3 o 1 l 2 7 2 2 2 1 1i7 M 3 1421 12 2 2 10 2 0 1 0 4 7 0 0 4 15 3C 7 71 5 7a G5 52 42 5 2a 1l 5 1 Q 0 0 11 54 58 G8 148 M 3 1425 9 69 20 o 4 7 23 6 1 12 1 S 2 20 51 13 80 72 c G7 53 75 S8 l 70 59 50 53 1 7 1 2 17 4 149 M 3 1430 0 0 0 S 5 40 40 0 2 2 0 1 6 G 7 5 o 2 7 12 13 4 86 2C 1 0 2 l D 1 0 2 0 0 1 150 K 3 14JS SJ 40 16 6B 34 26 0 C 1 S 0 3 $ 0 0 J 2 58 31 8 15 0 0 2 0 1 l 0 0 1 2 0 0 I
0 N N N N N N N N N N N d N N N N N N N N N N Ill N N N N N N N N N ~ N N N N E 3 ~ 3 l 4 4 4 4 4 4 4 4 4 4 5 5 S 5 5 S 5 5 5 S G G amp 6 6 6 6 amp amp 6 7 s 6 7 8 o 1 2 3 s 6 e 9 o 1 2 l s e o 1 2 J 4 s 6 7 e o 1 2
126 1 4 70 72 21 65 61 55 22 1 0 0 0 0 C2 86 S2 74 70 86 67 G 65 ampl 87 72 15 11 74 68 62 60 72 31 12 4 121 6 59 63 14 4l 32 1 3 3 2l 42 ao 66 71 7J o a amp1 62 ~s 68 8o s 41 ss 11 67 a1 41 J 39 amp7 ~pound 129 75 60 49 41 40 l4 ss 22 27 33 16 0 2 0 1 1 4 0 l 65 so 62 59 so 74 4 38 15 s l 4 1 1 5 1 0 l 129 1 62 32 o 14 a o 1 o o o o o 1 1 o o c a 45 10 G1 sa 64 67 O 69 70 63 62 zs 1 o 2 o 130 84 80 29 66 1G 1 3 1 0 34 D 14 l2 7C 76 80 88 g 78 6 77 0 83 59 57 62 78 85 Bamp 98 42 71 92 77 48 5 131 5 C4 74 32 43 14 Sl 27 1 2 S 0 0 14 8 0 2 0 J 54 77 59 l 52 72 62 65 23 19 4 g 4 0 2 1 0 0 132 o 4B 50 1 o o 2 o o o 2 a 2 o 1 o sa 12 4 sa 78 61 6e 76 11 33 45 11 3 27 o o o 131 11 55 43 60 Z6 35 1 0 0 6 17 4 20 17 25 51 5 G2 46 72 66 78 61 58 60 Sf 63 84 61 5 45 35 1 o o 0 0 134 1 80 63 51 6 62 22 9 0 2 0 1 0 1 1 0 a 0 0 61 7a 76 65 71 9a 74 77 63 G7 84 SS 56 58 68 C9 1 2 135 40 67 43 4 t1 22 S 2 5 J 0 l 2 5 5 Z 4 2 3 59 70 62 SZ 73 61 42 47 41 Cl C1 50 5 C7 $7 49 42 64 136 4 69 bullR 6 67 76 7l 33 24 2 20 1 e ~ 6 0 c D o 1 68 53 71 G9 70 59 73 GJ ampB 23 0 2 l 1 137 0 J6 ~middot 44 11 17 1 14 15 0 2 2 1 0 2 ~ 0 0 59 62 74 74 63 76 88 7amp 48 12 57 56 32 1 18 69 138 13 6 4 52 ll 62 0 36 20 2a 13 79 64 34 57 35 36 57 4 ~~ GS 64 51 5 70 70 68 66 79 SS C 79 60 C6 2C 2 21 139 0 6~ 3R 26 1 26 58 32 7 0 2 1 0 0 0 2 8 C6 6 7 71 73 77 82 18 64 79 66 8 2 11 10 77 52 63 61 140 74 74 bull C2 61 61 76 71 59 G 64 55 62 C3 5 CS 65 57 ll SC l 62 51 35 4 18 9 2 6 0 1 c 76 51 22 0 1 1bull1 o ~o ll 10 o o o o o o o a o o 13 o a a o 11 1 67 amp1 so amp4 o 46 10 laquo 1 2 1 o o o 142 R 12 u a o u bull 20 o 6 21 u u 1 2 J 1 o o n 65 ~2 o g sg 57 42 77 59 n 10 62 77 143 17 82 16 ZD 0 0 l 4 Q 5 4 1 28 47 57 amp6 12 0 2 59 60 58 65 QR 58 74 52 27 44 lC 38 11 1C 30 4 16 56 144 42 59 41 13 l 1 0 2 2 1 0 0 12 8 2 ~ 1 16 amp2 73 57 SB 77 7J 65 40 l amp3 l Sa CJ 47 7C 51 69 77 145 o s2 3e 37 o o 1 o o o 1 o o o 7 21 s 41 ampa amp9 amp7 a3 J 51 22 73 63 74 l4 lamp 32 2 1 1 o 14G 1 68 38 7 41 laquo2 1 z l 1 1 o 2 J o 4 o 1 o 55 13 a 61 68 7 sa 74 53 co t6 42 14 l 39 s a 147 55 52 53 4 46 61 16 ~ 0 0 4 C a 2 0 8 3 St 46 55 S8 55 70 51 52 C4 77 SO 40 17 2 1 4 15 32 148 0 80 St 40 16 11 0 0 1 lC 53 15 GO 62 24 45 51 22 58 65 65 58 57 60 52 SG 52 4amp i6 2 ampC 45 47 33 5 14t 1 61 JJ 3 1~ 0 0 0 0 Q 1 0 0 0 1 1 1~ 5 57 S 72 ~S 71 70 61 6 73 4 o 10 0 25 5) 7t l7 0 150 27 75 51 11 0 0 0 1 0 l7 24 0 2 0 0 l 0 1 52 56 Cl SG ca 75 5 61 lS 2 21 0 0 o 4 0 6 6
~ Ule SAS syliCa 09Se TUes~ ampepteabcr lt lS
G a A
0 so N Jl N N N rl K N N N II w Jrl II Ill N )I N N IC bull )I N Jl If N
ll IU t )I N N N N N N bull Jrl l t 1 l l 1 1 1 l l 2 2 2 z l a 2 2 2 2 3 3 3 3 3 s XP H 1 2 3 4 s 6 ~ 8 0 l 2 J c 5 7 8 c 1 2 3 4 s 6 7 II i c l 2 3 (
2 0 Q
152 H 3 1444 SS 63 Sll 73 79 s 214 0 1 0 l s 2 1 as 736S lSl M 3 1442 lS 4 0 0 s c 2 1 0 0 0 0 a Jl u 1 l 7 co 0 10 7 0 0 0 0 0 0 l 0
3 l 6 l 0 0 23 153 M 3 144 52 11 4 Jl 0 0 l 1 2 s 4 1 815 0 0 0 1 1 l 0 (I0 1 0 3 3 0 n 1 bull 11 0 1$4 M 3 1454 18 20 Cl 47 3 0 0 1 1 3 75 59 7l C3 5 4 1 4 13 22 45 2S 7 20 57 ~middot 40 0 a s 0 2 I 5 1$5 H 3 1458 26 41 58 Oll 0 a 1 0 512 0 J l 5 2 2 ll ll 5 0 1 1 0 2 2 0( 3 Zl 3 1 156 M 3 161 sa 11 a so J6 54 53 l 0 l 0 0 0 0 0 0 0 l 20 13 l 0 1 1 0 1 1 1 2g 75 95 7J 53 83 157 H l 1410 ZO 27 77 Sl 47 8 2 1 0 z c 1 ( 3 2 0 7 I 311 ll Ill 37 2 13 33 14 SG 69 40 7G 1 2 158 M l 1491 1Z 36 SS 57 4 2 74 74 IS 1 4G 0 10 66 98 40 65 38 68 94 57 32 JS 27 45 7 55 59 46 S7 41 40 0 15 M 3 1492 19 15 o 12 12 3 19 1 1 2 amp1s 21 1c a 4 4 1 43 10 4t J8 29 57 42 se 8 37 14 43 62 4) 56 50 16o M 3 19g 42 sz 7c amp2 t5 sz t2 11 2 21 38 79 so 12 s g 65 59 a 45 0 70 55 lS II l 6 1 14 21l 71 74 65 161 M 4 1401 0 4 3 1 amp5 72 S3 3 30 C6 1 3 1 17 7 2 3 l 20 34 21 II 0 0 a 5 0 0 14 11 5 3 0 lGl M 4 1407 49 4 2 1 3 2 2 3 C 1 16 7 1 10 2 0 l T 76 66 31 0 0 0 z 1 1 1 00 1 0 0 13 K 4 1414 66 7amp 74 79 73 43 s 8 2 l l 7 17 17 2 2 z 7 a s2 u ss 5 42 40 39 39 3 c 8 0 s 16~ M ltl 11 77 go 7G lto 97 s1 as so cg 96 1 34 1 27 55 73 55 60 7 55 58 61 10 l 9 0 3 112 2 1 165 M 4 1426 44 10 16 ~l 0 0 0 1 23 ~0 6 9 10 27 lO 13 1 11 2G JS 22 53 14 1 J s 21 2 5 0 2 6 l U6 M 4 1429 24 3 1 U 31 lS s 0 8 2 l 4 0 s 1 5 l 0 Sl Jl 36 Jl 66 6 0 32 64 72 5 70 6) 167 M 4 1432 31 34 0 0 1 3 z 0 0 D 521 a 0 6 22 19 64 53 0 0 0 0 0 2 0 0 1 5 3 0 1611 M 4 1433 1 40 19 t3 lB 13 2 0 1 s 8 4 23 26 66 34 14 30 51 211 49 14 cz 33 30 41 2 3 25 49 22 57 169 M t 1438 2 11 4 2 g s l 6 2~ lO 47 38 32 23 6 1 4 0 0 0 l 1 10 ) 0 0 1 0 0 170 H 4 143~ 24 84 39 s u s ll 17 3 5 4 4 4 2 9 l 9 7 66 10 llC 55 60 22 0 0 32 I 0 78 55 62 31 171 M 4 144$ 24 1 0 l c 1 1 l z 1 0 0 0 0 0 0 0 10 11gt 13 6 0 0 0 0 2 1 1 0 0 0 0 2 0 172 H 4 1451 40 l2 36 C4 48 13 23 63 47 57 42 C5 ll 21 l 2 l 10 C 10 17 C4 42 6C 57 amp6 52 l 63 61 62 0 72 73 173 M C 1459 32 55 71l 56 19 59 12 37 6 SS 74 57 0 0 1 0 1 47 28 25 52 86 41 30 69 71 74 C6 s 2 0 0 3 17ir M 4 UU 21 0 s 11 54 12 2 1 1 14 12 2 3 l 5 0 s 2 21 0 0 0 0 0 20 2 3 0 4 0 0 0 2 0 175 K 4 1465 6 a () 3 10 2 l l 1 1 2 2 I) 0 0 0 0 l 3l 20 12 0 28 0 1 0 l 3 1 () l 0 0
bull 4
0 N II N N N N N M N N N N N N Ill ~ N N N N N N N N N N N If If II N N I( Ill N N N 8 J 3 3 3 3 4 4 4 4 4 4 4 5 5 5 5 5 5 5 s 5 s 6 G G amp 6 7 7 7 s 5 6 7 6 9 0 l 2 3 4 5 6 7 8 9 0 1 2 l 4 s 7 s 9 0 l 2 3 5 6 II 9 0 1 2
1Sl 0 2 S 44 41 37 Q 0 Sl 1 36 Zf 0 1 3 Z 56 30 40 64 1gt0 72 CS 52 21 49 SO 32 6 0 1 1 IS l 1 1 0 152 3 0 79 49 33 30 sa 30 0 2 2 44 25 0 l 2 0 1 l 2 52 67 64 SB SB 65 81 63 56 57 62 69 66 41 C7 53 10 1 153 1 o sa o 11 1 2G o o o o amp 1 o o 1 14 ss s s 29 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 54 JC 12 1 2 l l 1 0 l B SO 54 amp2 47 51 S2 58 67 59 66 69 15 52 71 57 64 2 58 48 27 0 0 0 lSS 1 0 iS 64 22 2 0 J 0 0 19 3 Z 3 3 l 4 1 3 4 SG S 71 0 6~ 68 21 1~ 1 o 0 0 1 11 1 l 7 8 1SG 0 l 74 1l as 76 75 sa Sl 2 0 7 0 4 1 1 0 0 o 0 71 ampl 71 CG 0 ampl 75 69 78 8A 18 3 76 70 75 48 7 7 157 3 o 75 49 26 48 51 4 0 0 o 1 ll 4 D l 0 l 0 1 64 54 2 60 BG 76 74 76 5 51 amp9 80 62 60 51 63 67 51gt 158 3 1 82 29 S7 1 17 0 l B 0 1 l 0 0 4 30 51 72 20 74 69 61 74 83 77 79 6 6 65 GS 74 65 S 81 73 37 42 1S9 2 l 65 10 13 Q 0 0 0 1 4 7 53 37 30 10 l 14 27 0 C2 66 58 63 69 63 41 26 amp1 29 17 1 6 0 1 0 B D 150 67 64 78 77 2l 24 0 0 7 1 0 5 2 0 0 0 ll J 49 5amp 55 6 72 76 62 57 55 7Z 1 1 ll l 6 G 1 161 2 0 59 4 45 67 48 12 1 0 l 0 3 1 0 l l 2 3 0 68 71 72 G1 61 S SO 8 Q 64 10 66 59 amp7 80 3 86 0 152 0 0 72 8G 6G 5 46 40 lG 0 0 2 0 0 0 1 0 0 3 9 62 67 S 79 74 77 70 83 90 84 4l 42 11 0 8 14 5 163 2 0 27 47 18 8 7~ 52 51 12 0 7 2 31 0 2 S 2 4 0 77 63 63 5 BJ 61 7S 74 0 74 62 81 29 9 0 3 1 1 164 0 1 0 15 59 14 S lS 59 0 0 o 2 2 28 72 63 69 75 15 SB 48 42 47 58 64 S SO S 74 73 69 72 1 57 32 7 165 2 18 4~ 2 51 0 15 a 1 1 0 3 2 0 8 4 a 0 5 2 70 63 66 54 61 62 SO 4 45 48 51 51 3S 0 1 0 3 2 1amp6 so o 93 so 14 o o 2 o so 36 2 1 o o 1 c o o o sa 60 10 71 57 66 s 73 12 sJ 53 28 9 o o 3 167 o z 38 22 o o a 1 o o o 2 o 1 o o o o 2 5~ ~ so 75 77 7o eG 57 14 3 o s 1 a o 1 43 1 168 Z2 2 55 45 44 23 18 S 3 39 38 51 56 29 Z8 49 2 0 1 0 52 5l 5 53 68 78 CS $7 73 69 64 77 77 SJ 51 4S 36 16 0 0 41 15 1 Q 0 0 0 D l 0 3 0 7 3 7 G1 38 ll 60 Sl 63 61 92 87 BC 55 3 65 57 58 24 11 1 S 1 0 110 2 4 ampG ss se s 2 1 8 o 1 13 o a 1s 9a 79 amp8 47 G7 84 60 66 68 74 bull~ ss 76 71 31 1 o 32 ss Gs a as 111 o 1 sG 41 29 l 1 2 10 o J 1 o 1 o 1 1 o a 12 so sa 84 s 57 G2 4 53 2laquo 10 c 2J o 1 o 1 2 172 s5 68 6 J 49 52 21 23 12 l 1 16 o a o o 1 21 S9 42 75 11 65 78 1 11 47 ampamp a 3o o s 10 o o o o 1 173 0 2 62 61 tO 17 4 S 0 B 1 29 B 5 4 2 D 21 JS l) 58 55 60 73 80 65 71 65 54 S 72 G6 34 C 0 2 0 0 174 3 0 69 37 14 32 ~ D 0 1 0 0 0 0 0 0 15 22 46 35 59 68 CS 75 72 83 56 6 36 9 2 1 0 0 0 0 1 11s o o B4 sz ~s 29 2s 41 s o co S 2s Jt 22 1 o 3 so 63 54 12 76 s sa ss samp Jl to 20 35 59 so 4 6 1
The 6AS Sys~am 0958 uesd~y Scp~embe 29 1998 8
G R )
0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
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100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
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l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
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2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
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bull
Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
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Type II SS Mean Squaze P Value Pr gt F SoUCS
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~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
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1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
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0 4 0 0 c 5
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l 5 1 0 0 0
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
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30 20 62 32 sa 55 46 s
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92 93 94
r 1
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1752 l71lG 1773
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36 56 23
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
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20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
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65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
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lamp 0 0 e Q
l 0 2 2
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2
0 0 l
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1 1 0 2 0 0
3() 0 3 0
ll 0 6
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1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
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4 S4
2 74
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0 I) 1
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27 a 45 45
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0 37 25 52
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0 0 3 1 8 0
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61 53 uampe
3
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2 19 10 11 41
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4 60
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
fbbull as Syate~~~ 09511 fueacsay septetmer 29 u bull
c R A
0 so lf If N N N tt Ill II N N N II N N If ll N 1 w g N N )1 N N N IJf
B ampU r N N N N )l N 5 N N 1 1 1 1 1 1 l 1 1 1 1 2 2 2 2 2 2 2 2 2 3 l 3 J 3 3 s X J M 1 2 3 4 s II 0 1 z 3 4 5 6 7 8 9 0 1 2 3 bull 5 I 0 1 2 3 5 7S F 4 1774 17 13 25 20 1 16 41 69 l 1 4 5 7 0 7 4 3 1 l9 44 1 1 0 2 1 0 0 1 0 1 0 0 3 26 51 77 p 4 177G s 4 25 s 1 10 10 31 41 29 28 27 16 47 s o o 1 31 o 12 3 o 4 11 38 3 s so 47 amp4 bull bull 2 78 F 4 1783 10 28 4 49 43 4S 27 1 1 l 4 1 2 4 3 0 4 l 7 32 17 2 11 35 59 18 0 0 D 0 3 1 0 0 0 7t F 4 1787 30 11 11 9 1 2 4 1 0 1 3 19 6 0 1 3 1 1 32 42 53 27 7 55 57 42 44 1 D 6 12 0 D 4 l 80 F 4 197 13 17 3 0 4 24 58 23 1t 37 52 4 20 25 S 0 0 3 5 66 47 61 ~ 63 43 70 73 2 28 amp6 74 75 65 76 4~ 81 F S 1710 46 SD 7S l 14 54 53 76 3 2 40 89 38 39 Cl 6 3 5 38 32 14 17 3 1R 1 0 0 5 0 1 0 0 2 0 2 83 F S 1720 6 6 1 o 1 0 3 2 0 0 2 1 13 3 4 1 0 0 38 63 22 60 30 91 95 IS 74 89 Bl 90 51 8S 52 2 S BJ p 5 123 II JS 44 4l 7 59 26 3 7 2 4 2 l 3 2 2 4 2 3 13 5 12 17 25 24 0 1 2 5 30 13 44 2 0 0 84 F 5 1724 26 53 76 73 11 9 2 6 2 2 2 ~ 4 3 5 0 15 2cent 3 3S 66 53 51 78 46 51 62 6 5 5 78 70 33 1 16 es F s 127 14 12 1bull 2l 17 1s 11 11 o o a o 4 sc s~ 23 21 ze 44 23 cg so C4 sc 57 1 53 57 53 76 81 46 so 2 amp6 p s 1728 o o o o o e 48 22 6 2 c 3 2 J 2 1 a 2 57 19 2 51 1 13 s 2 o o o o o o o 87 F $ 1737 63 60 1 o 1 1 ~ 6 5 13 15 0 3 7 0 l 0 0 SO 24 41 0 0 2 0 0 0 1 1 0 5 2 0 0 0 88 F 5 140 12 4 0 10 8 19 41 1 1 1 0 2 0 3 1 l 2 0 50 57 34 43 24 7 9 0 0 2 0 1 0 0 2 0 0 89 F 5 1741 3 0 0 0 0 24 $1 6amp 65 72 42 69 14 4 3 11 5 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 90 F S 1743 32 53 4 0 3 74 52 CO l 9 0 5 5 G C S 4 6 13 6R 55 31 72 42 56 amp30 72 63 J CS 57 CR 12 72 ~1 F S 1748 31 4l 25 19 38 lG 0 l 1 0 3 1 6 0 1 C 0 28 39 5 0 0 -0 0 0 0 0 0 0 2 0 0 4 0 ~2 F 5 1752 27 48 51 56 56 1 4 SO 51 54 19 0 6 46 48 4 SO 27 55 60 57 58 68 80 71 83 46 74 73 39 13 51 56 72 61 93 F S 1766 12 16 30 55 18 2 2 15 4 4 1 2 2 5 Z 1 2 2 54 66 61 6 78 43 73 75 62 27 77 71 C6 61 75 44 94 F 5 1773 15 l l l 0 0 D 4 7 46 SO 31 1 0 2 0 0 0 8 0 0 1 1 l 0 0 1 0 0 0 0 0 0 D 0 SS F 5 1778 36 61 50 69 97 90 7 2 2 ll 40 S6 84 87 40 1 Sl 70 52 SS SO 44 60 4 63 59 54 47 71 26 2 0 13 3 96 p s 1784 17 42 31 3 1c s 7 3 3 2 o 9 4 5 7 1bull 24 54 59 70 ss sa ss 63 11 O 55 55 so 68 7J ce 3 27 97 F 5 1788 0 S 0 0 0 2 l l 15 44 58 5 0 l 0 0 2 0 1 0 1 0 0 0 0 0 0 10 30 14 0 0 0 0 0 9a r 5 178~ 2 68 6 31 4amp 1 22 63 69 7o 20 27 4c 20 4 ac 12 ss 3 o o o 2 3 l amp9 as 81 a 76 69 6 99 F 5 1793 15 l 0 8 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 l5 51 3 1 12 0 4 0 0 1 0 0 0 4 34 51
100 F s 178 55 75 e5 85 ss J 1 54 ao amp8 51 53 11 a amp7 76 10 sa 71 74 2 59 23 70 59 amp7 77 8 30 as as 67
0 ~ N N N N W N N N N W N N N N N N N N N N N N Ill N N N N N Ill N N N N W N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 S 5 S 5 5 6 6 6 G 6 6 6 6 G 7 7 s 6 7 8 p 0 l 2 3 4 5 6 7 8 9 0 l 2 3 4 5 6 7 8 9 0 l 2 l 4 s 6 7 8 9 0 l 2
2l 43 11 0 Q 0 1 5 2 0 4 0 0 4 14 13 54 64 6~ 64 4 68 64 GG 96 76 73 57 4 IS SG SO 6 335 n71 65 S 42 15 19 so 42 34 g 16 sc 45 4 ll 53 9 30 55 3c 44 47 47 49 54 4 ss 55 s1 S4 s2 ~ 2s 64 5 42 sa 12 78 1 37 23 S 12 20 10 0 52 90 42 0 2 0 1 5 2 0 1 72 91 ampl 73 ss 36 2 34 to 77 79 3amp 16 1 10 3 2 79 0 54 55 18 54 26 27 32 10 0 0 c 0 0 D 4 0 0 6 63 69 G2 52 42 33 2 0 0 D 39 71 55 54 2 0 0 80 79 66 32 lO 12 13 SZ 71 JS 0 0 0 0 0 0 0 0 0 1 s6 so 64 O amps 62 sa amp8 cz 45 39 cs 46 5 1 0 0 3 81 4 46 54 ao 11 0 0 1 0 l 1 0 1 0 3 1 0 0 l 70 71 GS 72 56 4S ZS 2 12 71 74 56 74 22 2 0 1 l 82 8 41 41 62 6 U 43 6G 23 0 a l a 0 1 0 0 0 0 SO 73 Gl 54 66 16 l 0 28 90 71 42 1 1 l 3 83 2 63 26 32 J 4 16 1 Q 2 0 3 5 12 21 49 15 35 9 61 76 61 58 65 Sl 70 59 71 57 39 60 89 60 66 28 49 84 65 7~ 45 58 65 14 1l 45 3 0 15 15 0 J 0 2 10 66 e 71 74 74 78 eo 76 Js 12 0 D 31 58 B 76 34 23 0 85 0 64 24 ss 17 ~0 0 D 1 Q 1 0 0 0 0 0 3 60 4 62 63 70 61 Gl 61 55 62 3 0 28 8 Q 0 0 2 SG l 36 53 46 3 2 22 48 6 0 0 0 0 0 3 17 4 53 54 so 43 73 60 61 10 l C2 il 62 47 53 61 4 69 U 0 97 0 59 29 s 1 0 0 3 0 2 0 3 0 1 0 4 0 3 1 66 so 11 67 82 7o e2 76 sa 69 sJ 11 0 7 3 0 1 0 811 0 60 35 26 27 20 35 16 0 0 1 0 0 0 1 2 1 4 0 57 69 71 74 84 71 65 65 69 72 4 68 63 78 44 G2 52 59 99 3 4ll 40 4 2 2 2 0 0 1 l 0 1 0 5 0 0 60 42 47 47 ss ss 42 53 42 3 1 10 2 43 52 61 32 1)90 66 68 51 l4 G lC 47 44 9 0 l 0 0 3 2 0 1 0 61 54 71 56 49 71 48 6 63 67 61 51 14 0 0 91 o sa 1 0 0 1 0 0 G 2 1 0 0 1 3 2 14 46 6 69 71 1 64 87 66 58 52 17 0 4 1 2s s3 71 aa s 2J 92 6~ 36 l4 52 47 1 1 4 s 5 1 4 0 0 1 4 0 52 63 SS 52 EJ 43 3 2 5 0 4 0 G 75 57 SS 4 2 93 74 47 66 2 32 77 47 61 65 33 3 1 8 3 2 1 3 2 0 71 70 69 70 83 7~ 57 54 68 65 61 1 l 1 24 73 78 94 18 25 23 14 lG 0 0 0 0 0 0 1 4 0 D 1 0 0 o ss 11 ampa so 40 52 0 0 1 0 28 34 77 JJ 4 1 1 95 l 57 20 4 27 S4 7 0 10 0 2 0 10 44 1 0 0 3 a s5 4e pound3 51 52 20 68 48 52 JS 2 0 0 1 0 0 13 42 16 77 59 44 39 0 2 1 3 0 l 0 1 1 0 l 1 l 0 ampS 55 70 60 63 57 SG 59 47 9 5 2 2 44 60 1097 0 ss 75 35 32 19 l6 61 59 20 15 30 53 7 Q 0 l 0 0 54 63 62 73 69 GS 70 59 52 S 33 0 7 0 14 54 71 5 91 68 68 64 21 0 47 56 59 68 11 1 7 0 2 2 0 0 6 2 amps S4 74 59 a2 amp9 72 70 6a amp4 11 76 5e 2 0 99 40 3i 53 ss 39 cent1 cent2 47 45 cs 14 3 0 0 2 l 2 1 0 2 63 54 61 SO 66 72 68 67 Sl 66 ampJ 55 52 SS Sl 65 61
100 90 79 54 73 59 46 63 59 55 41 71 68 9 SJ 13 0 3 o G6 59 G 59 62 55 73 45 2 1 s 9 61 58 54 21 lhe SAS Sytem 0~58 Tuesday Scptembvr a 11tll s
G R 11
0 s 0 ~ N N N N N N N N N N N N Ill N N N N W N N N N N N N N 11 E U l N N N N N N N N N 1 1 1 1 1 l 1 1 l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 s X 1 x 1 2 3 bull s s a ~ o 1 2 J 4 s a a 1 2 3 5 6 7 s 9 c 1 2 3 s
101 M 1 1402 3 bullbull s J a 3 4 o 5 7 2s e a o 3 1a 37 27 JB 42 laquoe 31 2 19 c 24 o s 3 2 c 102 K 1 l4D8 30 38 lamp 2s 44 o 33 bulls 11 22 10 2 o 2 o 1 1 o 4 o zs 11 2 sa 41 4 1 1 o 1 o o o o 3 103 M 1 1422 7 40 42 8 6 5 2 5 3 l 4 8 4 2 l 6 8 4 31 lC 24 12 36 65 42 39 10 2 t 2 1 l 1 4 10 104 M 1 1431 36 7 5 3 S l 4 14 2 0 0 3 2 4 16 13 16 27 5 G6 57 68 33 G2 72 64 71 43 76 6 39 67 74 Cl CC 105 M l 1436 l 17 l 12 30 0 1 1 1 l 1 0 0 3 1 0 l 3 42 22 8 0 0 0 0 0 6 37 13 35 7 0 0 0 2 106 M 1 14C 66 53 o 3 o o 1 1 o o 21 2 J l 1 11 12 21 o 11 1e 2 a o 2 1 o 1 2 o o a a 107 M l 1450 0 1 0 0 0 14 36 2~ 25 2 2 6 2 2 0 3 17 2 47 46 20 39 71 54 41 l 9 58 77 SS SG 43 l S 4 109 M 1 1457 3 3 0 1 1 0 0 2 0 0 1 0 0 0 1 2 1 Q 22 36 20 4B 19 0 1 0 0 0 0 0 0 1 Q 0 0 1o9 1 1462 10 10 s J6 12 16 14 10 o s c z 5 4amp 64 Ja e2 2 02 72 aa 94 as a6 eo as 95 sc eamp 78 ss J ss 110 M 1 146 42 0 7 8 11 6 10 J 17 19 3Z 1 7 8 4 8G 70 54 48 75 83 5amp 55 71 0 2 0 0 J 0 1 24 111 M 1 1468 51 G Z4 34 35 16 3 3 2 0 4 1 2 2 7 0 4 SO 81 69 80 73 74 72 3 17 72 3 0 0 6 J 4 1 1 112 M 1 10 10 2A 6 26 36 29 12 lO 4 1 2 1 4 1 4 1 2 2 17 13 s2 c2 a o a 1 1 2 o 2 2 o o o c 113 M 1 1472 J 9 13 34 34 l 0 0 4 0 1 l 4 2 0 l 3 20 69 10 29 0 Z9 2 0 2 0 0 0 4 0 S 1 0 2 114 M 1 1477 2 1 J 10 e 3 2 o o J z 4 1 o 3 11 21 60 17 26 1c 1 6 l o 3 26 3 14 1 o 11s M 1 1481 83 52 amps 41 14 24 38 68 54 9 1 2 s 1 2 5 o 3 s a o 57 87 73 12 59 so amp1 10 sa 71 s2 116 M 1 1485 33 70 47 1 19 77 71 59 77 3 3 e 5 12 4 3 6 13 78 22 C3 70 71 71 43 16 5 10 0 4 2 0 13 4 11 M 1 146 37 l l1 0 3BSS GS 8 19 57 70 62 34 11 2 2 4 4amp sa 14 1 0 6 27 63 55 SO 2 0 3 4 0 5 0 118 M 1 1490 36 12 19 16 15 10 14 4 2 S 3 0 5 4 1 Z 3 1 21 1 21 0 0 40 7G 86 75 61 9 D 1 0 0 0 119 M l 1494 13 15 Z 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 1R 10 0 0 amp 0 0 0 4 ll SS 36 51 20 0 0 120 M 1 1496 18 23 39 3amp 40 lQ 23 40 55 21 6 32 3 1 3 4 S 0 0 0 7 0 26 2 0 l 0 55 52 41 45 2 121 M 2 1405 SS 13 10 6 10 18 3 12 4 C 11 0 9 2 11 2 12 1 75 78 2 0 7 7 3 0 l 1 S 0 0 1 0 4 6 122 M 2 1406 6 43 80 64 47 i 5 1 6 S S 1 3 2 o 3 l 7G 44 41 46 l a 2 1 o 4 ~ 2 0 6 1 o ~ 123 M 2 1411 lS 26 51 R 9 11 1 2 l 0 0 l 0 0 0 1 0 0 30 6 61 63 22 6amp 13 65 Sl SO 16 0 1 0 1 0 2 124 M 2 1412 1 0 0 1 0 4 22 2 26 0 C 2 l 0 4 0 3 13 0 0 0 0 0 4 4 0 5 9 S 0 2 0 0 0 12s M a 1laquo1) 1 15 8 1 o 3 ss 5 co 47 1 o 30 Sl 88 64 4 89 41 9 10 apound 28 eo as 93 79 7S 90 79 as 1 63 84
o N x M N N N N ft N N bull H X bull N H N H W N ~ N N N raquo N N N - N N W M M N ft ~ a 1 J 3 3 4 4 4 4 4 4 4 4 4 4 S S 5 5 S S 5 5 S 5 6 6 6 6 6 6 G G 6 6 7 7 7 s 7 8 o 1 ~ 3 4 s G 7 I 9 o 1 2 3 4 S 6 7 8 9 o 1 2 J a 5 6 7 a o 1 2
101 5 41 GS 17 3 4 3 J 0 0 7 l 1 7 1 0 a 2 57 77 71 67 76 41 40 5 81 56 CJ 83 CG 51 55 61 GG 2 102 l 62 t 0 0 1 o o 1 1 1amp 10 12 54 2 lt 3 o CO 77 5amp S2 6 l o 0 11 70 6amp Sl 61 71 3t 47 2 101 2 C4 15 2 0 ~ 3 J 0 0 0 S 15 2 0 0 0 73 73 59 Sl C4 68 75 61 59 68 58 63 55 77 61 SO G3 14 10( g ~ 4o 41 0 o c o o 2 o o 1 c 21 11 o 1 4 55 51 78 11 65 amp2 co 65 ampG amp1 51 71 amp7 amp4 az 7 105 o 2 32 1 o o o o o o o o 2amp 14 o o 3 o 1 73 73 7S SG 2 63 Jc sa 31 38 11 2 2 5 4 10C 107 o 36 3 5~ ~ ~ ~i ci 1~ 2g ~ ~ ~ 1~ 3 1~ 1~ g ~ ~= ~~ ~~ ~ ~ a~ 7~ 5~ 7~ a~ ~ i ~i ~ ~ ~ 108 S~~ ~~ 12 o o o a o o o 1 1 o o 2 o 4 o tl 71 C3 ca 59 IJ ce ca 65 62 14 30 amp6 31 7 1 1 109 87 6 87 1 20 4 3 5 2 0 9 1 a 1 2 C 7 bull Cl 65 56 SA 65 37 80 51 26 22 S l5 G 4 0 3 11a 14 eo ~- 41 12 1 2 o 5 D laquo 1 o a 11 ca amp1 42 a 70 12 eo 72 72 71 73 56 73 sa J 2 Z 1 1 111 3 amp9 77 60 SS amp~ 2 0 3 0 29 43 18 0 2 J 0 2 0 amp6 73 7C 90 73 77 76 7l 78 71 62 73 ampS 71 63 Sl I 2t 112 12 SG 52 6 0 0 0 8 7 1 Gl 31 0 Q 0 0 0 0 0 55 86 16 G9 92 86 74 80 71 55 4G CO J 73 6 S 54 15 )1) 1 CO IS 32 37 0 0 0 1amp 69 53 52 0 0 1 0 0 0 0 10 88 71 l 70 70 17 69 47 55 20 0 0 1 0 114 4 79 53 6 0 1 4 2 2 21 48 3 5 1 5 2 0 4 65 77 82 77 7 54 71 82 6 7amp 64 GO 54 35 13 1 0 4 115 70 82 78 ampJ ~ 5 bullJ 47 a l1 4J 43 bulla JS 47 54 53 laquo7 63 59 o 57 amp8 10 76 79 73 1 74 66 30 19 a 6 11amp 3 1 18 27 0 o o 2 o o 3 2 4 0 2 l 2 C 28 65 64 74 0 53 amp8 S 72 20 1 amp l o 2 o 11 1 117 2 75 32 36 25 50 27 37 0 24 19 60 30 23 0 0 0 0 61 67 63 76 50 69 66 64 1 IJ 72 68 84 51 53 23 70 50 118 o 74 52 29 c 0 o ~1 25 J C 10 2 6 48 75 44 58 52 4 71 46 S 71 18 33 ~ 8 1 2 D 2 2 7 1 119 o amp2 bulla 17 sbull 42 so 45 52 1 1 11 3 o o o J o 1 83 7l 64 74 61 59 6Z 6 1 55 so 55 31 51 5Z z3 120 amp~ 51 so 2 57 49 45 8 a 15 41 4a 27 34 1 5 o 59 10 67 63 66 J2 zs 10 1 1 1bull c1 a 71 79 33 121 0 64 79 56 74 84 6S c 4 o ~ 0 0 0 0 7 SC 71 77 S 5 62 51 54 74 54 53 44 g 57 64 36 ~ l lamp 1 122 0 72 cc co ~ g 4 1 0 18 G J 1 17 5 50 54 5 0 CR 73 79 74 0 72 4 62 60 39 l 48 G2 5 77 78 4 123 o 2 o a 1 ss sz 3a 1c 12 o o o 1 o 1 1 o o G7 73 7amp 10 Gl 7 as 11 75 ampo 51 21 17 1 2 47 81 66 l2C 1 72 39 10 52 0 2 0 0 0 2 1 0 0 0 2 0 4 59 88 7S 79 73 66 60 3 )C 54 70 60 JO 12 1 Q g 1 12S R 47 2 70 1 o o o o 2 o o o o 1 o o 1 s 60 60 57 2 7o 71 69 o cs eg 71 6B sa
Tbe liAS S)n Osa fuaccay Septetllber 29 1116
G 1l A
0 s 0 Ill N N N N M N N N W N N W N N N N N N N N N N Ill Ill N N a EU I N N W K Ill N N N N 1 1 1 1 1 l 1 1 1 1 2 2 2 2 2 2 ~ 2 2 2 3 l l 3 3 J S X P H 1 2 J 4 s 6 a o 1 2 J 4 s 7 a o 1 2 3 c s bull o 1 2 3 c s
lZG H 2 1418 45 22 42 Cl 4 70 74 C4 S 2 2 C 1 0 l 0 0 1 61 42 2 1 0 2 1 21 12 64 31 8 53 0 0 0 1 12 M 2 1434 3 20 58 amp 11 8 2 10 19 45 72 4C 8 3 4 1 8 0 7( JQ 59 63 5 3 1 2 4 4 Q 1 4 7 2 1 1 126 M 2 1446 7 1 3 1 e 45 31 l7 o 1 l 4 o ~ o o o 5 54 75 sa 65 6amp 50 54 s ss 56 48 cs 63 se 57 59 12 M 2 1453 1 29 15 7 16 4 40 4 8 1 7 C 2 1 6 6 5 3 54 49 47 18 45 0 0 0 9 36 62 32 CJ 9 l A 130 K 2 1455 63 S7 57 80 63 0 1 63 10 0 1 11 6 34 10 2 2 11 81 6G 5 9 91 86 8S g 83 2 92 87 57 a ec 131 K 2 1456 16 2 17 C 3 4 l 14 1 3 6 8 32 SO 28 6 24 SJ 2 20 11 7 4 1 0 3 C 0 0 S 1 10 0 4 132 N 2 1460 QG QO 77 65 2 6 0 3 0 0 1 1 7 4 lD C J ~ SO S~ 72 55 0 0 1 J a l 0 5 J 0 2 11 0 121 M 2 146J so 4amp 6 52 5e sa 21 3 56 7 G1 s 35 35 10 28 54 15 54 s 52 52 56 21 4o 15 1 3 1 s 1 Jo 6o J bull 134 K 2 146 S1 12 0 0 1 0 0 3 37 82 22 JJ ~5 12 5 12 2 2 81 45 GO 35 86 a1 47 23 0 J 5 a 1 0 0 l C 135 K ~ 1bull11 ~ 33 16 o 7 o o o 2 1 3 12 2 2 7 16 sa 73 67 sc 43 59 6 o 5 1 o ~ J s ~2 47 s1 51 41 135 M 2 145 52 66 48 BS B 5 77 26 0 J 16 30 1 2 1 l 0 1 91 81 59 61 Jl 3 a 0 0 0 13 Sl 12 1 2 1 0 13 M 2 1479 3 10 J 0 0 0 2 1 l 5 33 18 10 3 S 2 J 0 52 48 21 0 1 8 C2 0 0 10 3P 39 26 0 0 l 13a M 2 1CI2 15 4 0 2 2 0 12 4 36 1 S 0 7 0 0 0 l 69 87 70 3 5 D 7 2 12 29 57 74 amp5 SJ 0 51 24 13 K 2 1amp95 16 18 24 32 27 l 1 1 0 1 0 2 5 26 5 3 10 48 18 52 7 15 1 57 6 72 55 32 65 0 0 0 0 1 1 140 M 2 1500 43 41 5 55 ~3 0 6 21 46 3 18 46 0 1 23 48 3~ 15 32 78 66 71 69 55 65 73 5 2 3 4 0 10 5 7 41 141 N 3 1403 0 0 0 1 0 2 0 0 l 0 0 0 0 0 0 1 0 0 ~ 12 18 D 0 0 0 a 0 0 0 0 1 0 0 1 0 142 M 3 1404 4 19 1 4 0 1 0 0 1 0 1 2 0 2 1 11 14 63 73 C4 89 59 90 8 1 57 II 53 2 0 2 0 0 143 bull J 1co 21 2 o 27 44 52 4 10 5 3 13 2 s e o a 4 44 65 61 6J sa 63 57 11 2s 22 c 1 5 o s 12 144 M J 1415 G 10 62 2 21 11 S 5 1 2 0 5 8 0 1 24 27 2 10 43 S2 82 27 S 4 5 0 l 2 0 1 J 7 1 145 K J lClG 1 2 9 19 2 0 0 16 4 0 0 Q 0 0 0 0 0 0 C 1C 11 8 14 16 19 0 11 0 35 3 0 1 0 Q 0 1laquo6 M J 1417 36 o 5 21 so so 3 a 3 a s 5 1 11 2 2 4 ~ 45 o 61 11 3 1 3 o 1 l 2 7 2 2 2 1 1i7 M 3 1421 12 2 2 10 2 0 1 0 4 7 0 0 4 15 3C 7 71 5 7a G5 52 42 5 2a 1l 5 1 Q 0 0 11 54 58 G8 148 M 3 1425 9 69 20 o 4 7 23 6 1 12 1 S 2 20 51 13 80 72 c G7 53 75 S8 l 70 59 50 53 1 7 1 2 17 4 149 M 3 1430 0 0 0 S 5 40 40 0 2 2 0 1 6 G 7 5 o 2 7 12 13 4 86 2C 1 0 2 l D 1 0 2 0 0 1 150 K 3 14JS SJ 40 16 6B 34 26 0 C 1 S 0 3 $ 0 0 J 2 58 31 8 15 0 0 2 0 1 l 0 0 1 2 0 0 I
0 N N N N N N N N N N N d N N N N N N N N N N Ill N N N N N N N N N ~ N N N N E 3 ~ 3 l 4 4 4 4 4 4 4 4 4 4 5 5 S 5 5 S 5 5 5 S G G amp 6 6 6 6 amp amp 6 7 s 6 7 8 o 1 2 3 s 6 e 9 o 1 2 l s e o 1 2 J 4 s 6 7 e o 1 2
126 1 4 70 72 21 65 61 55 22 1 0 0 0 0 C2 86 S2 74 70 86 67 G 65 ampl 87 72 15 11 74 68 62 60 72 31 12 4 121 6 59 63 14 4l 32 1 3 3 2l 42 ao 66 71 7J o a amp1 62 ~s 68 8o s 41 ss 11 67 a1 41 J 39 amp7 ~pound 129 75 60 49 41 40 l4 ss 22 27 33 16 0 2 0 1 1 4 0 l 65 so 62 59 so 74 4 38 15 s l 4 1 1 5 1 0 l 129 1 62 32 o 14 a o 1 o o o o o 1 1 o o c a 45 10 G1 sa 64 67 O 69 70 63 62 zs 1 o 2 o 130 84 80 29 66 1G 1 3 1 0 34 D 14 l2 7C 76 80 88 g 78 6 77 0 83 59 57 62 78 85 Bamp 98 42 71 92 77 48 5 131 5 C4 74 32 43 14 Sl 27 1 2 S 0 0 14 8 0 2 0 J 54 77 59 l 52 72 62 65 23 19 4 g 4 0 2 1 0 0 132 o 4B 50 1 o o 2 o o o 2 a 2 o 1 o sa 12 4 sa 78 61 6e 76 11 33 45 11 3 27 o o o 131 11 55 43 60 Z6 35 1 0 0 6 17 4 20 17 25 51 5 G2 46 72 66 78 61 58 60 Sf 63 84 61 5 45 35 1 o o 0 0 134 1 80 63 51 6 62 22 9 0 2 0 1 0 1 1 0 a 0 0 61 7a 76 65 71 9a 74 77 63 G7 84 SS 56 58 68 C9 1 2 135 40 67 43 4 t1 22 S 2 5 J 0 l 2 5 5 Z 4 2 3 59 70 62 SZ 73 61 42 47 41 Cl C1 50 5 C7 $7 49 42 64 136 4 69 bullR 6 67 76 7l 33 24 2 20 1 e ~ 6 0 c D o 1 68 53 71 G9 70 59 73 GJ ampB 23 0 2 l 1 137 0 J6 ~middot 44 11 17 1 14 15 0 2 2 1 0 2 ~ 0 0 59 62 74 74 63 76 88 7amp 48 12 57 56 32 1 18 69 138 13 6 4 52 ll 62 0 36 20 2a 13 79 64 34 57 35 36 57 4 ~~ GS 64 51 5 70 70 68 66 79 SS C 79 60 C6 2C 2 21 139 0 6~ 3R 26 1 26 58 32 7 0 2 1 0 0 0 2 8 C6 6 7 71 73 77 82 18 64 79 66 8 2 11 10 77 52 63 61 140 74 74 bull C2 61 61 76 71 59 G 64 55 62 C3 5 CS 65 57 ll SC l 62 51 35 4 18 9 2 6 0 1 c 76 51 22 0 1 1bull1 o ~o ll 10 o o o o o o o a o o 13 o a a o 11 1 67 amp1 so amp4 o 46 10 laquo 1 2 1 o o o 142 R 12 u a o u bull 20 o 6 21 u u 1 2 J 1 o o n 65 ~2 o g sg 57 42 77 59 n 10 62 77 143 17 82 16 ZD 0 0 l 4 Q 5 4 1 28 47 57 amp6 12 0 2 59 60 58 65 QR 58 74 52 27 44 lC 38 11 1C 30 4 16 56 144 42 59 41 13 l 1 0 2 2 1 0 0 12 8 2 ~ 1 16 amp2 73 57 SB 77 7J 65 40 l amp3 l Sa CJ 47 7C 51 69 77 145 o s2 3e 37 o o 1 o o o 1 o o o 7 21 s 41 ampa amp9 amp7 a3 J 51 22 73 63 74 l4 lamp 32 2 1 1 o 14G 1 68 38 7 41 laquo2 1 z l 1 1 o 2 J o 4 o 1 o 55 13 a 61 68 7 sa 74 53 co t6 42 14 l 39 s a 147 55 52 53 4 46 61 16 ~ 0 0 4 C a 2 0 8 3 St 46 55 S8 55 70 51 52 C4 77 SO 40 17 2 1 4 15 32 148 0 80 St 40 16 11 0 0 1 lC 53 15 GO 62 24 45 51 22 58 65 65 58 57 60 52 SG 52 4amp i6 2 ampC 45 47 33 5 14t 1 61 JJ 3 1~ 0 0 0 0 Q 1 0 0 0 1 1 1~ 5 57 S 72 ~S 71 70 61 6 73 4 o 10 0 25 5) 7t l7 0 150 27 75 51 11 0 0 0 1 0 l7 24 0 2 0 0 l 0 1 52 56 Cl SG ca 75 5 61 lS 2 21 0 0 o 4 0 6 6
~ Ule SAS syliCa 09Se TUes~ ampepteabcr lt lS
G a A
0 so N Jl N N N rl K N N N II w Jrl II Ill N )I N N IC bull )I N Jl If N
ll IU t )I N N N N N N bull Jrl l t 1 l l 1 1 1 l l 2 2 2 z l a 2 2 2 2 3 3 3 3 3 s XP H 1 2 3 4 s 6 ~ 8 0 l 2 J c 5 7 8 c 1 2 3 4 s 6 7 II i c l 2 3 (
2 0 Q
152 H 3 1444 SS 63 Sll 73 79 s 214 0 1 0 l s 2 1 as 736S lSl M 3 1442 lS 4 0 0 s c 2 1 0 0 0 0 a Jl u 1 l 7 co 0 10 7 0 0 0 0 0 0 l 0
3 l 6 l 0 0 23 153 M 3 144 52 11 4 Jl 0 0 l 1 2 s 4 1 815 0 0 0 1 1 l 0 (I0 1 0 3 3 0 n 1 bull 11 0 1$4 M 3 1454 18 20 Cl 47 3 0 0 1 1 3 75 59 7l C3 5 4 1 4 13 22 45 2S 7 20 57 ~middot 40 0 a s 0 2 I 5 1$5 H 3 1458 26 41 58 Oll 0 a 1 0 512 0 J l 5 2 2 ll ll 5 0 1 1 0 2 2 0( 3 Zl 3 1 156 M 3 161 sa 11 a so J6 54 53 l 0 l 0 0 0 0 0 0 0 l 20 13 l 0 1 1 0 1 1 1 2g 75 95 7J 53 83 157 H l 1410 ZO 27 77 Sl 47 8 2 1 0 z c 1 ( 3 2 0 7 I 311 ll Ill 37 2 13 33 14 SG 69 40 7G 1 2 158 M l 1491 1Z 36 SS 57 4 2 74 74 IS 1 4G 0 10 66 98 40 65 38 68 94 57 32 JS 27 45 7 55 59 46 S7 41 40 0 15 M 3 1492 19 15 o 12 12 3 19 1 1 2 amp1s 21 1c a 4 4 1 43 10 4t J8 29 57 42 se 8 37 14 43 62 4) 56 50 16o M 3 19g 42 sz 7c amp2 t5 sz t2 11 2 21 38 79 so 12 s g 65 59 a 45 0 70 55 lS II l 6 1 14 21l 71 74 65 161 M 4 1401 0 4 3 1 amp5 72 S3 3 30 C6 1 3 1 17 7 2 3 l 20 34 21 II 0 0 a 5 0 0 14 11 5 3 0 lGl M 4 1407 49 4 2 1 3 2 2 3 C 1 16 7 1 10 2 0 l T 76 66 31 0 0 0 z 1 1 1 00 1 0 0 13 K 4 1414 66 7amp 74 79 73 43 s 8 2 l l 7 17 17 2 2 z 7 a s2 u ss 5 42 40 39 39 3 c 8 0 s 16~ M ltl 11 77 go 7G lto 97 s1 as so cg 96 1 34 1 27 55 73 55 60 7 55 58 61 10 l 9 0 3 112 2 1 165 M 4 1426 44 10 16 ~l 0 0 0 1 23 ~0 6 9 10 27 lO 13 1 11 2G JS 22 53 14 1 J s 21 2 5 0 2 6 l U6 M 4 1429 24 3 1 U 31 lS s 0 8 2 l 4 0 s 1 5 l 0 Sl Jl 36 Jl 66 6 0 32 64 72 5 70 6) 167 M 4 1432 31 34 0 0 1 3 z 0 0 D 521 a 0 6 22 19 64 53 0 0 0 0 0 2 0 0 1 5 3 0 1611 M 4 1433 1 40 19 t3 lB 13 2 0 1 s 8 4 23 26 66 34 14 30 51 211 49 14 cz 33 30 41 2 3 25 49 22 57 169 M t 1438 2 11 4 2 g s l 6 2~ lO 47 38 32 23 6 1 4 0 0 0 l 1 10 ) 0 0 1 0 0 170 H 4 143~ 24 84 39 s u s ll 17 3 5 4 4 4 2 9 l 9 7 66 10 llC 55 60 22 0 0 32 I 0 78 55 62 31 171 M 4 144$ 24 1 0 l c 1 1 l z 1 0 0 0 0 0 0 0 10 11gt 13 6 0 0 0 0 2 1 1 0 0 0 0 2 0 172 H 4 1451 40 l2 36 C4 48 13 23 63 47 57 42 C5 ll 21 l 2 l 10 C 10 17 C4 42 6C 57 amp6 52 l 63 61 62 0 72 73 173 M C 1459 32 55 71l 56 19 59 12 37 6 SS 74 57 0 0 1 0 1 47 28 25 52 86 41 30 69 71 74 C6 s 2 0 0 3 17ir M 4 UU 21 0 s 11 54 12 2 1 1 14 12 2 3 l 5 0 s 2 21 0 0 0 0 0 20 2 3 0 4 0 0 0 2 0 175 K 4 1465 6 a () 3 10 2 l l 1 1 2 2 I) 0 0 0 0 l 3l 20 12 0 28 0 1 0 l 3 1 () l 0 0
bull 4
0 N II N N N N N M N N N N N N Ill ~ N N N N N N N N N N N If If II N N I( Ill N N N 8 J 3 3 3 3 4 4 4 4 4 4 4 5 5 5 5 5 5 5 s 5 s 6 G G amp 6 7 7 7 s 5 6 7 6 9 0 l 2 3 4 5 6 7 8 9 0 1 2 l 4 s 7 s 9 0 l 2 3 5 6 II 9 0 1 2
1Sl 0 2 S 44 41 37 Q 0 Sl 1 36 Zf 0 1 3 Z 56 30 40 64 1gt0 72 CS 52 21 49 SO 32 6 0 1 1 IS l 1 1 0 152 3 0 79 49 33 30 sa 30 0 2 2 44 25 0 l 2 0 1 l 2 52 67 64 SB SB 65 81 63 56 57 62 69 66 41 C7 53 10 1 153 1 o sa o 11 1 2G o o o o amp 1 o o 1 14 ss s s 29 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 54 JC 12 1 2 l l 1 0 l B SO 54 amp2 47 51 S2 58 67 59 66 69 15 52 71 57 64 2 58 48 27 0 0 0 lSS 1 0 iS 64 22 2 0 J 0 0 19 3 Z 3 3 l 4 1 3 4 SG S 71 0 6~ 68 21 1~ 1 o 0 0 1 11 1 l 7 8 1SG 0 l 74 1l as 76 75 sa Sl 2 0 7 0 4 1 1 0 0 o 0 71 ampl 71 CG 0 ampl 75 69 78 8A 18 3 76 70 75 48 7 7 157 3 o 75 49 26 48 51 4 0 0 o 1 ll 4 D l 0 l 0 1 64 54 2 60 BG 76 74 76 5 51 amp9 80 62 60 51 63 67 51gt 158 3 1 82 29 S7 1 17 0 l B 0 1 l 0 0 4 30 51 72 20 74 69 61 74 83 77 79 6 6 65 GS 74 65 S 81 73 37 42 1S9 2 l 65 10 13 Q 0 0 0 1 4 7 53 37 30 10 l 14 27 0 C2 66 58 63 69 63 41 26 amp1 29 17 1 6 0 1 0 B D 150 67 64 78 77 2l 24 0 0 7 1 0 5 2 0 0 0 ll J 49 5amp 55 6 72 76 62 57 55 7Z 1 1 ll l 6 G 1 161 2 0 59 4 45 67 48 12 1 0 l 0 3 1 0 l l 2 3 0 68 71 72 G1 61 S SO 8 Q 64 10 66 59 amp7 80 3 86 0 152 0 0 72 8G 6G 5 46 40 lG 0 0 2 0 0 0 1 0 0 3 9 62 67 S 79 74 77 70 83 90 84 4l 42 11 0 8 14 5 163 2 0 27 47 18 8 7~ 52 51 12 0 7 2 31 0 2 S 2 4 0 77 63 63 5 BJ 61 7S 74 0 74 62 81 29 9 0 3 1 1 164 0 1 0 15 59 14 S lS 59 0 0 o 2 2 28 72 63 69 75 15 SB 48 42 47 58 64 S SO S 74 73 69 72 1 57 32 7 165 2 18 4~ 2 51 0 15 a 1 1 0 3 2 0 8 4 a 0 5 2 70 63 66 54 61 62 SO 4 45 48 51 51 3S 0 1 0 3 2 1amp6 so o 93 so 14 o o 2 o so 36 2 1 o o 1 c o o o sa 60 10 71 57 66 s 73 12 sJ 53 28 9 o o 3 167 o z 38 22 o o a 1 o o o 2 o 1 o o o o 2 5~ ~ so 75 77 7o eG 57 14 3 o s 1 a o 1 43 1 168 Z2 2 55 45 44 23 18 S 3 39 38 51 56 29 Z8 49 2 0 1 0 52 5l 5 53 68 78 CS $7 73 69 64 77 77 SJ 51 4S 36 16 0 0 41 15 1 Q 0 0 0 D l 0 3 0 7 3 7 G1 38 ll 60 Sl 63 61 92 87 BC 55 3 65 57 58 24 11 1 S 1 0 110 2 4 ampG ss se s 2 1 8 o 1 13 o a 1s 9a 79 amp8 47 G7 84 60 66 68 74 bull~ ss 76 71 31 1 o 32 ss Gs a as 111 o 1 sG 41 29 l 1 2 10 o J 1 o 1 o 1 1 o a 12 so sa 84 s 57 G2 4 53 2laquo 10 c 2J o 1 o 1 2 172 s5 68 6 J 49 52 21 23 12 l 1 16 o a o o 1 21 S9 42 75 11 65 78 1 11 47 ampamp a 3o o s 10 o o o o 1 173 0 2 62 61 tO 17 4 S 0 B 1 29 B 5 4 2 D 21 JS l) 58 55 60 73 80 65 71 65 54 S 72 G6 34 C 0 2 0 0 174 3 0 69 37 14 32 ~ D 0 1 0 0 0 0 0 0 15 22 46 35 59 68 CS 75 72 83 56 6 36 9 2 1 0 0 0 0 1 11s o o B4 sz ~s 29 2s 41 s o co S 2s Jt 22 1 o 3 so 63 54 12 76 s sa ss samp Jl to 20 35 59 so 4 6 1
The 6AS Sys~am 0958 uesd~y Scp~embe 29 1998 8
G R )
0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
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100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
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l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
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2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
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bull
Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
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Type II SS Mean Squaze P Value Pr gt F SoUCS
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~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
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1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
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0 4 0 0 c 5
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l 5 1 0 0 0
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
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30 20 62 32 sa 55 46 s
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92 93 94
r 1
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1752 l71lG 1773
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36 56 23
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
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20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
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65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
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lamp 0 0 e Q
l 0 2 2
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2
0 0 l
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1 1 0 2 0 0
3() 0 3 0
ll 0 6
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1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
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4 S4
2 74
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0 I) 1
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27 a 45 45
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0 37 25 52
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0 0 3 1 8 0
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61 53 uampe
3
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2 19 10 11 41
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4 60
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
o N x M N N N N ft N N bull H X bull N H N H W N ~ N N N raquo N N N - N N W M M N ft ~ a 1 J 3 3 4 4 4 4 4 4 4 4 4 4 S S 5 5 S S 5 5 S 5 6 6 6 6 6 6 G G 6 6 7 7 7 s 7 8 o 1 ~ 3 4 s G 7 I 9 o 1 2 3 4 S 6 7 8 9 o 1 2 J a 5 6 7 a o 1 2
101 5 41 GS 17 3 4 3 J 0 0 7 l 1 7 1 0 a 2 57 77 71 67 76 41 40 5 81 56 CJ 83 CG 51 55 61 GG 2 102 l 62 t 0 0 1 o o 1 1 1amp 10 12 54 2 lt 3 o CO 77 5amp S2 6 l o 0 11 70 6amp Sl 61 71 3t 47 2 101 2 C4 15 2 0 ~ 3 J 0 0 0 S 15 2 0 0 0 73 73 59 Sl C4 68 75 61 59 68 58 63 55 77 61 SO G3 14 10( g ~ 4o 41 0 o c o o 2 o o 1 c 21 11 o 1 4 55 51 78 11 65 amp2 co 65 ampG amp1 51 71 amp7 amp4 az 7 105 o 2 32 1 o o o o o o o o 2amp 14 o o 3 o 1 73 73 7S SG 2 63 Jc sa 31 38 11 2 2 5 4 10C 107 o 36 3 5~ ~ ~ ~i ci 1~ 2g ~ ~ ~ 1~ 3 1~ 1~ g ~ ~= ~~ ~~ ~ ~ a~ 7~ 5~ 7~ a~ ~ i ~i ~ ~ ~ 108 S~~ ~~ 12 o o o a o o o 1 1 o o 2 o 4 o tl 71 C3 ca 59 IJ ce ca 65 62 14 30 amp6 31 7 1 1 109 87 6 87 1 20 4 3 5 2 0 9 1 a 1 2 C 7 bull Cl 65 56 SA 65 37 80 51 26 22 S l5 G 4 0 3 11a 14 eo ~- 41 12 1 2 o 5 D laquo 1 o a 11 ca amp1 42 a 70 12 eo 72 72 71 73 56 73 sa J 2 Z 1 1 111 3 amp9 77 60 SS amp~ 2 0 3 0 29 43 18 0 2 J 0 2 0 amp6 73 7C 90 73 77 76 7l 78 71 62 73 ampS 71 63 Sl I 2t 112 12 SG 52 6 0 0 0 8 7 1 Gl 31 0 Q 0 0 0 0 0 55 86 16 G9 92 86 74 80 71 55 4G CO J 73 6 S 54 15 )1) 1 CO IS 32 37 0 0 0 1amp 69 53 52 0 0 1 0 0 0 0 10 88 71 l 70 70 17 69 47 55 20 0 0 1 0 114 4 79 53 6 0 1 4 2 2 21 48 3 5 1 5 2 0 4 65 77 82 77 7 54 71 82 6 7amp 64 GO 54 35 13 1 0 4 115 70 82 78 ampJ ~ 5 bullJ 47 a l1 4J 43 bulla JS 47 54 53 laquo7 63 59 o 57 amp8 10 76 79 73 1 74 66 30 19 a 6 11amp 3 1 18 27 0 o o 2 o o 3 2 4 0 2 l 2 C 28 65 64 74 0 53 amp8 S 72 20 1 amp l o 2 o 11 1 117 2 75 32 36 25 50 27 37 0 24 19 60 30 23 0 0 0 0 61 67 63 76 50 69 66 64 1 IJ 72 68 84 51 53 23 70 50 118 o 74 52 29 c 0 o ~1 25 J C 10 2 6 48 75 44 58 52 4 71 46 S 71 18 33 ~ 8 1 2 D 2 2 7 1 119 o amp2 bulla 17 sbull 42 so 45 52 1 1 11 3 o o o J o 1 83 7l 64 74 61 59 6Z 6 1 55 so 55 31 51 5Z z3 120 amp~ 51 so 2 57 49 45 8 a 15 41 4a 27 34 1 5 o 59 10 67 63 66 J2 zs 10 1 1 1bull c1 a 71 79 33 121 0 64 79 56 74 84 6S c 4 o ~ 0 0 0 0 7 SC 71 77 S 5 62 51 54 74 54 53 44 g 57 64 36 ~ l lamp 1 122 0 72 cc co ~ g 4 1 0 18 G J 1 17 5 50 54 5 0 CR 73 79 74 0 72 4 62 60 39 l 48 G2 5 77 78 4 123 o 2 o a 1 ss sz 3a 1c 12 o o o 1 o 1 1 o o G7 73 7amp 10 Gl 7 as 11 75 ampo 51 21 17 1 2 47 81 66 l2C 1 72 39 10 52 0 2 0 0 0 2 1 0 0 0 2 0 4 59 88 7S 79 73 66 60 3 )C 54 70 60 JO 12 1 Q g 1 12S R 47 2 70 1 o o o o 2 o o o o 1 o o 1 s 60 60 57 2 7o 71 69 o cs eg 71 6B sa
Tbe liAS S)n Osa fuaccay Septetllber 29 1116
G 1l A
0 s 0 Ill N N N N M N N N W N N W N N N N N N N N N N Ill Ill N N a EU I N N W K Ill N N N N 1 1 1 1 1 l 1 1 1 1 2 2 2 2 2 2 ~ 2 2 2 3 l l 3 3 J S X P H 1 2 J 4 s 6 a o 1 2 J 4 s 7 a o 1 2 3 c s bull o 1 2 3 c s
lZG H 2 1418 45 22 42 Cl 4 70 74 C4 S 2 2 C 1 0 l 0 0 1 61 42 2 1 0 2 1 21 12 64 31 8 53 0 0 0 1 12 M 2 1434 3 20 58 amp 11 8 2 10 19 45 72 4C 8 3 4 1 8 0 7( JQ 59 63 5 3 1 2 4 4 Q 1 4 7 2 1 1 126 M 2 1446 7 1 3 1 e 45 31 l7 o 1 l 4 o ~ o o o 5 54 75 sa 65 6amp 50 54 s ss 56 48 cs 63 se 57 59 12 M 2 1453 1 29 15 7 16 4 40 4 8 1 7 C 2 1 6 6 5 3 54 49 47 18 45 0 0 0 9 36 62 32 CJ 9 l A 130 K 2 1455 63 S7 57 80 63 0 1 63 10 0 1 11 6 34 10 2 2 11 81 6G 5 9 91 86 8S g 83 2 92 87 57 a ec 131 K 2 1456 16 2 17 C 3 4 l 14 1 3 6 8 32 SO 28 6 24 SJ 2 20 11 7 4 1 0 3 C 0 0 S 1 10 0 4 132 N 2 1460 QG QO 77 65 2 6 0 3 0 0 1 1 7 4 lD C J ~ SO S~ 72 55 0 0 1 J a l 0 5 J 0 2 11 0 121 M 2 146J so 4amp 6 52 5e sa 21 3 56 7 G1 s 35 35 10 28 54 15 54 s 52 52 56 21 4o 15 1 3 1 s 1 Jo 6o J bull 134 K 2 146 S1 12 0 0 1 0 0 3 37 82 22 JJ ~5 12 5 12 2 2 81 45 GO 35 86 a1 47 23 0 J 5 a 1 0 0 l C 135 K ~ 1bull11 ~ 33 16 o 7 o o o 2 1 3 12 2 2 7 16 sa 73 67 sc 43 59 6 o 5 1 o ~ J s ~2 47 s1 51 41 135 M 2 145 52 66 48 BS B 5 77 26 0 J 16 30 1 2 1 l 0 1 91 81 59 61 Jl 3 a 0 0 0 13 Sl 12 1 2 1 0 13 M 2 1479 3 10 J 0 0 0 2 1 l 5 33 18 10 3 S 2 J 0 52 48 21 0 1 8 C2 0 0 10 3P 39 26 0 0 l 13a M 2 1CI2 15 4 0 2 2 0 12 4 36 1 S 0 7 0 0 0 l 69 87 70 3 5 D 7 2 12 29 57 74 amp5 SJ 0 51 24 13 K 2 1amp95 16 18 24 32 27 l 1 1 0 1 0 2 5 26 5 3 10 48 18 52 7 15 1 57 6 72 55 32 65 0 0 0 0 1 1 140 M 2 1500 43 41 5 55 ~3 0 6 21 46 3 18 46 0 1 23 48 3~ 15 32 78 66 71 69 55 65 73 5 2 3 4 0 10 5 7 41 141 N 3 1403 0 0 0 1 0 2 0 0 l 0 0 0 0 0 0 1 0 0 ~ 12 18 D 0 0 0 a 0 0 0 0 1 0 0 1 0 142 M 3 1404 4 19 1 4 0 1 0 0 1 0 1 2 0 2 1 11 14 63 73 C4 89 59 90 8 1 57 II 53 2 0 2 0 0 143 bull J 1co 21 2 o 27 44 52 4 10 5 3 13 2 s e o a 4 44 65 61 6J sa 63 57 11 2s 22 c 1 5 o s 12 144 M J 1415 G 10 62 2 21 11 S 5 1 2 0 5 8 0 1 24 27 2 10 43 S2 82 27 S 4 5 0 l 2 0 1 J 7 1 145 K J lClG 1 2 9 19 2 0 0 16 4 0 0 Q 0 0 0 0 0 0 C 1C 11 8 14 16 19 0 11 0 35 3 0 1 0 Q 0 1laquo6 M J 1417 36 o 5 21 so so 3 a 3 a s 5 1 11 2 2 4 ~ 45 o 61 11 3 1 3 o 1 l 2 7 2 2 2 1 1i7 M 3 1421 12 2 2 10 2 0 1 0 4 7 0 0 4 15 3C 7 71 5 7a G5 52 42 5 2a 1l 5 1 Q 0 0 11 54 58 G8 148 M 3 1425 9 69 20 o 4 7 23 6 1 12 1 S 2 20 51 13 80 72 c G7 53 75 S8 l 70 59 50 53 1 7 1 2 17 4 149 M 3 1430 0 0 0 S 5 40 40 0 2 2 0 1 6 G 7 5 o 2 7 12 13 4 86 2C 1 0 2 l D 1 0 2 0 0 1 150 K 3 14JS SJ 40 16 6B 34 26 0 C 1 S 0 3 $ 0 0 J 2 58 31 8 15 0 0 2 0 1 l 0 0 1 2 0 0 I
0 N N N N N N N N N N N d N N N N N N N N N N Ill N N N N N N N N N ~ N N N N E 3 ~ 3 l 4 4 4 4 4 4 4 4 4 4 5 5 S 5 5 S 5 5 5 S G G amp 6 6 6 6 amp amp 6 7 s 6 7 8 o 1 2 3 s 6 e 9 o 1 2 l s e o 1 2 J 4 s 6 7 e o 1 2
126 1 4 70 72 21 65 61 55 22 1 0 0 0 0 C2 86 S2 74 70 86 67 G 65 ampl 87 72 15 11 74 68 62 60 72 31 12 4 121 6 59 63 14 4l 32 1 3 3 2l 42 ao 66 71 7J o a amp1 62 ~s 68 8o s 41 ss 11 67 a1 41 J 39 amp7 ~pound 129 75 60 49 41 40 l4 ss 22 27 33 16 0 2 0 1 1 4 0 l 65 so 62 59 so 74 4 38 15 s l 4 1 1 5 1 0 l 129 1 62 32 o 14 a o 1 o o o o o 1 1 o o c a 45 10 G1 sa 64 67 O 69 70 63 62 zs 1 o 2 o 130 84 80 29 66 1G 1 3 1 0 34 D 14 l2 7C 76 80 88 g 78 6 77 0 83 59 57 62 78 85 Bamp 98 42 71 92 77 48 5 131 5 C4 74 32 43 14 Sl 27 1 2 S 0 0 14 8 0 2 0 J 54 77 59 l 52 72 62 65 23 19 4 g 4 0 2 1 0 0 132 o 4B 50 1 o o 2 o o o 2 a 2 o 1 o sa 12 4 sa 78 61 6e 76 11 33 45 11 3 27 o o o 131 11 55 43 60 Z6 35 1 0 0 6 17 4 20 17 25 51 5 G2 46 72 66 78 61 58 60 Sf 63 84 61 5 45 35 1 o o 0 0 134 1 80 63 51 6 62 22 9 0 2 0 1 0 1 1 0 a 0 0 61 7a 76 65 71 9a 74 77 63 G7 84 SS 56 58 68 C9 1 2 135 40 67 43 4 t1 22 S 2 5 J 0 l 2 5 5 Z 4 2 3 59 70 62 SZ 73 61 42 47 41 Cl C1 50 5 C7 $7 49 42 64 136 4 69 bullR 6 67 76 7l 33 24 2 20 1 e ~ 6 0 c D o 1 68 53 71 G9 70 59 73 GJ ampB 23 0 2 l 1 137 0 J6 ~middot 44 11 17 1 14 15 0 2 2 1 0 2 ~ 0 0 59 62 74 74 63 76 88 7amp 48 12 57 56 32 1 18 69 138 13 6 4 52 ll 62 0 36 20 2a 13 79 64 34 57 35 36 57 4 ~~ GS 64 51 5 70 70 68 66 79 SS C 79 60 C6 2C 2 21 139 0 6~ 3R 26 1 26 58 32 7 0 2 1 0 0 0 2 8 C6 6 7 71 73 77 82 18 64 79 66 8 2 11 10 77 52 63 61 140 74 74 bull C2 61 61 76 71 59 G 64 55 62 C3 5 CS 65 57 ll SC l 62 51 35 4 18 9 2 6 0 1 c 76 51 22 0 1 1bull1 o ~o ll 10 o o o o o o o a o o 13 o a a o 11 1 67 amp1 so amp4 o 46 10 laquo 1 2 1 o o o 142 R 12 u a o u bull 20 o 6 21 u u 1 2 J 1 o o n 65 ~2 o g sg 57 42 77 59 n 10 62 77 143 17 82 16 ZD 0 0 l 4 Q 5 4 1 28 47 57 amp6 12 0 2 59 60 58 65 QR 58 74 52 27 44 lC 38 11 1C 30 4 16 56 144 42 59 41 13 l 1 0 2 2 1 0 0 12 8 2 ~ 1 16 amp2 73 57 SB 77 7J 65 40 l amp3 l Sa CJ 47 7C 51 69 77 145 o s2 3e 37 o o 1 o o o 1 o o o 7 21 s 41 ampa amp9 amp7 a3 J 51 22 73 63 74 l4 lamp 32 2 1 1 o 14G 1 68 38 7 41 laquo2 1 z l 1 1 o 2 J o 4 o 1 o 55 13 a 61 68 7 sa 74 53 co t6 42 14 l 39 s a 147 55 52 53 4 46 61 16 ~ 0 0 4 C a 2 0 8 3 St 46 55 S8 55 70 51 52 C4 77 SO 40 17 2 1 4 15 32 148 0 80 St 40 16 11 0 0 1 lC 53 15 GO 62 24 45 51 22 58 65 65 58 57 60 52 SG 52 4amp i6 2 ampC 45 47 33 5 14t 1 61 JJ 3 1~ 0 0 0 0 Q 1 0 0 0 1 1 1~ 5 57 S 72 ~S 71 70 61 6 73 4 o 10 0 25 5) 7t l7 0 150 27 75 51 11 0 0 0 1 0 l7 24 0 2 0 0 l 0 1 52 56 Cl SG ca 75 5 61 lS 2 21 0 0 o 4 0 6 6
~ Ule SAS syliCa 09Se TUes~ ampepteabcr lt lS
G a A
0 so N Jl N N N rl K N N N II w Jrl II Ill N )I N N IC bull )I N Jl If N
ll IU t )I N N N N N N bull Jrl l t 1 l l 1 1 1 l l 2 2 2 z l a 2 2 2 2 3 3 3 3 3 s XP H 1 2 3 4 s 6 ~ 8 0 l 2 J c 5 7 8 c 1 2 3 4 s 6 7 II i c l 2 3 (
2 0 Q
152 H 3 1444 SS 63 Sll 73 79 s 214 0 1 0 l s 2 1 as 736S lSl M 3 1442 lS 4 0 0 s c 2 1 0 0 0 0 a Jl u 1 l 7 co 0 10 7 0 0 0 0 0 0 l 0
3 l 6 l 0 0 23 153 M 3 144 52 11 4 Jl 0 0 l 1 2 s 4 1 815 0 0 0 1 1 l 0 (I0 1 0 3 3 0 n 1 bull 11 0 1$4 M 3 1454 18 20 Cl 47 3 0 0 1 1 3 75 59 7l C3 5 4 1 4 13 22 45 2S 7 20 57 ~middot 40 0 a s 0 2 I 5 1$5 H 3 1458 26 41 58 Oll 0 a 1 0 512 0 J l 5 2 2 ll ll 5 0 1 1 0 2 2 0( 3 Zl 3 1 156 M 3 161 sa 11 a so J6 54 53 l 0 l 0 0 0 0 0 0 0 l 20 13 l 0 1 1 0 1 1 1 2g 75 95 7J 53 83 157 H l 1410 ZO 27 77 Sl 47 8 2 1 0 z c 1 ( 3 2 0 7 I 311 ll Ill 37 2 13 33 14 SG 69 40 7G 1 2 158 M l 1491 1Z 36 SS 57 4 2 74 74 IS 1 4G 0 10 66 98 40 65 38 68 94 57 32 JS 27 45 7 55 59 46 S7 41 40 0 15 M 3 1492 19 15 o 12 12 3 19 1 1 2 amp1s 21 1c a 4 4 1 43 10 4t J8 29 57 42 se 8 37 14 43 62 4) 56 50 16o M 3 19g 42 sz 7c amp2 t5 sz t2 11 2 21 38 79 so 12 s g 65 59 a 45 0 70 55 lS II l 6 1 14 21l 71 74 65 161 M 4 1401 0 4 3 1 amp5 72 S3 3 30 C6 1 3 1 17 7 2 3 l 20 34 21 II 0 0 a 5 0 0 14 11 5 3 0 lGl M 4 1407 49 4 2 1 3 2 2 3 C 1 16 7 1 10 2 0 l T 76 66 31 0 0 0 z 1 1 1 00 1 0 0 13 K 4 1414 66 7amp 74 79 73 43 s 8 2 l l 7 17 17 2 2 z 7 a s2 u ss 5 42 40 39 39 3 c 8 0 s 16~ M ltl 11 77 go 7G lto 97 s1 as so cg 96 1 34 1 27 55 73 55 60 7 55 58 61 10 l 9 0 3 112 2 1 165 M 4 1426 44 10 16 ~l 0 0 0 1 23 ~0 6 9 10 27 lO 13 1 11 2G JS 22 53 14 1 J s 21 2 5 0 2 6 l U6 M 4 1429 24 3 1 U 31 lS s 0 8 2 l 4 0 s 1 5 l 0 Sl Jl 36 Jl 66 6 0 32 64 72 5 70 6) 167 M 4 1432 31 34 0 0 1 3 z 0 0 D 521 a 0 6 22 19 64 53 0 0 0 0 0 2 0 0 1 5 3 0 1611 M 4 1433 1 40 19 t3 lB 13 2 0 1 s 8 4 23 26 66 34 14 30 51 211 49 14 cz 33 30 41 2 3 25 49 22 57 169 M t 1438 2 11 4 2 g s l 6 2~ lO 47 38 32 23 6 1 4 0 0 0 l 1 10 ) 0 0 1 0 0 170 H 4 143~ 24 84 39 s u s ll 17 3 5 4 4 4 2 9 l 9 7 66 10 llC 55 60 22 0 0 32 I 0 78 55 62 31 171 M 4 144$ 24 1 0 l c 1 1 l z 1 0 0 0 0 0 0 0 10 11gt 13 6 0 0 0 0 2 1 1 0 0 0 0 2 0 172 H 4 1451 40 l2 36 C4 48 13 23 63 47 57 42 C5 ll 21 l 2 l 10 C 10 17 C4 42 6C 57 amp6 52 l 63 61 62 0 72 73 173 M C 1459 32 55 71l 56 19 59 12 37 6 SS 74 57 0 0 1 0 1 47 28 25 52 86 41 30 69 71 74 C6 s 2 0 0 3 17ir M 4 UU 21 0 s 11 54 12 2 1 1 14 12 2 3 l 5 0 s 2 21 0 0 0 0 0 20 2 3 0 4 0 0 0 2 0 175 K 4 1465 6 a () 3 10 2 l l 1 1 2 2 I) 0 0 0 0 l 3l 20 12 0 28 0 1 0 l 3 1 () l 0 0
bull 4
0 N II N N N N N M N N N N N N Ill ~ N N N N N N N N N N N If If II N N I( Ill N N N 8 J 3 3 3 3 4 4 4 4 4 4 4 5 5 5 5 5 5 5 s 5 s 6 G G amp 6 7 7 7 s 5 6 7 6 9 0 l 2 3 4 5 6 7 8 9 0 1 2 l 4 s 7 s 9 0 l 2 3 5 6 II 9 0 1 2
1Sl 0 2 S 44 41 37 Q 0 Sl 1 36 Zf 0 1 3 Z 56 30 40 64 1gt0 72 CS 52 21 49 SO 32 6 0 1 1 IS l 1 1 0 152 3 0 79 49 33 30 sa 30 0 2 2 44 25 0 l 2 0 1 l 2 52 67 64 SB SB 65 81 63 56 57 62 69 66 41 C7 53 10 1 153 1 o sa o 11 1 2G o o o o amp 1 o o 1 14 ss s s 29 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 54 JC 12 1 2 l l 1 0 l B SO 54 amp2 47 51 S2 58 67 59 66 69 15 52 71 57 64 2 58 48 27 0 0 0 lSS 1 0 iS 64 22 2 0 J 0 0 19 3 Z 3 3 l 4 1 3 4 SG S 71 0 6~ 68 21 1~ 1 o 0 0 1 11 1 l 7 8 1SG 0 l 74 1l as 76 75 sa Sl 2 0 7 0 4 1 1 0 0 o 0 71 ampl 71 CG 0 ampl 75 69 78 8A 18 3 76 70 75 48 7 7 157 3 o 75 49 26 48 51 4 0 0 o 1 ll 4 D l 0 l 0 1 64 54 2 60 BG 76 74 76 5 51 amp9 80 62 60 51 63 67 51gt 158 3 1 82 29 S7 1 17 0 l B 0 1 l 0 0 4 30 51 72 20 74 69 61 74 83 77 79 6 6 65 GS 74 65 S 81 73 37 42 1S9 2 l 65 10 13 Q 0 0 0 1 4 7 53 37 30 10 l 14 27 0 C2 66 58 63 69 63 41 26 amp1 29 17 1 6 0 1 0 B D 150 67 64 78 77 2l 24 0 0 7 1 0 5 2 0 0 0 ll J 49 5amp 55 6 72 76 62 57 55 7Z 1 1 ll l 6 G 1 161 2 0 59 4 45 67 48 12 1 0 l 0 3 1 0 l l 2 3 0 68 71 72 G1 61 S SO 8 Q 64 10 66 59 amp7 80 3 86 0 152 0 0 72 8G 6G 5 46 40 lG 0 0 2 0 0 0 1 0 0 3 9 62 67 S 79 74 77 70 83 90 84 4l 42 11 0 8 14 5 163 2 0 27 47 18 8 7~ 52 51 12 0 7 2 31 0 2 S 2 4 0 77 63 63 5 BJ 61 7S 74 0 74 62 81 29 9 0 3 1 1 164 0 1 0 15 59 14 S lS 59 0 0 o 2 2 28 72 63 69 75 15 SB 48 42 47 58 64 S SO S 74 73 69 72 1 57 32 7 165 2 18 4~ 2 51 0 15 a 1 1 0 3 2 0 8 4 a 0 5 2 70 63 66 54 61 62 SO 4 45 48 51 51 3S 0 1 0 3 2 1amp6 so o 93 so 14 o o 2 o so 36 2 1 o o 1 c o o o sa 60 10 71 57 66 s 73 12 sJ 53 28 9 o o 3 167 o z 38 22 o o a 1 o o o 2 o 1 o o o o 2 5~ ~ so 75 77 7o eG 57 14 3 o s 1 a o 1 43 1 168 Z2 2 55 45 44 23 18 S 3 39 38 51 56 29 Z8 49 2 0 1 0 52 5l 5 53 68 78 CS $7 73 69 64 77 77 SJ 51 4S 36 16 0 0 41 15 1 Q 0 0 0 D l 0 3 0 7 3 7 G1 38 ll 60 Sl 63 61 92 87 BC 55 3 65 57 58 24 11 1 S 1 0 110 2 4 ampG ss se s 2 1 8 o 1 13 o a 1s 9a 79 amp8 47 G7 84 60 66 68 74 bull~ ss 76 71 31 1 o 32 ss Gs a as 111 o 1 sG 41 29 l 1 2 10 o J 1 o 1 o 1 1 o a 12 so sa 84 s 57 G2 4 53 2laquo 10 c 2J o 1 o 1 2 172 s5 68 6 J 49 52 21 23 12 l 1 16 o a o o 1 21 S9 42 75 11 65 78 1 11 47 ampamp a 3o o s 10 o o o o 1 173 0 2 62 61 tO 17 4 S 0 B 1 29 B 5 4 2 D 21 JS l) 58 55 60 73 80 65 71 65 54 S 72 G6 34 C 0 2 0 0 174 3 0 69 37 14 32 ~ D 0 1 0 0 0 0 0 0 15 22 46 35 59 68 CS 75 72 83 56 6 36 9 2 1 0 0 0 0 1 11s o o B4 sz ~s 29 2s 41 s o co S 2s Jt 22 1 o 3 so 63 54 12 76 s sa ss samp Jl to 20 35 59 so 4 6 1
The 6AS Sys~am 0958 uesd~y Scp~embe 29 1998 8
G R )
0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
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o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
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0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
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GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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17 68 17 68
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-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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0 l 0
1 2 l
4 1 0
c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
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3 61 59 63
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0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
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50 D
SD 49 5
4
8 0 2
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27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
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61 53 uampe
3
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Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
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ampe 0 1
0 0 5
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27 0
17
D l l
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0
0 55
0 0 s
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7 50
0 0 l
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54 54
0 0 0
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0 u
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0 0 4
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
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1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
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1 78 l
2 1(
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6 70 30 74
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ss 65 67 56017
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(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
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2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
~ Ule SAS syliCa 09Se TUes~ ampepteabcr lt lS
G a A
0 so N Jl N N N rl K N N N II w Jrl II Ill N )I N N IC bull )I N Jl If N
ll IU t )I N N N N N N bull Jrl l t 1 l l 1 1 1 l l 2 2 2 z l a 2 2 2 2 3 3 3 3 3 s XP H 1 2 3 4 s 6 ~ 8 0 l 2 J c 5 7 8 c 1 2 3 4 s 6 7 II i c l 2 3 (
2 0 Q
152 H 3 1444 SS 63 Sll 73 79 s 214 0 1 0 l s 2 1 as 736S lSl M 3 1442 lS 4 0 0 s c 2 1 0 0 0 0 a Jl u 1 l 7 co 0 10 7 0 0 0 0 0 0 l 0
3 l 6 l 0 0 23 153 M 3 144 52 11 4 Jl 0 0 l 1 2 s 4 1 815 0 0 0 1 1 l 0 (I0 1 0 3 3 0 n 1 bull 11 0 1$4 M 3 1454 18 20 Cl 47 3 0 0 1 1 3 75 59 7l C3 5 4 1 4 13 22 45 2S 7 20 57 ~middot 40 0 a s 0 2 I 5 1$5 H 3 1458 26 41 58 Oll 0 a 1 0 512 0 J l 5 2 2 ll ll 5 0 1 1 0 2 2 0( 3 Zl 3 1 156 M 3 161 sa 11 a so J6 54 53 l 0 l 0 0 0 0 0 0 0 l 20 13 l 0 1 1 0 1 1 1 2g 75 95 7J 53 83 157 H l 1410 ZO 27 77 Sl 47 8 2 1 0 z c 1 ( 3 2 0 7 I 311 ll Ill 37 2 13 33 14 SG 69 40 7G 1 2 158 M l 1491 1Z 36 SS 57 4 2 74 74 IS 1 4G 0 10 66 98 40 65 38 68 94 57 32 JS 27 45 7 55 59 46 S7 41 40 0 15 M 3 1492 19 15 o 12 12 3 19 1 1 2 amp1s 21 1c a 4 4 1 43 10 4t J8 29 57 42 se 8 37 14 43 62 4) 56 50 16o M 3 19g 42 sz 7c amp2 t5 sz t2 11 2 21 38 79 so 12 s g 65 59 a 45 0 70 55 lS II l 6 1 14 21l 71 74 65 161 M 4 1401 0 4 3 1 amp5 72 S3 3 30 C6 1 3 1 17 7 2 3 l 20 34 21 II 0 0 a 5 0 0 14 11 5 3 0 lGl M 4 1407 49 4 2 1 3 2 2 3 C 1 16 7 1 10 2 0 l T 76 66 31 0 0 0 z 1 1 1 00 1 0 0 13 K 4 1414 66 7amp 74 79 73 43 s 8 2 l l 7 17 17 2 2 z 7 a s2 u ss 5 42 40 39 39 3 c 8 0 s 16~ M ltl 11 77 go 7G lto 97 s1 as so cg 96 1 34 1 27 55 73 55 60 7 55 58 61 10 l 9 0 3 112 2 1 165 M 4 1426 44 10 16 ~l 0 0 0 1 23 ~0 6 9 10 27 lO 13 1 11 2G JS 22 53 14 1 J s 21 2 5 0 2 6 l U6 M 4 1429 24 3 1 U 31 lS s 0 8 2 l 4 0 s 1 5 l 0 Sl Jl 36 Jl 66 6 0 32 64 72 5 70 6) 167 M 4 1432 31 34 0 0 1 3 z 0 0 D 521 a 0 6 22 19 64 53 0 0 0 0 0 2 0 0 1 5 3 0 1611 M 4 1433 1 40 19 t3 lB 13 2 0 1 s 8 4 23 26 66 34 14 30 51 211 49 14 cz 33 30 41 2 3 25 49 22 57 169 M t 1438 2 11 4 2 g s l 6 2~ lO 47 38 32 23 6 1 4 0 0 0 l 1 10 ) 0 0 1 0 0 170 H 4 143~ 24 84 39 s u s ll 17 3 5 4 4 4 2 9 l 9 7 66 10 llC 55 60 22 0 0 32 I 0 78 55 62 31 171 M 4 144$ 24 1 0 l c 1 1 l z 1 0 0 0 0 0 0 0 10 11gt 13 6 0 0 0 0 2 1 1 0 0 0 0 2 0 172 H 4 1451 40 l2 36 C4 48 13 23 63 47 57 42 C5 ll 21 l 2 l 10 C 10 17 C4 42 6C 57 amp6 52 l 63 61 62 0 72 73 173 M C 1459 32 55 71l 56 19 59 12 37 6 SS 74 57 0 0 1 0 1 47 28 25 52 86 41 30 69 71 74 C6 s 2 0 0 3 17ir M 4 UU 21 0 s 11 54 12 2 1 1 14 12 2 3 l 5 0 s 2 21 0 0 0 0 0 20 2 3 0 4 0 0 0 2 0 175 K 4 1465 6 a () 3 10 2 l l 1 1 2 2 I) 0 0 0 0 l 3l 20 12 0 28 0 1 0 l 3 1 () l 0 0
bull 4
0 N II N N N N N M N N N N N N Ill ~ N N N N N N N N N N N If If II N N I( Ill N N N 8 J 3 3 3 3 4 4 4 4 4 4 4 5 5 5 5 5 5 5 s 5 s 6 G G amp 6 7 7 7 s 5 6 7 6 9 0 l 2 3 4 5 6 7 8 9 0 1 2 l 4 s 7 s 9 0 l 2 3 5 6 II 9 0 1 2
1Sl 0 2 S 44 41 37 Q 0 Sl 1 36 Zf 0 1 3 Z 56 30 40 64 1gt0 72 CS 52 21 49 SO 32 6 0 1 1 IS l 1 1 0 152 3 0 79 49 33 30 sa 30 0 2 2 44 25 0 l 2 0 1 l 2 52 67 64 SB SB 65 81 63 56 57 62 69 66 41 C7 53 10 1 153 1 o sa o 11 1 2G o o o o amp 1 o o 1 14 ss s s 29 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 54 JC 12 1 2 l l 1 0 l B SO 54 amp2 47 51 S2 58 67 59 66 69 15 52 71 57 64 2 58 48 27 0 0 0 lSS 1 0 iS 64 22 2 0 J 0 0 19 3 Z 3 3 l 4 1 3 4 SG S 71 0 6~ 68 21 1~ 1 o 0 0 1 11 1 l 7 8 1SG 0 l 74 1l as 76 75 sa Sl 2 0 7 0 4 1 1 0 0 o 0 71 ampl 71 CG 0 ampl 75 69 78 8A 18 3 76 70 75 48 7 7 157 3 o 75 49 26 48 51 4 0 0 o 1 ll 4 D l 0 l 0 1 64 54 2 60 BG 76 74 76 5 51 amp9 80 62 60 51 63 67 51gt 158 3 1 82 29 S7 1 17 0 l B 0 1 l 0 0 4 30 51 72 20 74 69 61 74 83 77 79 6 6 65 GS 74 65 S 81 73 37 42 1S9 2 l 65 10 13 Q 0 0 0 1 4 7 53 37 30 10 l 14 27 0 C2 66 58 63 69 63 41 26 amp1 29 17 1 6 0 1 0 B D 150 67 64 78 77 2l 24 0 0 7 1 0 5 2 0 0 0 ll J 49 5amp 55 6 72 76 62 57 55 7Z 1 1 ll l 6 G 1 161 2 0 59 4 45 67 48 12 1 0 l 0 3 1 0 l l 2 3 0 68 71 72 G1 61 S SO 8 Q 64 10 66 59 amp7 80 3 86 0 152 0 0 72 8G 6G 5 46 40 lG 0 0 2 0 0 0 1 0 0 3 9 62 67 S 79 74 77 70 83 90 84 4l 42 11 0 8 14 5 163 2 0 27 47 18 8 7~ 52 51 12 0 7 2 31 0 2 S 2 4 0 77 63 63 5 BJ 61 7S 74 0 74 62 81 29 9 0 3 1 1 164 0 1 0 15 59 14 S lS 59 0 0 o 2 2 28 72 63 69 75 15 SB 48 42 47 58 64 S SO S 74 73 69 72 1 57 32 7 165 2 18 4~ 2 51 0 15 a 1 1 0 3 2 0 8 4 a 0 5 2 70 63 66 54 61 62 SO 4 45 48 51 51 3S 0 1 0 3 2 1amp6 so o 93 so 14 o o 2 o so 36 2 1 o o 1 c o o o sa 60 10 71 57 66 s 73 12 sJ 53 28 9 o o 3 167 o z 38 22 o o a 1 o o o 2 o 1 o o o o 2 5~ ~ so 75 77 7o eG 57 14 3 o s 1 a o 1 43 1 168 Z2 2 55 45 44 23 18 S 3 39 38 51 56 29 Z8 49 2 0 1 0 52 5l 5 53 68 78 CS $7 73 69 64 77 77 SJ 51 4S 36 16 0 0 41 15 1 Q 0 0 0 D l 0 3 0 7 3 7 G1 38 ll 60 Sl 63 61 92 87 BC 55 3 65 57 58 24 11 1 S 1 0 110 2 4 ampG ss se s 2 1 8 o 1 13 o a 1s 9a 79 amp8 47 G7 84 60 66 68 74 bull~ ss 76 71 31 1 o 32 ss Gs a as 111 o 1 sG 41 29 l 1 2 10 o J 1 o 1 o 1 1 o a 12 so sa 84 s 57 G2 4 53 2laquo 10 c 2J o 1 o 1 2 172 s5 68 6 J 49 52 21 23 12 l 1 16 o a o o 1 21 S9 42 75 11 65 78 1 11 47 ampamp a 3o o s 10 o o o o 1 173 0 2 62 61 tO 17 4 S 0 B 1 29 B 5 4 2 D 21 JS l) 58 55 60 73 80 65 71 65 54 S 72 G6 34 C 0 2 0 0 174 3 0 69 37 14 32 ~ D 0 1 0 0 0 0 0 0 15 22 46 35 59 68 CS 75 72 83 56 6 36 9 2 1 0 0 0 0 1 11s o o B4 sz ~s 29 2s 41 s o co S 2s Jt 22 1 o 3 so 63 54 12 76 s sa ss samp Jl to 20 35 59 so 4 6 1
The 6AS Sys~am 0958 uesd~y Scp~embe 29 1998 8
G R )
0 so N N N W N N N N N N N N ll N N N N N N N N K N N N N B pound 11 I N N N N N N N N N 1 l 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 l J 3 l 3 S X l M 1 2 l 4 s 6 7 e 9 o 1 2 3 4 s s e 9 o 1 2 3 s 6 7 8 9 0 1 2 3
16 M 4 174 2 25 47 16 0 25 1G 83 16 1 3 4 S 4 0 l 21 49 17 12 42 18 2 1 1 1 4 6 71 94 IS 7 44 11 177 M 4 146 2 0 a 19 21 7 17 27 0 1 0 1 l 0 2 l ll 2 15 70 37 47 6Z 7 68 59 3 0 2 70 82 35 0 178 M 4 l43 11 10 65 amp3 57 73 62 46 l6 53 25 64 25 16 4 J o 3 11 23 11 o o o o a o o o o o o 2 1 179 ~ 1487 51 41 2s s2 53 4e 2 4l 57 62 sc 73 11 J2 13 to s so amp2 co amp5 sc 4 53 7o 64 SG 7 c 7S amp4 1so ~ bull 147 cg 20 1 14 12 31 12 J 2 1 3 1 2 s 4 11 s eo 9 so az 35 o o o 4 2 1 s o o o 2 181 M S 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 l 67 2 86 6 30 4 9 0 Q 0 0 47 182 M 5 1420 14 so 73 49 4 4 2 a 20 2 3 6 1 4 zs G s 1 62 77 77 4 62 72 73 4 34 3 cs z 4 eo ~2 73 163 M 5 1423 18 69 54 57 0 Q 0 1 3 0 5 14 10 60 61 1 l 0 52 28 S7 65 lS amp5 66 41 l 1 3 1 1 7 12 3 184 M S 1424 38 94 75 83 Bl tiO 59 45 48 83 66 3 62 87 47 78 61 GS GC 82 5~ 75 G2 (7 CP 57 SO 8 78 52 185 M 5 1427 26 48 6C 71 8 70 B1 54 l B 45 17 2 0 0 0 1 S 22 25 24 l 4 5 l 0 0 0 0 0 a a 0 2 186 K S 142a 21 33 37 44 4 lC 11 6 ) 2 l 15 8 10 9 4 6 lB 32 16 ampl 51 B 0 0 2 47 ampt tO SS SG 3 1 187 M S 1437 20 0 0 4 Z 1 Q 1 1 2 1 2 2 E 39 58 79 101 62 39 26 1amp 4 1 5 1 0 0 3 12 1 4 3 188 M 5 1440 16 9 6 0 2 l 0 2 l 0 7 1 14 51 6 l 3 S 63 73 23 Z4 37 J 0 2 0 3 0 l 0 9 S 0 189 M 5 1441 0 0 2 9 4 9 32 11 3 0 9 2S 16 0 32 22 32 5 3 6 11 65 43 la 6 4 0 1 3 0 0 o 0 0 190 K s lftl 44 52 J 24 o 6 63 lO lB 29 3 o a o o o o 2 73 75 96 77 87 845 a 73 43 6 o 3 o 2 o 11 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 o o l 1 5 z 16 63 21 16 2 1 192 M 5 1452 14 3 3 4 2 5 3 6 0 c 13 4S 4 77 82 56 27 4 72 12 0 39 72 71 58 1 31 2 S 0 9 4 C 6 193 M 5 146 59 51 17 13 l 11 10 1 29 S S 8 12 4 1 ll 12 65 97 82 77 77 72 66 86 99 72 79 4 71 81 55 2 2 194 M S 14l 1 1 3 1 1 0 2 9 2 0 1 2 2 l 3 12 3 1 7 0 0 0 4 2 0 l 0 0 1 1 4 C 15 46 195 X S 1478 59 27 24 18 0 3 Sl 78 54 1 82 3 2 71 41 60 23 26 14 10 S 0 a 1Z S2 8 27 40 2 1 0 196 M s 1484 4 82 so 12 46 ss 12 22 21 54 62 7o 75 76 ca 10 20 4 o 14 24 1 o 1 16 12 o 1 bull o o 2 o 1 M s 1488 o 14 4 o 1 s ag 63 s 93 16 az 63 2 12 69 7o 31 zo 22 11 o s o o a 2 o 2 5 o o o l9S M S 1fa9 26 44 12 4 10 8 18 1 13 3 0 0 4 0 4 16 SS 58 60 G6 ll a 0 9 2 16 S 1 6 0 0 2 15 lt M 5 1493 8 3 70 GO 0 0 l 0 0 0 1 2 0 0 l 1 12 31 56 Sa 34 19 52 52 2a 1 3 3 0 1 4 0 1 200 K S 148 Bl SO 69 1 3 22 76 S7 97 72 16 2 13 86 95 94 84 14 C2 37 7 1 0 2 8 0 0 7 1 60 3 82 77 lOS
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
bullbull 41-fbull - shy
14
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1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
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GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
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---- ---- --- -- --
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42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
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5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
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100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
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s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
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0 0 2 0 0 2 0 0 4 l 0 1 0 4
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K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
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l 76 62 ss
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1 77 24
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l 35 62
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0 5
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77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
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80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
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53 10
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cs l7J
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lS J3 37 6 1
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116 14
l 79
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32 65 a 6 0 1
45 0 A 1
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amp0 s l 2 3 1
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liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
0 N W bull N N N M K N N N N N N N N raquo N N X M N N N raquo raquo N N N N N N M N raquo N M N D 3 l 3 l 3 4 C c 4 4 C C 4 4 C 5 5 5 5 5 5 5 S 5 S 6 C C C 6 6 G G 6 6 7 7 7 c s 1 a o 1 2 3 c s 6 a t o 1 2 3 4 5 G 1 a g o 1 2 J c s 1 a o 1 2
176 bulls 30 6 l 11 20 31 0 14 0 2 c 14 12 J 1 0 0 3 1 55 C 70 g 52 C2 C4 ll 5C GC C2 51 0 72 2 177 3 8 66 5 z 15 0 0 0 2 1 0 0 1 C2 52 54 CS 18 Cl 3 58 69 4 59 68 54 CC 7 36 2C 1 0 1 19 CC 47 13 178 0 1 3 23 0 3 1 0 5 30 l 18 2 0 0 0 1 0 1 0 72 amp8 73 54 CJ 27 30 11 12 77 76 C3 12 61 amp5 35 8 Sl 17 62 7 c 52 50 J 10 30 20 I 55 30 48 48 72 53 1 72 11 67 C9 C 58 78 7S 2C 4 I 3 0 6 0 0 1 0 1ao o 8 Jg 55 31 o J 2 o 10 2 1 o 1 1 o o o 1 71 5amp ampo cc amp5 2c 33 o as 51 22 c s o o o 111 2 sa 79 c1 36 o a o a o 3 2 o o o o o 3 o 1c co o 62 c7 64 c~ 19 59 55 51 53 5o 2 sa 182 81 70 87 58 10 53 59 11 2 5 15 15 3 2sect CO 69 67 Cl 16 53 amp9 70 75 61 72 53 75 7amp 75 87 72 Ia 77 64 78 Cl 183 1 2 77 eo ampJ 71 samp z a c7 o 1e c s o 1 o o amp1 62 72 2 a 13 51 $2 co 11 O st S 76 5 11 18amp 70 l1 cc 53 cl G1 45 Cl 67 30 21 0 0 1 0 5 l D 3 1 73 63 CS l 76 64 68 6 73 Sl 70 67 72 77 CO 22 5 0 1as o 3 ampJ 54 )4 64 4 ~ o J o 1 o o 2 o o o o 10 se 6t 59 57 61 at 32 sc 59 22 cg 25 12 22 o 11G 0 5 38 27 l 0 40 52 0 0 0 3 0 7 0 0 2 0 S 52 51 C2 57 CS amp0 78 C 1 37 30 2 2 l Cl 51 27 0 0 111 o 1o o 55 2 s 3 s o 1 J 7 1 3 o o 2 c1 c1 55 sa 43 81 amp7 c7 5 s I 53 52 5o 12 1s 3o 188 0 4 91 52 96 61 13 0 0 63 53 17 3 0 J l 0 0 J 0 73 74 amp6 72 90 ampS 79 5C Cl CG 53 50 64 92 59 C J 18 0 0 4amp 28 17 0 S 1 1 0 2 0 2 12 26 32 51 39 46 37 C5 C3 IS 7C 74 10 75 c 72 Sft 81 73 75 70 5 68 43 10 1 81 25 1 o G1 23 c 1 o o o o 20 sc 59 21 1 58 73 65 as 7C 73 as 72 sa c1 amp4 61 3 G3 73 11 3 o 11 sa ss l o 1 1 1 2 1 1 o 2 3 1 s o l ao 73 57 82 a 72 71 73 10 77 74 7 11 3 51 73 192 J c5 Sl sz zo o o J 2 c ll ampJ amp3 28 38 2 o o 73 72 74 81 60 58 53 as 51 21 2 o 1 1 1 193 2 1 78 75 46 Sl JC 21 sbull C l9 21 6 17 1 l 8 6 0 58 68 63 6 5 3 G1 68 55 C7 4 l 0 bull 0 a 1 5 14 12 GG 31 59 12 34 53 0 32 0 0 1 0 l 0 0 1 0 l 51 67 CC 54 5 2 CB IS 66 57 CS C( 55 60 11 32 2 15 1 1 56 47 9 37 9 10 2 0 0 0 0 0 0 t 1 14 41 t3 GS 17 70 61 58 tl 14 3 C 1 0 2 0 0 0 0 0 16 J ao tJ ampo 55 20 o o 1 a 2 6 o a s a o J 1 10 72 11 ss ca 42 26 c 1 1 1 o o 2 J 2 197 3 0 so 10 61 ss 40 31 36 31 10 0 1 0 0 0 0 0 0 7J 57 61 65 63 57 5 56 44 30 co 59 10 cs 4 73 57 30 1e 35 1o t9 so 43 1 Js 10 1 o c s bull 6J 6 65 ampl s1 11 61 amp1 12 sa st amps 11 sbull l 199 1 0 68 5 GB 8 lO 19 C 6 Z lG 55 75 30 1 5 C 2 0 CS 62 71 51 64 58 6amp 53 71 45 4 6 0 0 1 12 59 76 200 70 68 IS 62 B l 0 0 5 4 0 2 0 5 0 4 0 6 36 70 GB 70 66 61 64 57 77 56 70 62 1 2 27 l 60 52
Study 1613 NBALL1aAT 0951 Tucaday epte~bar 29 ltt8 g
Cn-ral tiDM Model~ lra~ure Claam Ltvel Information
ClaDII Levels VaJJgtea
GIIOOP s 1 z 3 4 5
SEX 2 FM
Mwaber of oberva~iona in data oe~ bull zoo
NOTE ObD~~ions with miina v~lues will not be included in this ~=lyci ThWI only 1U observtt~oMI can be ued iJI tllia Malyci I
Stuey 1613 NIIALIlPAT 0958 Tueaclay Septeaber 2 1810
General Linear Moaels P~aeedur~ llel)9ated ICe~UNree ~1yai of ltarianebull ~bullpbullacea Measurebull Loval znf~mation
~epecdent variable m 112 N) ~ N6 ND 119 mo Nll nz Level of ny
Level of BLOCK 1 1
l 2
l 3
l 4
1 5
1 6
1 7
1 e
l 9
1 10
1 11
l 1
Dependent variable Nll NlC ms N16 117 tnll 1719 NZO K21 N22 1123 1124 LeOol o DAY
Level of srccr 1
13 l
1c 1
15 l
l6 1
17 1
18 l l
2 2
2 3
2 4
2 5
2
Dependent var~e N2S ~126 W2 me N29 NJO Nll N32 NJJ N34 raquoJS n Lcvo1 of D7Y
Level of 8LOCK 2 7
2 8
2 9
2 10
2 11
2 12
2 13
2 u
2 15
2 11amp
2 17
2 11
Depea~ent VariAblbull N37 1131 N3 uo Net bull2 N43 NU N4S 1147 Iwcl of DAY
tavel of aroclt l 1
3 2
l 3
3 4
3 5
3
2
J e
l 9
3 10
3 11
3 12
Dapondent variable N49 NSO JfSl N52 N53 NS4 M55 NSG NS7 NS6 M5t KO
Level o DAY Level af 8LOCK
3 13
3 u
3 lS
3 l
3 17
l 18 1
4 2
4 3
4 5 tgtependant varialgtle lf61 N62 11163 NGC R65 NG NG7 NU RG9 N70 1171 N72
L=al af DAY Level of BloOCit
4 B 4 9
6 10
4 11
4 12
4 1l 14
4 15
4 16
4 17
t 18
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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0 s C N H N N N N N N N N K N N N N N N N R N W N N N N N N B JU1 N N K N N N N N N 1 1 ~ 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 l l l 3 J J S X P liS 1 2 3 4 s G 1 a o 1 2 l 4 s 6 1 a o 1 2 J 4 s 6 1 8 g o 1 2 3 s 76 F ( 1774 17 13 25 20 l 1 (J 59 1 1 4 S 7 0 7 4 l 1 3 44 1 1 0 2 1 0 0 1 0 1 0 0 J 26 51 7 F 4 177G 6 4 25 5 1 10 10 36 41 29 28 27 1 47 5 D 0 l 31 0 12 l 0 4 I 38 37 65 60 6 (7 (7 54 44 27 7$ F 4 1783 10 28 4 49 43 46 27 1 l 1 4 1 2 4 3 0 4 l 7 32 17 2 11 35 69 1a 0 0 0 0 3 1 0 0 0 p 4 17a7 30 ll 11 l 2 16 0 1 3 19 0 1 3 1 l 32 (2 53 27 7 55 57 42 1 0 12 0 0 bull 3 ao v 1797 13 17 J o 4 24 sa 23 19 37 sz c 20 25 s o o J sg 6amp 47 61 l cJ 70 73 72 za 56 74 75 55 76 A1 v S 1710 46 10 75 73 84 54 53 76 3 2 40 89 38 3 63 76 37 5 38 32 14 17 3 18 1 0 0 5 0 1 0 0 2 D 2 82 F S 1720 6 6 1 0 1 0 3 2 D 0 2 1 13 2 4 1 0 0 JB 63 22 GO lO 91 95 IS 74 19 a1 0 Sl 85 52 2 5 83 F 5 1723 I 35 4~ 43 7 59 26 3 2 G 2 1 3 2 2 4 2 3 13 5 12 1 25 24 0 1 2 S 30 13 44 2 0 0 84 F 5 124 26 53 76 73 11 49 2 6 2 2 2 S 4 3 ~ 0 15 24 43 35 66 53 51 76 46 51 62 69 S 5( 76 70 ll 1 16 5 F 5 172 14 12 14 23 17 15 1 11 0 0 0 0 4 SC 59 2l 21 21 44 23 4 50 64 5 57 41 53 S 53 76 81 4G 50 2 ss F 5 1121 o o o o o a ca 22 6 2 3 2 3 2 3 a 2 57 19 2 s1 1 64 13 2 o o o a o 4 o o 87 F 5 1737 63 SO 1 0 1 1 2 6 5 13 15 0 2 7 0 l 0 D 80 24 41 0 0 2 0 0 0 1 I 0 S 2 0 0 0 SB F S 140 12 4 0 10 8 19 41 1 1 l 0 2 0 l 1 l 2 0 SO 57 34 43 24 7 0 0 2 0 1 D 0 2 D D 89 F 5 ~741 3 0 0 0 Q ~4 51 68 65 72 4Z 69 14 4 3 11 S 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 0 F 5 1743 32 53 4 0 39 74 52 CO 1 9 0 5 S G G S 4 G lJ 5a 55 31 72 42 5 6 30 72 ~3 37 CS 57 C6 12 2 91 F 5 14amp 31 42 25 19 38 lG 0 1 1 0 3 1 G 0 7 1 4 0 2a 39 5 Q 0 0 0 0 0 0 0 0 2 Q D 4 0 92 p 5 152 27 48 51 56 SG 1 4 50 51 54 1 0 6 46 48 4 50 27 55 60 57 58 e 80 71 Dl 4S 74 3 39 13 51 SG 72 Cl 93 F 5 166 12 16 30 55 13 2 27 15 4 4 1 2 2 S 2 l 2 2 54 66 61 7G 78 43 3 5 62 27 77 78 66 6 68 75 C4 94 V 5 1773 15 1 1 1 0 0 0 SD Jl 1 0 2 0 0 0 8 0 0 l 1 1 0 0 1 0 0 0 0 0 0 0 0 ~5 y s 177amp Jamp ampl ao amp9 7 o 7 2 2 11 40 56 a4 a1 co 1 53 o 2 sa so 44 Go 49 53 sa 54 7 11 26 2 a 13 1 9G F S 1784 17 42 ll 73 16 5 7 9 l 3 2 0 9 C 5 7 1amp 24 54 SS 70 55 5 55 63 71 70 SS 65 50 68 3 48 39 7 7 F 5 1788 0 S 0 0 0 2 1 1 15 44 58 S 0 1 0 0 2 0 1 0 1 D 0 0 0 0 D 10 30 14 0 0 0 0 0 ~8 F 5 178~ 2 64 31 amp4 bulle 1 22 61 69 10 20 21 76 44 20 c 84 12 rs 37 a o a 2 3 37 as as 11 a1 6 67 F 5 1793 15 l 0 I 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 36 51 3 1 12 0 4 a 0 1 0 0 0 4 34 51
100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
0
13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
l
19 2 2
1 1 0 so
lll K 1 1470 10 28 6 26 36 u u 30 4 1 2 1 4 1 4 l 2 2 112 M 1 1472 3 l3 34 34 1 0 0 4 0 1 1 2 0 1 J 20
2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
IC ts M M M M M K M M
1 2 1 2 z 2 2 2 a z
1412 Ull U18 1434 144G USl 14SS 1456 UampO 14l
9 l
45 37
7 u 53 16 IG so
l IS Z2 20
1 2 57 z
eo u
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
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Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
---
Manova Teat Cyen1t~ia ad axcc P Gtatiatieo fer tbl HYPotba~iamp ot DO DAY tffeet H Tvpe ru SSI~ tbUix tor E- z = Error sutP Matrix
Sbulll MC5 Xc9~
value F Nul l)i Dee DF Pr gt FStllticic
J 00001 Pillaibulla Traee 0677081 24307amp4 l 181gt oooou Hotel1ing-~wley Trace
Wil~ tutbda ozoJnnc Ul07U 18
32055424 2amp307amp4 3 1116 00001 RQYII Orcateat Root 32055pound24 243(17amp4 3 186 00001
bull~va Teat Criteria ~d P Approximamptio~ for the eypotheoibull of no DAYbullOROUP Sffoet H o Type Iti SSICP Matrix for DAYbullGROUP ~ bull E=cl S-CP Klltrix
s-3 JloiO tb2
Statilt~tic VAlue p -OF Dec DF Pr gt J
Wllkltl ambda oC2G3517 on65 12 24011 051 PillAir Traee ocsaoon4 02G7 12 s 05lS Hotc11ico-Lampwley Trace OOG017287 010 12 554 05203 Roy Createat Root 00462amp98 11727 4 1811 oo13S
waramp F Statictic tor Roybull Greatest Root i an ugper bound
Study 1513 ~LlRAT l1
~bullnera1 Lioeampr Koee12 Procedure Repeated tieeaurea ~Yi of Vari=ce
K5ova Teat Criteria and Exact F Staciatica for the HYP0tbo2~~ of no DAYbullSEX Effect H bull Type III SS~CP M3trix tor DAYbullsax pound = Error SSLCP Mamp~r1x
Sbulll MooOS Nl2
Valuo F Nlllll IJP Den DF Pr gt FStoatilltic
Wilb bull 1ubamp on43491 lJOll 3 166 02752 Pillimiddotc Trace OO~OSGS09 13018 J 1QG oI75Z Kotelling-Lawl~ Trace (l02099U9 13018 3 18li 02752 Roybull Greatest Rent a 0099689 13018 J 1R6 02752
M~cv3 Tee~ Crit~ria and F APDrox~aticaa for the Hypothesis o no CAYGROUP-SEX ~ffeee H -rype rn SStCP Matrix f= DAYGROWlEX l = Error ssre Matrix
sJ tfoall Nl2
Statiatic Value p Num DP Den DF Pr gt P
Wilkll lolUnbdA 093115680 11213 12 240la 03400 P11laibulls Trace 007029013 11276 12 564 D33CS Hoeellicg-~wley Tracbull 0072311761 111amp0 12 554 OHS7 Roys createet Root 0 03932046 111481 4 188 Ql214
Hanova T~~t Criteria ~nd Rxaet F Statistics for the HYPotheampi~ of no nLOCK ampffcct H =~e III SSCP ~trix or BLOCK E Error SS~CP Ha~rix
S=l M7S NBS
seaeitic ~lua F Jl1m D1 Den Pl Pr gtI
Wi1X ~ Q13pound1lQ(2 6420SS 17 172 00001 Pi1lai bulla lrc 08pound386958 64ZOSS 17 172 OOOOlV Hotelling-~owley Trace 634589567 642055 17 172 DODDl Roys Crbullatat ~oot 34589667 642055 17 172 00001
Ksnova ~eat C~iceria and P Appraximampeions for th9 Nypoth~~ie o~ no BtoeKbullGROUP Etect H bull Type III SSCP Matrix fel lLOCXbullCltOUP 1 Error SS~P Mauix
S Kbull Nl5 Sta~itic Vamplve NWI llF llen IgtF Pr gt F
Wilks bull t401baa 06354UC9 121111 GB G772SIS3 01185 Pillaibullz rraee OU4027G9 12206 GQ 700 01173 Hotcl1in~-Lawley Trace 048582247 1211 Ga 581 01200 noymiddota Greatebullt Root 011993amp 201116 17 175 00124
NOTE I scaistic for ftoybulla Orc3te1Jt Rooe ill middot= upper boun4
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
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4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
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100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
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101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
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G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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ClUB Level Values
GROUP 5 l 2 3 4 5
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N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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Pr r H bull F
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17 68 17 68
21lB5 944722 23BIl178889
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2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
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21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
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32 l 2 2 0 0 2
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21 2 1 1 a 0 0
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40 14
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l 5 1 0 0 0
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57 13 27
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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14 JO
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20
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0 22
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0
77 l
66 l
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23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
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15
3 0 1 0 0
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D 0 0
12 3 0 0 l 0 0 3 l
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15 10
0 3 0 l s 0
l4
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35 GG
0 17
3
0 1
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1 1 0
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92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
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0
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s
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
12 5
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lamp 0 0 e Q
l 0 2 2
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2
0 0 l
lJ l
32aG ll
0 0
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48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
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0 I) 1
65 0
25 0
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0
0 0
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50 D
SD 49 5
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8 0 2
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27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
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0 0 3 1 8 0
18
61 53 uampe
3
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Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
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ampe 0 1
0 0 5
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D l l
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0
0 55
0 0 s
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7 50
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54 54
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0 u
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
11ldy 14113 -u1UT
oeaeral Linear Modele Procedure Ropeate4 Meaaureo Acalylia ot VZiaace
MampDOVa Telt criteria and Exact r Statiaticc for tbe HYPo~c~ic of no B~bullszx Zffect H lytle III SSKP MatriX tor JIIIOCIIbullSZX l ~ Zrror ~CP Matrix
Sl MbullIS 11=85
DP Dfln or Pr gt pVampluo F
11 113 025t Statiltic
IOiliCS Lambda onlampUcs 13038 oZC59rlllaibullo trlSce Ol05330St 12031 17 172
12031 17 172 OZGS9Hotal1ina-Law1ey Traca Oll898US 120311 17 172 02659RoYS Greatest P~ot 01188195
Mampnova TOit criteria an4 P Appr~tions tor tbe Hypothesi~ of no BLOC~middot~o~middotCEX ~ffect H =rrPbull IU ssrcP Katrioc tor JtOCXbullcmourmiddotsEY 1 bull ~rcr s~P Matrix
Sbull4 N=6 Illbull IS
Value F NIDI DP Don DF Pr psut1ee1c
Gil 07031Willal tulbdl 0712)1684 OIUO n729Sl
09035 u 00 oUliOl2215tl5P11lilil Trace 682 07123Hote111ng-~awlcy ~ace Ol557885l ou 68 Roy8 Create=e ROOC 014642804 15073 17 175 oo
NOT~bull F Statistic for Royamp Croate=t aoct 18 an upper bound
Kampnova Test criteria and Exact F Statiatics for ebe Hypotheaio of no D~middotBLOCX Effect K =Type III SS~P Matrix for ~y~~ E lrro~ SS~CP Hs~~ioc 51 Kbull24S
P Dl Den CF Pt gt- FScatiatic VI~ lie lolla
015954848 l4 ZSl 51 138 00001Wllltbull taJolxh 14 2Sl7 51 138 o 0001amp-0840amp5152PillaiSI Troue llB 00001Hotelling-Lawley Trace 51676871amp 1( 2537 Sl
00001Roybull Greatest ~oot 516765728 142537 51 lJe
Manov~ TC3t Cric~ria and ~ Approxiaatioos for che ~otbeaiu of no oAy-BLOCXbullGROUP Effect H =Type III SS~CP Matrix for nAYmiddotB~ocxmiddotG~OUP E bull Error SSiCP Hatrix
Sbull4 1123 N=68
Value l Nwa DF Den tiF PrStatlatlc
Wille bull tuobda OliUlUJ 10058 20amp 5535858 04731 Pilli bull Trace 10SU0905 10082 204 SGamp 04545 Hotelliag-~wl~ Trace 10857523 10027 1-0C 546 04836 Roy CreateGt Root 050711817 14020 51 141 00629
Study 1613bull NBALLlRAT
Gearal Lin~ Hoaelo Procedure 1epeated urebull Analysi1 of variance
Kanova Ta~t criteria and lxact F Statia~ica tor tho Hypotbeaie of no CAYmiddota~middotszx Effect K = Type II SSCP Matrix for DAY~LCCKSEX E = Error SSCP Mstrix
5bull1 Kbull2CS N=8
Value NUIII DF Cen Dl Pr gt- FStatistic
lll 01U3Wilke LaJibda 0 675Bt770 1 2978 51 138 D1H3
Hote1lla-Law1oy Trac~ o us2a 12978 51 lll ouu Roye Greatest ~oot 0 G2328 12978 Sl 138 01U3
Pi11amp18 Trace o 32415230 12978 51
Nanova Teet Criteria and P Approximstiona for tho Hypothee18 or no C~YmiddotB~cxmiddotGROUPbullSEX lffcct H Type XII SSkCP MatriX Cor lIAYB~OCXGROUPSX E bull Error SSlCP Maerix
5bull4 1123 N6B
sea1ia1ic Value F lllwn OF Den Ill Pr gt r
OU1G 104 5535858 06911 Pi11aitl T~aee 101944663 0456 204 Slit 015715 Hate1liaa-Lawley T~aco 1COlSS2SO 0 378 S~
Milk= lalabdamp 0 JOCSil)O
20ol 070~9 aoymiddot= 4rcateet Root OSl~SP104 14725 Sl 141 0 OJ9B
NOTE F Staeibulleic ~or aoybulla Greatcat ~ot io M upper bound
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
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Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
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0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
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100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
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B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
8 Gtmeral tiDear ~1a lrccotdur
llcpeateltS Muaure11 MampJyaia of vadu~ Test11 of Hypeth for Betwean subjects Ettacta
Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
oaJ 051001lU99353U 31middot83835pound1
7SUS891228070 3JU4U599J711aror
t
aeceral Linear Models ProcedUro ~epeaeed Heaaures ~lycie ot V~ri~ce
Univariate Te=ts c HYPotheses fer Within Subjece tffectg
~juned Pr gt F TYPe ur ss Mean scruo~re I Value Pr gt P C - G H - FI)SScUCe
~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
07U Wecnealay Septeebtr 30 1t91 l
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
NS Jr7 NS Rll 1(9 )I]Q lf12 m3 m~ lflS lll6 N17 )Ill OBS SEX GROUP lUml lll an lfl
0 0 0 1 l n I 1707 13 17 19 16 25 5 2 2 2 2 bull 171amp 55 C1 70 5 10 n 37 ZG 4J 52 zs 1 1 0 5
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7 2 Gl F 4 1733 4 56 30 31 55 37 70 12 0 45 31 5 59 27 58
0 u 4 1731 7 bull0 1 0 0 l zs lS ti2 ze 0 0 0 1 0 0
1 0 0 3 2 070 c 1739 23 52 C1 46 45 0 28 2 39 10 s 7l 71 4 1745 22 35 amp9 52 30 24 25 30 JS 1 8 0 c 1 0 3 2
72 4 1751 55 34 33 43 tiD u Cl u 43 til sz 38 n u 30 31
73 4 1759 so 32 19 15 51 45 55 2~ 0 2 0 0 a 4 1 0 0 l 0 0 l6 4417U 5amp 27 7 13 l 2 s 3 0 a 37t F 10 30 39 1 0 l
75 F 4 1765 36 amp0 z 11 1 0 0 0 0 0 1 25 1 0 2 1 0 0 1 0 1 0 0 J 26 51 35
76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
Q 0 0 J 1 0 0 0 l71 F bull4 1783 7 32 17 2 11 35 C9 11 0 12 0 0 ~ 3 0 1787 32 42 53 27 7 5S 57 4l C4 1 0 6
80 4 179 59 6l C3 lO 73 72 2B 75 5 49 81 r s 110 38 32 u 17 3 18 1 0 0 s 0 l 0 a 2 0 2 51 85 52 2 5 8 22 60 30 91 95 85 14 19 81 a liZ s 1720 38 u
37 13 s 12 17 25 2C 0 1 2 5 30 13 44 2 0 0 2
84 F s 1724 u J5 66 53 51 46 51 2 69 57 sc 78 7a ll 1 16 513 I s 1723 57 53 81 amp6 50 2 0
85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
87 F s 1731 RO 2C u 0 0 2 0 0 0 1 1 0 s 2 0 0 0 0 0 0 1 0 0 2 0 0 088 I s 1140 so 57 34 u 2~ 7 0 2 2 0 0 0 1 3 1 1 J
II 5 17amp3 13 u 55 11 72 0 56 30 72 6J 37 45 57 58 12 2 5689 F 5 1741 32 40 24 21 15 1 1 0 3 0 Q0 0 0 0 0 0 2 0 0 0
1752 ss 60 57 sa u 80 1l 83 46 7~ 73 39 13 51 56 12 u 5291 J s 1748 21 39 s 0 0 0 92 F 5
r 5 1766 54 66 61 16 78 C3 73 75 52 27 77 78 66 u u 75 7493 0 0 1 0 0 0 0 0 0 0 0 11
I 5 1778 2 5amp so 60 49 Gl 58 s~ 71 26 2 0 13 l 1r 5 1773 8 0 0 1 l 1 5 F 5 1784 54 5 70 55 sa 55 63 71 70 55 5 so 68 73 48 3 27
0 0 0 0 Q 0 10 30 14 0 0 0 0 0 0F s 1788 1 0 1 n9Q 5 1789 114 72 liS 37 0 0 0 2 J 37 85 Ill 87 99 5 179l 52 36 51 l 1 12 0 0 0 8l 0 0 0 ~ 34 51 co
100 5 1798 58 71 9 62 c 23 70 76 59 67 77 n 30 16 6 G1 to 101 H 1 1402 37 27 lR 42 46 Jl 25 19 4 24 9 0 G 5 3 2 ~ s 102 M 1 1~08 0 2G l1 2 58 (l 4 3 1 0 1 0 0 0 0 l 3 103 H 1 1pound21 Jl l~ 2C 12 36 s 42 H 10 2 4 2 1 3 1
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107 K 1 usc 47 amp6 20 28 l1 54 4l l 9 sa 77 58 5amp 43 1 s 4 1 1De M 1 US7 22 36 zo 48 19 0 1 0 0 0 0 0 0 1 0 0 Q 0 106 M 1 1CC7 2l 0 11 19 109 Jlaquo l 1462 92 82 72 ae 94 86 Bll 80 BS 95 84 78 s 7l 56 87
l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
123 124 125 121gt 127 128 129 130 131 132 133 134 135 136 l37 138 139 1t0 141 142 143 lolol 145 146 1C7 146 14 150 ~~1 152
tf M M M K K H M H If M H M tf M M M tl M K M M M M M M K I(
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The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
g 2
l 55 1 3 0 10
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J 0 0 0 0 0 0 0
fi ll 43 38 G7 4 0 1119 M 5 1441 l s uo M s 1-amp43 7l 75 116 77 I 84 75 108 73 43 0 J 0 2 0 11
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0 s 2 lC u amp3 21 16 2 1lCbulllR 6l 26 13 0 1 1 Ul M s 3n 58 71 Jl 2 5 0 9 4 0
U2 M 5 5 14Gii 97 82 77 77 72 16 72 7t 54 7l 81 55 2 a 2 11452 72 u 0 39 72
193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
us 0 2 4 34 0 0 c1 IC s 1484 0 l4 24 1 0 1 16 12 0 1
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70 sa 31 0 0 2 16 5 l 6 0 0 2 1S lS 11 M s ue 0 0 199 H 5 1493 56 511 34 1 52 52 n 1 3 3 0 9 l 4 0 l 1
u42 37 7 1 0 z I 0 0 7 16 co fil 82 77 105 70200 K 5 11 1998Ctu4Y 1613 NMD18 RrT 07U WedllerJ~ ampeptCIIIbll1 30
5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
0 44
2 3 l 0
Ill 0
32 l 2 2 0 0 2
45 0 0
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0 2 0 2
62 2
21 2 1 1 a 0 0
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0 $$
0 2 1 g
40 14
3 0
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33 0 0
0 co
0 0 2
GS 59
l 5 1 0 0 0
53 l 0
0 C5
0 4 0
54 44 u
l 1
1 0 0 0 9 5
3 32
0 4 2
S7 79 Cl
0 0
51 0
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JD 2
0 u
0 0 1
4l 58 54
0 0
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0 0
2 39
0 1 2
57 13 27
0 a
57 2 0 2
12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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J 517 34
l 27 13
6 0
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14
14 JO
2 0
20
14
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43 16 13
0 22
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2 47
0
77 l
66 l
45
48 3
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35 0
23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
0 1 0 0
15 0 0 0 1 0 1 1
0 0 l 3
15
3 0 1 0 0
0 1 2 5 0 1 0 0 0 l 0 0
D 0 0
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0 3 1
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Q 0 0
15 10
0 3 0 l s 0
l4
0 0 0
35 GG
0 17
3
0 1
46
1 1 0
3 4 1 0 0 0
92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
52 32 1G
0
1 0
l u
0
4 65
0
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0
s
0
1 3 l
4 l 4
0 a 0
0 l 0
1 2 l
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c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
71 s
0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
o ual tin~~Ar Modele lJOeedure llepea~ed MttUIQes ACaJysia of VIUianee
Tell~ll of Hypctheae for Between su=eeta Bftects
Souret m rYIH Ul ss Hean SCIII~e I ~luc Pr gt F
4 l 4
2247410147977 2S2S3ll6amp9f0
L2Sf3G742G497
5618 525369- 25293669769 314141156624
019 044 oss
04201 05079 07001
Brror 118 L080l847CS4708 5amp67274705
Study 1613 ~L1aAT lS
oeaeral Linear Models ~eoebull~ure Repealed Kaaaure11 ~yaill ot VUimce
Univuiampte lCGIe ct JIY)0~hbulla fO Within SUbject Etfecu
1diuated Pr gt F
DF lype xn ss Mean sqwuo F value Pr gt F c - c H - F
DAY DAYbullGROUP DAYbullSlX ~ybullaaoUPbullSJX
l 12
)
u
1920757uu 2502396161 l22747U 4084lS108Sl
U02524972J2 2l4l 85111110 42(2 490396 340l46St04
20400 on 135 108
00001 07611 02SG7 0370G
ooaol o7529 02584 03717
00001 o 7625 02575 03711
ElrOr(DAY) Spound4 1770l044U813 3138483053
COZaechcuae-Ceiaser Epsilon =08997 ~-FelOI Ep~ilon c OIS77
AdiUStGC1 Pr 1
Source DV Type IIl SS Mean square F Value Pr gt F G- G K- I
ILOO BtOCKbullGROUPstoexbullsEX ~middotGROUPbullSet
17 611 17 68
132909825104 24823 577552
753187741gt 2U77494G93
8182252653 H50S26l1 l(G6Sil103 l555Sl3
1UJ9 091 lll 089
oooot 06835 03328 C 7JJS
00001 OGD03 03S1S oG3Gl
00001 01gt077 03510 ()64411
ErrortBLCCKl 319amp l28l470120021 400910amp13
Greenbouso-Geiaaer pailon bull 04099 Huynb-leldt ED11ilon =OU76
sourebull OF Type nr ss MeGO SQuare 1 ValUG Pr gt I Mjunelti c bull a
Pr F H- F
D11YbullBLOC1C DAYbulltnOCKbullGROU D)YbullstocKbullstxCAYbullBLOCKbullGROUPbullscx
51 204
51 204
42762320amp756 amp7035 727222 3550453180 70686685895
8384768760 426645722 66169252 34GS03352
2212 113 1154 091
00001 01080 00003 08028
00001 02124 oouG OUI9
00001 lll9SS C)0087D707l
Error(DAYlltOCKl 9588 3634043114 37019933
croennouce-Geiooer Epailcn =03131 Huynh-Pelch Epai1on bull 04$11
TOTAL P10
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
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13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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0 s 0 N N N w N N N N N N N ll N N N N N N N N N N N N It ~ N B u r N N N N N N N N N 1 1 1 1 l l 1 l l 1 2 2 2 2 2 a 2 2 2 2 3 J 3 3 3 3 s XP H 1 2 3 4 s 6 s g 0 1 2 3 c 5 6 e 0 1 2 3 5 G 7 8 9 0 1 2 3 bull s
101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
l 0 6 ss 52 41 20 211 2 12 9 75 78 29 0 7 7 3 0 3 1 5 0 0 1 0 4 6122 t 2 1406 6 gt~3 eo 64 47 5 s l 5 1 3 2 0 J 1 76 u 4l 46 1 e 2 1 0 G l 2 0 6 1 0 s s 123 t 2 1411 15 2 S1 8 9 11 1 2 1 0 0 2 0 0 0 1 0 0 30 9 amp1 Gl 22 amp6 13 65 5l so 16 0 l 0 1 0 2124 M 2 1412 9 1 0 0 1 0 422 2 26 0 0 0 3 13 1 0 0 0 0 0 4 5 5 0 2 0 0 0
1 15 8 0 1125 M 2 1413 1 3 58 59 40 47 o 3o 2
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3 u102 a 0 1 0 0 1 1 16 60 1z 54 l2 39 3 o 6o 77 s s2 Sol 6 1 0 sa n 71Q 18 70 34 2103 0 57 1S 2 0 l 3 3 0 0 0 S 15 lC 0 0 o 73 7J s SJ col 75 amp1 5 amps sa Gl 55 77 61 so u 84 104 Iolii 402 u 0 0 0 0 2 0 0 1 amp n 11 0 1 4 66 61 78 71 5 C2 76 60 66 66 amp1
Q Sl 8 4 82 79lOS 0 2J 32 l 0 0 D a 0 0 0 0 26 14 0 0 3 1 73 73 75 s c2 C4 l Jl sa 31 38 pound9 ll l 2 s 4
106 0 36 39 0 0 19 23 1 0 0 0 0 0 l 1 0 0 0 o ampe ampa 78 7R ao 71 55 76 ez a n u 51 2 4 107 1 77 33 58 54 45 58 16 za 4 l 3 16 35 16 11 0 1 35 64 36 Jl 7 2 1 0 4 1 s c l2 2 s 0 101 0 50 ZJ JZ 0 0 0 0 0 0 0 1 1 0 0 2 0 0 Ill 71 C3 CR Sll Dl 48 65 Cl 1amp lO 56 Jl 7 1 1 10 117 87 u 20 3 I s 2 0 II 1 ou 2 7 4 43 65 56 5 SA S 37 80 51 26 22 s lS 0 4 5 0 )llO lC 10 u 41 12 2 D 5 0 ol 1 0 e 11 ca Gl 42 a o 66 72 ao G8 2 amps 72 7 73 s 71 58 ] 29 26 1 1 111 3 6 77 0 55 65 26 0 3 0 l9 u 18 0 2 l 0 2 0 66 73 7C 110 7J 76 73 71 71 52 7) 65 71 63 51 eu 112 12 sc 5l 0 0 0 8 7GlUJl D 0 0 0 0 0 o 65 86 amp6 2 16 eo 71 65 cc ampo J 73 71 75 sc 15 113 1 60 as 12 37 0 0 0 0 1 0 0 0 Q 0 1 0 Q lC 53 52 o eo aa 78 7l 70 10 ss 20114 4 7 C) 0 1 4 2 2 21 411 37 5 1 5 2 0 c 65 77 82 77 77 Sol 71 82 amp7 7C Col 60 SC 35 13 1 0115 70 82 71 6J 65 75 43 73 31 43 43 48 35 64 53 63 s co 57 68 70 67 7 7] 1 74 66 30 1 0 1lG 3 n u 21 0 0 0 2 0 0 l 2 0 2 3 2 6 211 65 64 74 70 53 57 72 20 14 s 2 0 2 0 18 1 117 2 75 u 32 )6 25 50 27 37 0 2ol 19 60 30 23 0 0 0 0 61 67 63 75 so 66 64 71 113 72 84 68 53 23 70 50
0 14 52 29 4 0 21 2S amp 10 2 21111 0 l 2 ampce 75 sa sz 74 71 4C 57 11 11 JJ 27 8 1 0 2 2 1U Q 62 48 17 54 42 50 45 52 l 111 3 0 0 0 l 0 1 e3 73 amp1 59 amp2 61 ss o ss 37 se 52 2l120 2 57 cs e 8 lS 41 U 27 1 5 0 5 66 70 G7 C3 64 66 32 25 10 l 1 14 51 68 71 7 ll 51 so 34121 0 64 7 SG 74 14 65 4 4 0 2 0 0 0 0 7 ~4 71 77 56 57 S C2 S1 54 74 5amp 53 44 57 C4 J6 8 114 1 122 0 72 44 40 ol 0 1 0 19 3 1 17 56 so Sol 5 0 68 73 7 74 70 72 6~ 60 3 l 48 9ol 62 65 77 78 46 o 73 7o 63 11 as 77 75 ampo c1 21 11123 0 26 0 2 1 55 52 38 u 12 0 0 0 1 0 1 1 0 1 2 amp7 81 6amp 124 1 71 3 10 52 2 0 0 0 2 1 0 0 0 2 0 4 59 88 75 g 73 GO 39 34 SC 70 60 lO 12 1 0 0 l 125 87 2~ 70 1 0
0 0 0 0 2 0 0 0 0 1 0 0 1 5 50 50 57 62 70 71 co 5 77 63 8 71 58 76 51
$~u~y 1613 ~~lRAT 0744 We4aee~ Sbullptcber 30 1U8 16
c It A
0 s 0 N II bull It N N K H )I X II ll M Ill N N N N N N N N Ill N N N I pound u I N N II K N N N N Ill l 1 l l l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 J 3 3 s ) I H 1 2 J s I 9 0 1 2 ) 5
B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
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o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
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6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
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51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
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r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
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l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
8 Gtmeral tiDear ~1a lrccotdur
llcpeateltS Muaure11 MampJyaia of vadu~ Test11 of Hypeth for Betwean subjects Ettacta
Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~juned Pr gt F TYPe ur ss Mean scruo~re I Value Pr gt P C - G H - FI)SScUCe
~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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I 5 1778 2 5amp so 60 49 Gl 58 s~ 71 26 2 0 13 l 1r 5 1773 8 0 0 1 l 1 5 F 5 1784 54 5 70 55 sa 55 63 71 70 55 5 so 68 73 48 3 27
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
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l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
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Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
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153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
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4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
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bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
APPENDIX2 MOTOR ACTIVITY REANALYSIS -2
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
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13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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0 s 0 N N N w N N N N N N N ll N N N N N N N N N N N N It ~ N B u r N N N N N N N N N 1 1 1 1 l l 1 l l 1 2 2 2 2 2 a 2 2 2 2 3 J 3 3 3 3 s XP H 1 2 3 4 s 6 s g 0 1 2 3 c 5 6 e 0 1 2 3 5 G 7 8 9 0 1 2 3 bull s
101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
l 0 6 ss 52 41 20 211 2 12 9 75 78 29 0 7 7 3 0 3 1 5 0 0 1 0 4 6122 t 2 1406 6 gt~3 eo 64 47 5 s l 5 1 3 2 0 J 1 76 u 4l 46 1 e 2 1 0 G l 2 0 6 1 0 s s 123 t 2 1411 15 2 S1 8 9 11 1 2 1 0 0 2 0 0 0 1 0 0 30 9 amp1 Gl 22 amp6 13 65 5l so 16 0 l 0 1 0 2124 M 2 1412 9 1 0 0 1 0 422 2 26 0 0 0 3 13 1 0 0 0 0 0 4 5 5 0 2 0 0 0
1 15 8 0 1125 M 2 1413 1 3 58 59 40 47 o 3o 2
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3 u102 a 0 1 0 0 1 1 16 60 1z 54 l2 39 3 o 6o 77 s s2 Sol 6 1 0 sa n 71Q 18 70 34 2103 0 57 1S 2 0 l 3 3 0 0 0 S 15 lC 0 0 o 73 7J s SJ col 75 amp1 5 amps sa Gl 55 77 61 so u 84 104 Iolii 402 u 0 0 0 0 2 0 0 1 amp n 11 0 1 4 66 61 78 71 5 C2 76 60 66 66 amp1
Q Sl 8 4 82 79lOS 0 2J 32 l 0 0 D a 0 0 0 0 26 14 0 0 3 1 73 73 75 s c2 C4 l Jl sa 31 38 pound9 ll l 2 s 4
106 0 36 39 0 0 19 23 1 0 0 0 0 0 l 1 0 0 0 o ampe ampa 78 7R ao 71 55 76 ez a n u 51 2 4 107 1 77 33 58 54 45 58 16 za 4 l 3 16 35 16 11 0 1 35 64 36 Jl 7 2 1 0 4 1 s c l2 2 s 0 101 0 50 ZJ JZ 0 0 0 0 0 0 0 1 1 0 0 2 0 0 Ill 71 C3 CR Sll Dl 48 65 Cl 1amp lO 56 Jl 7 1 1 10 117 87 u 20 3 I s 2 0 II 1 ou 2 7 4 43 65 56 5 SA S 37 80 51 26 22 s lS 0 4 5 0 )llO lC 10 u 41 12 2 D 5 0 ol 1 0 e 11 ca Gl 42 a o 66 72 ao G8 2 amps 72 7 73 s 71 58 ] 29 26 1 1 111 3 6 77 0 55 65 26 0 3 0 l9 u 18 0 2 l 0 2 0 66 73 7C 110 7J 76 73 71 71 52 7) 65 71 63 51 eu 112 12 sc 5l 0 0 0 8 7GlUJl D 0 0 0 0 0 o 65 86 amp6 2 16 eo 71 65 cc ampo J 73 71 75 sc 15 113 1 60 as 12 37 0 0 0 0 1 0 0 0 Q 0 1 0 Q lC 53 52 o eo aa 78 7l 70 10 ss 20114 4 7 C) 0 1 4 2 2 21 411 37 5 1 5 2 0 c 65 77 82 77 77 Sol 71 82 amp7 7C Col 60 SC 35 13 1 0115 70 82 71 6J 65 75 43 73 31 43 43 48 35 64 53 63 s co 57 68 70 67 7 7] 1 74 66 30 1 0 1lG 3 n u 21 0 0 0 2 0 0 l 2 0 2 3 2 6 211 65 64 74 70 53 57 72 20 14 s 2 0 2 0 18 1 117 2 75 u 32 )6 25 50 27 37 0 2ol 19 60 30 23 0 0 0 0 61 67 63 75 so 66 64 71 113 72 84 68 53 23 70 50
0 14 52 29 4 0 21 2S amp 10 2 21111 0 l 2 ampce 75 sa sz 74 71 4C 57 11 11 JJ 27 8 1 0 2 2 1U Q 62 48 17 54 42 50 45 52 l 111 3 0 0 0 l 0 1 e3 73 amp1 59 amp2 61 ss o ss 37 se 52 2l120 2 57 cs e 8 lS 41 U 27 1 5 0 5 66 70 G7 C3 64 66 32 25 10 l 1 14 51 68 71 7 ll 51 so 34121 0 64 7 SG 74 14 65 4 4 0 2 0 0 0 0 7 ~4 71 77 56 57 S C2 S1 54 74 5amp 53 44 57 C4 J6 8 114 1 122 0 72 44 40 ol 0 1 0 19 3 1 17 56 so Sol 5 0 68 73 7 74 70 72 6~ 60 3 l 48 9ol 62 65 77 78 46 o 73 7o 63 11 as 77 75 ampo c1 21 11123 0 26 0 2 1 55 52 38 u 12 0 0 0 1 0 1 1 0 1 2 amp7 81 6amp 124 1 71 3 10 52 2 0 0 0 2 1 0 0 0 2 0 4 59 88 75 g 73 GO 39 34 SC 70 60 lO 12 1 0 0 l 125 87 2~ 70 1 0
0 0 0 0 2 0 0 0 0 1 0 0 1 5 50 50 57 62 70 71 co 5 77 63 8 71 58 76 51
$~u~y 1613 ~~lRAT 0744 We4aee~ Sbullptcber 30 1U8 16
c It A
0 s 0 N II bull It N N K H )I X II ll M Ill N N N N N N N N Ill N N N I pound u I N N II K N N N N Ill l 1 l l l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 J 3 3 s ) I H 1 2 J s I 9 0 1 2 ) 5
B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
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o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
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6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
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51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
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r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
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l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
8 Gtmeral tiDear ~1a lrccotdur
llcpeateltS Muaure11 MampJyaia of vadu~ Test11 of Hypeth for Betwean subjects Ettacta
Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~juned Pr gt F TYPe ur ss Mean scruo~re I Value Pr gt P C - G H - FI)SScUCe
~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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I 5 1778 2 5amp so 60 49 Gl 58 s~ 71 26 2 0 13 l 1r 5 1773 8 0 0 1 l 1 5 F 5 1784 54 5 70 55 sa 55 63 71 70 55 5 so 68 73 48 3 27
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
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l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
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Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
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153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
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4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
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bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
Scudy Ullt WAUlUT
G R A
0 S 0 N N N N N N N K 8 H N N N N N N N N N N N N N N N N N B E IJ N N N N N N N N N l 1 1 1 1 l l l l l l l 2 l l 2 2 2 l 2 3 3 3 3 3 3 6 X I M 1 ~ 3 bull 5 amp 7 a t o 1 2 3 c s amp 7 e o 1 2 3 bull s amp 7 e o 1 2 3 4 5
1 r 1 1102 45 sa 4 4 39 amps JJ 2 o 1 1 1 1 1 1 o o o o o J o a 1 amp a 2amp 35 2amp o 1 s 2 o 2 T l 1708 l 5 CJ 46 42 38 10 8 1 4 3 0 7 C 0 3 5 t 0 0 0 0 S 1S 42 BJ 34 22 6t 55 68 55 73 86 63 3 F 1 1722 33 58 amp2 29 6 7 J 5 C 9 0 5 8 22 56 SO 10 6 56 49 39 30 IS 43 69 6C 52 9 70 65 75 59 44 71 CJ 4 F l 1731 34 17 6 0 S 1 1 0 D 1 0 0 3 8 D 2 l 19 95 76 71 12 97 85 7E 79 80 80 14 73 63 66 76 75 83 5 F 1 1736 0 0 5 0 0 0 l l 3 2 3 D 8 4 3 0 1 0 0 1 1 0 0 0 2 10 9 4 0 0 3 2 0 6 p l 1747 32 71 37 65 2 4 2 0 0 3 2 1 2 0 1 S 3 0 4 9 D 0 0 3 C 12 C 0 C C 1 0 0 0 0 7 F 1 1750 2 S 0 o 7 19 27 16 6 S 3 S 2 4 3 2 2 7 78 S St 77 72 50 76 ampD 3amp 53 45 48 53 51 31 1 2 8 F 1 1757 34 45 67 64 40 56 33 1 D 1 2 0 2 2 l S 4 7 2 20 2 23 0 0 0 0 0 l l 0 0 2 0 0 g F l 1762 26 43 57 51 48 3 ~0 72 45 22 43 S 13 1 l l 1 1 64 77 67 73 74 79 46 71 76 5~ 41 7c 90 G~ BO
10 F 1 1767 14 ~ ll 26 4 4 4 16 7 8 8 7 15 6 3 15 7 amp0 56 5 63 47 63 60 7 G 54 41 59 G9 72 Sft 66 11 F 1 1768 6o az o 74 ae 45 61 10 o s es amp7 1 ts 77 aJ so zs a 1 o 2 o o o o o 1 o o 1 o 12 F l 1770 44 62 31 45 0 3 8 10 3 3 Q l l G C 2 2 0 58 3t 12 3 0 2 5 49 36 31 49 1 1 0 1 0 0 13 F 1 1772 47 60 63 45 45 33 I 1 1 2 l 4 4 C 3 3 1 $ 3S 1 24 34 45 33 ZS 0 0 4 0 3 9 0 l 14 F l 1777 70 60 30 65 7 38 57 51 54 41 2S 41 9 0 j 0 0 3 4 43 G l 1 20 6 1 2 0 0 0 1 2 0 15 F 1 1781 42 26 0 9 4 15 15 3 10 S 3 8 S 30 J 5 3 3 7 58 29 91 11 0 0 2 1 3 2 1 D 2 7 C 16 F l 1785 93 93 9 B 78 69 73 1 7 3 2 1 7 16 11 3 7 3 53 37 40 Sl 5 17 1 0 4 0 22 S 72 70 3S 6 0 17 F l 1786 61 59 77 CB 44 64 34 amp2 49 77 44 29 70 41 55 52 37 44 11 23 2E 16 5 41 26 41 0 44 24 0 0 1 1 a 0 18 F 1 170 30 57 73 3 21 0 25 71 85 68 69 55 C7 7 73 71 l 87 l 60 7 0 bull 53 36 33 23 3 24 34 G 52 1 0 1g F 1 17g4 6 C3 17 5 43 33 0 1 6 3 5 2 3 0 1 1 6 6 32 54 64 7 0 0 0 0 1 Q 2 1 a 1 3 3 20 F t 1796 19 5 3 Ja lamp 6 3 J o 14 s 4 20 o 1 3 o 4 45 43 27 so o 3 o a o c 2 o o o 1 6 21 F 2 1705 26 cg 46 so 39 54 11 12 59 58 51 6 2 2 2 e 2 4 35 65 so 51 71 eo 76 60 6 13 1 1 2 o o 2 2 22 r 2 1706 17 o 22 12 o 1 J J 4 2 2 3 a 1 o o 3 o 59 JS 55 70 ss so cs 15 58 ss 1 o o 1 o o o 23 F 2 1711 21 63 66 3amp 2 22 6 2 0 0 1 2 Q S 0 0 1 0 61 61 76 57 23 62 48 6 56 55 53 60 l 35 Sl S CS 24 ~ 2 1712 12 7 0 0 4 1 1 0 0 2 0 l 0 0 0 0 2 0 2 0 Q 0 0 0 l J 0 0 0 2 0 0 0 1 l 5 F 2 1713 9 Cl 36 16 0 28 22 33 1 6 4 1 10 2 5 7 6 12 0 0 0 1 1 D 0 0 2 0 l 0 2 0 a l 0
0 N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N N B 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 S S 5 5 5 5 S S S G 6 G C 6 6 6 6 6 6 7 7 7 s c 1 9 o 1 2 3 c s s 1 9 o 1 2 3 c s 6 7 s o 1 2 3 4 s s a o 1 2
1 0 5~ 3 9 14 0 0 0 0 S 0 1 S 0 C 0 3 0 4 Camp C2 CO GS 41 48 SS 28 51 64 57 27 l 3 64 SC 54 SO 2 5 25 2G Q 0 0 0 0 2 Q 2 lC 3 51 14 38 32 0 0 2 GS 4 1 l Sl 44 1 G 1 1 0 1 1 28 57 S2 3 6 SO 9 3S o 0 41 14 2 0 0 S S l 38 20 SS CG SO 69 60 71 76 71 79 74 62 68 53 Sl Sl 25 2 0 0 0 0 c 76 SG 33 21 32 1 64 16 0 0 0 c 52 0 46 7 33 23 0 70 81 70 67 eo 73 44 18 1 36 55 60 G9 15 2 3 2 5 0 56 JO 22 Q 27 36 26 3 0 0 0 14 0 0 0 2 0 0 amp9 57 70 SJ 66 3S 30 35 Jl 0 0 0 0 l 2 2 1 D 6 o 0 6 6 0 0 0 0 0 0 0 0 6 bull 0 0 0 0 0 61 6t 68 63 33 l 0 2 0 0 1 SO 65 JS 0 2 1 0 7 S 4S S2 26 l 42 18 C l 15 Cl 40 0 0 2 0 0 C a SS 7l 75 66 67 71 63 74 81 63 33 J 5 2 2 1 3 Gl 8 0 1 0 0 0 0 D 0 0 Z 0 0 0 D 0 0 a 0 0 67 59 57 63 70 57 48 57 47 49 50 0 0 2 39 59 GO 9 eo bulls 11 6 o o 1 a 1 c 1 o 27 6 1 59 s 34 ss cG 69 ee 12 73 6s 73 74 72 56 42 5o s1 amp9 s 64
10 55 GS 67 bull7 17 24 28 47 22 9 2 7 o 1 1amp co 61 6G 59 amp2 72 65 69 54 53 71 7 62 51 54 63 68 76 66 ampamp l 5 11 2 e 23 57 23 o o o o o o 1 1 2 o o o 1 o 56 7 62 6S ss s 79 53 57 s o o J o 1 o o o 12 0 46 0 20 S CD 0 0 0 0 0 0 0 1 0 0 0 l 0 54 68 6 S~ 5 60 54 62 55 S1 68 46 70 64 65 Ja 16 0 13 o s 64 c6 ze 1 o 2 6a ~o 26 s1 4D ze l o o o se so 61 sa cs 59 46 41 ampo 54 o 3 s o o 14 1s G3 ~s 44 31 2 a o o o o 15 sbull se c1 ss 68 se e 61 73 Go 47 s ss s1 73 co 52 11 14 4e sa 5e 12 a o 15 o 7G c ll sc 64 1s 42 51 e 2 z 74 11 2 1 1 2 3 56 63 Gl 54 72 56 co 4a 58 c2 67 s 63 63 40 78 amps 61 16 12 ss 10 amp2 $S 12 1 a 22 a 4 2 o o 1 o o o Gl sa 75 s J9 6o 6J s aJ 56 amps 5 63 ss aa Z7 13 o 1 8 54 CG 43 GO 59 44 0 0 0 0 4 1 0 5 4 2 4 2 GG G4 S2 G4 58 71 C2 67 72 6 62 25 0 S 23 77 5 18 0 17 32 43 0 20 0 D 9 71 60 1 28 D 0 0 lS SG 66 81 6C 70 82 66 64 ce 23 2 5 64 6 65 SO 33 6 31 61 19 11 43 8 5 SS 13 0 14 44 0 0 0 0 0 0 0 0 0 1 58 SS 74 61 4S 55 46 25 31 67 42 2 2 o 5 0 s 0 20 Jamp 58 4amp SS 24 35 S 39 7 15 0 1 2 0 0 0 1 39 C4 S1 54 GS SO 59 61 CS ~0 JG 54 3G 0 1 32 S8 S3 33 21 0 73 55 34 53 42 3a 31 0 0 29 42 9 53 19 0 0 3 0 68 55 68 53 61 61 53 35 D 0 D 3 1 1 1 27 41 6 22 Q 78 41 66 39 52 a2 46 55 27 so 61 54 2 0 1 7 0 0 68 65 9S 72 7~ 2 81 52 0 2 2 23 72 81 so ss 2 4 23 0 54 41 33 3 0 l 5 3 7 4 13 Sl 29 l 0 3 0 0 43 l CJ 55 60 amp7 5G 52 59 51 34 29 69 62 SO 4S 4 19 24 0 6 lO 4 0 0 l 2 2 0 0 0 l 0 D 6 15 41 0 64 72 76 58 1 G4 ~0 69 64 73 29 54 34 7 0 0 0 2S 25 0 16 0 0 6 20 0 Q Q 0 0 2 l 0 J 0 0 l l 58 57 57 70 3 57 16 0 l 1 53 71 59 57 21 1 2
s~uey 1613 NampALLlRAT 0744 Nedncodgty Sopccmbcr 30 1998 12
G R A
o So N N N N N N N N N N N N N N R N N N N N N N N N N N N B E t1 I N N N N N N N N N l l 1 1 1 1 1 l l 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 S C P N 1 2 3 s s 1 a ~ o 1 2 3 4 5 amp 7 a 9 o 1 2 l a 9 o 1 2 3 t s 26 P 2 111s co 79 72 ac s 1s o 10 2 4 3 J 3 o c 6 38 39 63 a3 ao s o o o o o 1 2 o o 27 T 2 17)4 40 38 50 3~ 1 2 l3 4 Cl 3 7 39 28 3 5 6 22 3 57 23 14 J 10 6 7 1 4 0 4 14 8l 92 75 77 79 2a 2 1746 23 2 o o 21 o o a o o a o o a o o o o 13 6 2 5~ 42 a so 12 64 53 52 9 1 7 o o o 29 r 2 l7Sl bull bull bull bull bull bull Jo 12 o 2 o 2 2 1 1 2 z 2 o 1 o o Jo Y 2 11ss 20 22 42 4a Js 14 2s 3 25 4S 4S 10 s 2 2 s ss sc 51 46 s2 21 1 17 sz a bull 4 4 2 o J 2 31 F 2 1756 ~3 65 14 4 0 23 7 2G 15 4 0 3 2 0 3 2 J 0 15 21 7 12 o o 3 l 3 0 2 J 0 2 4 2 2 32 F 2 1760 74 59 4C lC l 0 1 2 10 3 6 19 10 B 54 5 33 ( (2 (3 2 71 61 3 l l 3 2 0 1 3 J 0 2 33 P 2 1753 2 11 32 55 ss o 9 81 52 amps 1G 76 s cG 67 st 4 6 sz so amp5 65 s sa 45 17 amp o 35 59 cs 62 54 39 Jbull F a 17amp9 1 o 1 23 Jo 45 1 o 2 1 o o 1 2 o 2 J s 1 o 35 2 o o o 2 o o o o o o 1 o 2 35 F 2 1111 lB 32 31 14 1 3 1 7 s s 3 6 s 12 e c 2 a 19 38 11 s 1 o 2 o J ~ o s 1 1 2 2 3 36 F 2 175 24 37 39 ~2 0 27 G7 bullo l 0 1 l 5 3 6 l S 2 4 0 16 lS 3 0 0 0 0 1 l 0 0 2 0 0 0 37 F 2 1779 9 21 ll 4C 30 SS 10 4 24 56 10 l l 0 0 3 0 1 60 29 1 0 0 1 2( 15 53 49 4l 0 1 0 S 0 2 3B T 2 1782 79 58 4~ 75 59 57 73 47 D l Z 46 59 75 67 38 82 72 52 38 20 4 0 3 49 SS 43 53 amp1 57 7amp 54 9 D ~7 39 F 2 1795 G 19 44 4S 2S 0 6 0 S 0 3 2 2 0 l 6 1 41 65 75 19 1 11 14 74 78 82 70 70 18 0 2 1 (0 F 2 1900 10 15 J S 1C l S 4 8 4 2 0 1 1 1 3 19 12 26 27 24 90 53 30 48 81 2G 0 4 1 7 4 3 5 4 41 r 3 1703 2C 2 1 1 2 o 2 1 1 3 1 1 l 3 1 2 l 3 39 14 30 72 40 64 44 31 35 47 14 43 1 1 1 2 o 42 r 3 104 1 o o 1 1 o s 7 2 a 1 o J 1 o 3 o 13 31 24 44 29 42 50 38 71 17 67 1 2 bull o 1 43 r 3 1709 17 o o 4 2 3 1 2 1 1 8 3 1 14 3 9 c2 52 so 77 53 9 abull ampl 3 29 o 9 4 2 o o 1 44 P 3 1715 7 28 SS 48 22 0 18 58 S 20 53 10 6 S 0 4 S 3 1 ll 0 50 4 G 3C C3 2 84 54 G3 73 0 38 45 F 3 1716 1 17 13 21 0 0 16 19 2 2 0 2 C 0 2 1 J 2 29 G2 G( 6( 79 53 72 SS 58 Gl ~ 0 1 G 40 72 C1 46 F 3 11 bulla amp2 t~ 52 Gc 5 63 86 JS S 36 52 1 62 57 1 71 52 tJ 40 55 39 11 4 2 0 2 0 0 l 3 0 o 10 3 47 F 3 1721 56 7 60 45 2 13 CO 10 l 0 0 0 0 0 0 1 0 0 73 9 ~4 2 7~ Gl 1 D 2 0 1 D 0 0 0 0 5 48 r 3 1725 1s 3 1amp 52 11 n 1 2 5 c 7 o 3 e o 5 J2 samp 21 so 48 42 56 1 43 41 3 s 1 o o 1 2 2 3 49 P 3 1730 29 39 37 l 5 co s 2 1 s c 2 1 o o o 2 4 57 56 63 11 73 57 amp9 amp9 amp9 1o 41 2 1 2 o 2 12 SO F 3 1735 4( 25 0 6 19 24 0 2 6 l 0 0 1 2 1 10 2 0 tl 33 0 37 3C 0 l 0 0 2 0 3 0 C 1 1~ 47
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0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
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32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
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51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
62 D 15 3 67 59 64 60 51 47 S4 10 l 0 37 32 J 0 14 61 25 S9 27 amp5 34 1 0 0 D 0 0 0 0 0 11 41 29 GO 23 GO GZ CO til 5 lC 1l 34 21 0 2 2 0 3 0 0 0 4 56 87 C3 55 SC Cg amp2 CB 37 2 0 2 1 1 1 0 5 2n 0 a5 43 72 3 1 17 52 11 QJ 0 9 0 8 3 0 l o 69 7S 83 G9 74 71 72 amp cs 0 0 0 0 0 3 31 611 G2amp2 3 54 22 2 11 15 2 55 70 61 29 0 0 0 0 0 3 0 2 66 73 7 67 34 0 0 l l1 75 53 51gt 0 1 0 2 2 7G3 4 6C 73 Cl C~ ~l ~ 51 18 42 59 Camp 55 55 co 45 32 34 3 73 7 74 CC S 3 2 3 0 0 8 0 22 73 80 71 71 75l 18 lS 23 29 23 0 0 0 27 65 2 0 0 0 0 0 0 0 64 Sl 71 60 86 ~ 81 CO 52 47 67 93 64 73 30 17 77 406S a (8 7~ 45 74 56 5 6 0 4 32 3 2 2 0 c 0 1 56 70 66 58 72 58 0 1 5 61 sc 67 69 56 33 22 04 1 0 11 10 2 50 ll 10 1 0 1 2 0 2 l 2 St 58 73 GO 83 7C Cl 72 58 Gl 1 5 2 0 1 lS 32 lG7 Q 46 ss 20 41 ll C2 54 J 27 0 0 2 9 65 54 57 C1 57 58 CG 72 66 G1 53 GO 71 20 0 l 4 1 1 s 65 u s 68 2 7C u 4 l 19 39 51 62 CO 59 44 79 58 13 54 amp1 56 68 73 35 6C 5 5 0 l 0 31 C9 6 61 36 1 0 0 0 0 2 1c 11 amp1 54 27 ss 6o 6 74 a1 68 s 7 c2 2 1 1 3 1 9 7 3 10 1 3 0 e 0 0 70 0 70 S3 C7 l5 1 25 ss 29 0 17 32 29 3 1 3 0 0 0 61 68 65 72 S4 78 3 46 SC 15 0 0 23 63 65 7t 93 5571 2 11 11 5 0 2 0 2 3 0 1 2 0 1 0 0 o 78 8amp eo 76 B1 57 a 9 c CJ 9 l a 0 5 0 45 75 72 71 75 GO Gl C7 1 0 2 0 0 c 2 1 ~3 s 51 s5 bullbull 1 amp7 s2 c 4l cg 11 31 c7 38 20 3 ce co 20 373 J 2 20 1 0 l 0 u l 0 2 1 1 1 1 0 0 2 66 5 57 SC 5C CC 43 Gl Cl 3 l9 Sl 52 11 0 3 1 035 31 27 28 50 31 0 0 0 0 l 0 0 10 2 D 70 C9 72 57 48 67 56 25 11 37 0 1 1 3 71 73 40 D75 1 57 29 55 47 17 58 30 17 a 0 0 ua 4 a 0 0 0 2 5 s 69 ss amps 73 52 3 cs 5 14 0 2 0 1 2
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100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
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13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
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0 s 0 N N N w N N N N N N N ll N N N N N N N N N N N N It ~ N B u r N N N N N N N N N 1 1 1 1 l l 1 l l 1 2 2 2 2 2 a 2 2 2 2 3 J 3 3 3 3 s XP H 1 2 3 4 s 6 s g 0 1 2 3 c 5 6 e 0 1 2 3 5 G 7 8 9 0 1 2 3 bull s
101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
l 0 6 ss 52 41 20 211 2 12 9 75 78 29 0 7 7 3 0 3 1 5 0 0 1 0 4 6122 t 2 1406 6 gt~3 eo 64 47 5 s l 5 1 3 2 0 J 1 76 u 4l 46 1 e 2 1 0 G l 2 0 6 1 0 s s 123 t 2 1411 15 2 S1 8 9 11 1 2 1 0 0 2 0 0 0 1 0 0 30 9 amp1 Gl 22 amp6 13 65 5l so 16 0 l 0 1 0 2124 M 2 1412 9 1 0 0 1 0 422 2 26 0 0 0 3 13 1 0 0 0 0 0 4 5 5 0 2 0 0 0
1 15 8 0 1125 M 2 1413 1 3 58 59 40 47 o 3o 2
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3 u102 a 0 1 0 0 1 1 16 60 1z 54 l2 39 3 o 6o 77 s s2 Sol 6 1 0 sa n 71Q 18 70 34 2103 0 57 1S 2 0 l 3 3 0 0 0 S 15 lC 0 0 o 73 7J s SJ col 75 amp1 5 amps sa Gl 55 77 61 so u 84 104 Iolii 402 u 0 0 0 0 2 0 0 1 amp n 11 0 1 4 66 61 78 71 5 C2 76 60 66 66 amp1
Q Sl 8 4 82 79lOS 0 2J 32 l 0 0 D a 0 0 0 0 26 14 0 0 3 1 73 73 75 s c2 C4 l Jl sa 31 38 pound9 ll l 2 s 4
106 0 36 39 0 0 19 23 1 0 0 0 0 0 l 1 0 0 0 o ampe ampa 78 7R ao 71 55 76 ez a n u 51 2 4 107 1 77 33 58 54 45 58 16 za 4 l 3 16 35 16 11 0 1 35 64 36 Jl 7 2 1 0 4 1 s c l2 2 s 0 101 0 50 ZJ JZ 0 0 0 0 0 0 0 1 1 0 0 2 0 0 Ill 71 C3 CR Sll Dl 48 65 Cl 1amp lO 56 Jl 7 1 1 10 117 87 u 20 3 I s 2 0 II 1 ou 2 7 4 43 65 56 5 SA S 37 80 51 26 22 s lS 0 4 5 0 )llO lC 10 u 41 12 2 D 5 0 ol 1 0 e 11 ca Gl 42 a o 66 72 ao G8 2 amps 72 7 73 s 71 58 ] 29 26 1 1 111 3 6 77 0 55 65 26 0 3 0 l9 u 18 0 2 l 0 2 0 66 73 7C 110 7J 76 73 71 71 52 7) 65 71 63 51 eu 112 12 sc 5l 0 0 0 8 7GlUJl D 0 0 0 0 0 o 65 86 amp6 2 16 eo 71 65 cc ampo J 73 71 75 sc 15 113 1 60 as 12 37 0 0 0 0 1 0 0 0 Q 0 1 0 Q lC 53 52 o eo aa 78 7l 70 10 ss 20114 4 7 C) 0 1 4 2 2 21 411 37 5 1 5 2 0 c 65 77 82 77 77 Sol 71 82 amp7 7C Col 60 SC 35 13 1 0115 70 82 71 6J 65 75 43 73 31 43 43 48 35 64 53 63 s co 57 68 70 67 7 7] 1 74 66 30 1 0 1lG 3 n u 21 0 0 0 2 0 0 l 2 0 2 3 2 6 211 65 64 74 70 53 57 72 20 14 s 2 0 2 0 18 1 117 2 75 u 32 )6 25 50 27 37 0 2ol 19 60 30 23 0 0 0 0 61 67 63 75 so 66 64 71 113 72 84 68 53 23 70 50
0 14 52 29 4 0 21 2S amp 10 2 21111 0 l 2 ampce 75 sa sz 74 71 4C 57 11 11 JJ 27 8 1 0 2 2 1U Q 62 48 17 54 42 50 45 52 l 111 3 0 0 0 l 0 1 e3 73 amp1 59 amp2 61 ss o ss 37 se 52 2l120 2 57 cs e 8 lS 41 U 27 1 5 0 5 66 70 G7 C3 64 66 32 25 10 l 1 14 51 68 71 7 ll 51 so 34121 0 64 7 SG 74 14 65 4 4 0 2 0 0 0 0 7 ~4 71 77 56 57 S C2 S1 54 74 5amp 53 44 57 C4 J6 8 114 1 122 0 72 44 40 ol 0 1 0 19 3 1 17 56 so Sol 5 0 68 73 7 74 70 72 6~ 60 3 l 48 9ol 62 65 77 78 46 o 73 7o 63 11 as 77 75 ampo c1 21 11123 0 26 0 2 1 55 52 38 u 12 0 0 0 1 0 1 1 0 1 2 amp7 81 6amp 124 1 71 3 10 52 2 0 0 0 2 1 0 0 0 2 0 4 59 88 75 g 73 GO 39 34 SC 70 60 lO 12 1 0 0 l 125 87 2~ 70 1 0
0 0 0 0 2 0 0 0 0 1 0 0 1 5 50 50 57 62 70 71 co 5 77 63 8 71 58 76 51
$~u~y 1613 ~~lRAT 0744 We4aee~ Sbullptcber 30 1U8 16
c It A
0 s 0 N II bull It N N K H )I X II ll M Ill N N N N N N N N Ill N N N I pound u I N N II K N N N N Ill l 1 l l l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 J 3 3 s ) I H 1 2 J s I 9 0 1 2 ) 5
B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
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o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
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6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
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51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
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r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
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l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
8 Gtmeral tiDear ~1a lrccotdur
llcpeateltS Muaure11 MampJyaia of vadu~ Test11 of Hypeth for Betwean subjects Ettacta
Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~juned Pr gt F TYPe ur ss Mean scruo~re I Value Pr gt P C - G H - FI)SScUCe
~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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I 5 1778 2 5amp so 60 49 Gl 58 s~ 71 26 2 0 13 l 1r 5 1773 8 0 0 1 l 1 5 F 5 1784 54 5 70 55 sa 55 63 71 70 55 5 so 68 73 48 3 27
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
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l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
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Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
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153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
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4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
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bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
middot
0 N N w bull )I N a N N If II Ill Ill tl N N N N N N N N N N If N If If Jl )I N N N N N 8 3 3 l l 4 4 4 4 c s 5 5 5 s s 5 5 5 5 6 6 6 6 7 7 7
0 2 4 8 9 0 1 2- 3 c s 7 0 1 2 3 c 5 0 2s 7 8 1 3 s 7 bull t bull 1
a n 14 47 52 13 7 1 1 1 0 0 0 1 0 amp1 50 21 amp1 es 7c 12 Ac bullbull 7a 13 a1 1 0 0 32 73I27 75 76 70 0 l 1 3 2 10 0 1 5 l a 57 s1 o 66 ac es ee 3 10 7t aa 7 16 76 eo s1 34 1 0 5 21 0 55 37 bull3
0 0 0 0 0 1 0 1 0 0 1 0 0 1 0 74 63 l SO CO lG J 1 2 0 0 cz 2amp 7 1 1
a 1U 2 3 4 3 1 2 2 1 3 3 0 s 1 5 0 67 60 46 65 58 38 12 28 0 1 0 7 5i 30 1 0 1 0 lO 1 59 5 0 0 0 0 6 0 1 0 3 2 0 1 1 2 0 0 1 76 75 74 tl 75 S 52 31 0 46 17 0 0 0 0 0 0 0 0 2 0 0 1 7 C7 3C 75 61 71 amp2 7 71 51 amp7 63 72 39 l 0
0 0 0
5 0
32 o 53 n 13 0 0 0 1 l l 2 2 0 c 2 0 6 5 53 59 67 at aa a1 ac 11 52 0 11 D 0 0 i7 8 G7 2C 33 5 55 35 ll 11 ] 0 1 0 35 sc 38 C5 52 20 1 59 67 72 72 St 55 70 61 76 ampI 51 73 2 SC S2 17 0 0bull 1 Jo1 1 es 4 u n 21 u 1 0 1 Q l 0 1 0 0 l Q 1 78 72 78 Al 75 go 74 C2 75 71 84 6S 2 1 1 U 51 51 35 0 22 u0 n cli 30 s co 9 0 1 0 Q 0 0 3 0 1 0 1 0 36 58 55 65 50 7 69 43 50 6C 65 31 0 0 35 0 5amp 47 GS 68 28 4 0 1 ~ 0 1 5 0 0 5 1 0 0 51 65 GS 57 5 G1 4f 5 54 52 48 2 25 25 1 0 0 37 3 15 30 0 0 0 0 0 0 11 28 55 0 22 u 29 I 53 lt 75 88 5 74 73 75 43 l 1 G 54 62 GC 11 0 ll 72 ss tc te 53 32 53 St 46 ll 13 20 34 16 17 66 56 6C 56 51 BJ 64 70 48 (3 (4 10 10 C4 8 51 2 39 J 47 tO 26 4 3 l 0 3 2 1 0 0 1 1 l 0 5 51 4 56 6amp CO 0 SS 5l l 0 25 2 St 58 41 S 11 0 40 20 IS 55 1 CO 5 53 SO 58 27middot 5 3 55 5t 36 2 1 0 0 56 65 66 68 77 75 5 l 77 61 61 74 74 70 4 0 1 41 o 46 1s 20 12 5o Jl sz 11 cs 41 c1 25 samp 35 36 2a 29 G5 60 44 63 76 64 74 21 1 1 2 0 12 2 1 1 c2 s 55 c5 21 11 24 amp3 se ll 1 o 11 o 7 a 2 s 0 3 ss ss 62 59 amp1 s s sa amp7 sz J2 3 0 40 63 4] 2 75 75 86 25 z 1 0 3 Q l 3 3 0 17 65 14 0 3 48 79 70 61 7C 0 21 Q 0 s c cs 3 3 0 1 4 1l 25 l 511 7 15 40 43 24 23 58 4 0 3 0 1 0 3 1 59 sa 51 Cl 58 73 72 ampe amp3 ca 7l 11 l fS 16 7 1 45 at 22 c1 37 13 ce 42 2 1C 4G Cl 55 45 55 lamp 1 0 42 67 49 amp9 47 43 60 0 0 2 29 1 0 0 0 0
74 11 1 1 I 1U 0 l l 2 3 1 4 10 12 5 44 50 8 0 56 71 61 73 52 13 3 0 0 0 2 0 on 2 ( 1 C5 18 0 14 0 3 0 2 c 0 8 38 13 62 2 3 0 75 53 78 53 12 2 4 3 17 76 77 7t Cl 2C 5 CB o u a II 14 2 55 73 a l bulla u 1s 0 1 z a 0 3 B 65 66 64 65 67 5C 44 5 67 10 55 1 0 0 10 34 51 49 79 11 63 711 55 sa 76 65 ~a 73 56 amps 55 a 55 Ge G9 sc c2 lJ cs 75 so 4e se l sbull s 48 c 1 o 2amp o o so bull~ 68 51 t co al 0 0 0 0 6 Q 0 0 4 0 0 0 0 72 67 amp0 70 46 63 62 55 23 14 66 67 57 44 7 63
Study UU llliiAttlJtiiT 07CC Wednebullday Septomber lO 1911 13
G I A
0 s 0 N N N N N M II N N N N N N K N N N N II N N N N N K II EU 1 N N N N II N Ill N N l l 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 1 3 3 3 J 3 l s x r )I 1 2 l c s 6 7 8 1 2 l 4 5 6 I 0 1 2 l 5 6 7 a a 1 2 3 s 0 51 p 3 1742 1 0 0 0 0 0 0 1 0 0 0 0 0 0 0 0 0 0 35 3 0 0 0 0 0 0 0 0 6 3 28 34 l8 lO 11 52 p 3 17U 10 7 23 CJ 57 a bull 4 2 1 8 7 10 2 6 Sl SO 45 81 u 63 17 6C 15 53 78 52 71 47 1 1g 2 53 t 3 1749 1 5 0 0 20 22 1 3 ~ 0 1 J 1 0 0 1 3 ll6 0 4 4 5 49 0 0 0 2 1 1 0 0 0 2 54 F 3 1754 ll 4 27 15 1 20 co l8 41 31 1 3 2 2 0 6 3 0 1 JO 18 51 30 1 0 0 3 0 0 0 1 0 0 0 2 55 F 3 1S9 30 ll 21 1 5 2 0 3 4 s 12 2 l1 2l 55 n 95 80 0 5 6 0 0 4 0 0 0 0 1 0 2 7 0 56 F 3 1761 16 20 24 22 D 2 0 1 1 7 1 0 1 0 2 c J D 27 36 3 2 0 2 ) 0 J 0 2 0 0 2 0
2 0 1
51 F 3 1710 29 72 so 94 57 53 17 58 5 0 1 3 0 1 0 1 1 5 65 U 66 ZG ll co 55 21 5 57 45 2 1 3 2 2 l 5e r 3 1191 65 62 11 67 sz 19 0 1 16 85 72 S4 91 84 87 63 90 56 52 47 u 0 1 2C U 2C 0 0 Q 2 0 0 D 1 5 F 3 1~2 0 4 l 0 5 l 0 0 0 2 1 l 2 0 0 0 5 16 2 43 35 11 lO 3 0 0 0 1 0 0 1 20 13 l1 GO F l 199 5 69 10 81 65 74 74 43 S co 6amp 27 61 8 12 e 3 5 4 SG ~4 46 22 1 1 2 l 2 2 0 u 2 0 4 G1 r 4 1101 0 2 2 1 13 17 u u 6 47 G2 55 l 2 4 1 2 58 G5 71 O 2 7l co 5 0 1 2 0 1 1 1 0 2 G2 r 4 1707 Jl 41 8 0 0 3 9 9 0 1 1 1 0 0 0 s 3 a 13 11 19 u 25 s 2 2 2 2 4 0 0 9 0 1 63 r 4 171c 67 ea 64 eo 70 c~ 32 l4 2 2 2 2 2 6 2 4 ~ 61 70 59 0 52 37 26 43 52 25 l 1 0 5 0 3 u r 4 1719 55 6 61 60 u C8 7 0 l u 5~ 83 5S 7 2 s 0 so J2 22 19 19 CD 0 3 0 2 0 0 0 amp75 r 4 1726 41 68 S7 C9 C2 2 0 so 0 4 a 7 10 1 1 e 6 1 ~7 57 52 82 74 55 70 72 61 1 0 0 0 1 2 166 r 4 129 23 34 57 z 1 3l 44 liS 2 2 5 4 7 5 1 2 l 43 14 l5 66 34 0 0 0 0 2 2 1 0 1 12 59 67 r 4 1J2 2 l 54 54 53 65 18 1 l 50 16 5 l3 13 s 12 7 15 0 D 0 2 0 0 c 31 25 10ampB r 4 1733 sJ 61 ll 1 5 5 l 1 4 12 8 2 II 10 5 c a amp 8 56 30 39 55 37 70 76 12bull o 45 l1 SG 59 27 5169 F 4 17311 28 24 2 3 J 0 6 4 5 9 1 S4 41 43 27 l 1 1 7 0 1 D a 3 9 25 lS C2 28 0 0 0 1 0 0 70 F 4 1739 0 0 J l 22 25 0 4 s a 0 2 11 0 1 0 0 0 4 23 52 laquo C6 4S a ze 2 39 10 5 l 0 0 3 271 r 4 1745 26 34 24 15 0 0 3 5 1 0 1 1 1 8 6 0 c 2 22 JS U 52 30 7 24 25 30 l5 1 8 0 4 1 0 32 r c 1751 48 ampo C6 J2 62 61 83 21 0 55 70 S9 91 8 75 12 65 3C 33 43 60 41 6 43 G1 52 38 amp7 c1 ca JD 3173 r 4 1759 amp9 26 35 22 16 25 32 l 4 1 0 0 l c 2 s 50 32 19 15 51 45 55 u 0 2 0 0 0 01 074 F 4 lG4 52 48 36 31 13 2 2 7 s 3 1 s 7 l 7 33 54 27 66 13 l 2 s J 0 0 3 0 0 16 4475 p 15 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 36 co z l1 l 0 Q 0 Q 0 1 25 10 30 39 l 0
0 N N N N N N N N N N II N N rr II rr lll N N N N N N N N N I( N N N lf N N N N NII 3 J 3 3 4 c c 5 5 5 s 5 5 5 5 s 5 6 amp 6 amp 6 7 7 $ 6 7 8 0 l 2 bull3 5 6 8 9 0 1 2 3 4 5 7 e 0 1 l 3 5 6 8 0 l 2 Sl 0 C 36 0 0 0 0 0 0 C6 22 34 27 53 15 2G U Gpound 55 49 CS 65 56 sa 66 55 51 80 54 73 61 70 4852 1 70 pound6 59 58 19 lC 72 37 54 53 25 2 0 0 0 0 0 0 75 C7 79 72 61 CD 59 fi7 67 25 co 60 51 511 52 so 1
053 0 36 62 63 16 G l9 59 0 0 5 29 20 1 1 D 0 61 64 7S u 22 0 Ji 67 59 55 cz 0 0 3 sc 28 16 Zl 51 20 ) Q 0 1 1 l 0 0 1 0 0 2 0 65 60 72 69 81 68 58 74 81 ~0 54 11 1 1 0 1 355 o s 17 34 1 31 25 0 s 1~ 0 2 0 0 0 0 1 2 19 63 65 72 75 1 50 s~ n 54 12 21 0 1 0 )
56 0 69 57 C7 SS C8 C9 49 22 lB CO 55 16 g 0 J 1 0 2 54 61 70 C 56 5 75 3 55 54 66 48 53 57 Q 3 057 0 27 45 31 17 0 7 0 4 1 0 0 0 0 1 0 0 67 72 87 66 66 58 38 0 0 22 60 55 17 14 l 0 0SB l6 64 51 23 24 1 0 1 0 1 1 0 1 0 0 0 D 11 64 59 65 63 61 57 51 Camp 25 l9 JJ 12 D 1 19 30
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4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
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100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
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101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
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G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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ClUB Level Values
GROUP 5 l 2 3 4 5
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N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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Pr r H bull F
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17 68 17 68
21lB5 944722 23BIl178889
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2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
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21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
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32 l 2 2 0 0 2
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21 2 1 1 a 0 0
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40 14
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l 5 1 0 0 0
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57 13 27
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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14 JO
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20
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0 22
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0
77 l
66 l
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23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
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15
3 0 1 0 0
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D 0 0
12 3 0 0 l 0 0 3 l
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15 10
0 3 0 l s 0
l4
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35 GG
0 17
3
0 1
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1 1 0
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92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
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0
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s
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
12 5
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lamp 0 0 e Q
l 0 2 2
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2
0 0 l
lJ l
32aG ll
0 0
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48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
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0 I) 1
65 0
25 0
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0
0 0
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50 D
SD 49 5
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8 0 2
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27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
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0 0 3 1 8 0
18
61 53 uampe
3
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Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
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ampe 0 1
0 0 5
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D l l
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0
0 55
0 0 s
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7 50
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54 54
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0 u
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
bullbull 41-fbull - shy
14
G ~ 11
0 s C N H N N N N N N N N K N N N N N N N R N W N N N N N N B JU1 N N K N N N N N N 1 1 ~ 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 l l l 3 J J S X P liS 1 2 3 4 s G 1 a o 1 2 l 4 s 6 1 a o 1 2 J 4 s 6 1 8 g o 1 2 3 s 76 F ( 1774 17 13 25 20 l 1 (J 59 1 1 4 S 7 0 7 4 l 1 3 44 1 1 0 2 1 0 0 1 0 1 0 0 J 26 51 7 F 4 177G 6 4 25 5 1 10 10 36 41 29 28 27 1 47 5 D 0 l 31 0 12 l 0 4 I 38 37 65 60 6 (7 (7 54 44 27 7$ F 4 1783 10 28 4 49 43 46 27 1 l 1 4 1 2 4 3 0 4 l 7 32 17 2 11 35 69 1a 0 0 0 0 3 1 0 0 0 p 4 17a7 30 ll 11 l 2 16 0 1 3 19 0 1 3 1 l 32 (2 53 27 7 55 57 42 1 0 12 0 0 bull 3 ao v 1797 13 17 J o 4 24 sa 23 19 37 sz c 20 25 s o o J sg 6amp 47 61 l cJ 70 73 72 za 56 74 75 55 76 A1 v S 1710 46 10 75 73 84 54 53 76 3 2 40 89 38 3 63 76 37 5 38 32 14 17 3 18 1 0 0 5 0 1 0 0 2 D 2 82 F S 1720 6 6 1 0 1 0 3 2 D 0 2 1 13 2 4 1 0 0 JB 63 22 GO lO 91 95 IS 74 19 a1 0 Sl 85 52 2 5 83 F 5 1723 I 35 4~ 43 7 59 26 3 2 G 2 1 3 2 2 4 2 3 13 5 12 1 25 24 0 1 2 S 30 13 44 2 0 0 84 F 5 124 26 53 76 73 11 49 2 6 2 2 2 S 4 3 ~ 0 15 24 43 35 66 53 51 76 46 51 62 69 S 5( 76 70 ll 1 16 5 F 5 172 14 12 14 23 17 15 1 11 0 0 0 0 4 SC 59 2l 21 21 44 23 4 50 64 5 57 41 53 S 53 76 81 4G 50 2 ss F 5 1121 o o o o o a ca 22 6 2 3 2 3 2 3 a 2 57 19 2 s1 1 64 13 2 o o o a o 4 o o 87 F 5 1737 63 SO 1 0 1 1 2 6 5 13 15 0 2 7 0 l 0 D 80 24 41 0 0 2 0 0 0 1 I 0 S 2 0 0 0 SB F S 140 12 4 0 10 8 19 41 1 1 l 0 2 0 l 1 l 2 0 SO 57 34 43 24 7 0 0 2 0 1 D 0 2 D D 89 F 5 ~741 3 0 0 0 Q ~4 51 68 65 72 4Z 69 14 4 3 11 S 0 32 40 24 21 15 1 1 0 2 3 0 0 0 1 3 1 1 0 F 5 1743 32 53 4 0 39 74 52 CO 1 9 0 5 S G G S 4 G lJ 5a 55 31 72 42 5 6 30 72 ~3 37 CS 57 C6 12 2 91 F 5 14amp 31 42 25 19 38 lG 0 1 1 0 3 1 G 0 7 1 4 0 2a 39 5 Q 0 0 0 0 0 0 0 0 2 Q D 4 0 92 p 5 152 27 48 51 56 SG 1 4 50 51 54 1 0 6 46 48 4 50 27 55 60 57 58 e 80 71 Dl 4S 74 3 39 13 51 SG 72 Cl 93 F 5 166 12 16 30 55 13 2 27 15 4 4 1 2 2 S 2 l 2 2 54 66 61 7G 78 43 3 5 62 27 77 78 66 6 68 75 C4 94 V 5 1773 15 1 1 1 0 0 0 SD Jl 1 0 2 0 0 0 8 0 0 l 1 1 0 0 1 0 0 0 0 0 0 0 0 ~5 y s 177amp Jamp ampl ao amp9 7 o 7 2 2 11 40 56 a4 a1 co 1 53 o 2 sa so 44 Go 49 53 sa 54 7 11 26 2 a 13 1 9G F S 1784 17 42 ll 73 16 5 7 9 l 3 2 0 9 C 5 7 1amp 24 54 SS 70 55 5 55 63 71 70 SS 65 50 68 3 48 39 7 7 F 5 1788 0 S 0 0 0 2 1 1 15 44 58 S 0 1 0 0 2 0 1 0 1 D 0 0 0 0 D 10 30 14 0 0 0 0 0 ~8 F 5 178~ 2 64 31 amp4 bulle 1 22 61 69 10 20 21 76 44 20 c 84 12 rs 37 a o a 2 3 37 as as 11 a1 6 67 F 5 1793 15 l 0 I 10 27 27 5 7 0 4 11 0 2 5 5 8 1 52 36 51 3 1 12 0 4 a 0 1 0 0 0 4 34 51
100 F s 179 55 75 amp5 amp6 76 65 3 1 54 ao 58 61 53 11 D9 67 76 10 sa 11 G9 74 62 6~ 23 70 76 59 77 78 3o as
0 raquo N N N N N N N N ~ ~ N N N N N N N N N N N N N N N N W N N N N N N N N N B 3 3 J 3 4 4 C C C 4 G C 4 4 5 5 5 5 5 5 5 5 5 5 6 6 6 G 6 6 6 6 6 6 7 7 1 s 5 7 s 9 o 1 2 3 c 5 6 7 a o 1 2 3 4 s G a a 1 2 3 4 s 7 s 9 o 1 2
35 47 66 23 43 lS 0 0 0 1 5 2 D 0 0 414 12 54 G 69 6C 7t 68 6laquo 66 6 73 57 74 as 56 so 6 3 65 57 42 15 l 50 laquo2 34 9 11lt 54 45 64 Jl 53 ss ss s1 54 sa 69 25 ampa 59 t2 sa 12 78 l 3 23 5 12 20 10 0 52 90 42 0 2 0 1 s 2 0 1 72 69 81 63 73 ss 3G 2 lC 90 7 9 38 16 12 10 3 2 30 5~ 34 44 64
19 0 5( ss 18 54 2amp 2 32 lO 0 0 a D 0 0 4 7 0 0 62 63 62 52 42 33 2 0 0 0 39 71 55 5t 2 0 D eo 66 32 30 12 13 12 35 0 0 0 0 0 0 0 0 0 1 samp o 70 s 102 sa ss ca 45 39 45 cs s 1 0 0 3
4 54 20 llBl 0 0 l 0 1 1 0 1 0 3 l 0 0 1 70 l 65 2 GG 48 28 2 12 l 74 SG 74 22 2 0 1 1 82 a 41 u 62 6 14 43 66 23 0 0 1 2 0 1 0 0 0 0 80 73 G3 Gt GG 16 3 0 29 90 67 71 42 1 1 3 3 E3 2 63 2G 32 3 4 16 l 0 2 0 3 S 12 21 C8 15 35 9 61 G G1 58 GS Sl 70 59 1 57 3 66 0 89 ~0 66 28 49 84 65 79 45 58 65 14 13 45 l 0 15 1S 0 3 0 2 10 amp6 8 71 4 74 78 ao 76 38 12 0 6 0
a 31 sa 8 34 23
B5 0 amp4 24 55 17 JO 0 6 0 l 0 1 0 0 0 0 0 J 60 74 2 53 0 61 61 51 55 62 63 GO 2$ 8 0 D 0 2 SG 1 JG 53 34 2 la 48 G a a 4 0 0 0 0 J 17 4 SJ 64 SO 43 J 60 61 10 1 62 53 amp2 t7 53 74 sa cc87 0 59 29 s 1 0 0 3 0 2 a 3 a 1 0 4 0 3 1 6G 80 74 82 70 82 6 SB 69 53 11 0 3 0 I D as D 0 35 26 27 20 36 l6 0 0 1 0 0 0 1 2 1 4 0 57 71 4 94 1 cs 65 69 72 4 68 63 8 bullbull 62 52 59 89 3 40 2 2 2 0 0 l 1 0 l D 5 D 0 60 C2 47 47 SS 55 C2 53 64 42 3 1 10 2 u 52 n 32o SS 6S Sl l4 1 3 0 51 54 71 6C 64 GG G4 l 48 S7 63 67 61 51 14 0 015144744 Q 0 0 3 a 0 1 91 0 ss 1
0
13 0 l 0 0 6 2 c 0 1 2 2 14 46 67 59 71 91 64 81 6 6B 52 17 0 l 25 83 71 82 5 23
92 G2 45 l6 34 52 4 l 1 4 6 5 l 4 0 0 1 4 bull 0 52 63 55 SZ 63 C3 3 2 5 0 0 G 75 57 55 2 93 74 4 GG 72 l2 7 47 6l 65 33 3 1 8 J 2 l 3 2 70 71 70 G9 70 83 79 5 5 68 65 61 1P 3 l 2 1l 7894 lQ 25 23 lC 16 0 a 0 0 0 0 1 bull 0 D l 0 0 0 0 1 0 28 34 77 3l 1 1o ss sa 10 co 5295 1 57 20 4 27 54 7 0 10 0 2 0 10 9 0 0 3 o 55 48 53 51 s2 20 sa cs sa 35 2 0 0 1 0 0 13 42 96 77 58 44 3~ 0 2 1 3 0 I 0 1 1 0 l 4 1 l 0 65 55 70 so 63 57 56 59 47 s 9 44 60 49 10 2 2 0 55 75 JS 32 19 lG 61 59 20 15 30 53 7 0 0 l 0 o 54 63 62 73 69 ss 10 5 sz s 33 0 7 0 14 54 71 65 B 63 613 64 2l 0 47 SG 59 68 11 1 1 0 2 2 0 0 G 2 66 65 64 74 59 82 Gpound 89 72 0 C7 66 amp4 Bl 6 58 2 0 bullo 3~ S3 ss 39 41 42 45 48 14 3 0 0 2 1 2 l o 72 63 sc 61 so 66 72 8 51 3 55 52 55 53 ampS 61
100 90 9 54 73 59 47 46 63 53 55 41 71 GS 59 53 13 0 3 D 66 59 6 6 62 55 73 45 26 1 5 4 9 7~ 61 58 S4 21 Study 1613 NBALLlRAT OU WeampUIIiSay Septallber lO 1991
1S
Cl It A
0 s 0 N N N w N N N N N N N ll N N N N N N N N N N N N It ~ N B u r N N N N N N N N N 1 1 1 1 l l 1 l l 1 2 2 2 2 2 a 2 2 2 2 3 J 3 3 3 3 s XP H 1 2 3 4 s 6 s g 0 1 2 3 c 5 6 e 0 1 2 3 5 G 7 8 9 0 1 2 3 bull s
101 l 1 1402 7 39 44 5 3 0 3 4 0 5 7 25 8 6 8 0 3 10 37 27 38 42 4amp 31 25 19 4 24 9 Q 6 s 3 2102 H 1 1408 30 38 36 26 44 70 33 4S 71 22 10 2 0 2 0 1 l Q bull 0 2G 11 2 sa u 4 3 1 0 1 0 0 0 0 bull3lOJ M 1 1422 7 40 42 48 6 5 2 5 3 3 II bull 2 l 6 B 4 31 Jamp 24 12 3amp GS 42 l9 10 2 bull 2 l 3 1 t 1010( il 1 U31 38 7 s 3 5 l 4 14 2 0 0 2 2 16 1J 15 27 56 65 S 6S 33 62 72 54 71 43 76 6 39 67 41 GC105 M 1 1436 1 17 1 1 3() 0 1 1 l 1 1 0 0 ] 1 0 l 3 42 22 0 0 0 D 0 7 0 0 28 l7 13 35 010amp M 1 1447 9 66 53 0 0 0 213 0 0 1 l 2 3 J 1 ll 12 2l 0 11 18 4 2 0 0 2 1 D l 2 0 0 0 0107 M l 1450 D l 0 0 0 u 36 29 25 2 2 6 2 2 0 3 17 2 47 46 20 28 71 SA 41 3 9 SB 77 59 SG C3 1 slOB M 1 1457 3 3 0 l l 0 0 2 0 0 1 0 0 0 1 2 1 a 24 36 20 cs 1~ Q 1 0 D 0 0 0 0 1 0 Q 0109 H l 1463 10 10 5 36 12 16 14 10 0 s s 6 46bull 2 64 38 s2 2 82 72 ee BG a ao as 95 B4 86 78 s 73 sc 110 t 1 1467 laquo2 7 0 7 8 9 11 10 3 9 17 19 32 1 7 8 C 86 70 54 46 75 BJ 56 55 71 0 2 Q 0 3 0 1 24 111 M 1 1468 51 7 2C 34 35 15 l l 2 0 4 1 2 2 7 0 4 so 81 QQ 3 74 2 7l 87 2 J 0 0 6 3 4 1 1lll M 1 1470 10 28 6 26 36 29 12 30 4 1 2 1 4 l 4 1 2 2 1 13 52 42 0 0 0 l 1 2 0 2 2 0 0 0113 M 1 1472 3 l3 34 34 l 0 0 0 1 1 4 2 0 1 3 20 68 10 U 0 29 2 0 2 0 0 0 4 0 5 1 0 bull2114 t 1 1477 67 26 l 3 10 II l 2 0 0 3 3 4 1 0 J 11 27 60 44 66 17 26 1C 1 6 3 0 3 26 63 l4 4 1 D115 M 1 1481 e3 52 65 41 14 2C 36 66 54 9 l 2 5 1 2 s 0 3 7S 68 70 77 5 87 3 72 59 60 61 70 7 SB 11 72 52116 M 1 1485 33 70 4 1 lD l 59 77 3 l II s 12 4 3 G 13 8 22 4l 0 l I 43 6 16 S 10 0 4 2 013117 M 1 1486 3 64 3 31 0 38 56 65 a l9 57 7o 62 3t ll 2 2 4 46 58 14 1 0 2 63 55 so 2 D 3 4 0 5 0118 M l 140 3G 12 19 16 IS 10 14 G 2 5 3 0 5 4 1 2 3 1 21 1 21 0 0 9 CO 76 86 75 6B 9 D 1 Q 0 0119 M 1 144 13 lS 2 1 0 0 1 0 0 0 1 4 7 0 1 l 2 1 l 18 10 D 0 0 0 0 4 11 55 36 51 20 D 0120 M 1 146 18 23 39 3~ 40 )Q 23 40 55 21 6 32 7 3 l 2 2 s 7 0 0 0 7 0 26 2 0121 M 2 1405 65 13 10 6 10 lB 3 12 G 11 9
l 0 6 ss 52 41 20 211 2 12 9 75 78 29 0 7 7 3 0 3 1 5 0 0 1 0 4 6122 t 2 1406 6 gt~3 eo 64 47 5 s l 5 1 3 2 0 J 1 76 u 4l 46 1 e 2 1 0 G l 2 0 6 1 0 s s 123 t 2 1411 15 2 S1 8 9 11 1 2 1 0 0 2 0 0 0 1 0 0 30 9 amp1 Gl 22 amp6 13 65 5l so 16 0 l 0 1 0 2124 M 2 1412 9 1 0 0 1 0 422 2 26 0 0 0 3 13 1 0 0 0 0 0 4 5 5 0 2 0 0 0
1 15 8 0 1125 M 2 1413 1 3 58 59 40 47 o 3o 2
s1 ae 74 89 c1 9 10 amp6 2e G ao as 3 0 75 90 79 88 71 63 84
middot
0 N N N II II II N N N Ill N Ill N bull bull N II lil II II If 1f Ill bull M If bull N N bull K II N II 3 3 l l ol ol 4 4 4 4 4 5 5 5 5 s s s 5 5 5 6 5 5 6 7 7
6 7 8 9 0 l 2 3 ol 4 5 7 I 0 1 2 3 5 6 7 8 I 0 l z 3 bull 5 7 e 7
0 1 l
101
5 47 u 5 17 3 4 3 2 0 0 3
1 7 1 0 I 2 57 77 71 7C oll CO 56 81 SG 3 13
se ss u 26
3 u102 a 0 1 0 0 1 1 16 60 1z 54 l2 39 3 o 6o 77 s s2 Sol 6 1 0 sa n 71Q 18 70 34 2103 0 57 1S 2 0 l 3 3 0 0 0 S 15 lC 0 0 o 73 7J s SJ col 75 amp1 5 amps sa Gl 55 77 61 so u 84 104 Iolii 402 u 0 0 0 0 2 0 0 1 amp n 11 0 1 4 66 61 78 71 5 C2 76 60 66 66 amp1
Q Sl 8 4 82 79lOS 0 2J 32 l 0 0 D a 0 0 0 0 26 14 0 0 3 1 73 73 75 s c2 C4 l Jl sa 31 38 pound9 ll l 2 s 4
106 0 36 39 0 0 19 23 1 0 0 0 0 0 l 1 0 0 0 o ampe ampa 78 7R ao 71 55 76 ez a n u 51 2 4 107 1 77 33 58 54 45 58 16 za 4 l 3 16 35 16 11 0 1 35 64 36 Jl 7 2 1 0 4 1 s c l2 2 s 0 101 0 50 ZJ JZ 0 0 0 0 0 0 0 1 1 0 0 2 0 0 Ill 71 C3 CR Sll Dl 48 65 Cl 1amp lO 56 Jl 7 1 1 10 117 87 u 20 3 I s 2 0 II 1 ou 2 7 4 43 65 56 5 SA S 37 80 51 26 22 s lS 0 4 5 0 )llO lC 10 u 41 12 2 D 5 0 ol 1 0 e 11 ca Gl 42 a o 66 72 ao G8 2 amps 72 7 73 s 71 58 ] 29 26 1 1 111 3 6 77 0 55 65 26 0 3 0 l9 u 18 0 2 l 0 2 0 66 73 7C 110 7J 76 73 71 71 52 7) 65 71 63 51 eu 112 12 sc 5l 0 0 0 8 7GlUJl D 0 0 0 0 0 o 65 86 amp6 2 16 eo 71 65 cc ampo J 73 71 75 sc 15 113 1 60 as 12 37 0 0 0 0 1 0 0 0 Q 0 1 0 Q lC 53 52 o eo aa 78 7l 70 10 ss 20114 4 7 C) 0 1 4 2 2 21 411 37 5 1 5 2 0 c 65 77 82 77 77 Sol 71 82 amp7 7C Col 60 SC 35 13 1 0115 70 82 71 6J 65 75 43 73 31 43 43 48 35 64 53 63 s co 57 68 70 67 7 7] 1 74 66 30 1 0 1lG 3 n u 21 0 0 0 2 0 0 l 2 0 2 3 2 6 211 65 64 74 70 53 57 72 20 14 s 2 0 2 0 18 1 117 2 75 u 32 )6 25 50 27 37 0 2ol 19 60 30 23 0 0 0 0 61 67 63 75 so 66 64 71 113 72 84 68 53 23 70 50
0 14 52 29 4 0 21 2S amp 10 2 21111 0 l 2 ampce 75 sa sz 74 71 4C 57 11 11 JJ 27 8 1 0 2 2 1U Q 62 48 17 54 42 50 45 52 l 111 3 0 0 0 l 0 1 e3 73 amp1 59 amp2 61 ss o ss 37 se 52 2l120 2 57 cs e 8 lS 41 U 27 1 5 0 5 66 70 G7 C3 64 66 32 25 10 l 1 14 51 68 71 7 ll 51 so 34121 0 64 7 SG 74 14 65 4 4 0 2 0 0 0 0 7 ~4 71 77 56 57 S C2 S1 54 74 5amp 53 44 57 C4 J6 8 114 1 122 0 72 44 40 ol 0 1 0 19 3 1 17 56 so Sol 5 0 68 73 7 74 70 72 6~ 60 3 l 48 9ol 62 65 77 78 46 o 73 7o 63 11 as 77 75 ampo c1 21 11123 0 26 0 2 1 55 52 38 u 12 0 0 0 1 0 1 1 0 1 2 amp7 81 6amp 124 1 71 3 10 52 2 0 0 0 2 1 0 0 0 2 0 4 59 88 75 g 73 GO 39 34 SC 70 60 lO 12 1 0 0 l 125 87 2~ 70 1 0
0 0 0 0 2 0 0 0 0 1 0 0 1 5 50 50 57 62 70 71 co 5 77 63 8 71 58 76 51
$~u~y 1613 ~~lRAT 0744 We4aee~ Sbullptcber 30 1U8 16
c It A
0 s 0 N II bull It N N K H )I X II ll M Ill N N N N N N N N Ill N N N I pound u I N N II K N N N N Ill l 1 l l l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 J 3 3 s ) I H 1 2 J s I 9 0 1 2 ) 5
B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
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2 113 M 1 1477 1 3 10 II l 2 Q 0 J 3 1 0 3 31 27 114 M l l4Sl 113 52 ~5 Cl 14 24 38 68 54 l 2 s 1 2 i Q 3 ll5 K 1 1465 33 70 1 19 7 71 55 71 l J 8 s 12 3 6 13116 M l ueamp 37 37 31 0 38 56 65 8 19 57 70 G2 3-t 1lbull 2 2117 M l 14~ 16 13 19 u 1S lO 14 2 s 3 0 s 4 1 2 3 1 118 M l 1U4 13 15 2 1 0 0 1 () 0 0 l 4 0 1 1 2 1119 H 1 1(91 18 33 39 J6 4() 38 23 40 55 a 6 32 7 3 l 2 i 5120 H 2 1405 6S ll 10 6 10 18 l ll 4 ~ 11 0 9 ~ 11 2 12121 M 2 1406 6 middotU so 64 47 s s l 5 5 s l 7 3 2 0 13112 M 2 1411 15 2 51 8 u 1 2 l 0 0 2 0 0 Q 1 Q 0
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
113 14 125 12 127 lZD 12 130 131 132
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
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Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
123 124 125 121gt 127 128 129 130 131 132 133 134 135 136 l37 138 139 1t0 141 142 143 lolol 145 146 1C7 146 14 150 ~~1 152
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The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
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193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
0 44
2 3 l 0
Ill 0
32 l 2 2 0 0 2
45 0 0
0 ss
0 2 0 2
62 2
21 2 1 1 a 0 0
2 0
0 $$
0 2 1 g
40 14
3 0
23 1 l 0
33 0 0
0 co
0 0 2
GS 59
l 5 1 0 0 0
53 l 0
0 C5
0 4 0
54 44 u
l 1
1 0 0 0 9 5
3 32
0 4 2
S7 79 Cl
0 0
51 0
lO 0
JD 2
0 u
0 0 1
4l 58 54
0 0
55 a 2 0
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0 0
2 39
0 1 2
57 13 27
0 a
57 2 0 2
12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
14 0
1Z 11
J 517 34
l 27 13
6 0
u 0
14
14 JO
2 0
20
14
12 0
43 16 13
0 22
0 36
2 47
0
77 l
66 l
45
48 3
15 2
44 0
35 0
23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
0 1 0 0
15 0 0 0 1 0 1 1
0 0 l 3
15
3 0 1 0 0
0 1 2 5 0 1 0 0 0 l 0 0
D 0 0
12 3 0 0 l 0 0 3 l
0 3 1
a 0 0 0 0 1 1 3 2
0 1 0
45 z 0 I)
2 0 2 2
Q 0 0
15 10
0 3 0 l s 0
l4
0 0 0
35 GG
0 17
3
0 1
46
1 1 0
3 4 1 0 0 0
92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
52 32 1G
0
1 0
l u
0
4 65
0
6 33
0
s
0
1 3 l
4 l 4
0 a 0
0 l 0
1 2 l
4 1 0
c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
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middot
0 N N N II II II N N N Ill N Ill N bull bull N II lil II II If 1f Ill bull M If bull N N bull K II N II 3 3 l l ol ol 4 4 4 4 4 5 5 5 5 s s s 5 5 5 6 5 5 6 7 7
6 7 8 9 0 l 2 3 ol 4 5 7 I 0 1 2 3 5 6 7 8 I 0 l z 3 bull 5 7 e 7
0 1 l
101
5 47 u 5 17 3 4 3 2 0 0 3
1 7 1 0 I 2 57 77 71 7C oll CO 56 81 SG 3 13
se ss u 26
3 u102 a 0 1 0 0 1 1 16 60 1z 54 l2 39 3 o 6o 77 s s2 Sol 6 1 0 sa n 71Q 18 70 34 2103 0 57 1S 2 0 l 3 3 0 0 0 S 15 lC 0 0 o 73 7J s SJ col 75 amp1 5 amps sa Gl 55 77 61 so u 84 104 Iolii 402 u 0 0 0 0 2 0 0 1 amp n 11 0 1 4 66 61 78 71 5 C2 76 60 66 66 amp1
Q Sl 8 4 82 79lOS 0 2J 32 l 0 0 D a 0 0 0 0 26 14 0 0 3 1 73 73 75 s c2 C4 l Jl sa 31 38 pound9 ll l 2 s 4
106 0 36 39 0 0 19 23 1 0 0 0 0 0 l 1 0 0 0 o ampe ampa 78 7R ao 71 55 76 ez a n u 51 2 4 107 1 77 33 58 54 45 58 16 za 4 l 3 16 35 16 11 0 1 35 64 36 Jl 7 2 1 0 4 1 s c l2 2 s 0 101 0 50 ZJ JZ 0 0 0 0 0 0 0 1 1 0 0 2 0 0 Ill 71 C3 CR Sll Dl 48 65 Cl 1amp lO 56 Jl 7 1 1 10 117 87 u 20 3 I s 2 0 II 1 ou 2 7 4 43 65 56 5 SA S 37 80 51 26 22 s lS 0 4 5 0 )llO lC 10 u 41 12 2 D 5 0 ol 1 0 e 11 ca Gl 42 a o 66 72 ao G8 2 amps 72 7 73 s 71 58 ] 29 26 1 1 111 3 6 77 0 55 65 26 0 3 0 l9 u 18 0 2 l 0 2 0 66 73 7C 110 7J 76 73 71 71 52 7) 65 71 63 51 eu 112 12 sc 5l 0 0 0 8 7GlUJl D 0 0 0 0 0 o 65 86 amp6 2 16 eo 71 65 cc ampo J 73 71 75 sc 15 113 1 60 as 12 37 0 0 0 0 1 0 0 0 Q 0 1 0 Q lC 53 52 o eo aa 78 7l 70 10 ss 20114 4 7 C) 0 1 4 2 2 21 411 37 5 1 5 2 0 c 65 77 82 77 77 Sol 71 82 amp7 7C Col 60 SC 35 13 1 0115 70 82 71 6J 65 75 43 73 31 43 43 48 35 64 53 63 s co 57 68 70 67 7 7] 1 74 66 30 1 0 1lG 3 n u 21 0 0 0 2 0 0 l 2 0 2 3 2 6 211 65 64 74 70 53 57 72 20 14 s 2 0 2 0 18 1 117 2 75 u 32 )6 25 50 27 37 0 2ol 19 60 30 23 0 0 0 0 61 67 63 75 so 66 64 71 113 72 84 68 53 23 70 50
0 14 52 29 4 0 21 2S amp 10 2 21111 0 l 2 ampce 75 sa sz 74 71 4C 57 11 11 JJ 27 8 1 0 2 2 1U Q 62 48 17 54 42 50 45 52 l 111 3 0 0 0 l 0 1 e3 73 amp1 59 amp2 61 ss o ss 37 se 52 2l120 2 57 cs e 8 lS 41 U 27 1 5 0 5 66 70 G7 C3 64 66 32 25 10 l 1 14 51 68 71 7 ll 51 so 34121 0 64 7 SG 74 14 65 4 4 0 2 0 0 0 0 7 ~4 71 77 56 57 S C2 S1 54 74 5amp 53 44 57 C4 J6 8 114 1 122 0 72 44 40 ol 0 1 0 19 3 1 17 56 so Sol 5 0 68 73 7 74 70 72 6~ 60 3 l 48 9ol 62 65 77 78 46 o 73 7o 63 11 as 77 75 ampo c1 21 11123 0 26 0 2 1 55 52 38 u 12 0 0 0 1 0 1 1 0 1 2 amp7 81 6amp 124 1 71 3 10 52 2 0 0 0 2 1 0 0 0 2 0 4 59 88 75 g 73 GO 39 34 SC 70 60 lO 12 1 0 0 l 125 87 2~ 70 1 0
0 0 0 0 2 0 0 0 0 1 0 0 1 5 50 50 57 62 70 71 co 5 77 63 8 71 58 76 51
$~u~y 1613 ~~lRAT 0744 We4aee~ Sbullptcber 30 1U8 16
c It A
0 s 0 N II bull It N N K H )I X II ll M Ill N N N N N N N N Ill N N N I pound u I N N II K N N N N Ill l 1 l l l 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 J 3 3 s ) I H 1 2 J s I 9 0 1 2 ) 5
B 0 l 2 3 4 5 6 7 B 0 1 2 J 4 s 1ZGM2 14111 45 22 42 n G4 5 2 2 4 1 0 1 0 0 1 G1 42 2 1 0 2 68 10 74 1 2a 12 4 38 53 0 0 0 1127 II 2 1oll4 37 20 58 11 8 2 10 l9 45 72 44 R 3 4 l 8 0 74 38 59 n 5 3 1 2 0 1 2 1 lbull 7118M2 lUG 7 l 3 1 8 cs 31 37 0 l 3 ol 0 2 0 0 0 s 54 7i sa 65 66 so sc 59 ss 5 u u 63 511 5 u129 H 2 1453 U 2 lS 16 ol9 olO 4 B 1 4 2 1 6 6 s l 54 49 4 ll 45 a 0 0 l6 62 32 iiJ 1 1l0 H 2 1455 63 57 57 80 63 0 1 63 10 0 111 6 34 10 2 2 11 81 66 5 n 91 92 96 2 67 57 90 ubulle 85 a g 83 ll1 H 2 1456 16 2 1 3 3 14 1 3 a J2 50 28 24 Sl 24 ZO ll 7 l 0 J 4 0 0 5 l 10 0 132 H 2 14amp0 80 2 0 3 0 0
U 1 1 7 ol 10 4 3 4 so 55 72 66 0 0 1 J 0 1 0 5 J 0 2 11 0
133 H 2 l463 60 48 67 s2 sa 58 2l 3 56 olS JS J5 10 ze Slaquo 15 Sol 54 52 52 sa 21 40 16 1 39 1 5 1 30 0 3 4 114M2 un 51 12 0 0 1 0 0 3 37 82 22 ll 25 11 5 12 2 2 ampl 45 60 35 86 Bl 47 23 0 3 5 Q 1 0 0 3 115 I( 2 1471 26 33 16 0 0 0 D 2 l 3 12 2 2 16 se J G7 56 4J 5 6 0 s 1 0 7 3 5 22 47 S Sl amp1 136 M 2 1475 52 48 as ra 57 71 zamp 0 3 lG 30 1 2 1 l 0 1 91 81 59 6l 31 3 0 0 0 0 13 51 12 1 2 1 0137 M 2 147 3 10 1J 0 0 0 2 1 3 5 22 18 10 3 5 2 3 I) 52 41 a 0 7 8 4 9 0 0 0 1 0 10 J J 2138 K 2 lfB2 lgt 0 2 2 0 12 4 3G 19 5 0 0 0 0 J 59 17 Q ) 5 0 7 2 ll 29 57 74 GS Sl 0 51 24131 H 2 145 H 19 24 ll 27 1 1 1 0 1 0 2 s 26 s 2 0 48 ll 52 15 1 57 72 55 32 65 0 0 0 0 1 1140M2 1500 olJ 41 s 55 23 0 6 21 ol6 3 18 46 0 1 23 bulle 32 1s 32 7e 66 11 73 5 2 3 4 0 10 5 U ss G5 U1 M 3 1403 0 0 0 1 0 2 0 0 1 0 0 0 0 0 0 1 0 0 29 12 111 0 0 0 0 0 0 0 0 0 1 0 0 1 01amp2 N J 1cent04 4111 1 0 l 0 0 1 0 1 2 0 2 1 11 1 63 73 64 e 59 9D 68 95 61 57 liS S3 2 0 2 0 0 143 M 3 1409 2l 27 0 27 u 52 4 10 5 3 13 2 s 8 0 B 4 44 CS C1 C9 Gl 58 53 57 11 28 22 4 1 5 0 sn144M3 1laquo15 6 10 62 22 a 11 5 5 1 2 0 s 8 0 1 24 27 24 70 43 52 82 27 s 5 0 1 2 0 l J 7 ll4SMJ 14H 1 2 119 2 0 016 4 0 0 0 0 0 0 0 0 0 C lC ll 8 H u 19 Oll 0 1 0 0 0146M 3 U17 36 0 5 27 so so 3 8 3 8 s 5 1 13 2 2 2 45 Q 61 11 J 1 J 0 10 353 2 2 2 2U7 Ill l lol21 12 2 I 10 2 1 0 4 0 0 4 15 l4 77 7lQ s 70 65 52 42 5 20 13 5 l 0 0 o 11 sbull sa 5e
l 148 M l 1425 9 69 lO 0 7 4 7 23 6 1 12 1 s 2 20 s1 aJ eo 72 74 67 53 S 58 63 70 5 SO Sl 1 7 1 2 17
5 0 2 2 0 1 7 5 0 2 7 12 13 ol9 a 2amp 1 0 l l 0 l 0 2 0 0 bull114 H l 1amp30 0 0 0 s co 40 150 H l 1435 53 co 1~ a 34 2 0 4 16 7 5 0 l 5 0 0 l 2 sa 31 8 15 0 0 2 0 1 1 0 0 1 2 0 0 e
0 tl N N N N N N N N Ill N K If N N N N N II N ll II N N N N N If NN N N N N IfB 3 3 3 3 4 4 bull ol 4 4 s 5 5 5 5 s 5 5 5 5 6 6 6 6 6 6 7 7s ~ 7 8 9 0 1 2 3 4 5 I Q 9 0 1 2 3 4 ~ 7 8 9 0 1 2 3 4 5 8 0 1 ~ 126 1 64 70 72 21 65 68 55 zz 1 0 0 0 0 42 86 52 74 70 86 67 69 76 65 6l 7 72 7S 81 74 68 G2 60 72 43112127 5 amp3 l4 43 32 1 3 J 23 42 eo 11 7amp 73 Q a n Gz 75 n BO 59 66 651 4l ss 71 8141 3 39 67 74128 75 60 4 ol1 40 lol ss 22 27 )3 16 a 2 0 1 1 4 0 1 65 SD C2 U so 74 n Je 15 5 1 4 1 1 5 1 0 312 1 62 32 014 0 a 1 0 a 0 0 0 1 1 0 0 4 0 45 70 1 G7 58 54 57 70 7C C2 25 1 0 2 0130 84 80 29 66 16 1 3 1 0 34 0 u 32 16 80 1098 9 8 7 70 13 59 57 62 78 RS 84 U 42 69 7l 2 77 43 s131 5 74 32 43 14 53 27 1 2 5 0 0 u 8 0 2 0 l 54 77 sg 73 52 72 62 amps 23 19 ol 9 4 0 2 l 0 0132 0 76 48 so 1 0 0 z 0 2 7 0 0 2 0 2 0 1 o sa 87 72 74 sa 7amp c1 ca 78 JJ 45 11 3 21 0 0 0133 11 55 43 60 26 35 l 0 0 17 20 17 25 51 s C2 4C 72 66 71 61 58 GQ 54 Cl 84 61 57 45 15 1 0 0 0 01)( 1 80 63 51 6 62 22 0 2 0 1 0 1 1 0 0 0 o 61 70 76 65 71 a 74 71 l ac 55 55 se 1 21JS 40 67 1J 4 4l 22 ca
69 411 67 61 72 ll 24 2 20 1 8 i 2 s l 0 2 2 5 s 2 2 3 59 70 62 52 73 C1 ol2 amp7 amp4 63 61 50 5 amp~ $7 49 42 S4
13 2 0 0 0 0 61 68 ~ 53 71 70 59 7l 6J 65 68 23 0 21 l l137 0 36 54 11 17 1 14 15 0 2 2 1 6 0 2 2 0 0 64 5 62 74 74 74 l 7C 8B 76 48 72 57 S l2 1 1S Cll1JB 13 76 46 52 13 62 0 36 20 28 13 79 64 34 $7 3S 3 57 4 55 65 64 51 5 70 70 C6 79 55 67 711 60 66 2G 2 21139 1 26 sa 32 70 J8 l6 0 2 1 a 0 0 2 e 46 77 73 79 82 lamp 64 a 21 11 10 77 sz 63 114o 7t 74 62 68 67 76 11 s 76 ss 62 ampJ 6s 65 6s s1 31 s GJ 2 n 35 4 111 2 0 1 4 76 5l 32 0 l141 0 20 33 10 0 0 0 0 0 0 0 0 0 Q 13 0 0 0142 bull Ill 411 e 0 12 17 20 0 07171 61 SO 44 t GD 46 10 ol 1 2 l G 0 0 0
27 43 12 1 z 3 l 0 a u G7 65 72 70 5 57 42 GC C7 77 5P 7f 70 C2143 17 az 86 20 0 0 3 4 0 5 l 28 47 57 4C 12 0 2 -st co sa 65 88 SB 74 Sl 27 44 l4 ) 11 16 30 4 l 5144 laquo2 SP 41 ll 2 1 0 2 2 1 0 0 12 II 2 2 1 7 1pound 2 73 57 sa 77 73 Gs 40 1 43 l samp 43 74 se g 77145 0 52 38 37 0 0 1 0 0 0 1 0 0 0 21 5 41 4a 67 S3 7 71 Sl 22 73 63 7C 34 14 32 2 1 114C 8 68 38 7 Cl 42 1 2 1 1 1 0 2 3 0 4 0 l 0 l G9 78 61 68 50 74 53 40 42 14 36 2 5 8 0
147 55 52 53 411 46 61 16 2 0 0 4 4 0 2 Q 8 6 J s 55 51 5amp 70 amp1 sz amp4 ce so co 17 l 1 415 32148 0o eo co 15 11 0 C 61 36 53 15 0 C2 24 ol~ 59 22 51 65 65 GS 58 57 co S2 5C 52 ol( 66 62 46 4S 47 ll cs141 l Gl 33 J 12 0 0 0 0 0 1 0 0 0 1 u 12 S S7 7 72 76 71 70 c 0 10 0 25 53 37 0150 2 IS 51 6 11 0 0 0 1 61 730 37 u 0 2 0 0 1 0 1 52 56 61 56 I 75 U G1 25 a 21 0 0 0 c 0
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
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GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
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---- ---- --- -- --
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42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
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5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
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100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
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s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
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0 0 2 0 0 2 0 0 4 l 0 1 0 4
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K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
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l 76 62 ss
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1 77 24
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l 35 62
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0 5
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77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
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80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
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53 10
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cs l7J
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lS J3 37 6 1
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116 14
l 79
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32 65 a 6 0 1
45 0 A 1
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amp0 s l 2 3 1
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liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
Scudy 1613 JIBAUJJIAT 17
G ~ A
o so N W II N If lr N N Ill If N N N N If Ji1 )1 If N Ill N raquo N N N Ill II Z 11 I N N N N N N N N N 1 1 l l 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 S X 1 M 1 2 3 pound 5 6 7 8 9 0 1 ~ 3 bull 5 7 I 0 1 2 3 4 5 6 s 9 0 1 2 3 4
151 M l 1442 15 4 0 0 5 4 2 l 0 0 0 0 8 33 13 l l 7 40 0 10 7 D 0 o o a o 1 o z o o 1s2 x 3 1444 5s amp3 sa 73 79 5 2 1c o 1 a J s 2 1 2s amp6 83 64 64 73 s 7amp 64 28 3 1 1 0 0 23 153 K 3 14C9 52 11 4 33 0 0 6 2 l 0 2 5 1 4 G 0 1 3 s 0 3 0 0 0 1 1 1 1 0 4 11 0 0 154 K 3 1454 ~8 20 43 ~7 l 0 0 1 1 3 75 59 71 43 5 4 1 4 ll 22 45 25 7G 20 57 74 40 D 0 S 0 2 8 S 155 K 3 1451 2amp 41 58 0 11 0 2 l 0 $ 12 4 0 3 l 5 2 2 33 11 5 0 1 4 1 0 2 2 3 22 8 0 3 1 156 M 3 14G1 58 81 68 amp0 36 S4 Sl 1 0 2 0 0 0 0 0 0 D 1 20 13 3 0 1 1 Q 1 1 1 2 7S 95 73 53 3 157 x 3 1490 20 21 77 53 47 a 2 1 o 2 ~ 1 4 3 2 o 7 9 3 11 81 37 2 13 33 14 56 69 40 76 1 4 2 158 M l 1491 12 36 SS S7 49 92 74 7amp ampS 1 46 D 10 65 8 40 65 57 32 35 27 45 36 4 68 7 ss 59 46 57 41 40 0 1~ M l 1492 1 15 0 12 12 J 19 16 1 2 15 21 14 0 4 4 1 43 10 44 38 28 57 42 58 B 37 14 43 62 43 SG SO 160 K 3 1499 42 52 4 9 G2 amp5 52 42 11 2 21 38 79 50 72 56 69 GS 59 6 45 0 70 SS 35 8 1 6 1 14 28 71 74 65 161 K 4 1401 0 C 3 l 45 72 53 73 30 46 1 3 l 17 7 2 3 2 20 34 21 0 0 2 5 G 0 14 11 S l 0 6 1C2 M 4 1407 t 4 4 2 1 J 2 2 3 4 1 16 7 1 10 2 G 3 76 66 31 0 0 0 2 o 1 a 1 1 1 o o 1Gl K 4 1414 66 76 74 79 73 4J s a a 1 3 17 17 z 2 2 7 6 52 41 65 59 42 40 49 3 3 l 4 a o s bull 164 M 4 1419 s1 amp7 e go 76 go 51 as so G9 g 79 34 1 21 ss 7l 56 60 7 ss 58 61 10 1 0 3 1 12 2 1 165 M 4 1426 44 10 ~amp 21 0 0 0 1 23 20 6 5 10 27 10 13 l 11 26 35 22 53 14 1 3 5 ~6 21 2 5 0 2 1 166 M 4 1429 24 3 l 16 31 35 6 0 8 2 3 4 D S 1 5 1 0 83 31 69 36 31 0 l2 64 72 59 44 70 63 167 H 4 1432 31 3C 0 0 1 l 2 0 6 0 0 S 21 8 0 6 22 19 64 53 0 0 0 0 c 2 0 0 6 1 5 l 0 1GA M 4 14ll 17 40 19 43 38 ll 2 0 1 G 8 4 6 23 26 66 34 14 30 Sl 28 49 lt 42 33 30 41 22 36 25 49 22 S 169 M 4 1438 2 11 4 2 S 5 1 6 2S 30 47 lamp 3~ Camp 23 C 4 1 4 7 9 0 0 0 1 1 lG 7 0 0 1 4 0 0
1 80 55 60 22 0170 M 4 1439 24 84 l 6 19 45 33 17 3 5 4 4 4 2 9 l o J2 8 o t7 78 s~ 62 31 171 X 4 1445 24 l 0 l 0 1 1 1 2 1 0 0 0 0 0 0 0 10 16 13 6 0 0 0 0 2 l l 0 C 0 D 2 0 172 M c 1451 co 22 36 bullbull ca 13 23 63 t7 57 amp2 45 11 21 1 2 1 10 10 17 44 42 64 57 Sl 62 63 61 62 70 72 73 ~73 M ( 1459 3 SG 78 SG 19 59 12 37 62 55 74 57 0 6 0 1 0 1 47 ~8 2S 52 86 41 30 6t 71 74 46 s 2 0 0 3 14 M C 1464 21 0 5 ll 54 12 2 1 1 14 12 2 3 1 5 0 5 2 21 0 0 0 0 0 20 2 J 0 4 D 0 Q 2 0 17$ M 4 1465 6 2 0 3 10 2 l l l l 2 2 0 0 0 0 0 1 32 20 12 0 28 0 1 0 l 3 1 0 2 0 0
0 N N N N N N N N Ill N N N N W N N N N N N N N N N N N N N N N N W N N N N N N E l 3 3 3 3 4 4 4 4 4 4 4 4 4 4 5 5 5 5 5 5 S S 5 5 6 6 G 6 G G 6 6 6 G 7 s s s a a 1 2 l 5 6 7 a g o 1 a 3 s 7 a 9 o 1 z 3 c s 6 e o 1 2
151 0 l 59 44 41 37 0 Q 53 l 36 24 G D 1 3 29 56 30 40 64 GO 72 48 52 21 SO 32 G 0 l 1 15 1 1 l 0 152 3 0 79 4~ 33 30 SO 30 D 2 2 44 25 0 l 2 0 1 1 2 52 67 64 58 58 65 81 63 56 57 62 69 66 41 47 53 10 1 153 1 o sa a 11 1 26 o o o o s 4 1 o o 1 14 56 te 87 66 44 2 2 31 o o o o 1 4 o o s 10 57 45 154 12 27 12 63 S4 34 12 1 2 1 1 1 o 1 9 5o 54 62 s1 s2 se amp7 59 66 6 75 52 71 57 ampG 62 sa ce 21 o o o 155 1 0 75 22 2 0 3 0 0 ~~ 3 2 3 3 3 bull l l 4 56 75 71 70 68 27 19 1 0 0 0 1 11 1 3 8 156 60 37 74 71 as 76 75 58 51 2 0 7 0 4 l 1 0 0 0 0 71 63 6amp 70 Gl 75 69 78 BB 18 3 76 70 75 48 7 7 157 J 0 75 49 29 48 51 ~ 0 0 0 1 11 4 0 3 0 1 0 1 64 54 72 ampo BG 76 74 76 59 51 69 sa 2 0 51 amp3 67 56 l5a 2 1 a2 29 s1 1 17 a 1 a o 1 1 a o 4 20 s1 72 20 61 83 79 sa 69 amp5 amp5 74 G5 s7 11 73 37 t2 159 2 41 65 10 13 0 0 0 0 1 4 7 53 37 30 10 18 14 27 0 62 pound6 SA 63 69 63 41 26 61 29 17 1 0 1 0 8 0 1Go 67 64 78 77 21 2laquo o o 7 1 o 5 2 o o o 9 11 3 49 5G ~s 9 12 76 62 57 55 12 1 11 1 5 6 ~ 161 2 0 59 44 4S 67 46 12 1 0 1 0 3 l 0 l 1 2 J 0 68 71 72 ampl 61 67 SO 68 78 64 ao Camp 59 67 80 73 RG GO 162 o o 12 e6 59 48 co 1G o o 2 o o o 1 o o 3 9 62 amp 65 79 74 77 70 ss 83 90 94 43 42 11 o e 14 5 163 2 0 ~7 47 18 B 73 52 Sl 12 0 7 2 31 0 2 S 2 G 0 77 63 63 G7 83 61 75 7C GO 74 G2 81 29 9 0 3 1 1 164 o 1 60 15 5 14 57 15 58 0 D 0 2 2 29 2 63 69 75 15 59 46 42 47 58 64 59 SO 54 74 73 G9 72 61 57 3~ 67 165 2 18 fS 72 51 0 15 0 1 1 D 3 ~ 0 B 4 0 0 S 2 70 63 66 54 61 62 SO 46 48 51 51 35 0 l D 3 2 166 60 0 Y3 60 14 0 0 2 0 SO 36 2 1 0 0 1 4 C 0 0 58 GO 70 71 57 56 59 SG 73 72 Sl Sl 28 4 9 0 0 3 16 0 2 64 36 22 0 0 0 1 0 0 0 2 0 1 0 D 0 0 2 59 7 AO 75 77 70 86 57 14 3 0 5 l I 0 1 43 1 ~ampa J2 2 55 45 44 23 18 G J 39 38 51 56 29 28 49 2 0 1 D 52 51 65 53 6 78 65 51 73 64 69 77 77 53 51 45 3G 159 0 0 41 15 l 0 0 0 0 0 1 0 3 0 7 3 7 61 38 11 60 61 Gl 61 92 87 84 55 73 ampS 57 SB 24 ll l 5 l 0 170 2 4 86 GS 68 5 2 1 8 7 0 1 13 0 0 15 98 7~ 68 47 67 84 60 6 68 74 49 56 76 71 31 1 o 32 amp5 65 68 8$ 171 0 1 56 41 29 3 1 2 10 0 3 l 0 1 0 1 4 1 0 0 72 GO 6B 84 59 S 62 44 SJ 24 10 4 ~) 0 l 0 1 2 112 ss amp8 e8 37 49 s2 21 23 12 3 1 16 o o o o 1 21 59 42 75 11 GS 7s 79 71 47 amp4 e 30 o s 10 o o o o 1 173 0 2 G2 61 40 17 4 S a 8 l 29 e 5 4 2 0 21 JS 13 58 GS ampQ 73 80 65 71 65 54 6$ 72 56 l4 c o 2 0 o 174 l 0 8 3 14 32 4 0 0 1 D 0 0 0 0 0 lS 22 ~6 35 59 GQ G9 75 66 72 eJ SG 3G 9 2 1 0 0 0 0 1 175 0 0 amp4 52 45 29 25 6 t1 5 0 GO 75 28 34 46 22 1 0 3 60 ampJ 7~ 76 54 SO 56 SG 31 40 20 JS 5 SO 4 G 1
S~uey 1613 NIIMURAT 0744 Weclne~~dYbull Sel)tellber 30 Uti lll
0 R A
0 s 0 raquo N N N raquo Ill N If N N N N N N N N If NNNNJINlfN tl B pound t1 I N N N N Ill If ~ N N 1 1 1 1 1 1 1 l 1 1 2 2 2 2 2 2 2 2 2 2 3 3 l J 3 S X P M 1 2 3 4 5 7 8 ~ 0 1 2 3 5 6 7 8 a 2 4~ 1 3 5 6 7 e o 1 2 l bull
176 M 4 1474 42 25 47 16 0 25 76 83 16 1 3 4 S 4 0 1 21 11 12 42 1B 2 1 1 1 G 1 as 79 44 11177 K 1476 2 o a 19 21 7 11 27 o 1 o t 1 o 2 1 11 z 15 10 37 9 47 ~z 7 6 s 3 o 2 7o 12 35 o 178 M 4 1483 11 10 6~ Gl 57 73 62 46 36 53 25 64 2~ 1amp 4 3 0 3 11 23 11 Q 0 0 0 0 0 c 0 0 0 0 2 1 179 K 4 1i87 51 41 25 77 62 GJ 48 2 41 57 6~ 54 73 71 4 ll 13 40 56 50 62 40 GS 54 74 63 70 64 56 7 4 75 64 54 180 K 4 1497 49 20 l 14 12 ll 12 J 2 1 3 1 2 5 11 8 4 80 79 60 82 lamp 0 0 0 4 2 1 5 0 0 0 l 181 M 5 1410 l 17 6 6 0 0 0 0 0 7 0 4 2 0 2 J 0 Q 40 25 49 1 67 2 86 67 JO 7C 8 0 0 0 0 47 182 K S 1420 l 50 3 laquo9 C 4 2 8 20 2 3 6 1 4 25 6 S l amp2 77 77 76 62 72 73 4 34 3 45 24 80 72 73 183 M 5 1423 18 69 5C 57 0 8 0 1 3 0 5 14 10 GO 61 2 3 0 52 28 57 G5 35 GS 41 l 1 J 1 1 7 12 J18C M 5 1424 38 9l 75 93 81 76 60 69 45 46 63 66 l 27 C2 87 C7 78 61 65 GC 82 49 59 75 62 64 67 57 SO 68 I 52 185 M S 1427 2G 4A GC 71 82 70 1 SC l 6 fS 17 2 0 0 0 1 s 22 25 24 37 4 1 0 0 0 0 0 0 0 0 2 186 M s 1428 21 33 37 44 4 7 1bull 11 s 3 2 3 1s a 10 s bull amp 18 32 1G Gl 51 8 0 0 2 47 64 40 SS SG 3 1 ~87 M S 1437 20 0 0 4 2 1 Q 1 1 2 1 2 2 6 39 SB 7t 101 6~ 3 26 16 4 1 s 1 0 0 3 12 1 4 3 188 H 5 1440 16 9 6 0 2 3 a 2 1 D 7 19 7 51 6 1 3 S 63 7l 29 24 37 l 0 2 0 3 D 1 0 9 S o 1A9 H 5 1441 0 0 2 4 9 32 11 3 0 9 25 16 0 32 22 32 S 3 6 11 65 43 JB 67 4 0 1 3 0 0 0 0 0 190 H S 1443 44 52 37 24 0 6 63 30 18 29 3 0 0 0 0 0 0 2 73 S 86 77 87 84 15 108 73 43 6 0 3 0 2 0 191 M 5 1448 14 8 l 0 0 0 0 2 0 0 0 0 3 2 2 7 7 3 61 26 13 0 0 1 l 5 2 16 66 63 21 16 2 1 192 M S 14~2 14 3 3 4 2 5 3 6 0 4 13 45 64 77 82 56 27 4 72 12 D 39 72 71 59 71 31 2 5 0 9 4 o 6 193 M S 14ampamp 59 51 17 13 1 ll 10 17 29 S S 8 12 1 13 12 65 82 77 77 72 86 gg 72 64 71 l 55 2 2194 M 5 1473 1 1 3 1 1 0 2 2 0 1 2 2 1 3 12 3 1 7 0 0 0 4 2 0 1 0 0 1 l 4 4 lS 4 19 H 147Q 59 27 24 11 0 3 Sl 8 5C 1 7 92 4 3 2 71 47 sa 23 2~ 14 10 8 D 8 12 52 B ~7 40 9 2 1 0 196 M S 148C C 82 SO 72 4 59 12 22 28 54 62 70 75 42 70 20 4 0 lC 24 l 0 1 16 12 0 1 4 0 0 2 o 4 197 M 5 1498 0 14 4 D 1 B 29 63 59 76 93 AG 82 63 l 12 69 70 31 20 22 11 0 5 0 0 0 l 0 2 s 0 0 0 198 H S 14R9 2amp 44 12 ( lO amp 18 l 13 7 3 0 0 4 0 4 16 55 sa Go 31 o o 9 2 16 5 1 o o 2 15199 M s 193 s 3 7o 5o o o 1 o a o 1 2 o o 1 1 12 J1 ss sa 34 19 52 52 2s 1 3 3 o g 1 bull o 1 200 H 5 1498 81 80 6~ 1 3 22 76 87 A7 72 1 2 13 86 95 94 8C 14 laquo2 37 7 1 0 2 8 0 0 7 16 GO 63 amp2 77 lOS
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
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6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
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51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
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33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
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n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
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3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
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Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
123 124 125 121gt 127 128 129 130 131 132 133 134 135 136 l37 138 139 1t0 141 142 143 lolol 145 146 1C7 146 14 150 ~~1 152
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The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
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193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
0 44
2 3 l 0
Ill 0
32 l 2 2 0 0 2
45 0 0
0 ss
0 2 0 2
62 2
21 2 1 1 a 0 0
2 0
0 $$
0 2 1 g
40 14
3 0
23 1 l 0
33 0 0
0 co
0 0 2
GS 59
l 5 1 0 0 0
53 l 0
0 C5
0 4 0
54 44 u
l 1
1 0 0 0 9 5
3 32
0 4 2
S7 79 Cl
0 0
51 0
lO 0
JD 2
0 u
0 0 1
4l 58 54
0 0
55 a 2 0
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0 0
2 39
0 1 2
57 13 27
0 a
57 2 0 2
12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
14 0
1Z 11
J 517 34
l 27 13
6 0
u 0
14
14 JO
2 0
20
14
12 0
43 16 13
0 22
0 36
2 47
0
77 l
66 l
45
48 3
15 2
44 0
35 0
23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
0 1 0 0
15 0 0 0 1 0 1 1
0 0 l 3
15
3 0 1 0 0
0 1 2 5 0 1 0 0 0 l 0 0
D 0 0
12 3 0 0 l 0 0 3 l
0 3 1
a 0 0 0 0 1 1 3 2
0 1 0
45 z 0 I)
2 0 2 2
Q 0 0
15 10
0 3 0 l s 0
l4
0 0 0
35 GG
0 17
3
0 1
46
1 1 0
3 4 1 0 0 0
92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
52 32 1G
0
1 0
l u
0
4 65
0
6 33
0
s
0
1 3 l
4 l 4
0 a 0
0 l 0
1 2 l
4 1 0
c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
bull
0 N N M ~ raquo N ~ W W ~ ~ N N ~ N X X M M N N N N N M ~ K N N N N N N N w N N N D 3 3 3 l 3 C 4 4 4 4 C C 4 4 4 5 5 S 5 5 S S S 5 S 6 6 6 5 6 G 7 7 7 s s 7 a s o 1 2 l 4 s 6 7 a 9 o 1 2 3 4 s 1 a o 1 2 3 bull s 5 a o 1 2
176 45 3a 2 11 20 Jl a 14 o 2 c 1c 12 l 1 o o J 1 ss 7 70 52 62 64 Gl amp6 62 61 a 72 72 177 J a 66 59 29 lS 0 0 0 2 1 0 0 1 2 62 54 45 18 C3 l 51 69 7C 5 68 54 77 36 26 l 0 1 1 66 C7 13 178 o 1 3 22 o J 1 o s 30 3 11 2 a o o 1 o 1 o 72 69 11 54 cJ 21 30 11 12 77 71 cJ 12 ampl 45 JS a 52 179 62 7 74 62 49 SO 3 10 30 20 7 8 55 30 48 48 72 SJ 9 1 72 81 7 g 67 68 78 75 26 C I 3 0 0 0 1 0 110 0 8 39 55 11 0 3 2 0 10 2 1 0 1 1 0 0 0 1 71 64 0 66 24 33 70 85 61 22 c s 0 0 0 111 29 58 41 36 o a o 8 o 3 2 o o o o a 3 o 34 Go 10 62 54 76 c ac 4 6 G sbull 55 Sl 53 so 21 51 182 81 70 87 6 SB 10 53 59 11 2 5 15 15 J 25 6a 69 7 63 36 53 69 70 75 61 72 53 7S 7 75 I 72 II 77 51 1AJ 2 2 7 80 63 71 56 2 8 C7 66 0 11 C 5 0 1 0 0 61 52 12 12 78 13 51 52 0 l 70 59 57 55 1 59 74 Jl 18amp 10 31 Sl ~J 61 45 laquo1 Jo 28 a o 1 a 5 1 o l 1 73 63 s 73 7 11 69 7J 51 10 67 72 77 co 22 5 o 18S o J C2 54 34 C4 4 7 1 0 3 0 1 0 0 2 D 0 0 0 70 68 59 57 Gl 9 C9 32 64 5G S 22 59 25 12 32 0 1R 0 5 38 27 14 0 40 52 a 0 0 3 D 7 0 0 2 0 5 52 51 62 5 CS GO 78 74 Cl 37 30 2 2 1 42 51 27 0 0 18 0 10 90 55 47 2 5 G 3 5 0 l 3 7 1 3 0 0 2 41 49 6 55 64 58 43 11 57 47 57 65 78 53 52 50 12 15 30 118 o 91 s2 1 ll o o 53 53 17 J o 3 1 a a J o 73 6amp 72 a cs ss Gl ampc 53 so 12 s 4 l 189 a D CB 28 17 a 5 1 1 a 2 0 2 12 26 32 51 3 ampC l7 55 63 65 74 74 80 75 74 72 51 11 7l 75 70 69 76 68 C3 10 11 1 a1 zamp 1 o 51 23 c 1 a o o o 20 ss s 21 1 51 73 ss 7 as 7 73 a6 12 sa 97 61 ec c1 3 6 63 73 191 3 o 11 sa s l o 1 1 1 2 1 1 o 2 3 1 5 o 63 eo 73 57 a2 78 72 11 73 10 77 7amp 79 18 3 51 73 192 3 65 53 52 20 0 0 3 2 4 33 amp3 63 28 38 C 2 D 0 66 66 73 72 74 81 60 58 Sl 8S G1 21 2 0 1 1 1 193 2 1 78 75 CG 51 Gcent 34 28 5amp C 39 21 4 17 1 3 R 0 58 68 63 6S 59 l 61 68 65 67 G4 1 0 c D e 1 59 194 9 12 l1 59 12 34 53 o 32 0 D 1 0 1 0 0 1 0 1 61 67 64 Spound 59 52 amp8 GS CC 57 55 co 4amp 81 32 29 15 1 1 $6 47 9 37 10 2 0 0 0 0 0 0 C 1 1C Cl 43 5 7 70 61 58 (J 14 3 C 1 0 2 0 0 0 0 0 1J6 c 3 eo 43 so 55 20 a o 1 a 2 6 o o s o 34 1 10 72 71 55 se c2 26 c 1 1 1 o o 2 l 2 17 3 o so so 61 ss co c4 31 36 37 10 o 1 a o o o o o 73 S7 61 5 amp3 57 56 5C 44 3o so 59 10 45 73 G7 Jo 111 3S 70 74 C9 60 43 amp7 61 35 10 6 6 16 D C S 9 7 63 6 45 3 Sl 71 61 61 7 76 76 72 C9 5B 5 65 71 54 l i7 1 1 0 SB 65 68 8 30 3 4 6 2 16 55 75 30 1 5 4 2 0 65 G2 71 51 6C 58 64 53 71 4S 6 0 o 1 12 59 76 200 70 66 65 62 a l 0 0 S 4 0 2 0 S 0 4 0 6 36 70 68 70 G6 Gl 64 69 57 77 5 70 62 1 Z Z7 53 0 62
Study 1613 NBAILlRAT 0744 Wedaeday SeptabGr lO 1991 11
General Lineaz Mocela Procedure Clabullbull Level IDformat~o~
C11lB8 Valuout
GJIOtn s 1 2 3 4 5
2 FM
Mumbor of observations in dAe~ set 200
Nan ObSIGZVgttion witlt aiosiM value will coc be included in ehia ampnily8la Tbuo oaly 1 cbZV~eion can be u~ed ic thio IIZialYIIill
Study 11l alJLILL1AAT 044 Wedne2dey scpt~r 30 1t8 20
GenerAl Linear Hede1a Procedure Repeated Keasuze~ ~y$i8 of ~riance
R4peated KeeauroD Level Inro~ition
Dependent v~iablc Nl rr Nl N4 NS 116 lt7 )18 N N10 Nll Nll
Lavel of DAY l l 1 1 1 1 l 1 l l 1 1 tevel af fL~ 1 2 3 4 s 7 B 9 10 ll 12 Deprnoenc variable Nl3 Nl4 N1S N16 N17 11118 NU 11120 N2l N22 N2l N2C
Levol of DJIt l 1 1 1 1 l 2 2 2 2 2 2 Level of BLOClt 13 14 15 lG 17 18 l 2 3 5 6
Dependant Vhriable N2S 11126 112 me 11129 NlO N31 Nll NJJ N34 lfl5 ll36
Levc1 of Dlt 2 2 2 2 2 2 2 2 2 2 2 2 Level of BLOCJ 7 B 9 10 1l 12 13 14 15 16 17 18
D~end~nt variable NJ7 N38 NJ9 N40 NU NU N43 NU N4S 114 N47 Nn
Love1 of DAY J l l 3 3 3 3 3 3 3 3 3 Levcl of lltOCK 1 2 l 4 ~ 7 8 g 10 11 ll
Dapendent Variable NU WSD NSl NS2 153 N54 N55 NSS NS7 NS8 NS9 IIGO
Level of D1Y l J l 3 J J 4 4 c 4 c 4 Leve1 at m~ 13 14 15 lG 17 18 1 2 ~ 4 5
D~ndent variabla N6l N6Z NG3 Jl64 1165 He 1168 IIU NO 1171 W72N Level of DaY 4 4 4 4 4 4
Level of BLOCX 7 e 10 ll lZ 1l 14 lS u 17 u
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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ClUB Level Values
GROUP 5 l 2 3 4 5
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N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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Pr r H bull F
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17 68 17 68
21lB5 944722 23BIl178889
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2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
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21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
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32 l 2 2 0 0 2
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21 2 1 1 a 0 0
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40 14
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l 5 1 0 0 0
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57 13 27
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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14 JO
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20
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0 22
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0
77 l
66 l
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23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
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15
3 0 1 0 0
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D 0 0
12 3 0 0 l 0 0 3 l
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15 10
0 3 0 l s 0
l4
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35 GG
0 17
3
0 1
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1 1 0
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92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
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0
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s
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
12 5
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lamp 0 0 e Q
l 0 2 2
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2
0 0 l
lJ l
32aG ll
0 0
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48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
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0 I) 1
65 0
25 0
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0
0 0
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50 D
SD 49 5
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8 0 2
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27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
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0 0 3 1 8 0
18
61 53 uampe
3
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Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
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ampe 0 1
0 0 5
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D l l
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0
0 55
0 0 s
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7 50
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54 54
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0 u
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
middot
Kanova _~ criteria and zxa=~ r s~a~iatica fo~ ~be ftypoebesia of ao CAY 2fect H TrPe IIX S~CP Mattix for ~y r = Error SSfoCP lberix
S=l M-OS Nc92S
amptadstic Value Na DP con DF 1r F
Wilkl Iulbda 020261902 2t52137 3 17 00001 lillampill -race on7320ta 2452137 l 187 00001 Ho~elllao-Lawloy Trace 33U0990 as2137 3 187 011001 aoybullo Greatea~ Roo~ JJ3t0990 1amp52137 l 1117 00001
Mo~gtova Teat Criteria aDd P Appzlteraquoei-~lons for lbe KYPo~hel o DO DAYbullGRCn EffeCI H = Typo ZZZ GS~l Ha~rix Cor DAYbullGtOUP B bull amp=or SSCI Ma~rix
Sbulll MO 1112 s lr gt Psca~iatic Value l -DF Den Dl
Willca LullxA 0803amp4 0 12 4950(7 04G7l Plllaie Trace o0608l8amps 09180 u 567 0485 Hote1liua-Lawloy Tzaee 0063370GS ouos 12 557 042 Roys Greatest Reoc 005054747 231114 4 119 oos~
NOTB P Staclccic fer 1oya -eeoc Root ill m upper bound
General Linear Hodele Procedure Repeated KaampGure Analysis ot variance
MADOvo Test Criteria and ampMace F sc~cictiec for lh~ Hypoche~ie or no D~VmiddotSEX Effee~ H bull 7ype IXI SSCP Matrix fer CAYbullszx E =Error SSCP Katri~
s-1 McOS NZS
Scamptiatic vuue F Num DF Den Dl Pr gt r
WilkS~ 0971121872 13879 3 187 02C71 lillai) Trace 002178128 13871 3 187 02C71 Hot~llin9-L3Wley Trace 002225amp27 13S7 3 187 02479 Roy) GreateJ5 loot 002225amp27 13879 3 187 02(79
Hanova Tec crlceria an~ r Approximations for the Hypacbeaia opound no PAYOROUPbullszx 2poundtect H =7ype III SSCP Macrigtlt for DAYbullGROUP0 SEX pound Error SSCP Mamptrix
53 MbullO ll1gt925
Scatltic Value r NW11 DF Den Dr lr F
WilU ta111bdl 073U843 10102 12 415041 03133 Egtillail ltn-aee 0 OSS79S28 107amp0 12 561 0371 Ho~o1li1Lg-L~wley Trace 006874608 10637 12 557 03888 Roys ~qcee toot 003903539 1844-t 4 181 01220
Manova Teet Criteria and Exact r Seatistics for the Hypothesis of no ampLOCX Effect H =type JIX SSampCP Matrix fer BLOC E bull E=or SSIltCP Matrix
$=1 175 N-ess st~-ti~~ie Value F Num DF Dan DF Pr r
Willca tunbcb 01350859 li4 8665 17 13 00001 Pillaibull s Tr11ce os643nn 648565 17 113 QOOOl Hotell1ngbullL3Wley Trace 6374159 C4 8565 17 173 00001 Roys Crebull~e~ koCC 63741US9 648565 l7 173 00001
KampnoYa ~-middot~ eriteri3 3nd P ~~oKiacicnbull for the HY~~hasis of no BLOCKbullcaoUP Ettac~ H bull 7ype SS~CP Matrix fer BLQC~bullGROUI E bull Error BG-CP Hatrix
S HbullG 11=55
pStatiedc Votlue Nllll DF Don DP Pr gt F
Willes~ 0 G398SUG 12072 G81219amp 01309aPlllioibull a Trlce 041834623 12193 68 70 01214 HotellingbullLAwley Trace DU756567 12044 68 586 01337 Rcybulls Greamp~c=t Rooc 018683510 lSl4l 17 17G 00178
NOTZbull r Statiacic for Roys Orcampt~ot ~ooc ia an uppar bouccl
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
l
19 2 2
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GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
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8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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17 68 17 68
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-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
71 s
0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- bull- -
amprMiy 1513 RaampLL1aM Z2
CDeral LiDear Model~ Procedure ~JOtC lleUUrlll Analysic of Yariance
ftampOova Tebullc crireri4 and Bxacr r srarilticbull for rh~ RYPampthaaio of ac RLOCKbullSIX Effect H Type Ul as~P Matrix tor atOCICbulllIX bull Bnor ampSICP Matrix
Sol 1fbull 5 N=85S
Value F -Cr tlen DF Pr gt Psraciric
Wilko r-bda Olt5409G2 11117 1 173 onao Pil1ampis Trace 010amp59038 118117 1 173 02780 Hotal1inqbullLaw1ey Trace 011680730 11187 17 173 02110 ROYI Greatcr Root 011680730 1188 17 173 02780
ovs Teet Critaria and 1 ~roduricm for tile IIYPOthcis of DO BtOCX0 0ROt7PEX affect K ~ type SSCP Hatrix for BLOCKmiddot~middotSBK S = 2rror SSCP Macrix
B=4 ~6 Nbull855
Sutiltic Yalue JIWII DF Pen Dr Pr r
07115lamp24 o~oC C8 C812196 06851 Pillai Trace 032370936 09116 Cllwilu middot Lallbda 70fo 067CII HotellinqmiddotLawley Trace OlSIIZI5U 0903amp CQ U6 063fj Roybull~ ar~areet Joor 01fo527173 15040 17 l76 0017
Kanova Teor criteria 3nd exact F Statiatica for rhe HYootnesis of DD PAYBLOCX ~feet H TYPO Ill SS~P Matrix tor PAYBLOCK amp bull Error SSSCP Matrix
S1 ~2amp5 N=68S
etl~itiC Value F )11111 DF D DF Pr gt F
Wil~middot lalllbS 01~011757 1(ZP10 S1 139 00001 Pi1Jibullo Traee OII3U3243 142910 51 139 00001 Hoee11ina-Lawley Trace 5230 u2no Sl 139 00001 Roybullbull Greampteat Rooc 52434609amp 142910 51 139 00001
N3nove Teec criraria and F Approxi~tiona for che Hypochc~i= of no D~YmiddotBLOCKbullCROUP Effect H bull Type tn SSSCP Matrix for DAYbullBtOCltCROUP Z = Error SSCP Murix
S( Hbullll tr~ns
Stacistic Value p Nwa tw Den DF Pr F
Wil~ Lalnbcl1 021135H41 10147 204 SS 5771 ouzc Pil1aibullbull Trace 1 0005349 10169 20( 568 04352 Hore1lina-Lawley Tr~bull 1501amp4378 10120 20C 550 04520 ~oymiddot Grea~eat Root 050658553 1105 Sl U2 0osu
NOTE 1 Satiaeie for ampoybulla Creatct Root ibull an upper boud
scuay 1613 NBALLlJAT 07fo4 Wednead3y SepteMber 30 1991 23
Ceneral ~inear Mo4ela Proeodure Rapeared Keaeurea Analyaiu of variance
Manova Teet criteria and Exact r Seariatica poundor che Hypocheeie o~ no D~YBLOcxbullSpoundX Ettect H Type l~ SSSCP Maerix tor DYBLCCXSZX E Brror SS~P Matrix
1=1 M=24S NbullCas su~iscic ~lue r N1111 PF Dan DF Pr gt F
Wilks L4lliiXI4 0 672bullUS ll 13273 51 139 01001 fi11aill Traee 032750487 13273 51 139 01001 Hote111DOmiddotLaw1ey Trace 04861 1323 51 139 01001 ~ymiddota Greatest Root Q 481 ll2l 51 1l9 01001
Manovn To=t cri~er1a ampnd P ApproximDtion for t~bull nyporhc=ic of no PAYbullBLQCXbullCRCOPbulls~ 2ff~ct H Type III ~SCP M~erix for DAYILOC~middotCROUP0SEX E =2rror SSCP Mntrix
Sfo MZ3 NbullCGS
lltampCiiCiC Value F NUllgt Dr DaQ pp IT F
Wilicg bull LalllbdL 03041572 09496 zoe 5575771 OUSJ Pilllli bull a Trace lOU808 09528 204 568 OGSSO Hore11ingmiddotLawley Tracbull 140U8872 oun zobull 550 OG7CZ Roybulla ara~cc=t ~or OS4492U9 15172 51 142 oo2n
NOTEbull P Stamptiltic for Roybull areatea~ ~ot ia an upper bOUDd
I_ o I o ~-- -bullbull --0gt -middot bull bull bull middot-bull gt
Study 1613 KBALL1BAT 2amp
General willear Model rocedure ltepeaead K-urea Malyais of Varianco
lellt ol ftYpochu_ for lleCWGen SUbees lltfects
middot
Pr Souree TYPe ur samp MeanS~bull F value
4 2473bullbull 60S229S Cl83 651C3 074 108 03117 l 31113050933 )013 OSOUJ73 053 045 4 128417200302 321199300075 osamp 06920
Error 1119 108ClS6032S292 573amp CAC6330
25 omiddotu WecneDd~ Septal])er 30 199amp
Geceral ~ineaz Modela Procodure Repeated Me--rao llnalyais of VltUianee
UD1var1a~ Testa ol ftYpotbeoe5 for Within subject Efbullcta
source til -rype rn ss Mun SUUe P Vamplue Pl gt F llcliuoted G- G
Pr F H- r
llliY llAYCIROUP llliYbullSE llliYbullGltOtlbullSEC
l 12
3 12
194221 171041 258UampSOS19 133CJU0733 3870707818
6442G051014 2237 Ol754J 4U18l02U 3225589847
20640 071 142 lOJ
QQQQl 0733 023amp5 0amp208
00001 07237 02312 04193
00001 07l2SI 02377 04202
Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
17 68 1 69
l342535850782 23789832823
1292 321amp5 24423345409
1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
00001OSBl 03812 0amp239
00001 oampG82 0320 06321
Error (BLOCK l213 12l9573913Ubull 40l3Gl318
GreenhoU2ebullGeiaaer EPSilon- 0cent100 HUyUk-Pel~t EpBilon bull 0446
soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
Pr l H - r
tuYmOCK PJIYbullnteerbullGROUP PliYbullBtOCKbullSE~ ~YbullBtOCKbullGROUPbullSBX
51 204
51 204
42~135918326 8406G456994 362 197325 72229239655
8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
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6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
10 F 5 1710 46 so 75 73 amp4 54 SJ T6 3 2 40 89 38 39 83 76 3 5 Ill F 5 1720 6 1 II 1 0 3 2 0 0 2 l 13 2 l 0 0 aamp F s 1723 8 JS 44 43 7 59 26 3 7 2 4 l 1 3 2 l 4 2
33 li 5 l7U 26 53 76 3 11 2 6 2 2 2 s 4 3 s 0 15 24 84 l s 1727 14 12 14 13 17 lS 17 7 1l 0 0 0 0 4 54 23 215
l s 17211 0 0 0 0 0 8 olB 22 6 2 4 J 2 3 2 3 8 2s86 l s 1737 63 60 l 0 l 1 2 6 5 13 lS 0 2 7 0 3 0 0 87 F 5 1740 12 0 10 II 1l ol1 1 l 1 0 2 0 3 l 3 2 Q a a s 1741 3 bull0 () 0 0 24 51 68 65 72 42 u u 3 11 s Q ag s 1743 32 53 0 39 52 40 l 9 0 5 5 6 6 5 6 90 l s 148 Jl 42 25 l9 38 16 0 1 l 0 J l 0 7 l 0 91 l 5 152 27 48 51 56 56 1 c so Sl 54 19 0 46 C8 so 27 92 l 5 l7G6 12 lG 30 ss 18 2 2 lS 4 l 2 l 5 2 l 2 2 93 F s 1773 lS l 1 1 0 0 0 4 7 so 31 1 0 2 0 0 0 94 F 5 1718 36 61 80 69 0 7 2 2 11 40 SG 8 87 GD l 53 70 95 s 184 17 42 31 3 16 s 7 I 3 3 2 0 9 5 7 14 24 96 F 5 1788 a 5 0 0 0 2 1 l lS u 58 s 0 1 0 0 2 0
F s 1789 27 68 31 48 l 22 63 i9 70 20 27 76 44 20 4
n F 5 17 15 l 0 8 10 27 l7 s 7 0 11 0 2 5 s 8 1 99 F s 11n ss 75 BS 76 65 3 l Sl 80 6ampbull G1 53 ll 89 67 76 10
lQQ M 1 1402 7 u s ) 0 0 5 7 25 8 G a 0 J 1() lOl M l 1401l JO 38 36 26 44 70 33 4gt 1 22 10 2 0 2 0 l 1 0 10l M 1 l422 7 40 42 a 6 5 2 5 J 3 B 2 J 6 8 bull103 M 1 1431 38 5 3 s 1 4 14 2 0 0 2 2 bull 16 13 16 27 104 M l 1436 1 17 l 12 30 0 l 1 l 1 1 ) 0 3 1 0 1 l lOS M l l447 9 66 53 0 3 0 0 l l 0 0 a 2 3 J 1 11 12 105 M 1 14SD 0 1 ) 0 0 u 3 29 25 2 2 6 2 2 0 3 17 2 107 M l 1457 J 3 0 l l 0 0 2 D 0 1 0 0 0 1 2 1 0 lOB M 1 1462 10 10 s 36 lZ 16 1C 10 0 5 2 5 6 C6 64 lB 112 109 M 1 1467 42 1 0 7 e 11 6 10 3 9 l 32 7 ll 4 110 M 1 1458 Sl 24 34 35 16 J 3 Q 4
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3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
~s reX GMUP ANtlC Ill N2 Nl 114 NS If N7 NB JllO Jill tn2 Xl3 H14 H1S lflS H17 Jl11
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Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
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Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
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~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
Scudy 1613 NKP18 IIAT Tbe SAS syaca
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76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
123 124 125 121gt 127 128 129 130 131 132 133 134 135 136 l37 138 139 1t0 141 142 143 lolol 145 146 1C7 146 14 150 ~~1 152
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The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
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193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
0 17
0 4 0 0 c 5
54 4J
0
0 44
2 3 l 0
Ill 0
32 l 2 2 0 0 2
45 0 0
0 ss
0 2 0 2
62 2
21 2 1 1 a 0 0
2 0
0 $$
0 2 1 g
40 14
3 0
23 1 l 0
33 0 0
0 co
0 0 2
GS 59
l 5 1 0 0 0
53 l 0
0 C5
0 4 0
54 44 u
l 1
1 0 0 0 9 5
3 32
0 4 2
S7 79 Cl
0 0
51 0
lO 0
JD 2
0 u
0 0 1
4l 58 54
0 0
55 a 2 0
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0 0
2 39
0 1 2
57 13 27
0 a
57 2 0 2
12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
14 0
1Z 11
J 517 34
l 27 13
6 0
u 0
14
14 JO
2 0
20
14
12 0
43 16 13
0 22
0 36
2 47
0
77 l
66 l
45
48 3
15 2
44 0
35 0
23 0 l 0 6 0 D z 9 6
0 1 0 2 0 1 0 2 0 0 0 2
0 1 0 0
15 0 0 0 1 0 1 1
0 0 l 3
15
3 0 1 0 0
0 1 2 5 0 1 0 0 0 l 0 0
D 0 0
12 3 0 0 l 0 0 3 l
0 3 1
a 0 0 0 0 1 1 3 2
0 1 0
45 z 0 I)
2 0 2 2
Q 0 0
15 10
0 3 0 l s 0
l4
0 0 0
35 GG
0 17
3
0 1
46
1 1 0
3 4 1 0 0 0
92 93 94
r 1
s s s
1752 l71lG 1773
45
25
36 56 23
34 72 14
52 32 1G
0
1 0
l u
0
4 65
0
6 33
0
s
0
1 3 l
4 l 4
0 a 0
0 l 0
1 2 l
4 1 0
c 3 0
0 2 0
IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
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Error tlliY l 567 1 778550 6658 313G173Gii1
Greenbo~e-Geiaaer EPsilon =09000 HUyUk-reldt EPQilon c 09578
Sourot Ill 1)lpe rrr ss Mean SQuare F Value Pr l 1ajusud G- G
Pr r H- p
MOCK mocxbullGROUI nocrmiddot~-t mocrbullcmotngtbullSpound1
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1972697105 3416SD483 4280100 359161i844
19676 06 lCI 08
1)0001 o 7641 03798 071amp1
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Error (BLOCK l213 12l9573913Ubull 40l3Gl318
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soureA Ill Type rrr SS Me= Square I 1uc lr gt F Adjut~ a- G
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8351694673 41211047$ ill45C50 354064100
2193 108 187 1193
00001 02CI211 00002 01537
00001 02126 00116 06525
00001 02799 00073 075
Errcr CllAY~BLOCIl 39 3610294 7lSOZZ 380 775466
GreenhouDDbullObulli~~er ~ampilon bull HUynh-Feldt ~ailon bull
03822 044B4
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OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
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17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- ----
Study lll IMDltRAT 07 l D Wecltlei(Say Scptenber JO lta
Tile SU 5yatUI
1 NlC tn7 IU8)13 115 N5 W1 Ill IllI lrlO IIIU lf12 lrl3 anbull lflS
ODS SX CIIOUl JllfM m ~ 0 a 1 F 1 1702 45 51 4 u 65 u 2 0 1 1 l 1 1 1 a
5 1 1708 1 s t3bull amp2 38 10 8 1 4 3 0 7 0 3 1a 62
3 ) 1 1722 ll 58 52 2 7 3 5 0 0
8 0 0
5 0 bull3
u a s 0
so z l u
r 1 1731 34 17 IS 0 5 1 l 3 0 1 0
0 5 0 0 0 1 1 3 z 3 0 5 1 1747 3Z 71 37 u 2 z 0 0 3 2 l z 0 1 5 J aJ 1 1736 0
6 F 5 3 s 2 J 2 2 7 1 1750 z 5 0 0 7 lP n 1 7 T 0 1 2 0 2 z 1 1 1757 )4 45 amp7 u co 56 33 1 bull bulla 1 17amp2 43 57 51 48 l 20 72 45 22 (J s lJ 1 1 l 1 1
F F 1 17 2u g 11 4 4 4 7 II B 7 15 3 lS
10 2 1 70 10 IS 17 1 45 77 83 u 1 1768 60 12 10 74 81 65 cs u s ll 2 2 03 3 0 ~ l 6 4F 1 1770 H 62 31 45 0 3 I 101Z 1 2 1 4 3 l 1 s 1 177Z 47 50 63 45 45 ll II 113 30 55
ll 57 58 ampl 25 41 0 3 0 0 14 1 1777 70 Q s l2C 0 15 15 3 10 5 3 8 5 30 l r 1 1781 C2 15 7 l 2 1 7 16 11 J 7 393 79 1amp u 73 1u F 1 1715 3 u 52 3777 415 (( u 34 62 77 a 70 41 5517 F 1 1786 n 59
57 73 21 Q 25 7l 85 u 6 55 7 73 71 u bullbull 18 F 1 1790 30 3 1 63 5 ~ middot~3 0 1 19 F 1 171amp 6 42 17 6 u n 0 1
Q0 u 5 20 1 l 0 420 F l 1716 u s 3 JB zc 3 J
6 1 2 z B 22 1705 26 C9 50 3 54 17 12 s 58 51 21 r B 1 0 0 J 0
22 T 2 1 J 3 bull 2 2 3 Q1706 17 0 22 12 0
0 5 0 0 1 13 F 2 1711 21 l )6 2 22 6 2 0 0 1 2
Q Q 0 0 0 0 2 0 24 2 1712 12 7 0 0 c 1 1 0 2 1
10 2 s 7 6 120 28 22 33 1 125 F 2 1713 u 36 16 l 3 3 a
F 2 17111 79 72 8 56 76 1S 0 10 z 42C 0 1 2 33 u 43 3 1 39 21 3 6 22 3 27 F 2 1734 co 38 so 3 0 0 0 0 02 23 29 0 0 27 0 0 0 0 0 0 0 0
a F 2 1755 lO Zl C2 6 48 35 1421 F 1 66 25 3 25 45 45 10 5 2 2 5
23 7 2G 15 0 3 2 0 3 2 3 0lO F 2 175~ (J 65 u 0 31 F 2 10 7C 5 u 14 1 0 1 2 10 3 u 46 10 s 54 s 2l
1763 2 17 32 55 55 0 49 11 52 5 1G 76 5 51 5 32 F 2 1 0 2 1 0
Q 2 2 31 033 F 2 1769 1 0 23 30 4S bull
7 5 5 J 5 8 12 8 2 2
2 1775 H 37 39 52 0 27 40 1 0 1 1 5 3 5 1 s 235 F
2 1779 21 ll 4C 30 55 10 4 u 56 10 1 1 0
H F 2 1771 38 32 31 l4 l l 1
0 J 0 136 F
2 1782 79 58 49 75 SJ 57 7937 F 0 1 2 45 75 38 82 72 0 5 0 5 0 3 2 2 1 1
H F 2 1100 10 15 J 5 10 1 $ 8 4 l 0 1 l 1 J u38 F 2 1795 6 18 44 45 25 0 amp
12 1703 26 2 1 1 2 0 2 l l J 1 1 1 J 1 2 1 3
40 F 3 u F 3 170 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13
1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52Cl l 343 T 3 1715 7 28 55 t8 22 0 18 58 s 20 SJ 10 s 0 c 5
2 p 1n6 1 17 13 n 0 0 15 19 2 2 0 2 4 0 2 1 JJ lT17 48 52 ce 52 s 63 86 lS 5 36 52 91 Cl 57 1 1 52cs F J
(6 1721 56 7 co bulls 2 13 bullo 10 1 0 0 0 0 0 0 1 0 0F 3
1725 15 3 16 52 ll I 1 2 s 7 0 3 a 0 li SG32F 3 u F 3 17l0 29 38 37 37 5 40 GS 2 l 5 2 1 0 a 0 2 c
a so F
F 3 l l742 l 0 0 0 a 0 0 1 0 0 0 0 0 0 0 0
10 0
2 0
51 F 3 1744 10 2J 43 57 2 2 2 l a 7
(9 1735 25 0 6 19 2ol 0 2 6 3 0 0 1 2 1 LO 2
3 17U l s 0 0 20 22 t J 2 a 1 3 1 0 0 1 352 F 3 1754 ll 27 15 1 20 40 JB 41 31 1 J 2 2 0 J 053 F
F l 1758 30 31bull 21 1 5 2 0 3 s 12 2 ll 23 55 t5 110
ss F J 1761 16 20 24 2ll a 2 0 sc 1 l 7 1 0 1 0 2 4 3 0
F J 1780 29 72 50 84 57 SJ 1 58 5 0 l J 0 l 0 1 l 5 57 J 11 49 55 62 81 61 52 19 0 16 85 72 54 91 GC I GJ 0
3 12 0 1 0 G l 0 0 0 2 1 1 2 0 0 0 5 1656 S9 F 3 17 pound9 ao ll2 cs 43 sc 60 56 27 61 8 12 e 3
0 F 4 1701 ~ 0 2 2 l 13 17 22 2 47G amp2 55 1 2 4 1 z u F 4 1707 31 (1 8 0 0 3 9 9 0 1 1 1 0 0 a 5 l a
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
65 J 4 1729 2l 34 S7 2 l 31 65 7 2 z 5 7 s l 2 1 66 F 4 1732 29 17 S4 69 5( S3 6S 11 1 1 so 16 13 13 5 67 l 4 17ll 53 6l 17 1 5 5 3 1 u a 2 II 10 s 4 8 68 F 4 173$ 2amp 24 2 3 3 0 ( 5 II 1 5t u 43 27 3 1 1
r 4 17311 0 0 l 3 22 2$ 0 4 5 0 0 2 11 0 1 0 0 0 70 F 4 174S 26 34 24 lS 0 0 3 s 1 0 1 1 l I 0 4 26 71 F 4 17Sl 47 43 48 80 (6 32 82 61 83 21 0 55 70 59 87 7S 12 72 F 4 1759 amp9 26 35 22 16 25 4 32 1 1 0 0 3 4 2 s 13 F 4 1764 52 (8 36 31 ll 2 2 7 s 3 amp 1 5 7 3 4 7 23
l 74 F 4 1765 0 0 0 0 0 0 0 0 0 2 2 0 0 1 0 1 0 0 75 F 4 1774 17 13 2S 20 1 16 43 6 l 1 4 s 7 0 7 4 J l 76 F 4 1776 6 4 25 s 1 10 10 39 41 29 ze 27 1amp 47 5 0 0 l 77 F c 1783 10 26 4 u 43 27 1 1 1 1 2 3 0 4 1bull78 F 4 17117 JQ 11 ll l a c 16 () 1 3 19 6 () 1 3 1 l 79 F 17 13 17 3 Q ( 24 Sll ~3 l9 37 52 4 ao zs s 0 0 l
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GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
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69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
71 s
0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
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75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
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7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
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18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
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59 75 70
40 66 10
0 1
69
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80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
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3 61 55 87 51
17 62
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0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
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57 l 9 0
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65 1 0 0 0
so 90 11 45
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cs l7J
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lS J3 37 6 1
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l 79
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66 13 52
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sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
bull bull
2
middot-- -- --middot -middot --l bullbull-~~~n bull -
be SA$ S)r8telll 07bull30 lledne~ Septllll)er 30 Ull bull
-- _ __
OJIS SX GROU1 ANIM N1 112 1113 lf4 IllS N N7 K N10 ~ll N12 Jill Ill( N1S Mlamp Nl7 N16
F i 1714 amp7 18 64 80 70 cs 32 34 2 1 7 2 z 2 z 63 r c 1719 ss 6 61 80 4B 7 0 3 I I Sl 83 56 7 2 5 0
p 4 172G 41 611 49 42 2 0 so 70 44 8 10 l 2 II 6 64
l
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GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
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lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
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17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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1752 l71lG 1773
45
25
36 56 23
34 72 14
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
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3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
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71 7
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60 c l
2 0 3 1 l 0
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lamp 0 0 e Q
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2
0 0 l
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32aG ll
0 0
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1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
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4 S4
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
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72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
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l1 ll
1 0
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0 69
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76 12 67
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a 63
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l se
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147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
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46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
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71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
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sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
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62 66 70 78 87 57 71 65 72 54 52 61 27 68
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54 52 69 61 50 63
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B 54
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l 6401amp 74 (8 72
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as 69 76 61
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sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
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67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
3 the SA$ SyampJtbull 0730 Wednc~y ampeptembtr 30 198
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Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
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lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
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S1 Kbullf$ llBSS
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Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
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Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
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5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
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Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
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17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
5
bull
Study ltil3 ~Ul
OCgt=al L1nr Mocole Proclfdure elaaa Level Xnforaat1oa
elaaa revl Valuo
s l z 3 4 s 2 FH
Study 1511 MKD14PIIT 073D Wednesday Scpteftber lO 1991
GenerAl Linear Ho~els foccdure llcpeaeed Muaurca Azxllya1a of Varilll
Repeated Kbullaaure~ Level Info~cioa
N~ N7 N8 )19 NlO Nll 11112N1 N2 N3 N4 JotSDcpe~Sdeot vuiable s G 7 8 II 10 ll 12Level of B1IXIt l 2 3
Dcpen4ent v rilble NU Nl4 NlS )116 W17 Nll
Leve1 ot nee~ 13 lltamp 15 lS 17 lB
~ftCVa rest criee1ia d Exact l seoeioei= tor tho Hypothesis of no BLOCX EUact H bull Typo 11 ~ Matrix for aLOCX E = Errer SSCP Matrix
lbulll H=75 NbullB55
Statistic VltLluo F NlUI Ill Den DP Pr gt F
lfilkc bull raa1gtamp 059720n4 G8537 17 173 00001 illaibulle Trace ocaZ9SZG G8637 17 173 00001 Hotellin~middotLowley Trace 067laquoamp663 G8amp37 17 173 00001 Roybulls Greatest Root 057ltamp46763 5amp637 11 173 00001
DDV3 Teet Cr1terib and r APPrcxieicn~ for the nypoebe~i of no aLOCXbullCROCP Effect H bull TYPe XXX SSOP Hamperix for BLOCXbullCROUP E bull Error SSCP ~trix
Sd K=6 NbullOSS
Stoltllleic value F Nwa PF Oen Pl Pr gt l
Wille~bull Lalnbch 0 65217laquo74 11095 59 5812195 02628 Pillai bull=Trace 038618262 110amp3 ampS 704 a2G79 HoeellicgbullLawley Trace 04Cll7993 11127 68 65 02S7S Roybull Orea~68t Root 0 212698 22021 17 176 gOOS6
NotE F St~tietie fer acybulla Gre-tebullt Roo~ 111 an IIPPbullr )ouncl
Kane~ Ta2t Criteria and Exact r scatistios tor the Hypothesis ot no s~middotsBX Ettcct H =Type III SSCP Matrix for SLOC~bullscx E =Error SS4CP ~~trix
S1 Kbullf$ llBSS
SlaliBtic Value r Nllm OT Den Dl 1r gt l
Will-s bull Llula 091918007 08948 17 113 0510 PillOli rraee 008081993 aee 17 173 0510 HotcllingmiddotL5Wl~ Tracbull 0011792511 089U 17 113 05810 Roybulls cre~ceot Root 008792611 08ltamp11 17 173 05810
Stu~ 1613 NKD1CRAT 0730 We4De8aay September 30 18 Gener~ Linear Kodbulllbull Procedure
Rbullpeated Measures Anolygic of Variance
MOlno Tce Criteria and P ApproxiiMtiona for tha Hypoheais ot 110 BtOCXmiddotG~OuPbullSX llfect H =1ypl III SSCP Matrix fo JLocttbullCJDIJPbullSIl E c ErJcr SSOCP Motix
Samp Kbull6 N=SSS
Staeiotic Value r NUll DF llen D7 lr gt F
Wilbobull ~ 01258370 09015 Gll 6lU91i 06938 lill41 IJ TrliCII 032036831 09014 68 04 06114 Hotel1ingmiddot~awley Trace 03SUS1 09059 G8 686 06890 lcys Grealca~t Root o12~2oil32 18866 1 176 00218
NQTE P SCAtiscic for ~middots Greatc=e Root ie an upper bound
07]0 WedDebullday lept~r lO 1111
8 Gtmeral tiDear ~1a lrccotdur
llcpeateltS Muaure11 MampJyaia of vadu~ Test11 of Hypeth for Betwean subjects Ettacta
Type II SS Mean Squaze P Value Pr gt F SoUCS
10210U2amp7348 zssznonl7 occ 0 353 1zuampno2 7 299Cll02 020 o amp556
oaJ 051001lU99353U 31middot83835pound1
7SUS891228070 3JU4U599J711aror
t
aeceral Linear Models ProcedUro ~epeaeed Heaaures ~lycie ot V~ri~ce
Univariate Te=ts c HYPotheses fer Within Subjece tffectg
~juned Pr gt F TYPe ur ss Mean scruo~re I Value Pr gt P C - G H - FI)SScUCe
~ 00001 0000117 1399 533321 IOU1UOU 225 00001llroctt 00280 o oau 00758CSJ 43lG04 136JILQCJbullCROUP 32873 JUOJR 053211 04894 OUil17 SCSOUJ990 JJZ 381C11 03mocJtbullscx on oano 07711 078U19583120857 287 87071MOClCOROUPbull Sllle B
1143574924561 JSS9llZ34trror (8LOC1tl 3213 oreebbouoe-Geiabullbullr Epoilon =04881
HuYnh-Feldt Epsilon = OSJGB
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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30 Ollillll 1924639000000
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
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GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
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3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
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4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
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57 J 54
22 J 25 72
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11 55 274
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lS Sl 23 5 n 33
l 0 l 0 1 0
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so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
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171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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92 93 94
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
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3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
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0 1 0 0 0 0 0 0 4
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1 30
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71 7
16 0 Q
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1 1 0 2 0 0
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2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
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56 co
0 37
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
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07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
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0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
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l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
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1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
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85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
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bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
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5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
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GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
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II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
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10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
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42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
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so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
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171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
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0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
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I)
22 66 n S
2
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15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
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53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
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116 14
l 79
3 D
43 45 1
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45 0 A 1
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amp0 s l 2 3 1
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liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- ---- middot-middot middot--- -middot
1he SAS Sylll- 0744 Wcdfteamp4ay September 3 0 uu 2
NS Jr7 NS Rll 1(9 )I]Q lf12 m3 m~ lflS lll6 N17 )Ill OBS SEX GROUP lUml lll an lfl
0 0 0 1 l n I 1707 13 17 19 16 25 5 2 2 2 2 bull 171amp 55 C1 70 5 10 n 37 ZG 4J 52 zs 1 1 0 5
0 0 3 ~
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7 2 Gl F 4 1733 4 56 30 31 55 37 70 12 0 45 31 5 59 27 58
0 u 4 1731 7 bull0 1 0 0 l zs lS ti2 ze 0 0 0 1 0 0
1 0 0 3 2 070 c 1739 23 52 C1 46 45 0 28 2 39 10 s 7l 71 4 1745 22 35 amp9 52 30 24 25 30 JS 1 8 0 c 1 0 3 2
72 4 1751 55 34 33 43 tiD u Cl u 43 til sz 38 n u 30 31
73 4 1759 so 32 19 15 51 45 55 2~ 0 2 0 0 a 4 1 0 0 l 0 0 l6 4417U 5amp 27 7 13 l 2 s 3 0 a 37t F 10 30 39 1 0 l
75 F 4 1765 36 amp0 z 11 1 0 0 0 0 0 1 25 1 0 2 1 0 0 1 0 1 0 0 J 26 51 35
76 p 4 1114 39 u 1 77 p 177 J1 0 n J 0 e lll 37 65 60 67 47 ~7 64 27 GS
Q 0 0 J 1 0 0 0 l71 F bull4 1783 7 32 17 2 11 35 C9 11 0 12 0 0 ~ 3 0 1787 32 42 53 27 7 5S 57 4l C4 1 0 6
80 4 179 59 6l C3 lO 73 72 2B 75 5 49 81 r s 110 38 32 u 17 3 18 1 0 0 s 0 l 0 a 2 0 2 51 85 52 2 5 8 22 60 30 91 95 85 14 19 81 a liZ s 1720 38 u
37 13 s 12 17 25 2C 0 1 2 5 30 13 44 2 0 0 2
84 F s 1724 u J5 66 53 51 46 51 2 69 57 sc 78 7a ll 1 16 513 I s 1723 57 53 81 amp6 50 2 0
85 I 5 1727 28 23 Cl sa SG 57 amp1 53 0 0 0 0 0 0 186 F 5 1728 57 19 2 51 1 64 13 2 a
87 F s 1731 RO 2C u 0 0 2 0 0 0 1 1 0 s 2 0 0 0 0 0 0 1 0 0 2 0 0 088 I s 1140 so 57 34 u 2~ 7 0 2 2 0 0 0 1 3 1 1 J
II 5 17amp3 13 u 55 11 72 0 56 30 72 6J 37 45 57 58 12 2 5689 F 5 1741 32 40 24 21 15 1 1 0 3 0 Q0 0 0 0 0 0 2 0 0 0
1752 ss 60 57 sa u 80 1l 83 46 7~ 73 39 13 51 56 12 u 5291 J s 1748 21 39 s 0 0 0 92 F 5
r 5 1766 54 66 61 16 78 C3 73 75 52 27 77 78 66 u u 75 7493 0 0 1 0 0 0 0 0 0 0 0 11
I 5 1778 2 5amp so 60 49 Gl 58 s~ 71 26 2 0 13 l 1r 5 1773 8 0 0 1 l 1 5 F 5 1784 54 5 70 55 sa 55 63 71 70 55 5 so 68 73 48 3 27
0 0 0 0 Q 0 10 30 14 0 0 0 0 0 0F s 1788 1 0 1 n9Q 5 1789 114 72 liS 37 0 0 0 2 J 37 85 Ill 87 99 5 179l 52 36 51 l 1 12 0 0 0 8l 0 0 0 ~ 34 51 co
100 5 1798 58 71 9 62 c 23 70 76 59 67 77 n 30 16 6 G1 to 101 H 1 1402 37 27 lR 42 46 Jl 25 19 4 24 9 0 G 5 3 2 ~ s 102 M 1 1~08 0 2G l1 2 58 (l 4 3 1 0 1 0 0 0 0 l 3 103 H 1 1pound21 Jl l~ 2C 12 36 s 42 H 10 2 4 2 1 3 1
10 Q
104 H 1 H3l 56 66 57 61 33 u 72 64 11 ~) 76 67 39 67 74 64 alOS H l 1436 amp 22 ll 0 0 0 0 0 31 13 35 7 0 0
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0 2 45 2 0 0 2 l 0 1 2 0 0 0 0 0
107 K 1 usc 47 amp6 20 28 l1 54 4l l 9 sa 77 58 5amp 43 1 s 4 1 1De M 1 US7 22 36 zo 48 19 0 1 0 0 0 0 0 0 1 0 0 Q 0 106 M 1 1CC7 2l 0 11 19 109 Jlaquo l 1462 92 82 72 ae 94 86 Bll 80 BS 95 84 78 s 7l 56 87
l(110 M l UG 86 70 54 a 75 83 56 ss 7l 0 2 0 0 J 0 1 24 111 M 1 1U8 81 69 80 73 74 72 73 87 3 072 0 6 3 4 l 1 3 112 H 1 131470 17 52 u 0 0 0 1 l 2 0 1 z 0 0 0 4 12 113 M 1 1472 u 10 29 0 29 2 0 2 0 0 0 ~ 0 s 1 0 2 1 114 M 1 1477 60 44 66 17 26 14 1 6 3 0 l 16 63 14 1 0 4 115 11 1 1481 75 CB 70 77 57 87 73 72 59 GO 61 70 67 59 71 72 52 70 116 M 1 1485 71 22 43 70 7l 7l ~3 67 l6 s 10 0 2 0 13 J 117 M 1 1486 46 58 14 l 0 27 63 ss so 2 0 bull3 0 s 0 2 118 M 1 l490 21 1 21 0 0 9 ~0 76 116 75 68 0 1 0 0 0 0
M lUC 1B 10 0 0 0 0 0 1l 55 H 51 10 0 0 0ll 1 l M 1 7 0 0 0 i 0 26 2 0 1 0 6 55 52 n 46 62120 l121 M 2 lampOS 75 78 2i 0 7 3 0 3 1 s 0 0 1 0 ~ 0
122 11 2 1406 76 41 l a 2 1 0 ~ 1 2 0 6 1 0 5 0
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
123 124 125 121gt 127 128 129 130 131 132 133 134 135 136 l37 138 139 1t0 141 142 143 lolol 145 146 1C7 146 14 150 ~~1 152
tf M M M K K H M H If M H M tf M M M tl M K M M M M M M K I(
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M H M M M M M M tl M M M M 11 H M M H
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The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
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U2 M 5 5 14Gii 97 82 77 77 72 16 72 7t 54 7l 81 55 2 a 2 11452 72 u 0 39 72
193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
us 0 2 4 34 0 0 c1 IC s 1484 0 l4 24 1 0 1 16 12 0 1
0 2 5 0 0 0 l 0 17 M 5 1411 31 20 22 11 0 s 0 0 0 2
70 sa 31 0 0 2 16 5 l 6 0 0 2 1S lS 11 M s ue 0 0 199 H 5 1493 56 511 34 1 52 52 n 1 3 3 0 9 l 4 0 l 1
u42 37 7 1 0 z I 0 0 7 16 co fil 82 77 105 70200 K 5 11 1998Ctu4Y 1613 NMD18 RrT 07U WedllerJ~ ampeptCIIIbll1 30
5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
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07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
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4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
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8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
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032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
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24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
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27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
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K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
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0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
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l 76 62 ss
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1 77 24
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l 35 62
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0 5
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77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
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80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
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53 10
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cs l7J
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lS J3 37 6 1
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116 14
l 79
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32 65 a 6 0 1
45 0 A 1
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amp0 s l 2 3 1
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liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
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-
bull 1 ----- bullbull-bull ~c~n -- ---- --middot -middot~-middotmiddot --middot r bullbullo wu
the SAS Sycn- 0744 lfAdneacry Septe~~bor lO lJJI 3
OB ~ GROUP AIIM Hl W2 Nl N4 NS N6 m R8 119 flO W11 JtU 1113 N14 Jfl5 Rlli W11 1111
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wr-_--- ~io -oilmiddot c ar_ Ifmiddot-- bull _ _- middot-middot rifrnn r bull amp) )(J
The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
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l 55 1 3 0 10
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193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
us 0 2 4 34 0 0 c1 IC s 1484 0 l4 24 1 0 1 16 12 0 1
0 2 5 0 0 0 l 0 17 M 5 1411 31 20 22 11 0 s 0 0 0 2
70 sa 31 0 0 2 16 5 l 6 0 0 2 1S lS 11 M s ue 0 0 199 H 5 1493 56 511 34 1 52 52 n 1 3 3 0 9 l 4 0 l 1
u42 37 7 1 0 z I 0 0 7 16 co fil 82 77 105 70200 K 5 11 1998Ctu4Y 1613 NMD18 RrT 07U WedllerJ~ ampeptCIIIbll1 30
5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
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error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
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07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
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4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
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II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
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27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
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31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
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J 2 179 30 Sl 32 53
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lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
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0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
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s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
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7 50
0 0 l
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54 54
0 0 0
64
0 u
0 5
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
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1 78 l
2 1(
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72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
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147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
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46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
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sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
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70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
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62 66 70 78 87 57 71 65 72 54 52 61 27 68
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as 69 76 61
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(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
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2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
4
__
wr-_--- ~io -oilmiddot c ar_ Ifmiddot-- bull _ _- middot-middot rifrnn r bull amp) )(J
The ampAS llyaCUI 0744 ~ Sepc~r 30 uta
1om( N1 112 Nl NC llli 116 117 N8 119 WlO Ml1 N12 1113 )114 1115 1116 N17 1118 oas SEX CMI11 75 67 u 57 50 8 78 52 70 3l 18 K s 1amp24 61 5 112 59 2
0 0 34 5 1 0 0 0 0 0 0 0 a 185 K s 1427 22 25 24 37 40 3 l 0 s UG K s lC28 18 12 16 63 51 II 0 0
g 2
l 55 1 3 0 10
5 lCJ7 u 39 26 4 l s l 0 0 lZ18 M 0 1 0 9 s 0 0 4 liB K s 1440 u 73 2 l24 37 3 0 2 0 3
J 0 0 0 0 0 0 0
fi ll 43 38 G7 4 0 1119 M 5 1441 l s uo M s 1-amp43 7l 75 116 77 I 84 75 108 73 43 0 J 0 2 0 11
3 0 l
0 s 2 lC u amp3 21 16 2 1lCbulllR 6l 26 13 0 1 1 Ul M s 3n 58 71 Jl 2 5 0 9 4 0
U2 M 5 5 14Gii 97 82 77 77 72 16 72 7t 54 7l 81 55 2 a 2 11452 72 u 0 39 72
193 tf 4 120 2 0 1 0 0 1 1 4 15 46M s 1471 7 0 0 194 K s 1478 23 26 14 10 8 0 8 12 52 8 27 40 2 1 0 1 1
us 0 2 4 34 0 0 c1 IC s 1484 0 l4 24 1 0 1 16 12 0 1
0 2 5 0 0 0 l 0 17 M 5 1411 31 20 22 11 0 s 0 0 0 2
70 sa 31 0 0 2 16 5 l 6 0 0 2 1S lS 11 M s ue 0 0 199 H 5 1493 56 511 34 1 52 52 n 1 3 3 0 9 l 4 0 l 1
u42 37 7 1 0 z I 0 0 7 16 co fil 82 77 105 70200 K 5 11 1998Ctu4Y 1613 NMD18 RrT 07U WedllerJ~ ampeptCIIIbll1 30
5 General L1Dear Models lrocCilN
Claae ~middotl ~nformation
ClUB Level Values
GROUP 5 l 2 3 4 5
SIX 2 FK
N111ber of observations in dampta cet zoo
St~ 113 NND1RRAT 6
caneral Linear Hodols Procedure Repeated Meaaures Analysis of ~iance Repeated KeasurDD Level Inform~tion
1114 NS rqG N7 NS N9 NlO All NHPGponclant V=~e N1 N2 N3
10 11 121 2 l 4 5 7 8 Level of BLOCK
11117 NlBDepcn~nt V~ribullble N13 11114 IUS Nl 14 15 1G 17 18Level of BLOCX 13
Kano~ Test Cr1teria and ExAct F Statistics for the Hypothesis of no BLOC~ Zffect H ~ Type IX ss~c~ Haeix tor BUOCK E = Error SSCP H~crix
S=l Kbull7S WaGG
Statitie VaJue I NWIgt D1 Den Dl Pr gt J
Willca Lampllllda 0 amp11196100 1061 17 174 00001 ~illampia Trace 051103200 106971 17 174 00001 Hocellino-Lawley ~~ce 104512362 10 li971 17 174 00001 Roybulla Greatest Root 104512362 106971 17 174 00001
Kanova Tast eiteria and F Approxim3tio~ for the HYPothG~ia of no BLOeKbullGROUP Btfect H = Ty~amp III SSCP Matrix for nLOCKbullGROUP E ~ Error SSCP Matrix
S4 Hbull6 Nbull8
Statla~ic VaJue F lllwn Dl Den PF Pr gt Wilkls bull IAlllbda 0 6111713 7 10004 68 6851439 0 4796 Pillale Trace o 3Sl4566C 10029 68 7011 04736 Hotel1inabullLawley Trace o 31320026 09975 68 0 04UO RoyS Cre~togt Root 015479121 lamp1U 17 17 00653
NOll F Statitic for lloybulla Greatest Root igt upper boWid
Man~ Tce Criteria nd poundxact F Ctatictice for the HYPothesi~ of no DLOCKbullSEX Efface H =Type III SS~P MAtrix for lllOOCbullstX E bull SITOr sscp Matrix
5bull1 H=75 N=l6
Statiatic Value F llll8l Ill Den PP Pr gt
Willct bull LUIIc1a 0817581135 lZC) 17 174 ouu Pil1airJ lrce Oll2411C5 129Gl 17 174 01995 Hotbullllin~middotLswley Traee 01264amp41 12963 17 174 01995 Roy 3 Oreatellt ltclot Ol2CU941 12963 17 l 011195
bull
St~ 1613 XMD18RAT cecaral Linnr Madel l~ceedure
lilepeatell Keasuns AMlyaU or Vuiance
MampAOVil IUt criteria and F ApproxMticnbull for the ~thuis of ao BOCRGROUPbullAX zffeet II gtype III S~C Mat~ix tor BtOOtbullGlOUPSEX E =hror SSCP Matrix
Sbullt M=fi Naampli
Btltictic value p lolWII DT Den Df Pr gt 1
Willes Lillftbda tillaibull bull Trace Hotel1ino-Lawloy~aee Roy c Greaceat Root
071103290 G3Ul07711 03472106amp Ol2tl79fi
08$7~ 0110 011809 lJSJS
69 69 fiB 17
6851U9 07270 708 07137 690 07402 177 01amp51
~ p BtiLtiaeic for Joybull~ Greaeeat Root ia m upper bOund
07~( ~ec~ ~aptaaber 30 19911
8
Gecerampl tlne= Modelbull Procedure 1epcated Heuurws AnalY81B of Vari=ce
Tectc of HYPotheses for Between SUbjccta Zffccca
SOIUCe DF oryp rr ss r Vamplue lr f
~ 1S7GS27111111 l94lll7777711 060 06601 1 4
30 Ollillll 1924639000000
30~3361111 4BllSl7SOOOO
ooo 074
09~57 05613
error 190 124173809166667 5535 G3U03S
0744 wednesday september 30 1998
General Linear Modela P~ee4ure ~epeated Kbulla~urec Analyeia of VDri3nce
univ=iampcc leacs of Hypoth~ for W1tnin subject Zffeers
ScUJce raquo 1YP4 Jtr GG tlcltm ampquare F Value Pr r Adjusted C- G
Pr r H bull F
DtoCf moettbullGROUP BteettbullSpoundx BtOCXbullGJlOUPbullSG
17 68 17 68
21lB5 944722 23BIl178889
7Sl20513BI 26334600000
127B74085l3 351076160 443061146 387273521
2~84 oaa lOJ 090
00001 09551 DU6S 0681
00001 07196 04024 06001
aoool Q73Q~ ouu oaoao
Zrror(lLOCKI 3230 1384143058333 41851123
GreenhoU2e-Geioocr 2pai1onHuynh-Fe14t Epsilon
- 03amp65 a 03983
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
5 0 l
4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
r l 170 17 32 C3 0 20 0 0 g 7l 60 1 211 0 0 0 li 56 le 0 0 144 0 0 0 0 0 0
F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
4 4
4
4
1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
St
18 58 59
75 51 70
75 67
57
57 J 54
22 J 25 72
4 55
3 53 ll 50 27 3 21 66 42 2J 55
2 Sl 23 cs
l 20
0 47 ll 63 20 35 55 23 lS 75 ll
11 55 274
0 n
I ll
lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
2
0 5
10 42 u
0 15
1 0 1
211 59
0 42 10 27
55 51
0 6 2
54 64 1
ss 0 2 0
sa 30
0 34
0 32
7C 18
0 0
so JC
0 29
2 0
Cl 31 17
0 9
52 10
amp1 u 27
4 33 27 31
0 0 3 0
l7 0 0 1
16 90 a
21 59 GS 32 10
0 57
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0 4 0 0 c 5
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40 14
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l 5 1 0 0 0
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12 34 l 0
so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
F r F r
5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
6
Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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66 l
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0 1 0 2 0 1 0 2 0 0 0 2
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15 10
0 3 0 l s 0
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0 17
3
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92 93 94
r 1
s s s
1752 l71lG 1773
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25
36 56 23
34 72 14
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0
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
8
100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
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60 c l
2 0 3 1 l 0
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0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
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1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
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50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
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30 6 0
27 0
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D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
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0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
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0 39 59 17
0 15
0 0 0
S4 0
20 12 55
2 l9 C7 Cl 47
3 0 2 0 0
u 45
0 4 7
65
l 36 56 42
4 1 0bull0
23 amp4
0 J J
26
3 61 59 63
3 0 2 0 I)
1 sa
0 7 0 0
0 59 GB JS ~9
3 0 3 0 0 0
16 0 s s l
1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
0 15
l 14 Cl
0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
1 53
0 0
GS 3
60 c l
2 0 3 1 l 0
18
0 7 2 0 1
12 5
u 2
lamp 0 0 e Q
l 0 2 2
53 7
54 15 21
0 l
3$ 0
16 11
2
0 0 l
lJ l
32aG ll
0 0
16 2 2
48 3
1 1 0 2 0 0
3() 0 3 0
ll 0 6
61 0
1 0
1 3 8 3 0 l 0 0 0
C2
2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
711 27 32 29 17
56 co
0 37
0 63
0 l
4 S4
2 74
4
0 I) 1
65 0
25 0
42 5 8(
0
0 0
75 0
50 D
SD 49 5
4
8 0 2
43 2
27 a 45 45
l
7 16
l 73
0 37 25 52
8 4 0
n 69
6 47
0 0 3 1 8 0
18
61 53 uampe
3
~-amp 1
lS 2
Jl 52 (8 31
2 19 10 11 41
0 l
0 0
37 43
4 60
2 3
ampe 0 1
0 0 5
43 0
30 6 0
27 0
17
D l l
4 2
23 olll
0
0 55
0 0 s
3S 3 0
0 34
7 50
0 0 l
47 2 0
75 l 1
54 54
0 0 0
64
0 u
0 5
71 s
0 0 4
53 ZB
0 58 1 0
77 0
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
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46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
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(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
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2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
---- ---- --- -- --
~-
07 lO ~e4ay Spt-ber 30 1tampStudy 1513 MMDa2~T
u alii Nl N9 NlO N11 Nl2 Nl3 N14 NlS Nl6 11117 111111
OliS ux ctOUP lUItM w N2 N3 1(4 tiS ~
4 0 3 0 4g 14 D 0 0 0 5 0 1 5 01 1702 55 31 r 0 0 0 0 2 0 25 l4 53 51 14 31 32 0 0 2 F l 17011 25 25 0 50 sa5 l8 zo0 0 Cl lC 2 0 0 l
4 F 1 1731 sc ll 21 32 u 1C 0 0 0 4 52 70 41 7 ll 0
1 1736 0
3 p 1 l72Z so 35 23 0
sc lO 22 0 27 36 28 3 D 0 0 u 0 0 0 2 0 5 r 0 0 0 0
8 0 0 0 0 0 0 0 0 6 6 r 1 17U 0 D 0 0 2
211 41 111 4 1 15 4l 40 0 0 21 1750 4S 52 317 r 2 0 0 0 0 0 0 0 00 0 0 0 0 0
II F 1 1757 19 0 0 1 0 27 1 59 Sll 340 0 1 0 1
SJ F 1 17U 45 11 G1 5J1767 $ 6 I 2amp 28 22 II 2bull 0 1 lS co
10 F 1 0 0 0 0 0 1 l 2 0 0 0 l 017amp8 89 23 57 23 0ll r 1 0 0 0 1 00 0 0 0 0 0 0 14B 0 20 57 4012 r 1 1770 21 2 0 0 0 28 1 0 19 amp0 30 26 51 401 1772 u 413 0 0 0 15 54 59 41 56 R 51 a
1~ l 1771 n 25 l1 2 0 0
1 2 376 33 SG u 18 42 51 II 2 a 7( ll 2 1 r l 17111 fi415 D 0 0 16 l 17115 $5 70 2 57 58 l2 1 0 22 0 2
0 0
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4 2 4 2 17 l 11116 54 66 CJ 0 59 0 0 0 0 4 1
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F l 114 Cl 48 5 IS lJ D 1 0 1 0 l 0 0 0 l 3P IC 20 r l 1 58 46 55 24 35 5 u 15
032 31 0 0 42 53 19 0 0 3
22 I 2 1706 21 r 2 1705 73 66 34 53 C2 2
Q l 7 0 078 amp1 116 u 52 12 55 27 so n 5amp 2 7 c 13 51 1 0 JC1 33 l 0 l s J 2
24 F 2 1712 10 4 0 0 1 2 2 0 0 023 r 2 1711 S2 1 0 0 15 u
0 0 0
l 0 0 1 10 0 0 0 0 2 l 02S J 2 1713 16 0 0 20 7 1 1 2 0 Q 0 1 0 7 u so 2l r 2 1118 61 u 47 52 lJ2 57 51 0
27 2 17)4 76 70 8 0 0 3 1 3 2 10 0 l 5 1 8 0 1 0 0 4 l 0 0 l 0
28 2 1746 55 37 3 0 0 0 0 l 42 2 3 3 1 2 a 1 3 J 0 5 l 5 0 4
2t r 2 1753 0 0 3 2 0 1 1 1 17 0 0 0 D a 0 0 0 2 a 0 l 7 47 u30 r 2 1755 5 5 0 D 0 c 7 0 1
31 I 2 l75C 46 0 2 7 0 5l2 r 2 1760 n 77 13 0 0 0 1 l 1 2 2
35 56 )II cs 52 20 u11 0 1 a 1 4 0 ll r 2 l7ampl 55 JS ll 1 14 1 0 l 0 1 0 1 0 0 3 0 l17amp9 85 cs 53 2734 2 0 1 a 1 0
Ji F 2 1771 6 4G 3D 54 40 0 l 0 0 0 0 3 0 0
r 2 1 15 0 0 0 0 0 0 ll 28 3G 0 22 44 29 a Sl u47 6S u 28 0 1 2 0 1 s D 0 5 1
J 2 179 30 Sl 32 53
59 46 38 ll 20 36 16 17 Gil 56
lB r 2 17112 55 6t 48 39 F 2 1795 47 40 2G 49 39 l 0 l 2 l 0 0 l 1 l 0 0
u y 1703 46 15 1e 12 so 31 i2 ll 45 u 4l 25 56 35 J6 2e 2940 F z uoo as 55 61 50 54 53 so 58 2 s l 55 S9 JC 2 1 0 0 7 0 2 s 0 J
42 p 3 170 55 CJ 21 ll 24 G3 58 Jl 1 0 11 3 17011 75 75 86 25 2 1 0 l 0 l 3 3 0 17 65 14 0 J
43 r r 3 1715 25 Gl 15 40 43 a 23 58 46 0 3 0 l 0 l l
0 42 672 16 4G 43 55 45 ss 1amp 1middot~ F l 1716 22 Cl 3 13 48 4245 59 4446 I 3 1717 74 11 1 l 1 19 0 1 1 ~ 3 l 4 10 12 47 P J 1721 cs 18 0 24 0 3 a bull2 ~ 0 a 38 13 C2 2 3 (9 r 3 172~ 61 28 e 24 l 55 73 l 41Q 15 0 1 2 0 0 r 49 p 3 1730 8l 63 78 55 58 7G 65 58 73 6amp S 65 48 6B 66 54
1 0 a 0 0so F 3 1735 68 51 17 40 23 0 0 0 0 0 0 0 0 0 0 46 22 34 27 53 15 26 42
J 17lt14 70 511 58 u 341 72 37 54 S3 25 2 0 0 0 0 0 051 F 3 1742 47 3amp 0 0 0 52 F 53 F J 174 62 63 6 1C n 59 0 0 s 29 20 1 1 0 0
1 0 1 0 0 2 01754 QC 4111 21 51 20 l 0 0 1 3 0 ss F 3 158
5 17 34 l 31 25 0 s 15 0 a a 0 0 0 1 2 19
56 F 3 1761 57 47 55 48 ~9 49 12 38 40 55 16 0 3 l 0 2
57 F J 180 27 45 ll n
54 F 3
17 0 7 0 4 1 6 0 0 0 0 1 0 0 0 0 llsa r J 1Hl $( 51 23 24 H G 0 l 0 1 1 0 1 0 0
i9 F J 1H2 45 34 l 0 0 0 0 0 0 0 0 ll 41 62 2 0 15 J
0 F J 179 0 62 40 53 s 36 13 34 21 0 2 2 0 l 0 0 0 u r 1701 89 43 72 36 51 17 52 u 83 70 n 0 e 3 0 1 0
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
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1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
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so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
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171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
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39 35 21 55 7J
9 64 41
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58 JZ 1 n 60
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16 0 s s l
1 20 11 48 55
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0 1 0 0 0 0 0 0 4
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1 30
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71 7
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2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
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0 37
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
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15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
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53 10
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cs l7J
0 6
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32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
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amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- __ -- --middot bull bull l -- - -middot bull --~ ~ -middot - -middot bull middot-~ ~~ -~ middot~ ~~
Study lC13 IIHI)22 raT 0730 ~day SCp~-ber 30 18 20
OBS SEX G1lOtll JUIJi Nl N2 an 114 liS R6 N7 litamp m N10 Nll lillZ )11) 1114 NlS NH )(17 1115
52 ampJ amp4 65 66 67 amp8 59 70 71 72 J
75 76 77 78
F r F F F F F F F r F F F F F l F F
4 4 4 4 4 4
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1707 1714 1711 1726 172 1732 173l 17la 1739 1745 1751 1759 1754 1765 1774 177 1783 1787
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18 58 59
75 51 70
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11 55 274
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lS 5 1
31 43 19 12 54
lS Sl 23 5 n 33
l 0 l 0 1 0
a17 l9 so 20 2amp
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55 51
0 6 2
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so S1 92 BJ 84 85817 611 ampI 10 91
r r p r F F
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5 s s 5 5 s s 5 s 5 s
171710 1720 1723 1714 1727 172amp l73l 1no 1741 1743 1746
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Al 63 71 64 31l 59 60 49 ll58
32 54 41 26 45 24 53 29 35 40 51
1
30 20 62 32 sa 55 46 s
26 4
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92 93 94
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IS r s 1778 57 20 4 2 5amp 7 0 lO 0 2 0 10 u 9 0 0 3 0 96
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100 lD1 102 103 104 105 106 107 lOS 109 llO 1ll
I F F H M M K M Y M M M M M
s s 5 s 5 1 1 1 1 1 l 1 l 1 1 l
784 1788 17119 1793 1798 1402 1408 1432 U3l 1C36 1447 usa 1457 1452 1467 1466
58 55 66 3~ 79 47 49 57 49 29 lG 77 50 69 80 69
C4 5 G-4 53 sc
62 l
co 32 39 JJ 23 117 54 71
39 35 21 55 7J
9 64 41
l 0
58 JZ 1 n 60
0 l2
0 39 59 17
0 15
0 0 0
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2 l9 C7 Cl 47
3 0 2 0 0
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65
l 36 56 42
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3 61 59 63
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0 7 0 0
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3 0 3 0 0 0
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1 20 11 48 55
0 11J 2 0 0
20 0 2 0 0
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0 1 0 0 0 0 0 0 4
21
1 30
3
71 7
16 0 Q
0 0 3 1 9 l
43
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2 0 3 1 l 0
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1 1 0 2 0 0
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ll 0 6
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1 0
1 3 8 3 0 l 0 0 0
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2
0 0 2 0 0 2 0 0 4 l 0 1 0 4
bull0 Ul 113 114 115 116 117 1lB 119 120 lU 122
K M K If K H H H M M M
l l l l l 1 l 1 1 2 2
1470 1472 1471 1491 1415 14SG 1490 1494 1496 1405 l406
s60 79 94 61 75 74 52 51 64 7Z
52 as GJ 112 68 64 52 t8 so 79 u
32 6
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0 37
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4 S4
2 74
4
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ampe 0 1
0 0 5
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D l l
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54 54
0 0 0
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0 0 4
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0 58 1 0
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~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
~--gtgto ctCJbull rmiddot_ r ~ -n _11 bull-l rbull-oJi-Jnt r bull ir-_
0730 Wednbullmiddot~middot SOpt~r 30 ltlStudy 1613 RMD22~ 21
W17 lUIm 118 ~~~ NlO Rll 1112 NlJ me NlS me OilS SliX GROUP 1KIl all an lfl IJI4 115 0 1 0 1 1 0 0 lZJ K 2 lCll Z6 0 2 1 55 52 38 1C 12 0 0
u 10 52 0 2 0 0 0 2 1 0 0 0 2 0 124 M 2 1amp12 72 0 1 5
M 2 1413 29 70 1 Q 0 0 0 2 Q 0 0 0 l 0 115 0 0 42 8G S2 74 70
lUll 64 10 72 21 G5 u 55 22 1 0 0nli M 2 8 127 H 2 1434 0 lGl 1C 43 74 32 1 3 3 23 42 10 56 7l 74 73 0
60 u Cl co 3amp ss 22 27 33 16 0 2 0 1 11211 H 2 lUG
2 1453 32 0 l4 0 0 1 0 0 0 0 0 1 l 0 0 0 12 K 2 32 7C 76 eo 86 6g 78
2 1455 80 29 C6 15 1 l 1 0 34 0 u1)0 H 3 53 27 l 2 s 0 0 14 8 0 2 01456 64 Jl 43 14l31 K l 2 0 2 0 0 2 0 2 0 1 0 1460 4Q so 19 0 0 132 M 2
0 6 17 74 20 17 25 Sl 5 52 132 M 2 1463 ss 43 50 26 35 1 0
0 0 0 02 0 1 0 l 1134 Ill 2 146 80 G3 51 6 62 22 9 0 3 22 s 2 5 3 0 2 2 5 5 2 2
135 H z 1471 u li7
Cl 33 2C 2 20 1 2 0 0 0 0 lJii M z 1475 u 67 bull 0 2 2 0 0 137 M z lol79 36 sc u 1l 0 36 zo 28 13 19 44 Jf 57 35 lli 57 41 1 lC 15 0 2 2 1
14112 76 46 52 33 2 1311 M 2 0 0 2 I 461495 li7 Je 26 1 2G 51 32 0 2 1 0l3J M 2 140 M 2 1500 74 64 GZ G8 76 71 s 76 u 55 6Z 63 GS liS 65 57 31
141 M l 1403 20 3J 10 0 0 0 0 0 a 0 0 0 0 ll 0 0 0 Q 0
142 M 3 UOoamp ez u 6 0 12 17 20 2
0 27 Cl u 1 2 l 1 0 28 C1 57 12 0
143 K l 1409 62 e 20 0 0 3 c 0 5 1 8 2 2 1 H0 2 0 u1U M 3 1415 51 4l 13 2 1 2 1 0
l 0 0 0 1 0 0 0 21 59 C1 ce145 M 3 1416 52 38 37 Q 0
l 1 0 z 3 0 0 l 0146 tf ) 1417 68 38 1 n 42 1 2 1 147 tf 3 1421 52 53 li1 16 2 0 0 4 0 2 0 a amp J sbull 148 M l 1425 eo co u ll 0 0 67 51 36 53 15 60 2 2( 45 5 22
Q 0 0 a 0 1 19 12 s14 M 3 1430 61 33 3 12 0 0 0 1 0 Q 1 0 li 24 Q 2 0 0 l Q 1
150 M J 1435 75 51 11 0 J 1442 57 u Ji 0 0 53 1l 36 24 6 0 1 l 29 56 30 co151 M 230 2 2 44 l5 0 1 2 0 l 1lSZ K 3 1444 41 ll 30 so 0
153 H J uu 58 0 11 1 2~ 0 0 0 0 s c 1 0 0 l l4 SG ca 154 H 3 usc 72 CJ 54 Joamp lZ 1 2 1 1 l 0 1 a so Sl u 51
155 H 3 1458 7 64 22 2 0 ) 0 0 19 3 2 l 3 l 1 l (
l 0 0 0 0156 H 3 UGl 71 ee 7G 75 511 51 2 0 7 0 1
Q 0 1 0 l157 M J 1480 75 2ll 48 51 4 0 0 0 1 11 4 3
lO 72 201491 82 57 1 0 l 8 0 1 1 0 a 4 51158 K l 2
0 1
0 0 0 1 4 i 53 37 30 10 11 l4 27 015 K 3 1492 amp5 10 13
21 0 0 1 l 0 5 2 0 0 0 9 1l 3lliO H 3 141~ 78 7 2 1 3 01G1 K 4 1401 59 u cs 67 48 12 1 0 1 0 l l 0 1 2
40 0 0 0 0 1 0 0 j12 ) 1407 72 8 59 45 16 0 2
12 0 0 2 5 1 c 07 Ci 18 8 73 sz Sl 2 311Gl H 4 uu 72 63 n 7S 15lS 59 14 57 15 58 0 0 0 2 2 28uc M 4 lCl GO 165 11 4 1426 45 72 51 0 15 0 1 1 0 J 2 0 R 4 0 0 5 2
UG H U29 93 50 14 D 0 2 0 so 36 2 1 0 I) l c 0 0 0
167 M 4 1432 64 38 22 0 0 0 1 0 0 0 2 0 1 0 0 0 0 2
4 U33 ss cs amp4 23 18 G J Jg 38 51 56 a 2Q 49 1 0 1 01611 M 114 1U8 u 15 l 0 a 0 0 0 1 0 3 0 7 3 7 l 38 170 M 4 1439 16 55 68 5 2 1 8 7 0 l 13 0 0 15 18 calU H
1445 56 Cl a 3 1 2 10 0 3 1 0 1 0 1 4 1 0 0171 H lZ H 1451 118 37 52 u 23 12 3 1 16 0 0 0 0 l 21 59 42 173 H usg 52 61 40 17 4 5 0 l 2 8 s 2 0 2l JS ll
174 M 1464 68 37 14 32 4 0 0 bulll 0 0 0 0 0 0 lS 22 46 35 15 11 c 1465 l4 S2 45 a 25 6 41 s 0 amp0 75 28 34 22 1 0 3 176 M 4 1474 G7 2 ll 20 31 0 14 0 2 4 14 12 3 1 0 0 3 l 177 H 4 147G 66 59 29 15 0 0 0 2 1 0 a l G2 u 54 45 18 C3
178 M 1483 3 23 0 3 1 0 s 30 3 u 2 0 0 0 1 0 l 0 17 N 4 1487 74 6~ sa 37 10 30 20 7 II 55 30 CQ ampB 72 53 1
S5 31 0 3 1 0 10 2 1 0 l l D 0 0 1lBO M 147 66 3 lBl H 5 1410 71 41 J 0 8 0 I 0 3 2 0 0 0 a 0 l 0 34
182 M 5 lUO 87 69 58 10 53 59 ll 2 s 15 15 3 25 GO 63 36 183 11 s 1423 77 80 G3 71 56 2 e 47 9 0 18 4 5 0 1 0 0
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
_- _ w- __ middot__ u-ul middot----middot-middot w~ ---- --~ -middothmiddotmiddotmiddot-middotmiddot
e r Proe~wo
bull
St~ 113 8MD22~~ D7tlO weecea4aY Sept~r 30 1991 22
OilS SBX aaotn raquomt Nl an Wl )lS we N7 wa lll9 llllO ml Nll N13 Nit IllS )116 1117 NlS ()184 K 5 1424 44 53 43 u 45 n 67 30 28 0 0 l 0 s l 3 l
111i H s 1427 G2 54 34 1 0 3 0 1 0 0 2 0 0 0 0 19G M s 142 38 27 14 0 40 52 0 0 0 3 0 7 0 0 2 0 s 52 187 M s 1437 90 55 47 2 s l s 0 1 J 7 1 J 0 0 2 41 saa g s 1440 91 52 96 61 13 0 0 63 53 l 3 0 3 1 0 0 3 0 111 11 5 1441 u 28 17 0 s 1 1 0 2 0 2 12 25 32 51 39 37 uo K s 1443 ll 26 1 0 61 23 4 1 0 0 0 0 20 56 59 21 l 1111 M 5 1448 7l 58 ss 3 0 l 1 1 2 1 l 0 2 3 1 s 0 uz M s 1452 55 53 52 20 0 0 3 2 JJ 63 6J 28 38 2 0 0 U3 M i 146amp 78 7$ 51 64 34 28 54 4 39 21 4 17 1 3 8 6 0 14 M s 1473 56 31 59 12 34 SJ 0 32 0 0 1 0 1 0 0 1 0 1 195 If 5 1478 SG 47 9 37 10 2 0 0 0 0 0 0 4 1 lC 41 43 196 H s l484 80 43 60 ss zo 0 0 1 8 2 6 0 0 s 0 34 l 197 K s 1CIIB 50 GO 51 ss 40 44 ll 35 37 10 0 1 0 0 0 0 0 0 18 K s 14l 74 u 60 43 47 6l 35 10 6 16 0 s 9 67 63 19S Jl s 1493 68 65 68 8 30 3 2 16 55 75 30 1 s 4 2 0 200 fl s 1496 65 1gt 6 1 0 0 5 4 0 z 0 5 0 0 6 l 70
Study 1amp13bull NKDI2ampAT 07bull30 Wedaea~ SU~tembcr JO 1998 2l
General IJnca- Koclels Poee41ue Claa2 Level nformatio~
C1US Lsvols values
GROUP s 1 2 3 4 s SEX 2 PM
Nwnber of cb5~va11ons in clampta nt 200
Study 16 0730 Wodnaday SepceMb~r 30 198 2
Gonoral Linear Mo Repeated Kea~urc~ Analysis of Variance ll~a~ Maaour Level Infon~amption
Cep~6ent Variable Nl N2 NJ N4 NS NS N7 N8 Nl NlO Nll N12
L~el ot BLOCK 1 a 3 s r 7 8 9 10 ll 12 bepend~nt Var~ablo N13 Ill( NlS N1 Nl7 N18
tcvcl of BLOCK 13 l 1S lS 17 18
Maacva Test Criteria and ~ec F seaeiaeiea for the ftypotheampla of no BLOCK Effect U = Type ttt SS~CP Nltrix for 11100 E Error SStCP Macrix
Sl M=7S JsG
Statistic Value F Nwn Cl Den DF 1
Wilks~ OlOCBUS 8738GO 17 174 DOODl Pilli bull 1 lrce 089515305 873860 17 174 00001 Hotolling-~w1ey Trace 853771180 87 l860 17 174 00001 Roybulls Greacese ~ooc B5377lla0 87 38GO 17 174 00001
Manova Tqoc criteria acd P ~oximations tor the RYPocheis of no BLOCXGROUP Erteet R =Type ss~CP Matrix tor BLOCKbullaaour E =Error ss~op Matrix
s~bull M~G 111=86
stacitie valuo F Num ElF Den DF Pr gt F
Wilks Lambda 08ampi9309 10132 sa 6BSl(39 04514 Pilla s Trace OlSSSG lOl7l 68 708 0442 Hocellir~middotLampwley Trace 03~7606 10093 68 690 04599 Roye Creamptest Root 017558379 1881 17 177 00277
NarE F ~eaeiacic fer Aoya Greampeese Root ill an uppor bound
Manova Test Criteria and Exaee P seaeiaeicc for the HYpothesis ot no ucoCKbullsEX Effect K a TYPe III SS~CP Matrix far BLOCXbullSEX E Error SSCP Macrix
Sl MS N=B6
StlCIatic Value F Null ElF Don ElF Pr gt f
Wilks llllllbda 07731390 29935 17 1 00001 Pillai bullg lraco 022amp211amp10 tl35 17 14 00001 Hotal1ingbullLawley Trace 02946amp0 291l3S 17 174 00001 Roya Grc~tea~ Root 029270 ZJ93S 17 17amp 00001
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
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1 77 24
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l 35 62
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I)
22 66 n S
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15 41
0 411 11 70 60 57
0 5
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9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
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53 10
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cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
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116 14
l 79
3 D
43 45 1
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45 0 A 1
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0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
25 General tinear K~h Prceedu1
Rcpeampucl Keuurea Malr~is of Vari~~~~ee
Man~ Tee Criteria and r A~~ions for the Hypothe=ibull of no a~middotOROUPbullamptx Effect K =Type lU SSfltcP tberix for lltOC~middotCROUPbullBEX It = Error ampSCP Murix
8bull4 Mbull6 8G Value F N11111 DP Den DF I gt
Staeietic 06640317 11077 68 851419 02658
Willt8 LaiObcb lgtillai bulls ornebull QJCOQU 11060 68 708 02685 ~~ellingbullLawley Trace 04372179 11092 G8 no 02533
2101l 17 177 oooukoyl CrateRC RoCC o2oZCG871
Study lll NMD22RAT
Gen1ral ~Deat Hodelbull Prcebullclura ltiiPGll~ld lile=uree Malysill 01 ~riARce
leata of RYPCth for JJetween Sllbj 1gtCC~ Effect
s urce
GMUP SEX CIOUlbullSEX
Error
CF
4 l
bull 190
type Ut SS
aaaaun2222 101336111111
20SU402777711
oUG0932888U89
57203430556 lO 13 3 G11111l S200059444
F Value
026 0-middot 238
Pr gt F
09025 0amp971 0053
StUQy 1613 ~T
Source
BtOCK ltOCKGRCUl BICCJtbullscx BZOCKbullGROUPbullSEX
PF
17 68 17 68
C1neral Linear Mode1a Procedure Repoaecd Mesures Analysis ot V~rianco
Univ~ri~tbull TeDe~ of Rypo~heses tor W1th1 SUbject Effectbull
TYrgtC III SS Mean SQUIUtlt P Value
607750738889 3550 043464 lOSSJ 1amp397 152776 358781651 10 20074618889 1180859935 )49 22318467222 lU 212753 07
Pr gt l
00001 OJ48G 00001 05503
Aciiunel1 c - c
00001oJn3 00006 05162
Pr gt F H bull F
00001 037 00004 oS1U
v
ErrcrllltOCK) Jl30 1094257911111 338779539
~bullbullnbouaabullCai2~er pcilo~ =o4SG3 Huynhmiddotleldt Epsi1a~ ~ 05001
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
0 1
53 10
0 l
cs l7J
0 6
73 8 3
32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- __ --middot~-
__ middot-- -
StucY 1613 ~RAT 0730 lfedDeoday Saptber 30 1ttamiddot 2B
ODS SEX cmotJP ANIM Nl W2 all 214 NS N6 N7 N9 lll9 al10 N11 Nl2 N13 14 NlS NlG Nl7 V1B
1 F 1 1702 69 u 60 65 41 48 55 28 51 57 27 l 3 64 5~ 54 so z 1 1708 64 n 65 61 73 53 44 41 fi l l 0 1 l 28 57 52 3 F 1 1722 69 60 71 71 79 n fiB Sl 51 53 25 2 0 0 0 0 4 F 1 1731 10 Ql 70 6 110 73 u 18 1 36 ss 60 15 9 J 2 5 F 1 1736 57 70 53 66 36 30 35 l1 D 0 0 0 1 2 2 l 0
p 1 1747 61 64 63 33 1 0 2 0 0 1 so 65 35 0 2 l 0 1 F 1 1750 65 12 75 66 6 71 63 74 81 33 3 5 2 1 l 3 61 8 F 1 1757 67 Sll 57 n 70 57 45 $1 0 50 g 0 0 28 39 59 60 9 F 1 1762 55 69 aa 72 73 65 73 72 56 42 60 51 ltamp9 n 510 F 1 1767 62 72 5 59 5ltamp 53 1l 78 62 51 5 63 68 6amp 111 s11 F 1 17615 56 19 62 fiB 55 51 Sl S7 5 0 0 3 0 1 0 0 0 12 r J 1770 Sltamp 611 59 Sll 59 60 54 G2 55 6J 61 46 70 liS 30 l6 0
1J r l 1772 58 co 51 58 C5 59 u n 60 Sltamp ltamp0 l 5 0 0 14 F 1 1717 amp1 13 60 G7 51 55 51 73 40 52 ll 14 4e 58 58 12 0 0 15 F 1 1181 56 63 6l 54 72 SG GO 48 58 42 G7 lil amp3 (0 711s 8 ~ 16 r l 1785 61 60 75 5 60 ampl 59 83 56 GS 59 lil 65 80 27 13 03 s17 F 1 1786 GG u 52 6t 58 71 62 6 72 66 62 25 0 5 23 77 18 p 1 1790 81 64 711 82 u 48 23 29 5 64 GS so 33 31 61 lt p l 171ltamp 58 55 7( n 46 55 4C 25 3l G7 C2 29 2 0 8 0 s 0 20 1 17U 51 54 65 sa 59 61 ampS sa 36 64 54 3G 0 1 31 58 52 ll n p 2 1705 GB 55 ce 53 61 61 53 35 0 0 0 l 1 1 1 21 u 22 f 2 1706 GB 65 88 72 79 62 8l 52 0 2 2 23 72 8l so ss 2 23 F 2 1711 43 37 63 ss GO 56 52 59 51 3C 29 69 62 so ce 19 24 F 2 1712 7 76 68 11 60 69 64 73 sc 34 7 0 0 D 282 25 F 2 1713 sa 57 67 70 73 57 16 0 3 1 6 53 7l 59 57 21 1 226 F 2 118 61 85 7C 72 8t ampG 88 8 78 113 81 1 0 0 Jl 73 27 F 2 173ltamp 66 114 88 8B 93 70 79 Ill 77 86 76 liD 51 34 l 0 4 i 2B F z 1146 74 63 61 50 co 36 36 1 2 0 0 42 14 47 7 1 1 2 r 2 153 67 6Q 5 SB 38 62 211 0 l 0 7 55 30 l 0 l Q 30 F 2 1755 76 75 14 61 91 75 69 55 52 2 G 0 0 4C 77 67 610 31 r 2 1756 75 61 11 C6 77 71 51 G7 G3 72 J9 19 0 0 0 0 0 32 F 2 17amp0 53 59 67 19 811 81 114 77 52 0 11 0 0 0 S7 611 67 24 33 r 2 170 59 67 72 72 5 ss 70 Cl 76 48 58 73 G2 54 52 1 0 0 34 F z 169 78 72 78 83 7S 90 14 42 75 78 84 65 2 1 l 29 58 Sl 35 P t 1771 36 5 55 liS 50 li9 ltamp3 so 64 65 31 0 0 22 64 14 0 36 p 2 175 61 65 6S 67 gs 61 57 54 52 CB amp2 25 25 1 0 0 31 F 2 1719 75 BB 59 74 l 75 n 43 1 1 6 54 62 64 46 111 c 38 F 2 1782 64 56 amp1 83 6 70 48 63 64 eo 80 69 54 56 GB Sl 2 l9 F 2 1795 58 74 SG GS GO GO 55 53 1 0 zs 72 59 58 4l 57 ll 0 40 F 2 1800 55 GS 66 6R 77 75 67 75 63 77 68 68 74 70 ~ 0 1 41 T 3 1703 65 60 44 63 76 64 74 21 1 1 2 Q 22 2 1 4 1 42 r 3 1704 55 55 62 59 41 6 59 57 58
52 32 3 0 40 Gl 43 F 3 1709 48 C9 79 70 fil 74 0 21 0 0 5 66 45 3 0 13 44 F l 171S 59 52 51 62 64 66 13 72 Gil 61 Gil 73 Ill 63 GS 16 7 l cs F 3 1716 49 ltamp9 47 43 60 48 0 0 29 5 66 45 29 l 0 0 0 0 46 F 3 1717 so 68 60 66 71 61 73 52 13 3 0 0 0 2 0 0 21 2 () ~ 2 171 60 64 76 62 78 53 22 2 4 4 3 17 76 77 19 42 24 s 4ll F 3 1725 68 65 66 64 67 5465 59 6 70 55 l 0 0 10 3C 51
F 3 1730 42 33 4G 75 50 u 511 71 54 5 48 9 4 1 Q 0 02so r 3 1735 72 67 60 70 4G 63 62 67 55 67 23 lC 66 67 57 79 G3 SG ~8 Sti 51 80 5 7l Gl 10 79 48 9 151 1 3 1742 55 65 55 GG 52 r 3 1744 75 19 72 61 40 59 67 67 as 40 GO 51 5R 52 so 653 F 3 1741 amp2 lipound 76 75 64 22 0 38 S7 59 S 74 (2 0 0 354 F 3 1754 6S GO 72 59 81 68 58 69 74 81 70 54
0
lli 1 l 0 1 lss I l 115B amp3 55 12 69 69 75 61 46 so 55 amp1 54 72 21 0 1 IJ l56 r 3 ~761 54 Ill 70 4 56 57 75 63 ss G4 6ltamp 66 48 53 57 0 3 057 3 1780 pound7 72 87 GS 6G 58 lA 0 0 22 so 6ltamp 55 17 H 1 0 058 Y 3 119l 64 5 65 63 G1 S 51 as 4 39 33 12 0 1 19 JO )59 1792 67 59 64 GO 59 51 47 54 10 3 0 37 32 3 0 1ltamp 61 2560 3 1719 GG 87 63 55 5 69 51 68 31 2 0 2 1 l 1 0 5 2lil r 4 I7Ql 69 75 83 amp9 74 71 72 75 ltampS 0 0 D 0 0 3 39 59 61
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
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1
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55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
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63 74
60 St
81 55
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n 63 7amp 66
6 10 55
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61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
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72 l 5 l
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27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
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l1 ll
1 0
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0 69
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147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
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1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
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71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
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62 66 70 78 87 57 71 65 72 54 52 61 27 68
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54 52 69 61 50 63
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B 54
6 56 63 77 12 26 70 56 75 60
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l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
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sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
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0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-- ---- middot--middot-middot --middotmiddotmiddot -middotmiddot middot-middot-middoth- middot-middotmiddot -shyr shy
S~~ 1613 lliMDSt KAT 0730 Weclluday Sept~er lO lttl n
086 SIX GPOUP Nml N1 112 113 N4 ~middot NS alii 117 N8 1110 1111 1112 N13 me 1115 JllG Nl Wll 1 r 4 no 73 l4 0 0 1 Zl 5 53 Sfi D ~ 0 2 z li3 4 1714 73 7B 74 75 63 2 J 0 0 I 0 22 7l 10 7l 7l 75 4 1719 81 71 co II ll CD 52 47 li7 u li4 13 JO 17 40 liS bull 121i 56 70 C6 58 u 72 511 60 11 57 I5IJ 54 ct 56 33 22 0 55 F 4 1729 59 611 13 co Ill 76 63 72 58 1 5 2 0 l 35 32 1 67 I c 17l2 58 46 2 1 53 amp0 n 20 D 3 4 ~ 2 5 liS fill 4 1133 54 n 515 u 73 35 5
bull5 0 l 0 l2 C9 C1 2C gu f 173amp 56 co ll 68 sc C2 2 1 1 l 1 7 l 1 70 II bull 173P
lil 68 t5 72 54 78 63 54 15 0 0 23 tl 65 n tl cs
71 F bull 1745 78 80 7pound 81 57 ce 74 63 3 2 0 5 0 cs 75 12 F bull 1751 48 Cl S7 52 ttl 43 49 ll ll 47 38 20 l9 u 40 0 l 3 p 1759 66 75 56 66 amp6 43 C8 36 3
53 52 11 0 3 1 0
74 I 176laquo 70 72 5 bullbull 67 s 25 ll 0 l 1 39 ll 47 73 co 0 75 l 1755 65 C5 55 55 73 52 u 59 14 0 2 0 1 2 76 F 4 177C 54 64 74 68 76 73 5 74 as 56 so J 77 F 1776 C7 u 55 ss 51 54 52 u 2S 59 amp1 511 12 7amp II 4 1713 72 81 n 73 55
36 2 34 90 77 38 u 12 10 3 2
r 4 178 62 u u 51 2 33 27 0 0 0 H 71 55 54 2 0 0 eo F lP7 56 ao 70 55 n se 42 45 45 u 5 l 0 a l 81 r 5bull 1710 70 71 5 72 66 411 Z8
az 12 71 56 H 22 2 0 1 1 82 T s 1720 eo 73 Cl 56 lC 3 0 21 10 71 41 1 1 3 7 l Ill 5 1723 u n 58 55 51 70 59 71 57 6G 66 4960 28 l 0u F 5 1724 71 74 II 110 l8 12 0 0 31 58 87 76 J4 23 0 85 5 1727 60 62 S3 70 u 61 n 55 63 3 60 21 I 0 0 0 2 16 F 5 1728 51 64 50 3 73 60 u 10 1 62 53 53 67 74 n u287 l 5 1737 65 110 74 G7 Ill 0 12 75 58 6 53 11 0 7 l 0 1 0 88 F s 1740 57 67 7l 71 65 65 n 72 n 53 78 44 62 52 5t 8 r 5 141 60 42 47 47 55 42 53 u l l 10 2 43 5255 64 1 31 0 F s 1743 61 5( 71 amp9 7l 48 l 67 61 51 0 0ln 5 1748 69 71 n u 87 66 68 52 17 a 4 1 25 BJ Tl 82 59 23 n F s 1752 52 63 55
~2 n CJ 3
2 5 0
0 6 TS ss 291 F 5 1766 70 71 70 69 70 IJ 57 S4 u 65 61 3 1 24 73 781
4 F s 1173 56 77 u 60 40 52 0 0 1 0 n 34 ll 1 1
F 5 1711 55 48 Sl 51 52 20 58 48 52 l5 2 0 0 1 0 u0 139 r s 1784 65 55 0 lO 63 57 56 59 41 9 5 44 co u 10
fi s 2 5
z97 T 5 1788 54 GJ 152 3 70 59 52 57 33 0 0 14 54 71911 F 5 1781 G6 liS 64 74 5 82 89 72 70 Ge 64 Ill 76 58 z 0 gg F s 13 72 63 54 u so 66 72 GB G7 51 56 63 H 52 55 53 6S n
100 r 5 17t8 GC 59 6~ G2 ss 73 45 26 1 5 4 t lil 58 sc u101 Ill 1 1402 57 77 71 G 41 40 56 81 56 63 113 66 58 55 1gt1 26 102 Ill 1 1408 50 77 56 52 5 5 1 0 0 18 0 a sa 61 71 34 47 2C103 Ill l 1422 73 73 59 Sl u 68 75 fil 58 63 55 77 50 0 5 9 61 14104 Ill l lC31 66 61 Ill 1 65 52 76 60 6G n SB 78 67 64 R2 59 79105 I l 1436 73 13 5 56 62 64 63 36 SA ll 38 lit 2 2 5106 M 1 1447 CB sa 67 78 B ao 71 55 76
8 6a 63 ll 51 5
s 2
1
4
l
107 M 1 1450 35 t 36 Jl T 2 l 0 l 5 8 22 2 0108 M l US7 Ill 71 63 68 83 ca 4A 55 62 l( 30 ll 7
5
109 If l 1462 43 65 56 59 58 65 37 eo 51 2t 22 5 JS 0 4 l0110 I 1 lU7 70 72 10 68 72 72 J 56 73 sa 293 26 l l111 M l 1468 73 75 0 73 77 76 73 78 7l 62 73 71 CS3 liS 51 n1lZ M 1 140 65 86 86 u Z 86 74 80 71
55 co 73 73 78
e u75 54llJ l 1472 80 88 7A l 0 70 87 6P 47 ss 20 g 0
1 0 1 0114 M l 1477 65 77 112 77 77 54 l 82 67 76 64 GO 54 35 13 4115 M 1 1481 47 63 59 GO 57 GQ 70 67 76 79 13 61 CG JO 0
0 11G M 1 14115 65 64 74 70 53 fi8 57 2 20 14 5 2 0
n 0 12 lll117 1oamp86 67 15 ti9 54 7l u I 1 61 63 so u 113 72 G8 84 53 23 70 so118 I l U90 52 74 71 S l 18 33 27 e 1 2 0 2 2 7 2119 Jl l loamp94 83 73 61 59 n 62 51 5 0 55 J7 58 52 2l120 0 6415 l 1496 5 63 56 32 25 10 1 1 14 61 61 71 79 ll121 M 2 1405 S 57 62 Sl 51 74 54 44 H 57 64 ll S3 36 1 14 1111 M 2 140 68 3 79 70 n 74 62 co 39 3 48 It 62 GS 77 78
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
0 2
48 0 0 0 l
42 J ll
a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
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53 10
0 l
cs l7J
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32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
3 D
43 45 1
GS l 0 D 0 6
n 47
8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
30
-- ---- middot---shy middot--middot -shy
G1udy 1613 NMDS 1AT 0730 Wednes~ SlpCISIIgter 30 ltlll_
OilS SEX Gl0111 Allm Nl N2 IQ NC xs at6 117 IIS N10 1111 Nl2 1113 N14 NlS 1116 N17 1118
12~ 124 125 126 127 128 12 130 131 Ul 1l3 U4 135 136 137 138 13 140 141 lU 143 144 HS 14G
M M M M M K M K 11 M K K K rt M K M M 11 M M M M M
2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 l 3 3 3 3 3
1tl1 lU2 1U3 1416 llaquoH 1446 1453 1455 1456 1460 1463 1469 1471 1475 1(79 1U2 105 1amp00 UOl 1404 1(09 1415 1416 1417
67 Sl GO 86 61 65 45 67 54 511 7Z C1 59 61
55 69 56 71 611 59 liil 69 65
73 a a co 67 62 sa 70 77 77 8
70 70 58 59 fiS 77 ampJ l 57 60 73 67 73
76 S 57
5 62 51 70 51 72 78 62 51 52 64 18 G2 67 65 58 57 83
70 79 n ca
83 73 51 65 52 53 74 Sl 7J 61 ~1 73 65 58
78
amp3 3 70 5 10 so 511 51 52 amp8 ss 71 73 71 74 59 35 so 70 88 77 73 u
6fS
71 4l SJ
57 72 71 50 10 61 6 7( 70 82bullu 58 73 51
5 60
7 66 47 67 62 62 Cl 54 74 (2 70370 u 18 0 59
ampS 22
17 31 60 72
311 70 78 55 G8 63 77 C7
s 611
9 60 57 52 (0 73 50
75 l( 65 7S 41 15 76 as 23 76 84 63 (4
l Qll 66 79
2 (6(2 27 1
63 74
60 St
81 55
5
84 H 78 1
n 63 7amp 66
6 10 55
43
53
61 70 77 74 71
1 70 18bull33 57 amp6 61 55 u 55 a D 4
57 34 63 34 40
27 co 63 68
4 63 (2
45 (5 55 so 68 72 67 27
1 l
17 3 54 14
17 30 I 62 81
1 62 69
4 71 25 56 59 23 $7 7 11
z 59 ll bullU 32 42
l 12 71 60 Cl 1
25 71
0 31
1 58 67
0 56 Gil 10 7pound
1 78 l
2 1(
2 1
72 l 5 l
12 2
27 0
68 57 27 32 66 77 51
6 70 30 74
1 36
D
l1 ll
1 0
7 1 0 0
u middot~ 1 26 52 22
0 69
58 1
29
81 0
76 12 67
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48 0 0 0 l
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a 63
0 0
52 16 651
s
l se
4
3 0 s 0 0 0 2
1 6J ll 1
1 0
77 56 77
0 a
147 us 149 150 151 lS2 153 154 l55 156 157 1SB 159 lSO 161 1152 163 164 us 1amp6 167 1118 169 170 J71 172 173 l74 175 l7amp l77 1S 179 190 181 1B2 183
M M M K M K M It K K M N M M M l M M K M M I(
tot M K M M M M M M M M li M M I(
) J 3 3 3 3 3 3 3 3 3 3 3 J 4 4 4 4 4 4 4 4
4
4 4 4 4 4 4 4 4 t 5 5 s
1421 145 1(30 1(35lUZ uu lCU 1454 1458 1amp61 1480 1491 l4t2 1411 1401 1407 14U 119 1t2G 1429 1432 1(33 1438 1U9 1445 1451 1459 1464 14GS 14(1476 1483 14117 14 l4l0 l4ZO 1423
46 58 57 52 64 Sl 87 52 56 71 64 74 62 56 68 62 77 51 70 58 59 52 60 67 72 75 58 59 60 55 63 72 72 71 GO $3 n
ss 65 67 56017
58 75 fil 54 69 66 55 71 S3 411 63 liD 77 51 61 u 60 71 65 68 63 amp9 58 61l Ill 64 70
62
ss 66 72
172 u
71 79 72 6l SB 69 72 GS 53 42 66 70 80 65 63 60 61 65 60 69 64 76 69 73 67 60 Cl 70 72
56 6S
sc 48 58 29 59 70 66 60 74 63 72 61 79 67 47 5( 1l 75 53 61 66 84 7S 73 75 72 70 74 54
75 72
70 se 71 (Q 52 58
2 66 69 70 116 83
7G 51 74 BJ Sll 61 57 77 68 12 68
s79 ao 66 76 69 59 (3 67 (4 li 61 79
amp1 57 70 75 n 55 31 59 58 63 77 63 52 67 77 6l
62 66 70 78 87 57 71 65 72 54 52 61 27 68
47 72 BJ
52 60 51 59
Bl 0
75 27 75 79 41 57 so 70 75 s so GS 86 GS 84 G2 (7 71 83 so 62 54 30 78 24 14 53 sa
54 52 69 61 50 63
0 52 u Cl 26 55 58 66 7( so 56 57 S ss 56 44 64 liS 56 56 64 64 11 75 ll 49 69 52
611 56 73 25 32 51gt a
71 1
7S 59 69 61 72 78 83
1Go $( ampli 73 14 73 73 53
B 54
6 56 63 77 12 26 70 56 75 60
77 52
4 2 6
57 Q
57 Q
88 51 ampS 29
l 6401amp 74 (8 72
3 G9 GS 71 2( 31) 65 36 31 64 36 77
as 69 76 61
so 4(
0 21
0 C2 1
C4 a
18 69 65 17
7 80 u 62 73 51 53
D
57 31 JO
0 72
I 40 66 26
8 (9
59 75 70
40 66 10
0 1
69
62 0 J
80 74
1 11
0 81 69 51 Sl s
59 sa
1 4 s
66 2
20
1 (3
3 61 55 87 51
17 62
0 0 1
0 sa
l 76 62 ss
G 1
59 (2 29 72 35 28
1 77 24
0 23 10 34
l 35 62
0 12
I)
22 66 n S
2
25 0
15 41
0 411 11 70 60 57
0 5
li7 11
9 61
0 4 8
77 ll 32
0 0 4 0
59 61 1
61 6 4
51 88
l 45 53
4 l
5 27
l 75 51 Bl
1 6
80 0 0
57 l 9 0
53 1
65 1 0 0 0
so 90 11 45
0 5
53 77
4
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cs l7J
0 6
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32 0 0 1
Sl s
s0 0 2 0
72 66 35
0 0
so459
lS J3 37 6 1
10 57
0 7 7
37 a 1
116 14
l 79
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43 45 1
GS l 0 D 0 6
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8 1 0
n 79
32 65 a 6 0 1
45 0 A 1
56 42
0 G
amp0 s l 2 3 1
31i D
liS 2 1 0 1 1
66 13 52
0 0
sa 611 38
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
(~~middot ~~r-bull __middotrbull bull bull bull c --~~-J~-c II bull-- bull _r __ middot-middotmiddot r If
Study Ull IJIICI)59 ItA C7lC w~day Sept~r 30 191
31
OIIS
184 us 18G U 118 119 190 Ul U2 U3 U4 us U6 1 U8 n200
szx
M H H H M K H H K N H K K H M H K
CllOUP
5 s s 5 5 5 5 5 s 5 5 s s s s s s
ANIH
1U4 1427 1428 1431 1440 uu 1CCl 1411 US2 1amp56 U3 1478 U84 1488 1489 1493 1498
Nl
73 70 51
middotn GS sa 63 GIS 58 61 65 amp7 J 45 65 611
N2
u u G2 G7 Gl 73 10
ampa G u D 57 63 6Z 70
112
GS
S 55 66 65 65 73 73 u
G7 72 Cl 53 n (6
ItS
l 6 51 57 65 60
58 72 0 7C 74 79 115 51 a2 72 74 Gil St sc 59 70 1 71 55 n u n 51 u G4 G1
)17 Nil Jl10
u 68 73 51 ampl
l2 711 14 u 3 10 43 81 41 57 65
56 63 110 7S 74 72 58 7C 7) 86 72 51 12 71 73 56 81 n 60 58 53 amp3 u 68 65 G2 58 65 66 57 4iB 4l 14 l 6 42 u c 6 S7 5 56 JO fi1 79 76 76 72 58 64 53 7l cs u 57 7 56 70
seuey 1613 ~SkAt
N11
70 56 2
65 66 11 710 85 G4 15
1 l
GO
4 69
1112
67 5
a 711 53 73 6l 17 u 1
0 1
59 ~~~
2
1113 ICU ns 72 co Z 25
1 u 51 Sl S2 so so t2 7S 70 59 u 61 3 79 l8 21 2 0
0 0 55 co
2 0 0 8 0 0
10 45 49 59 65 7l
0 0 1 19 2 27
0730 Nedneaday
11116 1117 aile
21 s 0 12 32 c 27 Q 0 12 15 30 n 4 l 76 II Cl 6 Gl 7l
3 u J 1 1 1 I 1 51
81 l2 29 0 0 0 2 3
73 67 lO 54 73 87 12 st 53 0 62
SeJ)tUr 3o uu n
oeaeral tUaer Models Procedure c~bull Level Tnformatioa
ClABII 1-nllll VBlu
~OUP s 1 2 J 4 5
SEX 2 FM
NIISiber gf oburvatioaa in data set bull 200
Study 1613 NKDS9RAT 0730 weaneadaY SeDte~r lO 1998 J3
G~eral Linear Hoeela Proceaure ltepeAttd Meaaurea Analysis of Vllriance ft-te4 Measures Level Info~tion
Depencene Variable Nl N2 Nl Wamp NS 1117 Nl m WlO N11 Jill
Level of DLOCK 1 2 4 s 6 7 8 9 10 11 12
Dependent Vrbble W1l IIIU N15 N16 N17 Nl8
ZRVltl of BtOCX 13 14 lS 16 l lA
Manova ~eat ~iteria and 2Kac P sestiaeic for the Hypothepoundiamp of no BLOCK Ettect H bull IYPbull III SSIOC MBtrix for BtOCX =Error SSlCP Matrix
S=l lj7 s N=l6
Statiuic Value F 11uft llF Don DJI Pr gt F
Willebull lllmbda Pillsic Traee Hotellina-Lawley Trace Ro~middotmiddot Greateat Root
020zllS2 Q 7li7B6471 347111175 39471817S
404006 404006 4Q4DOG40400
17 1 17 17
17amp 00001 174 00001 14 00001 174 00001
Manova Tebullt Criteria ana F Approxiaaeiona for ~e Hypo~ebullibull of no ~LOCKbullGROUP Ettect H a Type rrr G~CP MAtrix for BLOCXbullGROUP E = Error SSlCP Matrix
S4 Ngt86
scacitic Value F Nllll DF Den llF lr gt 1
willa bull tllllbch 066D869tS 11216 68 6851439 02430 Pillaibullc Trace Hotelliao-Lawley Trace Roymiddot~ Gr~at~at Root
031808949 OUJQBzll 020230424
11187 11240 21063
flB GS 17
708 0247~ uo 02191 177 000115
NOTE Y Statistic tor Roys Greatest Root is an upper bound
Maaova Te~t Crit~ia ampDd Exact F Statistics for tbe Hypotnesis ot no ~middotSEX H = Type III SS~CP Matrix for BtOOKbullSEX E bull Error SSCP Matrix
Effect
Se1 Hbull75 tlbull86
StU18t1C Vbulllue p Nlllll OF Dan OF Pr gt P
Willes La~ lIUai bull s ttacc
090USO OOUU924
1057amp 1057G
1 17
174 0399l 174 OJ9ll4
Hotbulllling-~wlbully Trace ~middot Greatest Root
010ll2SU 010332561
1057G 10576
17 17
17C 03994 114 01
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
= middot--middot - shy
0130 Wcdncsampy eepc-o= 30 1191 bull 34
Gecual Linear Ko4els Procedure Repeated Measures Analyeia ot Varlaneo
MADovamp TC3t criceia aa4 P Approxiaaciona for cbo HYPocbbullbulllbull of no ~-aRCVPmiddot~~ Effccc H ~ c=rep ampcrix for nocttbullCIIOUPbullssx I bull Rrror sssotP xacrix
Sbullbull N-8C
ampcacicic Value -I)F Den DP Pr gt r
wilemiddot zaabdA Pillampi bull a Tr Hoccllica-Lawley Trace ftoye Greacest Root
071335017 0320amp1U4 03SGUOU 01pound24008
oos00 0903G 159U
ca C8 n 17
5151439 06893 708 058411 690 05937 177 DOCBO
NOn F Staciscic for Roy Oreatee Root i an upper tgtcuncs
0730 Wednoa~y Sapcmber lO 1991 35
Geftera1 Ltaear Ko~elbull Proceaure ~tuecl Meaaurebull llnamplyaie ot Variencbull
Tezca opound HYPotheaea for aetwampen SUbjecta Effoeta
Source Dl lYraquoe UI SS NOM Square F Value lr gt r 2148894277776 5l72 23569444 220 00710 16167 12250000 1UG7 12250000 661 0010
4 273644277778 8411069444 028 010
uo 4U8S4 GC722222 2UGCOJ4064l
l
lG Scv~ 1613 NMDSIRAT 030 WOdnabullday Sepcembar lO 1991
Coneral Linaar Modal2 P~eedure RapeaCed Keaurec Analyi of Variance
univsriaee Teoea of Hypochesea for wiehin Subjecc poundffecca
Source DF fype III SS Mean Square r Valu~ Pr gt F Ac~UCed c- c
Pr F H - F
mocx ltOCXbullG011P Broex~srx
liLOekbullotltOUPbullStx
17 68 1 611
11134641013119 26845817ll2 11456012500 28504 417222
~115tl 829(13342606 67388Jn68 419183183
u~l3 o~s 1G2 101
OOOCIL OSIS2 0051G 0amp24
00001 05352 01376 0 amp539
00001 05398 01310 04549
Error cILOCRl 3230 13448$810278 4l~3G43B
Greeahoue-Geisser Epsilon = 03567 Huynh-Pcl4c 2pailoa =0382
TOTAL P30
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
APPENDIX 3 ADDITIONAL MOTOR ACTIVITY HISTORICAL
CONTROL
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 1111894 031098
TESTING DATES 022194-022494 1011497- 102797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 477 225 397 336
SD 214 232 236 290
BLOCK 2 MEAN 543 208 369 256
SD 169 192 219 184
BLOCK 3 MEAN 609 234 445 372
SD 214 272 253 239
BLOCK 4 MEAN 590 242 411 400
SD 157 263 228 278
BLOCK 5 MEAN 416 256 308 370
SD 236 247 267 246 BLOCK 6 MEAN 425 243 358 288
SD 248 231 290 234 BLOCK 7 MEAN 434 207 400 320
SD 299 251 318 276 BLOCK 8 MEAN 462 104 284 308
SD 240 191 274 287 BLOCK 9 MEAN 369 131 266 357
SD 294 197 295 300 BLOCK 10 MEAN 397 196 290 345
SD 264 266 287 212 BLOCK 11 MEAN 370 96 255 368
SD 256 214 256 270 BLOCK 12 MEAN 415 142 284 326
SD 269 266 271 233 BLOCK13 MEAN 400 242 176
SD 277 262 189 BLOCK 14 MEAN 414 218 186
SD 246 253 195 BLOCK 15 MEAN 359 305 293
SD 278 287 271 BLOCK 16 MEAN 266 298 338
SD 254 306 285 BLOCK 17 MEAN 220 224 357
SD 275 246 248 BLOCK 18 MEAN 212 238 407
SD 202 251 276 TOTAL MEAN 7379 2284 5592 5806
SD 2150 1965 3370 2943
1
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
bull MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194- 022494 1 01497 - 1 02797 1998 1998
ROUTE Subcutaneous Oral (Gavage) Diet Diet
NUMBER OF RATS 19 20 20 20
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK MEAN 477 400 308
SD 271 330 340
BLOCK 2 MEAN 618 372 215
SD 284 353 292
BLOCK 3 MEAN 744 506 357
SD 366 392 270
BLOCK 4 MEAN 687 494 412
SD 283 373 344
BLOCK 5 MEAN 540 360 430
SD 403 362 390
BLOCK 6 MEAN 502 455 354
SD 329 477 372
BLOCK 7 MEAN 552 576 400
SD 496 580 390
BLOCK 8 MEAN 560 419 421
SD 413 508 503
BLOCK 9 MEAN 472 364 464
SD 443 518 489
BLOCK 10 MEAN 493 394 410
SD 413 510 348
BLOCK 11 MEAN 490 374 464
SD 453 491 399
BLOCK 12 MEAN 499 449 435
SD 360 539 402
BLOCK 13 MEAN 516 333 208
SD 470 446 301
BLOCK 14 MEAN 527 336 222
SD 367 566 289
BLOCK 15 MEAN 467 414 366
SD 421 532 419
BLOCK16 MEAN 333 427 450
SD 359 535 465 BLOCK17 MEAN 230 269 448
SD 344 423 393
BLOCK 18 MEAN 220 353 554
SD 301 524 517
TOTAL MEAN 8930 7295 6916
SD 3726 6208 4670
2
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
~MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBRVAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 359 225 477 4 SD
BLOCK 2 MEAN 344 208 543 4 SD
BLOCK 3 MEAN 415 234 609 4 SD
BLOCK 4 MEAN 411 242 590 4 SD
BLOCK 5 MEAN 338 256 416 4 SD
BLOCK 6 MEAN 329 243 425 4 SD
BLOCK 7 MEAN 340 207 434 4 SD
BLOCK 8 MEAN 290 104 462 4 SD
BLOCK 9 MEAN 281 131 369 4 SD
BLOCK10 MEAN 307 196 397 4 SD
BLOCK 11 MEAN 272 96 370 4 SD
BLOCK12 MEAN 292 142 415 4 SD
BLOCK 13 MEAN 273 176 400 3 SD
BLOCK14 MEAN 273 186 414 3 SD
BLOCK 15 MEAN 319 293 359 3 SD
BLOCK 16 MEAN 301 266 338 3 SD
BLOCK 17 MEAN 267 220 357 3 SD
BLOCK 18 MEAN 286 212 407 3 SD
TOTAL MEAN 5265 2284 7379 4 SD
3
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
s MOTOR ACTIVITY DAY 14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg FEMALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 79
FEMALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 395 308 477 3 SD
BLOCK 2 MEAN 402 215 618 3 SD
BLOCK 3 MEAN 536 357 744 3 SD
BLOCK 4 MEAN 531 412 687 3 SD
BLOCK 5 MEAN 443 360 540 3 SD
BLOCK 6 MEAN 437 354 1502 3 SD
BLOCK 7 MEAN 509 400 576 3 SD
BLOCK 8 MEAN 467 419 560 3 SD
BLOCK 9 MEAN 433 364 472 3 SD
BLOCK10 MEAN 432 394 493 3 SD
BLOCK 11 MEAN 443 374 490 3 SD
BLOCK 12 MEAN 461 435 499 3 SD
BLOCK 13 MEAN 352 208 516 3 SD
BLOCK14 MEAN 362 222 527 3 SD
BLOCK 15 MEAN 416 366 467 3 SD
BLOCK 16 MEAN 403 333 450 3 SD
BLOCK17 MEAN 316 230 448 3 SD
BLOCK 18 MEAN 376 220 554 3 SD
TOTAL MEAN 7714 6916 8930 3 SD
4
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
MOTOR ACTIVITY shy
DAY14 POSTPARTUM
HISTORICAL CONTROL DATA F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE 134 290 2-004 2-005
TYPE OF STUDY Dev Neurotox Dev Neurotox Dev Neurotox Dev Neurotox
FINAL DRAFT REPORT MAIL DATE 111894 031098
TESTING DATES 022194 - 022494 101497- 102797 1998 1998
ROUTE Subcutaneous Ora (Gavage) Diet Diet
NUMBER OF RATS 20 20 20 20
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 460 204 409 216
SD 240 195 273 190
BLOCK 2 MEAN 552 240 454 234
SD 181 241 289 204
BLOCK 3 MEAN 514 235 522 279
SD 192 250 261 242
BLOCK 4 MEAN 512 258 516 313
SD 272 238 227 263
BLOCK 5 MEAN 408 251 474 230
SD 229 245 248 264
BLOCK 6 MEAN 468 218 392 279
SD 252 251 316 290
BLOCK 7 MEAN 490 184 416 294
SD 206 253 288 283
BLOCK 8 MEAN 440 196 548 294
SD 267 243 289 333
BLOCK 9 MEAN 339 183 506 232
SD 267 225 241 300
BLOCK10 MEAN 335 238 396 179
SD 272 265 323 228
BLOCK 11 MEAN 372 120 461 168
SD 227 168 307 190
BLOCK12 MEAN 292 138 368 170
SD 219 234 269 185
BLOCK 13 MEAN 304 348 252
SD 253 311 291
BLOCK14 MEAN 396 456 248
SD 216 366 262
BLOCK 15 MEAN 424 388 233
SD 256 303 284
BLOCK 16 MEAN 384 336 220
SD 268 318 256
BLOCK 17 MEAN 373 414 286
SD 238 291 273 BLOCK18 MEAN 344 436 296
SD 263 322 316 TOTAL MEAN 7405 2464 7840 4422
SD 2173 2004 2997 3141
1
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
J MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY
FINAL DRAFT REPORT MAIL DATE
TESTING DATES
ROUTE
NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN
SD
BLOCK 2 MEAN
SD
BLOCK 3 MEAN
SD
BLOCK 4 MEAN
SD
BLOCK 5 MEAN
SD
BLOCK 6 MEAN
SD
BLOCK 7 MEAN
SD
BLOCK 8 MEAN
SD
BLOCK 9 MEAN
SD
BLOCK 10 MEAN
SD
BLOCK 11 MEAN
SD
BLOCK 12 MEAN
SD
BLOCK 13 MEAN
SD
BLOCK 14 MEAN
SD
BLOCK15 MEAN
SD
BLOCK 16 MEAN
SD
BLOCK17 MEAN
SD
BLOCK 18 MEAN
SD
TOTAL MEAN
SD
134
Dev Neurotox
111894
0212194- 022494
Subcutaneous
20
567
431
720
420
747
536
742
556
578
462
642
425
706
467
650
507
468
465
431
410
460
346
366
350
500
533
626
523
646
522
486
431
509
434
418
361
10261
5293
290
Dev Neurotox
031098
101497- 102797
Oral (Gavage)
20
2-004 2-005
Dev Neurotox Dev Neurotox
1998 1998
Diet Diet
20 20
388 153
338 169
450 180
352 203
554 226
370 243
570 278
374 275
550 218
382 303
453 322
469 376
508 328
440 375
714 346
499 468
670 264
421 427
515 204
525 354
598 178
475 236
508 160
536 233
444 254
515 327
608 269
574 321
512 253
507 374
438 253
574 335
550 370
509 421
622 330
589 425
9652 4588
5109 4006
2
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBRVAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS 80
MALE RATS- DAY 14 POSTPARTUM
NUMBER OF MOVEMENTS
BLOCK 1 MEAN 322 204 460 4 SD
BLOCK 2 MEAN 370 234 552 4 SD
BLOCK 3 MEAN 388 235 522 4 SD
BLOCK 4 MEAN 400 258 516 4 SD
BLOCK 5 MEAN 341 230 474 4 SD
BLOCK 6 MEAN 339 218 468 4 SD
BLOCK 7 MEAN 346 184 490 4 SD
BLOCK 8 MEAN 370 196 548 4 SD
BLOCK 9 MEAN 315 183 506 4 SD
BLOCK 10 MEAN 287 179 396 4 SD
BLOCK 11 MEAN 280 120 461 4 SD
BLOCK 12 MEAN 242 138 368 4 SD
BLOCK 13 MEAN 301 252 348 3 SD
BLOCK 14 MEAN 367 248 456 3 SD
BLOCK15 MEAN 348 233 424 3 SD
BLOCK16 MEAN 313 220 384 3 SD
BLOCK17 MEAN 358 286 414 3 SD
BLOCK 18 MEAN 359 296 436 3 SD
TOTAL MEAN 5533 2464 7840 4 SD
3
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
80
MOTOR ACTIVITY DAY14
POSTPARTUM HISTORICAL CONTROL DATA
F1 GENERATION CriCDregBR VAFPiusreg MALE RATS
CODE
TYPE OF STUDY SUMMARY FINAL DRAFT REPORT MAIL DATE
TESTING DATES STUDIES TOTAL ROUTE AVERAGE MINIMUM MAXIMUM INCLUDED RATS NUMBER OF RATS
MALE RATS- DAY 14 POSTPARTUM
TIME (SECONDS) SPENT IN MOVEMENT
BLOCK 1 MEAN 369 153 567 3 SD
BLOCK 2 MEAN 450 180 720 3 SD
BLOCK 3 MEAN 509 226 747 3 SD
BLOCK 4 MEAN 530 278 742 3 SD
BLOCK 5 MEAN 449 218 578 3 SD
BLOCK 6 MEAN 472 322 642 3 SD
BLOCK 7 MEAN 514 328 706 3 SD
BLOCK 8 MEAN 570 346 714 3 SD
BLOCK 9 MEAN 467 264 670 3 SD
BLOCK 10 MEAN 383 204 515 3 SD
BLOCK 11 MEAN 412 178 598 3 SD
BLOCK 12 MEAN 345 160 508 3 SD
BLOCK 13 MEAN 399 254 500 3 SD
BLOCK 14 MEAN 501 269 626 3 SD
BLOCK 15 MEAN 470 253 646 3 SD
BLOCK 16 MEAN 392 253 486 3 SD
BLOCK17 MEAN 476 370 550 3 SD
BLOCK 18 MEAN 457 330 622 3 SD
TOTAL MEAN 8167 4588 10261 3 SD
4
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
rmiddot
APPENDIX4 REGRAPHS OF F1 BODY WEIGHT DATA
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
65
55
45
25
15
BODY WEIGHTS - PREWEANING F1 GENERATION MALE RATS
Figure 2A
()_ 1shyJ ()
~ 35
5 8 12 14
DAYS POSTPARTUM
18 22
-+-0 (CARRIER)
-01 MGKGDAY
-ir-10 MGKGDAY
---30 MGKGDAY
-100 MGKGDAY
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
BODY WEIGHTS - POSTWEANING F1 GENERATION MALE RATS
Figure 28
550
450
6 350 I shyI C) jjj
~
250
150
72 79 8623 30 37 44 51 58 65
-+--0 (CARRIER)
-01 MGKGDAY
-Jr-10 MGKGDAY
~30 MGKGDAY
---100 MGKGDAY
DAYS POSTPARTUM
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
BODY WEIGHTS- PREWEANING F1 GENERATION FEMALE RATS
Figure 3A
65
55
- 45()-1shyc ()
~ 35
25
15
-+-0 (CARRIER)
-01 MGKGDAY
--lr-10 MGKGDAY
---30 MGKGDAY
---100 MGKGDAY
5 8 12 14 18 22
DAYS POSTPARTUM
-middot
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
-
BODY WEIGHTS- POSTWEANING F1 GENERATION FEMALE RATS
Figure 38 350~----------------------------------------------------------~
300
250
~ 1shyc 200 ()
~
150
100
-+-0 (CARRIER)
-01 MGKGDAY
-b-10 MGKGDAY
~30 MGKGDAY
__100 MGKGDAY
~+-~~~----~----------~----~----~----~~----~----T---~ 23 30 37 44 51 58 65 72 79 86
DAYS POSTPARTUM
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-
1613-002 (For EPA Informational Purposes Only) F1 GENERATION MALE RATS
5 109 15 103 12 103 14 104 15 11 15 8 183 23 169 25 17 26 174 25 181 26 12 288 31 275 48 277 28 281 32 29 32 14 355 36 334 44 346 3 348 35 36 36 18 466 48 444 48 458 35 468 46 474 42 22 621 66 589 66 608 51 607 69 624 64 23 656 76 622 79 637 6 638 77 659 73 30 1122 111 1098 111 1101 102 1107 105 1135 116 37 1725 155 1713 16 1701 156 1713 149 175 176 44 2353 196 235 196 2324 188 235 18 2387 219 51 2975 243 2984 244 2937 224 297 228 3015 261 58 3543 304 3573 273 3505 249 3544 257 3615 309 65 3988 337 4038 33 3957 279 4019 288 4089 359 72 4379 396 447 363 4354 315 4402 342 4479 428 79 4682 462 4815 388 4681 349 4766 378 4837 45 86 4926 54 5192 503 4924 352 4922 356 5084 456
F1 GENERATION MALE RATS 5 104 14 98 15 97 14 98 14 103 14 8 174 22 16 3 16 24 165 25 172 24
12 275 27 258 48 266 27 269 32 277 32 14 341 32 322 53 33 29 334 35 343 36 18 446 41 424 61 438 33 448 46 453 43 22 588 52 56 8 574 46 573 66 586 62 23 616 58 586 92 597 53 598 73 615 68 30 994 95 992 106 99 83 993 95 1014 103 37 1385 121 1403 13 1391 105 140 12 143 145 44 1718 13 1735 153 1709 121 1722 148 1744 188 51 1954 155 1984 174 1966 135 1987 159 1989 225 58 2185 186 2228 216 2202 175 2242 184 2243 27 65 2377 208 2442 246 240 192 2431 204 2428 296 72 2508 248 2577 242 2518 178 2567 268 2596 35 79 2621 247 2712 258 2626 204 2715 264 2779 393 86 2694 244 280 292 2766 236 2772 284 2862 394
- Structure Bookmarks
-
- Div
- 1 0 0 1 1 0 5 7 2 0 1 0 3 l 0 3 0 13 1709 ll 0 0 4 z 3 1 2 1 1 8 3 1 14 3 9 l2 52
-