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19/11/2012
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Australia-New Zealand Marine
Biotechnology Network:
Our treasure in the Sea
Oceania Biodiscovery Forum 2012
Eskitis Institute, Griffith University 19 November 2012
Professor Wei Zhang. Director CMBD
Raymond Tham. Manager, CMBD
The Australian Government
DSEWPaC, SPREP
Centre for Marine Bioproducts Development
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The Flinders Centre for
Marine Bioproducts Development
A cross-faculty Centre for innovation, education
and commercialisation in
Marine Bioproducts
Project Title
Australia-New Zealand Marine
Biotechnology Network (ANZMBN) Professor Joseph Baker
Professor Chris Battershill
Professor Wei Zhang
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Project Title
Australia-New Zealand Marine Biotechnology Network (ANZMBN)
An active forum in which to exchange ideas and
develop collaborations between researchers,
technologists, industry and Government colleagues
and other interested parties towards the
advancement of marine biotechnology in Australia
and New Zealand.
Australia-New Zealand Marine Biotechnology Network
Currently ~150 members
Research collaborations
A Network of capabilities, facilities and knowledge
Funding opportunities
Creating discovery and development pathways
Publicising and sharing marine biotechnology “wins”
Commercialisation of marine bioproducts
Influencing policy on marine biotechnology
Intellectual Property & Benefit Sharing
A vision for the future
An Australia-New Zealand Agreement on Marine Biotechnology:
Paving the way for an Oceania Agreement?
Regular research symposia at AMSA/NZMSS conferences
Developing solid ‘platform’ for the above eg CRC & ARC CoE
Complement DSEWPaC and SPREP Oceania engagement
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How Will ANZMBN Work? Hosted by the Centre for Marine Bioproducts Development (CMBD) at
Flinders University with a Steering Committee of key representatives from ANZ.
Initially it will consist of a database of interested persons and organizations,
with their affiliations and expertise.
Specific collaboration projects by interest groups
Quarterly newsletter will be developed to disseminate information about
Marine Biotechnology issues and events
Regular research symposia will be organized at AMSA/NZMSS conferences
Events
Resources
Student
profiles
Jobs
Recent
publications
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Sponge
Team Flinders
University
+ SARDI (Jason Tanner, Alex Dobrovolskis)
9 The Network in action!
Marine Biotechnology Industry: a rapidly growing sector
for RD&E Collaborations
Functional
Bioactive
Compounds
Harvest from
the Sea
Transgenic
Production
Chemical
Synthesis
Mariculture
Cell Culture
Commercial
Production
New Products
New Industry
Marine
Discovery
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Why is Marine Biotechnology important
to science and industry?
Zhang and Tham, Adapted from
Baker, 2011 in comms, QLD DEEDI
Collaborations • AIMS, MISA, Griffith Uni, CSIRO and Australian Antarctic Division
ANZ marine biotechnology R&D & Industry Platform:
• Marine biodiscovery (focus on species) to
• Marine bioproducts development (focus on functional products and
applications) to
• Marine bioproducts commercialization (focus on benefits to the
society such as economic return, new industry and job growth)
Our speciality to complement Eskitis:
• Licensed access to Southern Waters biological megadiversity
• Extraction and fractionation technologies: High & low molec. Wt.
• Sustainable & amplified cell culture / aquaculture production
• End-user product targets: non-pharmaceutical / alternatives
• R&D clients in SA, NZ, China and USA.
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ANZ
Marine
Biotechnology
Network
Flinders University
SARDI
Uni. Adelaide
SA Herbarium
MISA
WAMSI
ASEAN & Pacific Islands
AIMS
Griffith / Eskitis
Qld Museum
AMSA
SIMS
CSIRO
Australian
Antarctic Division
Waikato University
NZMSS
USA, S. Americas,
Japan, Korea, China
NT Museum,
CDU ABS Capacity
Development
Initiative /
Nagoya Protocol
(Source: WoRMS discovery of marine species
http://www.marinespecies.org/aphia.php?p=stats)
Exponential Speed of New Marine
Species Discovery
(Slide Courtesy of Prof John Hooper)
20-50
years
?
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Publications of Marine Natural Products 1971-2010
-4-
No of publications on marine natural products in ISI database
(Topic=‘marine natural products’).
No of publications
Year 2010
20-50
years?
0
100
200
300
400
500
600
700
800
900
1000
1100
2000 2001 2002 2003 2004 2005 2006 2007 2008 2009
Nu
mb
er
of
co
mp
ou
nd
s/y
ea
r
Year
New Marine Natural Product Discovery
2000-2009
2032….2062
20-50
years
?
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Strategic positioning, literally.
Baker, 2011 in comms, QLD DEEDI
NERM, 2012
•70,000km continental
coastline
•8.6 million km2
continental marine
territory
The world’s
least explored
region
•16.1 million km2
oceanic jurisdiction
An exclusive resource
Phylum No. of
species
%
endemic
References
Algae Chlorophyta 124 30 Womersley (1990)
Phaeophyta 231 57 Womersley (1990)
Rhodophyta ~1140 75 Womersley (1990)
Sponges >800 58 Hooper & Lévi (1994)
Bryozoans ~850 38 Barnes & Griffiths (2008)
Molluscs 19 000 95 Poore (1994)
Brachiopods 23 87 Richardson (1997)
Echinoderms 347 56 O’Hara & Poore (2000)
Crustaceans
~800
40 Poore (2004)
Cnidarians jellyfishes 38 Southcott (1982)
hydrozoans ~250 30 JE Watson pers. comm.
Pycnogonids 71 30? D Staples pers. comm.
Ascidians 368 93 Kott (2005, 2006)
Fishes 612 78 Gomon et al. (2008)
Endemic species of Southern Australia Waters – courtesy of Scoresby Shepherd (in press, 2012)
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CMBD Board of Advisors
The Centre is privileged to have a Board of Advisors made up of luminaries in industry, science and government,
who support the strategic efforts of the Centre in establishing a Marine Biotechnology industry in Australia and
towards Flinders University as a focal point for research and industry engagement. The Board convenes three
times a year and advises on management on the international, national and State viewpoints on science and
industry, strategic activities and pathways, and industry and government engagement of the Centre.
The Board is supported by a secretariat in the Centre and can be contacted at [email protected]
Programs of the CMBD
© 2011 Flinders University
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Marine Bioproduct Discoveryand Development
Education, Trainingand Commercialisation
Marine Bioprocessing andBiorefinery Development
Analysis & Characterisat ion
Extraction & Fractionat ion
ProductCommercialisation
SustainableProduction Processes
Industry Needs
CMBDFlinders
BioactiveCompoundDiscoveries
Bioactive Product Development
Industryuptake / upscaling
BioprocessDevelopment
Compounds
Library
Development
• Compatible
Systems
• Shorten lead
Times
• Increase
Access
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Bioprocess Innovation & System Integration
Specialist services in a one-stop shop
Marine Bioresources: Sponges
Sponge Biodiscovery and Functional Applications @ Flinders University, SARDI
2010 Flinders University and SARDI
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HeLa human cell line Dr Jenny Jing Jing Wang
Antibiotics & Antifungal agents
PhD Mohammad Mehbub
Cultures grown on agar media tested for antifungal activity and showing antifungal
activity against Fusarium
A52 crude extracts showing activity against Staphylococcus aureus
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3
4
9
16
31
33
34
36
38
39
43
46
52
53
61
67
68
69
74
Act 4, 9, 16, 33, 34,
39, 52, 67, 69
showed activities
against
Staphylococcus
aureus
Act 33, 36 and 68
were found to be
active against
both fungus,
Fusarium and
Rhizoctonia
Act 52, 39 and 33
showing the
highest level of
inhibition.
Marine Bioresources: Microalgae
NCRIS / Alge & Biofuels Facility @ SARDI West Beach
Biorefinery optimisation @ Flinders University
2010 Flinders University and SARDI
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Marine Biofuels and Biorefinery
Pioneer of the BioRefinery Concept Some of Australia’s largest Microalgae Biofuels projects
Producing high value co-products not just fuels
The Biorefinery Concept
2011 Tham
Marine
Bioresources
Aquaculture
/ Mariculture
Seafood
Processing
Novel
Sources (eg.
Cell Culture)
METABOLITES
Primary
Proteins
Carbohydrates
Lipids
Secondary
Small molecule
compounds
(Alkaloids,
Terpenoids,
phenols)
Enzymes
Peptides
Food
Non-
Food
General
Nutrition
Supplements
Plant / animal
agricultural
chemicals
Pharma-
ceuticals
Cosmeceu-
ceuticals
Biofuels Fuel energy for
agriculture
operations and food
transport and
storage
Therapeutic /
preventative
medicine /
topical applications
Pest / Disease
control and
prevention
Soil conditioning
Plant and animal
nutrition
Food
Ingredients
BIO-
PRODUCTION
Novel
sustainable
methods for
large scale
production
BIO-
PROCESSING
Novel
sustainable
methods for
greater yield
and quality
Biorefinery Process Pathway
© Flinders University, Australia
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Marine Bioresources: Macroalgae
Macroalgae Biodiscovery Product Development @ Flinders University
Australian Kelp Products Pty Ltd, Beachport / Millicent
2010 Flinders University and SARDI
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Red Algae
Pretreatment
Buffer extraction
Crude protein Algal residue
Fractional precipitation
Ion exchange
Chromatography
Residues
micronutrients & minerals
Bromo-peroxidase
DEAE- Sepharose chromatography
R-Phycoerythrin
Molecular Sieve
Chromatography
Alkaline reaction
Agar
Photo-bleaching
Agar extraction
Post-purification
Pre
-trea
tme
nt
Fra
ctio
na
tion
Animal feeds
Na2O MgO Al2O3 SiO2 P2O5 SO3 K2O CaO MnO2Fe2O3 NiO ZnO SrO Cl Br I0
10
20
30
40
50
Algal materials of Gracilaria lemaneiformis
Residues after comprehensive utilization
Co
mp
on
en
ts
of in
org
an
ic e
le
me
nts (%
)
Marine Kelp–Based Bioprocessing &
Bioproducts
$15,000/g
$10,000/g $100/kg $1-5/kg
© 2010 Flinders University
Seafood Bioproducts Innovation for Health
“Seafood for Seafood” technologies Turn seafood co-products into high value functional foods
Enhance quality and reduce spoilage
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Result:
Demonstrable pathway to product output and value
creation
BIOREFINERY CONCEPT: Seafood
2007 – 2009 Zhang and Tham © Flinders University, Australia
Recent Media Coverage
National TV, Radio, Press and online news
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Acknowledgements
South Australian Premiers Science and Research
Fund (PSRF) and the Office of the Chief Scientist
Board of Advisors
DVC (Research) & RSO
Faculties & Schools executives
FCIC, Neuroscience, Proteomics, FAL, LMSC
Flinders Partners & Industry Partners
Australian Seafood CRC
Marine Innovation South Australia
Bio-Innovation SA / Ausbiotech
Australian Marine Science Association
SARDI Aquatic Sciences; Food Innovation
Media partners: SAPRO, Elsevier, Springer,
FSG, CRC Press, SSA
The Flinders Centre for
Marine Bioproducts Development
Talk to us today to find out what you can
do with
marine bioprocessing and
bioproducts [email protected]