auburn university mri research center. facility overview ● three story – 45,000 sf building ●...
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Auburn University MRI Research Auburn University MRI Research CenterCenter
Facility OverviewFacility Overview
●Three story – 45,000 SF building●MRI systems
■ 3 Tesla (T) open-bore whole body■ 7T whole body
●Designed to support research and clinical operations■ Animal facilities
Short-term holding facility Minimally-invasive procedures area
■ Training for faculty/staff/students
●Funded by a $21M State bond issued in 2007
Auburn University ObjectivesAuburn University Objectives
●Increase AU research funding■ Establish AU as a leader in MRI research■ Enhance AU’s reputation as a major research
university■ Attract businesses/industries to the AU
Research Park
●Provide additional healthcare capabilities for the region
AU MRI Research CenterAU MRI Research Center
●Partnership between■ Auburn University■ Siemens Healthcare■ East Alabama Medical Center■ Alabama Imaging Inc.■ University of Alabama at Birmingham (UAB)■ International
Central South University (China)Siemens Corporate Technology (China)
Auburn Research ParkAuburn Research Park
First FloorFirst Floor
Second FloorSecond Floor
AU Research
The Orthopaedic Clinic
USAARL
Third FloorThird Floor
Rehab Works – EAMC
AU Kinesiology
Auburn Neurosurgery
Proposed Operating ScenarioProposed Operating Scenario
●EAMC/AI controls 3T and clinical area■ 8 hours/day (8AM-4PM) Mon-Fri■ Lease at market value
●AU controls 3T■ 16 hours/day (4PM-8AM) Mon-Fri■ 24 hours/day Sat, Sun, holidays
●7T is research only■ AU control 24/7
TimelineTimeline●June ‘09 – Order equipment●July ‘09 – Building design●July ‘09 – Begin seminar series●Jan ‘10 – Begin construction●Summer ‘10 – Begin training●Sept ‘10 – Construction complete●Oct ‘10 – 3T/7T install●Oct ‘10 – Begin 3T operations●Spring ‘11 – Begin 7T operations
Current and Potential Current and Potential Research ProjectsResearch Projects
● Coil design & Manufacture■ Technology commercialization■ Wireless technology
● Orthopedic Injury/Rehab■ Auburn Athletics / Andrews Orthopedics
● fMRI/Cognitive Neuroscience■ Autism■ Psychology / Human Sciences
● Communication Disorders■ Audiology■ Speech Pathology
● Advanced cardiac imaging■ UAB collaboration (NIH)
● Fat Imaging■ Diabetes and obesity
● Metabolic/Molecular imaging■ MRS/MRSI■ Alzheimer’s disease (NIH)
3T Open-Bore MRI3T Open-Bore MRI
●FDA certified for clinical use
●70 cm bore
●173 cm length
3T Open-Bore MRI3T Open-Bore MRI
Standard ApplicationsStandard Applications
●Neurology
●Angiography
●Cardiac
●Body
●Oncology
●Orthopedic
●Pediactric
●Scientific
Spine Imaging at 3TSpine Imaging at 3T
●4-channel neck coil
●24-channel spine coil
Axially-Loaded Lumbar Spine Axially-Loaded Lumbar Spine MRIMRI
Advanced Applications - DESSAdvanced Applications - DESS
●Increased cartilage/fluid contrast
Advanced Neuro ApplicationsAdvanced Neuro Applications
●fMRI acquisition/analysis
●Diffusion
●Perfusion
●BOLD Imaging
●Advanced Functional Neuro
InVivo Esys fMRI SystemInVivo Esys fMRI System
7T MRI7T MRI
MAGNETOM UHF Community (22 sites):MAGNETOM UHF Community (22 sites):1. Massachusetts General Hospital, Boston, USA
Imaging since 08/2002
2. Institute for Neuro-Biology, Magdeburg, Germany
Imaging since 02/2005
3. New York University, NYC, USA
Imaging since 03/2005
4. Center for MR Research, Minneapolis, USA
Imaging with Siemens console since 12/2005
5. Gachon Medical School, Seoul, Korea
Imaging since 04/2006
6. Oregon Health, Portland, USA
First images 12/06
7. Erwin Hahn Institute for Magnetic Resonance, Essen, Germany Imaging since 09/2006
8. Center for Imaging in Biomedicine, Lausanne, Switzerland
Imaging since 11/2006
9. Max Plank Institute, Tübingen, Germany (9.4T)
Imaging since 07/2007
10. CEA, Paris, France
Imaging since 02/2007
11. CEA, Paris, France, 11.7T
to be installed 2013
12. UPMC, Pittsburgh, USA
former GE system converted to Siemens
Imaging since 05/2007
13. Max Plank Institute, Leipzig, Germany Imaging since 07/2007
14. Medical University of Vienna, Vienna, Austria
Imaging since 04/2008
15. DKFZ, Heidelberg, Germany
Imaging since 08/2008
16. Forschungszentrum Jülich, Germany (9.4T/900)
Imaging since
17. HUP, Philadelphia, PA, USA
Imaging since 06/2008
18. MDC, Berlin, Germany
Imaging since 12/2008
19. CAS, Beijing, China
To be installed in Fall 2009
20. Oxford University, Oxford, UK
To be installed in spring 2010
21. Auburn University, Auburn, Alabama, USA
To be installed Fall 2010
22. CMRR, Minneapolis, USA
To be installed in fall 2010
Other Siemens 7T Installations in USA
●MGH/ Harvard/ MIT
●NYU
●Penn
●Minnesota
●Portland, Oregon
●Pittsburgh
High-Field ImagingHigh-Field ImagingT2-weighted imaging of the human hippocampus
1.5T 7.0T
Functional MRI (fMRI)Functional MRI (fMRI)
Van der Zwaag, et al, Neuroimage. 2009 May 14
fMRI at 1.5T, 3.0T, 7.0TfMRI at 1.5T, 3.0T, 7.0T
Van der Zwaag, et al, Neuroimage. 2009 May 14
fMRI at 1.5T, 3.0T, 7.0TfMRI at 1.5T, 3.0T, 7.0T
7.0T 1.5T
Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7
7.0T 1.5T
Behr, et al, Skeletal Radiol. 2009 Sep;38(9):911-7
Spatial ResolutionSpatial Resolution
3T 7T
fMRI BOLD 3.0 / 2.5 mm6 0.5 / 3.0 mm3
Brain0.5 / 1.0 mm7
1.0 / 1.0 mm7
0.05 / 2.0 mm4
0.7 / 0.7 mm5
Musculoskeletal 0.30 / 2.0 mm2 0.15 / 1.0 mm1
1. Regatte, et al, JMRI Vol.25, 2 Pages: 262-2692. Kuhl, et al, Radiology. 2008 Apr;247(1):16-353. Yacob, et al, Neuroimage. 2007 October 1; 37(4): 1161–
11774. Nakada, Brain and Development ,29 (6), July 2007, 325-3355. Thomas, et al, JMRI 2008 November; 28(5): 1266–12726. Miller, et al, J Neurophysiol 99:1969-1982, 20087. Wiggins, et al, Magn Reson Med, 56(1), 216-223, 2006
SpectroscopySpectroscopy
●Proton spectroscopy (3T and 7T)■ Single voxel■ Chemical shift imaging
●Multinuclear spectroscopy (7T only)■ 7Li, 13C, 17O, 19F, 23Na, 31P
MRI - CoilsMRI - Coils
Small Rodent MRISmall Rodent MRI
Small Animal MRISmall Animal MRI
Fat ImagingFat Imaging
Fat Detection & QuantificationFat Detection & Quantification
