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Annual Report 2012

Australian and New Zealand Intensive Care Research Centre

2 3

Director 3

About the ANZIC-RC 4

Aims 5

Governance 6

Staff 7

PhD Scholars 8

Adjuncts 9

Visitors and Affiliates 11

Senior Research Fellows 12

Awards 13

Research Grants Active in 2012 14

NHMRC Funding Graphs 16

Publications 17

Publications Graphs 21

Presentations 22

Table of Contents Director Year 2012 was again marked by increasing research productivity and success of the ANZIC Research Centre. There were 79 journal publications, 1 book and 5 book chapters. An exciting five year NHMRC Centre of Research Excellence grant was funded, based at the ANZIC Research Centre: the Centre of Research Excellence for Patient Blood Management in Critical Illness and Trauma.

The ANZIC-RC is now the methods centre for six current NHMRC funded multicentre clinical trials: two of these trials commenced recruitment in 2012 (PHARLAP and TRANSFUSE) and a third new trial (SPICE-EGDS) is underway.

International collaborating sites and regions for the ANZIC-RC clinical trials have been established in France, Finland, Hong Kong, Ireland, Germany, New Zealand, Saudi Arabia and Singapore.

Administered from within the Research Centre, the Monash Partners Academic Health Science Centre’s Critical Care, Trauma and Perioperative Medicine Theme is now well established, and building and developing trials and planned programs within the University and southern Melbourne public and private hospitals.

I would like to thank our team of staff, adjuncts, students, affiliates and visiting researchers for their dedication to our Centre and its remarkably prolific research projects and programs.

Professor DJ (Jamie) CooperDirector ANZIC-RC

4 5

The Australian and New Zealand Intensive Care Research Centre (ANZIC-RC) is the National Health and Medical Research Council (NHMRC) and Monash University funded national centre for development, coordination and execution of pivotal multicentre randomised controlled trials (RCTs) in critically ill patients. The outcomes of its research have changed medical care in Australia and internationally, improved patient outcomes and lowered health costs. The parallel role of the ANZIC-RC is a national teaching centre for doctoral, postdoctoral and international clinician researchers in critical care medicine.

It was established in February 2006 within Monash University’s Department of Epidemiology and Preventive Medicine, based in the Alfred Medical Research and Education Precinct (AMREP) in Melbourne.

The ANZIC-RC offers a range of services, from research advice to complete project management, that are available to all Australian and New Zealand intensive care clinicians (including doctors, nurses and allied health professionals). Advice and assistance is available from experienced intensive care unit (ICU) researchers, data management/bio-statistical consultants, project managers, epidemiologists and health economists. The Centre coordinates and conducts comprehensive research programs including observational studies; feasibility projects; and large multi-centred, interventional, randomised controlled trials. It has the ability to support small, medium and large clinical trials.

About the ANZIC-RCThe principal aims of the ANZIC-RC are to:

• Conduct high impact, large-scale, investigator-initiated clinical trials designed to determine best and most cost-effective practice in Intensive Care Medicine (ICM)

• Increase the quality of clinical trial design and biostatistical analysis in this field

• Be readily accessible to all Australian and New Zealand clinician-researchers in critical care

• Expand the national and international reach of large Australian and New Zealand led trials

• Introduce systems to integrate research results into clinical practice by promulgating research-based practice guidelines

• Develop integrated clinical research programs that provide the training ground for future clinical trialists in the field of ICM

• Encourage and support clinician researchers in research theory, study design, study conduct, data analysis and scientific writing

Aims

6 7ANZIC-RC Governance - Advisory Board Members

Prof DJ (Jamie)

Cooper Co-DirectorANZIC-RC

Prof Rinaldo Bellomo

Co-DirectorANZIC-RC

Prof John

McNeilHead

SPHPM Monash

A/Prof Mary White

President ANZICS

Prof Steve WebbChair

ANZICS-CTG

A/Prof Dave

PilcherChair

ANZICS-CORE

A/Prof Rob

BootsScientific Officer

CICM

Mr Peter

GallagherCommunity

Representative

Dr Colin

McArthurNew Zealand

Representative

ANZIC-RC Staff

Ms Siouxzy

Morrison Research Centre

Manager

Ms Lynne

MurrayResearch Centre

Manager (Acting)

A/Prof Alistair Nichol

Intensivist

A/Prof Michael

BaileyStatistician

Dr Carol

Hodgson Senior

Research Fellow

Dr Dashiell GantnerSenior

Research Fellow

Ms Emma Ridley

Nutrition Research Fellow

Ms Lisa

HigginsResearch

Fellow

Ms Lorraine

LittleProject Manager

EPO-TBI Study

Mr Tony

TrapaniProject Manager

POLAR Study

Ms Victoria Bennett

Project Manager PHARLAP Study

Ms Bridget

Ady Project Manager

TRANSFUSE Study

Ms Amanda Martin

Administration Manager

MsBelinda Howe

Project Manager ARISE & SPICE

Studies

Dr Maija

KaukonenSenior

Research Fellow

8 9ANZIC-RC PhD Scholars and BMedSc Students ANZIC-RC Adjuncts

Mr Eldho Paul

PhD Scholar

Ms Elizabeth

MoorePhD Scholar

Ms Lisa

HigginsPhD Scholar

Dr Neil

OrfordPhD Scholar

Dr Cécile

Aubron

Dr DarylJones

Dr Peter

Kruger

DrRafidah

AtanPhD Scholar

Dr Antoine

SchneiderPhD Scholar

Mr Ralph

TrammPhD Scholar

DrRuwan

WijemunigePhD Scholar

DrNor’azim Mohd

YunosPhD Scholar

Dr Daryl Jones

PhD Scholar

Dr Neil

GlassfordPhD Scholar

Dr Helen

AcklandPhD

Completed 2012

A/ProfAndrewDavies

A/Prof Jeff

Presneill

Dr Colin

McArthur

ProfJohn

Myburgh

A/ProfSandraPeake

A/ProfVille

Pettilä

A/Prof Dave

Pilcher

Dr Cristina

Morganti-Kossmann

MsLynetteNewby

Mr Simon Landes

BMedSc (Hons)Completed 2012

10 11ANZIC-RC Adjuncts (continued) ANZIC-RC Visitors and Affiliates

ProfSteveWebb

DrAndrew

Westbrook

Mr Mick

Stephenson

MsTricia

Williams

Ms Shirley

Vallance

A/ProfYahya

Shehabi

Dr Ian

Seppelt

ProfMichaelReade

Ms Sherly

LiAffiliate

Ms Rhiannon

TateAffiliate

Dr RakshitPanwarVisitor

(Australia)2011-2

ProfGilles

CapellierVisitor

(France)2011-2

Dr Matthieu Schmidt Visitor

(France)2012-3

DrHeatherWaddyAffiliate

DrAdrianPraegerAffiliate

DrGuillaume Carteaux

Visitor(France)2010-1

Dr Tài

PhamAffiliate

12 13Awards

DrAndrew

Westbrook(Ireland)

2008

Dr Cécile

Aubron(France)

2010

Dr DarylJones

(Australia)2006

Dr Carol

Hodgson(Australia)

2011

DrDashiellGantner

(Australia)2012

A/ProfVille

Pettilä(Finland)

2009

Prof AlistairNichol

(Ireland)2007

Dr Maija

Kaukonen(Finland)2012-3

ANZIC-RC Senior Research Fellows (2006-2013)In 2012, Emma Ridley travelled to five countries to learn from international experts in nutrition assessment in critically ill patients and indirect calorimetry as part of her Peter Mitchell Churchill Fellowship (awarded in 2011). Emma’s study tour included the Clinical Research Evaluation Unit (CERU), Kingston General Hospital and Queens University, Kingston, Canada; Rabin Medical Centre, Tel Aviv, Israel; Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland; the 34th European Society of Parenteral and Enteral Nutrition (ESPEN) Congress, Barcelona, Spain; and Cosmed, Rome, Italy. (Picture left: Ms Emma Ridley presenting to the ANZIC-RC Advisory Board.)

Recipient Award Awarded by

Ackland HM Recipient of the Spinal Research Award for the best paper presented at the 23rd Annual Scientific Meeting of the Spine Society of Australia, Sydney, Australia, 27- 29 April, 2012: Ackland HM, Cameron PA, Wolfe R, Malham GM, Varma DK, Fitt GJ, Cooper DJ, Rosenfeld JV, Liew SM. Outcomes at 12 months following early MRI in acute trauma patients with persistent midline cervical tenderness and negative CT.

Spine Society of Australia

Ackland HM PhD Awarded, Thesis Title – Correlation of clinical and radiographic findings with long term outcomes in trauma patients with acute cervical discoligamentous injury

Monash University

Aubron C Senior Medical Staff Prize for Clinical Research for poster: Aubron C, Bailey M, McQuilten Z, Pilcher D, Hegarty C, Martinelli A, Magrin G, Diaz P, Irving D, Cooper J, Bellomo R. Does the duration of blood storage impact on prognosis of criticaly ill patients? A multicentre observational study.

The Alfred Research Week

Bernard S Frank McDermott Award for 2012 for RSI Paper: Bernard S, Nguyen V, Cameron P, Masci K, Fitzgerald M, Cooper J, Walker T, Myles P, Murray L, Taylor D, Smith K, Patrick I, Edington J, Bacon A, Rosenfeld J, Judson R. Prehospital rapid sequence intubation improves functional outcome for patients with severe traumatic brain injury: A randomized, controlled trial. Ann Surg. 2010 Dec;252(6):959-65.

National Trauma Research Institute (NTRI)

Cooper DJ AMREP Research Prize 2012 (for the article describing original clinical research published in the journal with the highest impact factor in 2011): Cooper DJ, Rosenfeld JV, Murray L, Arabi YM, Davies AR, D’Urso P, Kossmann T, Ponsford J, Seppelt I, Reilly P, Wolfe R; DECRA Trial Investigators; Australian and New Zealand Intensive Care Society Clinical Trials Group. Decompressive craniectomy in diffuse traumatic brain injury. N Engl J Med 2011;364(16):1493-502. [IF: 53.484]

Alfred Medical Research and Education Precinct

Dixon JB Senior Medical Staff Prize for Clinical Research for poster: Dixon JB, Schachter LM, O’Brien PE, Jones KM, Grima MT, Brown W, Bailey M, Naughton MT. Surgical Versus Conventional Therapy For Weight Loss Treatment Of Obstructive Sleep Apnoea: A Randomised Controlled Trial.

The Alfred Research Week

Gantner D TBI Acute Care Fellowship with the Centre of Excellence in Traumatic Brain Injury (CETBIR) for 2013 Centre of Excellence in Traumatic Brain Injury (CETBIR)

Ridley E Scholarship to attend the Advanced Leadership Program in 2014 Women and Leadership Australia

Shehabi Y 2012 Research Citation Award, SCCM conference, Houston, Texas, USA, for outstanding contribution to the Society of Critical Care Medicine for the SPICE study abstract: Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur CJ, Seppelt IM, Webb SA, Weisbrodt L and Sedation Practice in Intensive Care Evaluation (SPICE) Study Investigators and the ANZICS Clinical Trials Group. Early intensive care sedation practice predicts long-term mortality in ventilated critically ill patients. (The SPICE study was coordinated by Belinda Howe, ANZIC-RC)

American Society of Critical Care Medicine (SCCM)

14 15Research Grants Active in 2012 (continued)

Title Agency / Grant Type

Chief Investigators Year/s of Funding

Total Amount

Administering Institution

PHARLAP-RCT: Multicentre RCT of open lung strategy including Permissive Hypercapnia, Alveolar Recruitment & Low Airway Pressure in patients with ARDS

NHMRC #1021203 Project Grant

Nichol AD, Davies AR, Hodgson C, Bersten A, Fraser J, Cooper DJ

2012 - 2015 $997,538 Monash (ANZIC-RC)

POLAR-TEG: Understanding how hypothermia impairs coagulation in severe TBI patients

ISCRRProject Grant

Cooper DJ 2012 $50,000 Monash (ANZIC-RC)

Public Health Postgraduate Scholarship Extension NHMRC Scholarship

Higgins L 2012 $14,304 Monash (ANZIC-RC)

Senior Medical Staff Advanced Trainee Research Scholarship

The AlfredScholarship

Gantner D 2012 $2,500 Alfred

SOFTER: A prospective, observational study of critical illness related changes in bone mineral density, bone turnover and calcium metabolism

Intensive Care Foundation (ICF)Project Grant

Orford N, Kotowicz M, Pasco J, Henry M, Bellomo R, Bailey M

2012 $28,000 Monash (ANZIC-RC)

Supplemental Parenteral Nutrition in Critically Ill Patients: Pilot Randomised Controlled Study

Baxter Healthcare CorporationProject Grant

Davies A 2012 - 2014 $324,350 Monash (ANZIC-RC)

TEAM: Trial of early activity and mobility in ICU ICF Project Grant

Hodgson C, Webb S, Harrold M, Denehy L, Berney S, Bellomo R


TRANSFUSE-RCT: Standard issue transfusion versus fresher red blood cell use in intensive care

NHMRC #1020694Project Grant

Cooper DJ, Nichol AD, French C, Street A, Bellomo R

2012 -2015 $2,761,870 Monash (ANZIC-RC)

ATACAS: Completion of the ATACAS Trial NHMRC #1009203Project Grant

Myles P, Silbert B, Cooper DJ, McNeil J

2011 - 2014 $3,328,614 Monash (ANZIC-RC)

PHARLAP-RCT: Multicentre RCT of open lung strategy including Permissive Hypercapnia, Alveolar Recruitment and Low Airway Pressure in patients with ARDS

The Alfred Research Trust Project Grant

Davies AR, Nichol A, Hodgson C, Cooper DJ, Tuxen D, Higgins A

2011 - 2013 $121,070 Monash (ANZIC-RC)

ANZIC-RC: National Centre for Intensive Care Research Enabling Grant Renewal

NHMRC #606978Enabling Grant

Bellomo R, Cooper DJ, Myburgh J, Finfer S

2010 - 2015 $2,500,000 Monash(ANZIC-RC)

BLISS: Bacterial load in severe sepsis NHMRC #632622Project Grant

Iredell J, Brown S, Webb S, Stanley K, Nichol A, Bailey M

2010 - 2014 $647,738 Westmead Hospital

Management of refeeding syndrome in critical illness: An AuSPEN endorsed multicentre clinical trial


Doig GS, Simpson F, Caterson I, Davies AR, McLean A

2010 - 2012 $1,308,800 University of Sydney

Nephro-protective effects of L-amino acids in critically ill patients: A multi-centre randomised controlled trial


Doig GS, Bellomo R, Davies AR, Simpson F, Reade M

2010 - 2012 $829,300 University of Sydney

TBI Program: Early Interventions to improve outcomes after traumatic brain injury (EPO-TBI and POLAR)

TAC/VNI #D162Program Grant

Cooper DJ, Cameron P, Bernard S, Rosenfeld J, Nichol A

2010 - 2015 $2,086,100 Monash (ANZIC-RC)

Australian Postgraduate Award APAScholarship

Moore E 2009 - 2012 $78,476 Monash(ANZIC-RC)

EPO-TBI RCT: A randomised controlled trial of erythropoietin in ICU patients with traumatic brain injury


Bellomo R, Cooper DJ, Street A, Nichol A, French CJ, Presneill JJ

2009 - 2013 $1,848,475 Monash (ANZIC-RC)

POLAR-RCT: A randomised controlled trial of prophylactic hypothermia in severe traumatic brain injury


Cooper DJ, Bernard S, Nichol A, Presneill J, Cameron P, Myburgh J

2009 - 2013 $1,958,075 Monash (ANZIC-RC)

Public Health Postgraduate Scholarship NHMRC Scholarship

Higgins L 2009 - 2011 $85,827 Monash (ANZIC-RC)

Total $31,547,188

Research Grants Active in 2012Title Agency /

Grant TypeChief Investigators Year/s of

Funding Total

AmountAdministering

InstitutionANTISEPSIS: AspiriN To Inhibit SEPSIS trial; an ASPREE substudy to measure the benefit of low dose aspirin in the prevention of severe sepsis

NHMRC #1041986 Project Grant

Eisen D, Leder K, McBryde E, Wolfe R, Pilcher D, Woods R

2013 - 2016 $391,879 Monash

IRONMAN-RCT: Intravenous Iron or Placebo for Anaemia in Intensive Care

Govt of WA, Dept of Health F-AA-12440SHRAC Research Translation Project Grant

Litton E, Webb S, Farmer S, Richards T, De Keulenaer B, Towler S

2013 - 2014 $200,000 Royal Perth Hospital

NHMRC Practitioner FellowshipLevel II

NHMRC #1044787Practitioner Fellowship

Bellomo R 2013 - 2017 $228,270 Austin

NHMRC Practitioner FellowshipLevel II

NHMRC #1041922Practitioner Fellowship

Cooper DJ 2013 - 2017 $380,450 Monash (ANZIC-RC)

RELIEF: Restrictive versus Liberal Fluid Therapy in Major Abdominal Surgery


Myles P, Bellomo R, Christophi C, Corcoran T, Forbes A, Peyton P, Story D

2013 - 2016 $2,384,173 Monash

SPICE Sedation Practices in Intensive Care Evaluation - Randomised Controlled Trial (RCT)


Shehabi Y, Bellomo R, Reade M, Seppelt I, McArthur C, Bailey M, Howe B

2013 - 2017 $2,752,725 Monash (ANZIC-RC)

TBI Acute Care Fellowship - Capacity building by developing KT in TBI trials

Centre of Excellence in Traumatic Brain Injury (CETBIR)

Gantner D 2013 $100,000 NTRI

TEAM: Pilot randomised controlled trial of early mobilisation in critically ill patients to improve functional recovery and quality of life

The Alfred Research TrustsProject Grant

Tipping C, Bradley S, Cooper DJ, Hodgson C


Alfred-Monash ICU Research Fellowship Alfred ICUFellowship

Ackland H 2012 - 2013 $50,000 Alfred

ARISE-RCT: Australasian Resuscitation in Sepsis Evaluation Continuation Funding

(NHMRC) #1021165Project Grant

Bellomo R, Cameron P, Cooper DJ, Peake S, Webb S, Delaney A, Holdgate A

2012 -2013 $349,790 Monash (ANZIC-RC)

Blood-CRE: Centre of Research Excellence for Patient Blood Management in Critical Illness and Trauma

NHMRC #1040971Centre of Research Excellence

Cooper DJ, Phillips L, Bellomo R, Cameron P, Reade M, Isbister J, French C, Myles P, Webb S, McNeil J

2012 - 2017 $2,498,407 Monash (ANZIC-RC)

CETBIR: Centre of Excellence in Traumatic Brain Injury Research

TACProject Grant

Gruen R, Rosenfeld J,Cooper DJ, Bernard S, Cameron P, Fitzgerald M, Ponsford J, Morganti-Kossman C

2012 - 2014 $1,226,636 NTRI

Effect of ECMO on long term disability in severe ARDS

Intensive Care Foundation (ICF)Project Grant

Pellegrino V, Hilton A, Nichols M, Cooper DJ, Davies A, Nichol A, Board J, Reynolds C, Hodgson C

2012 $10,000 Alfred

Improved early outcome predictions for patients with traumatic brain injury

Coopers Brewery FoundationProject Grant

Cooper DJ 2012 $30,000 Alfred

INFORM: Informing Fresh versus Old Red Cell Management: A large simple phase III RCT

Canadian Institutes of Health Research (CIHR)Project Grant

Eikelboom J, Arnold D, Cooper DJ, Crowther M, Devereaux PJ, Gallus A, Kurz A, Phillips L, Roxby D, Sessler D, Teague M, Warkentin T, Webert K

2012 - 2015(Canadian

$1,606,292)

$1,564,125 McMaster University (Canada)

Intensive care management and quality of survival of acute respiratory distress syndrome

NHMRC #1035050Early Career Research Fellowship

Hodgson C 2012 - 2015 $294,892 Monash(ANZIC-RC)

Multimodal MRI imaging in severe TBI patients to determine structural impact of DECRA craniectomy surgery and early prognostication: Pilot studies

ISCRRProject Grant

Cooper DJ 2012 $50,000 Monash (ANZIC-RC)

Nutrition therapy in adult patients requiring ECMO in Australia and New Zealand

Australasian Society of Parenteral and Enteral Nutrition (AusPEN)Project Grant

Ridley E, Davies A, Nyulasi I 2012 $10,000 Monash (ANZIC-RC)

16 17

Publications Journal Publications

1. Ackland HM, Cameron PA, Wolfe R, Malham GM, Varma DK, Fitt GJ, Cooper DJ, Rosenfeld JV, Liew SM. Outcomes at 12 Months Following Early Mri in Acute Trauma Patients with Persistent Midline Cervical Tenderness and Negative CT. Spine (Phila Pa 1976) 2012.

2. Ackland HM, Wolfe R, Cameron PA, Cooper DJ, Malham GM, Varma DK, Fitt GJ, Rosenfeld JV, Liew SM. Health resource utilisation costs in acute patients with persistent midline cervical tenderness following road trauma. Injury 2012;43:1908-16.

3. Atan R, Crosbie D, Bellomo R. Techniques of extracorporeal cytokine removal: a systematic review of the literature. Blood purification 2012;33:88-100.

4. Aubron C, Cheng AC, Pilcher D, Leong T, Magrin G, Cooper DJ, Scheinkestel C, Pellegrino V. Infections acquired by adults who receive extracorporeal membrane oxygenation: risk factors and outcome. Infection control and hospital epidemiology : the official journal of the Society of Hospital Epidemiologists of America 2012;epub ahead of print 12 Dec.

5. Aubron C, Syres G, Nichol A, Bailey M, Board J, Magrin G, Murray L, Presneill J, Sutton J, Vallance S, Morrison S, Bellomo R, Cooper DJ. A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients. Transfusion 2012;52:1196-202.

6. Bellomo R, Ackerman M, Bailey M, Beale R, Clancy G, Danesh V, Hvarfner A, Jimenez E, Konrad D, Lecardo M, Pattee KS, Ritchie J, Sherman K, Tangkau P. A controlled trial of electronic automated advisory vital signs monitoring in general hospital wards. Critical care medicine 2012;40:2349-61.

7. Bellomo R, Bailey M, Nichol A. Letter by Bellomo et al regarding article, “Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest”. Circulation 2012;125:e288; author reply e9.

8. Bellomo R, Kellum JA, Ronco C. Acute kidney injury. Lancet 2012;380:756-66.

9. Bellomo R, Kellum JA, Ronco C. Author’s reply - Acute kidney injury. Lancet 2012;380:1905.

10. Bernard SA, Smith K, Cameron P, Masci K, Taylor DM, Cooper DJ, Kelly AM, Silvester W. Induction of prehospital therapeutic hypothermia after resuscitation from nonventricular fibrillation cardiac arrest*. Critical care medicine 2012;40:747-53.

11. Brieva J, Opdam H, Jones D. Predicting the time to death after withdrawal of life sustaining therapy: implications for organ donation. Critical care medicine 2012;40:342-4.

12. Bucknall TK, Jones D, Bellomo R, Staples M. Responding to medical emergencies: System characteristics under examination (RESCUE). A prospective multi-site point prevalence study. Resuscitation 2012.

13. Bye N, Turnley AM, Morganti-Kossmann MC. Inflammatory regulators of redirected neural migration in the injured brain. Neuro-Signals 2012;20:132-46.

14. Chalwin RP, Moran JL, Peake SI, Flynn S, Pieterse J, Williams P. Assessing the performance of a continuous infusion for potassium supplementation in the critically ill. Anaesth Intensive Care 2012;40:433-41.

15. Chua HR, Baldwin I, Bailey M, Subramaniam A, Bellomo R. Circuit lifespan during continuous renal replacement therapy for combined liver and kidney failure. J Crit Care 2012;27:744 e7- e15.

16. Chua HR, Glassford N, Bellomo R. Acute kidney injury after cardiac arrest. Resuscitation 2012;83:721-7.

17. Chua HR, Schneider A, Bellomo R. Bicarbonate in diabetic ketoacidosis - a systematic review. Ann Intensive Care 2011;1:23.

18. Chua HR, Venkatesh B, Stachowski E, Schneider AG, Perkins K, Ladanyi S, Kruger P, Bellomo R. Plasma-Lyte 148 vs 0.9% saline for fluid resuscitation in diabetic ketoacidosis. J Crit Care 2012;27:138-45.

19. Cooper DJ, Myburgh J, Finfer S, Heritier S, Bellomo R, Billot L, Murray L, Vallance S. Albumin resuscitation for traumatic brain injury: is intracranial hypertension the cause of increased mortality? J Neurotrauma 2012.

20. Cooper DJ, Rosenfeld JV, Wolfe R. DECRA Investigators’ Response to “The Future of Decompressive Craniectomy for Diffuse Traumatic Brain Injury” by Honeybul et al. J Neurotrauma 2012;29:2595-6.

21. Coulson TG, Pilcher DV, Graham SM, Snell GI, Levvey BJ, Philpot S, Teo A, Davies AR. Single-centre experience of donation after cardiac death. Med J Aust 2012;197:166-9.

22. Davies AR. Enteral nutrition in ICU: small bowel or stomach? And how much? Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:99-100.

23. Davies AR, Morrison SS, Bailey MJ, Bellomo R, Cooper DJ, Doig GS, Finfer SR, Heyland DK. A multicenter, randomized controlled trial comparing early nasojejunal with nasogastric nutrition in critical illness. Critical care medicine 2012;40:2342-8.

24. Eastwood G, Bellomo R, Bailey M, Taori G, Pilcher D, Young P, Beasley R. Arterial oxygen tension and mortality in mechanically ventilated patients. Intensive care medicine 2012;38:91-8.

25. Eastwood GM, Peck L, Young H, Lipcsey M, Glassford NJ, Schneider AG. Benchmarking participant recruitment in intensive care clinical trials. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:94-5.

26. Gantner D, Nichol A. Treatment of severe sepsis. Anaesthesia & intensive care medicine 2012;13:199-203.

27. Gillon S, Radford S, Chalwin R, Devita M, Endacott R, Jones D. Crisis resource management, simulation training and the medical emergency team. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:227-35.

28. Glassford NJ, Myles P, Bellomo R. The Australian approach to peri-operative fluid balance. Curr Opin Anesthesio 2012;25:102-10.

NHMRC Funding Graphs (ANZIC-RC Administered Grants)

18 19 Publications

Journal Publications (continued)

57. Peake SL, Chapman MJ, Davies AR, Moran JL, O’Connor S, Ridley E, Williams P. Enteral nutrition in Australian and New Zealand intensive care units: a point-prevalence study of prescription practices. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:148-53.

58. Philpot SJ, Pilcher DV, Graham SM, Snell GI. Lung recruitment manoeuvres should be considered when assessing suitability for lung donation. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:244-5.

59. Pilcher J, Weatherall M, Shirtcliffe P, Bellomo R, Young P, Beasley R. The effect of hyperoxia following cardiac arrest - A systematic review and meta-analysis of animal trials. Resuscitation 2012;83:417-22.

60. Praeger AJ, Westbrook AJ, Nichol AD, Wijemunige R, Davies AR, Lyon SM, Wills JL, Bailey M, Rosenfeld JV, Cooper DJ. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:10-3.

61. Prowle J, Bagshaw SM, Bellomo R. Renal blood flow, fractional excretion of sodium and acute kidney injury: time for a new paradigm? Curr Opin Crit Care 2012;18:585-92.

62. Ridley EJ, Davies AR, Murch L, Nyulasi I, Tierney A, Heyland D. Excellence in Nutrition Therapy: Lessons from the International Nutrition Survey and the Best of the Best Awards. ICU Management 2012;12:17-20.

63. Rosenfeld JV, Maas AI, Bragge P, Morganti-Kossmann MC, Manley GT, Gruen RL. Early management of severe traumatic brain injury. Lancet 2012;380:1088-98.

64. Saxena MK, Hodgson CL. Intensive care unit acquired weakness. Anaesthesia and Intensive Care Medicine 2012;13:145-7.

65. Schneider AG, Baldwin I, Freitag E, Glassford N, Bellomo R. Estimation of fluid status changes in critically ill patients: Fluid balance chart or electronic bed weight? J Crit Care 2012;27:745 e7- e12.

66. Schneider AG, Eastwood GM, Seevanayagam S, Matalanis G, Bellomo R. A risk, injury, failure, loss, and end-stage renal failure score-based trigger for renal replacement therapy and survival after cardiac surgery. J Crit Care 2012;27:488-95.

67. Schneider AG, Lipcsey M, Bailey M, Pilcher DV, Bellomo R. Relationship between illness severity scores in acute kidney injury. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:53-5.

68. Schneider AG, Uchino S, Bellomo R. Severe acute kidney injury not treated with renal replacement therapy: characteristics and outcome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27:947-52.

69. Schneider AG, Warrillow S, Robbins R, Jones DA, Bellomo R. An assessment of the triage performance of the efferent arm of the rapid response system. Resuscitation 2012.

70. Shehabi Y, Bellomo R, Reade MC, Bailey M, Bass F, Howe B, McArthur C, Seppelt IM, Webb S, Weisbrodt L. Early intensive care sedation predicts long-term mortality in ventilated critically ill patients. American journal of respiratory and critical care medicine 2012;186:724-31.

71. Thomson A, Subramaniam K, Davies A. Nutritional therapy in acute pancreatitis--time to take stock. Nutrition 2012;28:731-2.

72. Tipping CJ, Young PJ, Romero L, Saxena MK, Dulhunty J, Hodgson CL. A systematic review of measurements of physical function in critically ill adults. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:302-11.

73. Varley J, Pilcher D, Butt W, Cameron P. Self harm is an independent predictor of mortality in trauma and burns patients admitted to ICU. Injury 2012;43:1562-5.

74. Vetro J, Koutsogiannis Z, Jones DA, Canestra J. A case of methylene chloride poisoning due to ingestion of home-distilled alcohol and potential new treatment with ethanol infusion. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:60-3.

75. Wilson N, Nhung N, Higgins A, Kvizhinadze G, Baker MG, Blakely T. A national estimate of the hospitalisation costs for the influenza (H1N1) pandemic in 2009. The New Zealand medical journal 2012;125:16-20.

76. Young P, Beasley R, Bailey M, Bellomo R, Eastwood GM, Nichol A, Pilcher DV, Yunos NM, Egi M, Hart GK, Reade MC, Cooper DJ. The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:14-9.

77. Young P, Hodgson C, Dulhunty J, Saxena M, Bailey M, Bellomo R, Davies A, Finfer S, Kruger P, Lipman J, Myburgh J, Peake S, Seppelt I, Streat S, Tate R, Webb S. End points for phase II trials in intensive care: recommendations from the Australian and New Zealand Clinical Trials Group consensus panel meeting. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:211-5.

78. Young PJ, Saxena M, Beasley R, Bellomo R, Bailey M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K. Early peak temperature and mortality in critically ill patients with or without infection. Intensive care medicine 2012.

79. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M. Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 2012;308:1566-72.

PublicationsJournal Publications (continued)

29. Godfrey G, Pilcher D, Hilton A, Bailey M, Hodgson CL, Bellomo R. Treatment limitations at admission to intensive care units in australia and new zealand: Prevalence, outcomes, and resource use. Critical care medicine 2012;40:1-8.

30. Hanna J, Nichol A. Status epilepticus: an intensive care medicine problem. Anaesthesia & Intensive Care Medicine 2012;13:148–51–51.

31. Hanna J, Nichol A. Acute renal failure and the critically ill. Anaesthesia and Intensive Care Medicine 2012;13:166-70.

32. Hellewell SC, Morganti-Kossmann MC. Guilty molecules, guilty minds? The conflicting roles of the innate immune response to traumatic brain injury. Mediators of inflammation 2012;2012:356494.

33. Hew S, Nichol A. Acute pancreatitis: an intensive careperspective. Anaesthesia and Intensive Care Medicine 2012;13:171-5.

34. Higgins AM, Harris AH. Health Economic Methods: Cost-Minimization, Cost-Effectiveness, Cost-Utility, and Cost-Benefit Evaluations. Crit Care Clin 2012;28:11-+.

35. Hilton AK, Bellomo R. A critique of fluid bolus resuscitation in severe sepsis. Crit Care 2012;16:302.

36. Hodgson C, Carteaux G, Tuxen DV, Davies AR, Pellegrino V, Capellier G, Cooper DJ, Nichol A. Hypoxaemic rescue therapies in acute respiratory distress syndrome: Why, when, what and which one? Injury 2012.

37. Hodgson CL, Hayes K, Everard T, Nichol A, Davies AR, Bailey MJ, Tuxen DV, Cooper DJ, Pellegrino V. Long-term quality of life in patients with acute respiratory distress syndrome requiring extracorporeal membrane oxygenation for refractory hypoxaemia. Crit Care 2012;16:R202.

38. Howell JA, Gow PJ, Angus PW, Jones RM, Wang BZ, Bailey M, Fink MA. Early-onset versus late-onset nonanastomotic biliary strictures post liver transplantation: risk factors reflect different pathogenesis. Transpl Int 2012;25:765-75.

39. Ishikawa K, Calzavacca P, Bellomo R, Bailey M, May CN. Effect of selective inhibition of renal inducible nitric oxide synthase on renal blood flow and function in experimental hyperdynamic sepsis. Critical care medicine 2012.

40. Ishikawa K, Wan L, Calzavacca P, Bellomo R, Bailey M, May CN. The effects of terlipressin on regional hemodynamics and kidney function in experimental hyperdynamic sepsis. PloS one 2012;7:e29693.

41. Jones D. Improving risk stratification--detecting physiological deterioration. Resuscitation 2012;epub ahead of print 10 Nov.

42. Jones D, Drennan K, Hart GK, Bellomo R, Webb SA. Rapid Response Team composition, resourcing and calling criteria in Australia. Resuscitation 2012;83:563-7.

43. Jones DA, Dunbar NJ, Bellomo R. Clinical deterioration in hospital inpatients: the need for another paradigm shift. Med J Australia 2012;196:97-100.

44. Le Roux PD, Cooper J, Guntupalli KK, Silbergleit R, Daily J, Geocadin R, Wijman CA, Suarez JI. The critical care research networks experience. Neurocritical care 2012;16:20-8.

45. Lipcsey M, Eastwood G, Jones D, Wanek K, Castegren M, Tonnesen E, Bellomo R. [Prevalence of partially treated supralabial hirsutism in dictators]. Ugeskrift for laeger 2012;174:3078-81.

46. Lipcsey M, Eastwood GM, Woinarski NC, Bellomo R. Near-infrared spectroscopy of the thenar eminence: comparison of dynamic testing protocols. Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine 2012;14:142-7.

47. Lipcsey M, Woinarski NC, Bellomo R. Near infrared spectroscopy (NIRS) of the thenar eminence in anesthesia and intensive care. Ann Intensive Care 2012;2:11.

48. Loekito E, Bailey J, Bellomo R, Hart GK, Hegarty C, Davey P, Bain C, Pilcher D, Schneider H. Common laboratory tests predict imminent death in ward patients. Resuscitation 2012.

49. McIntyre T, Taylor C, Eastwood GM, Jones D, Baldwin I, Bellomo R. A survey of ward nurses attitudes to the Intensive Care Nurse Consultant service in a teaching hospital. Australian critical care : official journal of the Confederation of Australian Critical Care Nurses 2012;25:100-9.

50. Miles LF, Bailey M, Young P, Picher DV. Differences in mortality based on worsening ratio of partial pressure of oxygen to fraction of inspired oxygen corrected for immune system status and respiratory support. Critical Care and Resuscitation 2012;14:25-32.

51. Mills J, Oliver A, Sherwin JC, Frydenberg M, Peters JS, Costello A, Harewood L, Love C, Redgrave N, van Golen KL, Bailey M, Pedersen J. Utility of RhoC and ZAG protein expression as biomarkers for prediction of PSA failure following radical prostatectomy for high grade prostate cancer. Pathology 2012;44:513-8.

52. Moore EM, Bellomo R, Nichol AD. The meaning of acute kidney injury and its relevance to intensive care and anaesthesia. Anaesth Intensive Care 2012;40:929-48.

53. Morimatsu H, Ishikawa K, May CN, Bailey M, Bellomo R. The Systemic and Regional Hemodynamic Effects of Phenylephrine in Sheep Under Normal Conditions and During Early Hyperdynamic Sepsis. Anesthesia and analgesia 2012.

54. Nadim MK, Kellum JA, Davenport A, Wong F, Davis C, Pannu N, Tolwani A, Bellomo R, Genyk YS. Hepatorenal syndrome: the 8th international consensus conference of the Acute Dialysis Quality Initiative (ADQI) Group. Crit Care 2012;16:R23.

55. Ng SY, Semple BD, Morganti-Kossmann MC, Bye N. Attenuation of microglial activation with minocycline is not associated with changes in neurogenesis after focal traumatic brain injury in adult mice. J Neurotrauma 2012;29:1410-25.

56. Paul E, Bailey M, Van Lint A, Pilcher DV. Performance of APACHE III over time in Australia and New Zealand: a retrospective cohort study. Anaesth Intensive Care 2012;40:980-94.

20 21

Publications GraphsPublicationsBooks

1. Morganti-Kossmann MC, Maas A, Raghupathi R, Editors. Traumatic Brain and Spinal Cord Injury: Challenges and Developments. New York, USA: Cambridge University Press: ISBN 978-1-1070-0743-7; 2012.

Book Chapters

1. Davies AR, Cooper DJ, Rosenfeld JV. Chapter 9: Intensive care management of head injury. In: Rosenfeld JV, ed. Practical Management of Head and Neck Injury. Chatswood, Australia: Churchill Livingstone (Elsevier): ISBN 978072539562; 2012:Pp212-22.

2. Moore E, Bernard S, Cooper DJ, Nichol AD. Chapter 2: Therapeutic Hypothermia: clinical history, mechanisms of action, common complications, current indications and future research directions in the critically ill. In: Valdez Delgado JI, Fernandez Garza VG, eds. Hypothermia: Prevention, Recognition and Treatment. New York, USA: ISBN 978-1-61942-551-4: Nova Science Publishers; 2012:43-68.

3. Moore E, Bernard S, Cooper DJ, Nichol AD. Chapter 3: Prophylactic Hypothermia in Traumatic Brain Injury. In: Valdez Delgado JI, Fernandez Garza VG, eds. Hypothermia: Prevention, Recognition and Treatment. New York, USA: ISBN 978-1-61942-551-4: Nova Science Publishers; 2012:69-90.

4. Nichol AD, Rosenfeld JV, Cooper DJ. Chapter 17: Future perspectives for the treatment of TBI patients: decompressive craniectomy, hypothermia and erythropoietin. In: Morganti-Kossmann C, Raghupathi R, Maas A, eds. Traumatic Brain and Spinal Cord Injury: Challenges and Developments. New York, USA: Cambridge University Press: ISBN 978-1-1070-0743-7; 2012:pp205-15.

5. Teo A, Davies AR. Chapter 18: Brain death. In: Rosenfeld JV, ed. Practical Management of Head and Neck Injury. Chatswood, Australia: Churchill Livingstone (Elsevier): ISBN 978072539562; 2012:pp311-6.

22 23 Presentations - National / International

Date Conference Location Name Title Role/s

2012Jun

Critical Care Nursing Continuing Education, 13th Annual Meeting ICE

Melbourne, Australia

Stephenson M Using therapeutic hypothermia to protect the brain

Invited Presenter

2012May

6th Alfred ICU Advanced Mechanical Ventilation Conference


Davies A • International Mechanical Ventilation Results

• Session 3

• Invited Presenter

• Chair

2012May



Hodgson C Session 2 Chair

2012May



Pilcher D High Frequency Oscillation Invited Presenter

2012May

College of Intensive Care Medicine (CICM) ASM


Cooper DJ What about the blood? Invited Presenter

2012May

CICM ASM Melbourne, Australia

Capellier G • Is it time for permissive hypoxemia in the intensive care unit?

• VALI - is it preventable?

Invited Presenter

2012May

CICM ASM Melbourne, Australia

Bellomo R The kidney Invited Presenter

2012Apr

23rd Annual Scientific Meeting of the Spine Society of Australia

Sydney, Australia

Ackland HM Outcomes at 12 months following early MRI in acute trauma patients with persistent midline cervical tenderness and negative CT

Invited Presenter

2012Mar

Australian Society for Infectious Diseases ASM

Perth, Australia

Aubron C Infections acquired by adults on ECMO: risk factors and outcome

Invited Presenter

2012Mar

ANZICS-CTG 14th Annual Meeting on Clinical Trials in Intensive Care

Noosa, Australia

Kruger P STATINS Trial Extended Results Invited Presenter

2012Mar


Noosa, Australia

Peake S ARISE-RCT Update Invited Presenter

2012Mar


Noosa, Australia

Hodgson C TEAM Trial Update Invited Presenter

2012Mar


Noosa, Australia

Trapani T POLAR-RCT Update Invited Presenter

2012Mar


Noosa, Australia

Bellomo R EPO-TBI RCT Update Invited Presenter

2012Mar


Noosa, Australia

Shehabi Y • SPICE Pilot Study Results• SPICE III Definitive Trial

Invited Presenter

2012Mar


Noosa, Australia

Davies A PHARLAP-RCT Update Invited Presenter

2012Mar


Noosa, Australia

Nichol A TRANSFUSE-RCT Update Invited Presenter

2012Mar


Noosa, Australia

Gantner D RELIEF Trial Invited Presenter

2012Mar

ANZICS-CTG Research Coordinator Workshop

Noosa, Australia

Murray L Research 101 Invited Presenter

2012Mar


Noosa, Australia

Little L Budgeting for studies Invited Presenter

2012Mar


Noosa, Australia

Howe B How to decipher a Clinical Trial Agreement (CTA)

Invited Presenter

2012Mar


Noosa, Australia

Hodgson C The Australian and New Zealand Intensive Care Research Centre

Invited Presenter

Presentations - National / International Date Conference Location Name Title Role/s

2012Nov

3rd Nutrition in the Critically Ill Symposium Melbourne, Australia

Ridley E • The Alfred ICU Enteral Guideline: Hot off the press

• How to critique an ICU paper: The EDEN Trial?

• Chair• Invited

Presenter

2012Oct

AusPEN ASM Adelaide, Australia

Ridley E • Lessons for building nutrition research capacity in Australasia

• Indirect calorimetry

Invited Presenter

2012Oct

Australian and New Zealand Intensive Care Society / Australian College of Critical Care Nurses (ANZICS/ACCCN) Intensive Care Annual Scientific Meeting (ASM)

Adelaide, Australia

Paul E The Australian and New Zealand risk of death model: Predicting mortality more accurately in intensive care units

Invited Presenter

2012Oct

ANZICS/ACCCN Intensive Care ASM Adelaide, Australia

Trapani T Propofol Related Infusion Syndrome (PRIS) causing unexpected death of a patient with severe traumatic brain injury: a case report

Invited Presenter

2012Oct

ANZICS-Clinical Trials Group (CTG) Spring Research Forum

Adelaide, Australia

Davies A • PHARLAP-RCT Update• Novel Trial Design

Invited Presenter

2012Oct

ANZICS-CTG Spring Research Forum Adelaide, Australia

Gantner D TRANSFUSE-RCT Update Invited Presenter

2012Oct


Cooper DJ • Centre of Research Excellence for Patient Blood Management (Blood-CRE)

• POLAR-RCT Update

Invited Presenter

2012Oct


Shehabi Y SPICE-RCT Update Invited Presenter

2012Oct


Panwar R • Standard care or individualized mean perfusion pressure targets in shock - a feasibility study

• Conservative or liberal O2-targets in ventilated patients - a pilot feasibility study

Invited Presenter

2012Jul

4th Alfred International Symposium on Extracorporeal Membrane Oxygenation (ECMO) and Ventricular Assist Device (VAD) Support in Critical Care


Higgins A Resource Containment and Clinical Leadership Rural ECLS Perspective: ECMO - Justifying the cost

Invited Presenter

2012Jul

4th Alfred International Symposium on ECMO and VAD Support in Critical Care


Hodgson C ECMO in Asia Pacific: Differences and driving quality: Walking, physical therapy and follow up

Invited Presenter

2012Jul

4th Alfred International Symposium on ECMO and VAD Support in Critical Care


Bellomo R Improving research design in ECLS: Doing more, doing it better and doing it cheaper

Invited Presenter

2012Jul

6th International Conference on Safety, Quality, Audit and Outcomes Research in Intensive Care


Paul E Mortality Prediction in Australian and New Zealand Intensive Care Units: Eight Models Are Better Than One

Invited Presenter

2012Jul

ANZICS-CTG Winter Research Forum Melbourne, Australia

Hodgson C TEAM Study Update Invited Presenter

2012Jul

ANZICS-CTG Winter Research Forum Melbourne, Australia

Howe B ARISE Interim Analysis Invited Presenter

2012Jul

Australian Red Cross Blood Service Research and Development Group Meeting

Melbourne,Australia

Cooper DJ TRANSFUSE Study Invited Presenter

The Alfred Centre Level 6, 99 Commercial RoadMelbourne, Victoria, Australia 3004anzicrc.monash.org

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