AUTHOR INDEX*

Abelson, R. M., 427 Adler, N. T, 290 Adrian, E. D., 442 Agranoff, B. W, 179,203,

214 AI-Hachim, G. M., 199,207,

319,342 Aldridge, W. N., 156, 197,

207 Alluisi, E. A., 141,757 Allyon, T, 359 Amorico, L., 190, 192, 193,

202,211 Amer. Conf. of Governmental

Industrial Hygienists, 2, 54, 265,287

Anderson, D. K., 380,395 Andjelkovic, D., 188,207 Andrew, W., 431,434 Anger, W. K., 129-153,440 Annau, Z., 73,105-127,289,

309,346, 347, 424, 443 Armitage, S. G., 319,342 Aronow, W. S., 54, 54 Artho, A., 295, 306 Axelrod,j., 114,726 Azrin, N. H., 359, 369

Babad, A. A., 271,288 Bachand, R. T, 4, 26, 30, 33,

34,47,53,54,55,61,69, 70,72,145,757

Back, K. C., 146, 757 Baddeley, A. 0., 62, 77 Baetjer, A., 289 Bajgar,j., 188,207,214 Bales, R. E., 285, 288

Baker, C. B, 64, 77 Baldwin, B. A, 238 Banham, K. G., 62, 77 Banks, A., 173, 194,207 Barantsevich, R. P., 194,205 Barckow, D., 196,207 Baretta, E. D., 4, 26, 30, 33,

34,47,53,54,55,61,69, 70,72,145,757

Barlow, C F., 188, 189,204 Barnes,j. M, 172, 197,207,

202 Barofsky, I., 115,725 Bartlett, D., 30, 54, 103 Battig, K., 210, 293-309 Beard, R. R., 1-27,29,30,

33,34,47,48,50,51,52, 53,54,56,57,59,60,61, 69,77,75,103,130,145, 147,149,750,152,211, 238, 263, 289, 425, 436, 441,443

Bell, A., 245, 267 Bender, W. M., 5, 25 Benedict, N., 248, 249, 267 Benson, B., 373 Bergeron, R. T., 392, 393 Berglund, F., 430, 434 Berlin, M., 430, 434 Bernard, C., 439 Berry, C. A., 195,204 Bignami, G., 59,127,152,

155-215, 238, 262, 289, 290,347,348,371,373, 397,426,444

Bills, A. G., 78, 702 Birren, J E., 434, 435 Blake, W. D.,jr., 112,725

Blanton, F. L., 352, 370 Bloom, F. E., 437 Blough, D. S., 7,25 Blum, j S, 430, 434 Bohdanecky, Z, 195,202, 203 Bokums,j. A., 188, 190,204 Bondareff, M., 431, 434 Boren,Jj., 250, 254, 267 Bouley, G, 305, 307 Bovet, D., 187, 198,206, 3D5,

307 Bovet-Nitti, F, 305. 307 Boyce, A. M., 248, 267 Boyd, E. M, 199,202,206 Brandsteter, B., 271, 288 Brazier, M. A., 8, 25 Breen, R. A., 245, 267 Brestkin, A. P., 156,206 Brimblecombe, R. W., 156,

173,194,195,202 Broadbent, D. E., 13,25,78,

703 Brodeur,j., 180,202 Brodie, R. E, 173. 174, 199,

203 Brody, B., 431, 434 Bucher, H. K., 8, 25 Buck, W. B., 218, 225, 226,

227,228,229,230,233, 234,236,237,244,267, 262

Bueno, O. F. A., 127, 185, 203,211

Bures,J., 195,203 Burkart,j. K., 131,757 Burn, J B., 277,287 Burt, G S., 57, 104,241-263,

397

* Numbers in italics are the pages on which the References are listed.

447

448

Cahoon, R. L., 62, 69, 71 Campbell, E. H., 257,261 Campbell, S. A., 106, 125 Cantino, D., 433, 434 Cardon, P. V., 228, 237 Carlini, E. A., 127, 185,203,

211 Carlton, P. L., 190, 192, 193,

203 Carpenter,]. A., 8,25 Carro-Ciampi, G., 185,203 Carson, T., 218, 234, 236,

237 Cascorbi, H. F., 271,287 Case, T.]., 191,204 Casterline,]. L.,]r., 173,

174,199,203 Catania, A. C., 138, 150 Chance, M. R. A., 352, 369 Charney, N. H., 185,203,

212 Chenoweth, M. B., 265-291 Chikos, P. M., 5, 26, 30, 47,

51,53,54,55,61,69,72, 145,146, 151

Chiodi, H., 69, 71 Chippendale, T.]., 179, 185,

186,203 Chow, K. L., 166,203 Christensen, H. E., 146, 151 Ciappi, 0., 194, 204 Citron, B. P., 379, 393, 394 Claeys, R. R., 248, 249, 261 Clark, F. C., 355, 369 Clark, G., 156, 189, 193, 194,

197,203,208,213 Clark, W. W., 402, 406, 416,

417,418,424 Clarkson, T. W., 344, 345 Clegg, D.]., 320, 342 Cliff, W.]., 187,204 Coburn, R. F., 105, 125 Cohen, M., 180,210 Cohen, S. D., 172,203 Cole,]., 430, 434 Cole, K. C., 442 Collison, H. A., 32, 54 Commins, B. T., 146, 151 Consolzaio, F., 69, 71 Cook, L., 356,369 Coombs, S., 401-427

Coon,]. M., 169,170,172, 197,204,207,210

Cooper, H. P., 194,204 Coult, D. B., 173,202 Cronholm,]. N., 243, 261 Czieleszky, V., 173, 174, 194,

203

Dahms, T. E., 5, 21, 22, 23, 25,61,71

Daigneault, E. A., 198, 203, 426

Dale, H. H., 442 Dale, W. E., 249, 261 Dalglish, F. W., 172, 173,

174, 179, 192, 194, 195, 209

D'Amato, C.]., 312, 343 Daneo, L. S., 433, 434 Davies, D. R., 13, 25 Davis, G. A., 179,203,214 Davis, K. B., 244, 261 Dawson, A. B., 322,342 DeAcetis, L., 373 Deane, C. C., 173, 202 Debijadji, R., 113, 125 Deichmann, W. B., 248, 261 Dembicki, E. L., 319,344 DeMuth, G. R., 298, 307 Denenberg, V. H., 333, 343 Denz, F. A., 172,202 Desi, 1., 173, 174, 194,203,

244,261 Deuber, A., 296, 301,307 Deutsch,]. A., 190, 193,203 Deutsche Pharmakologische

Gesellschaft, 156, 203 Dews, P. B., 27, 59, 214, 215,

257,261,290,291,352, 355,369,374,395,398, 436, 439-445

DiU, A. B., 69, 71 Dilts, S. L., 195, 204 Dinman, B. D., 5, 25, 30, 54 Dobbing,]., 189,204 Dockens, W. S., 185,209,211 Dominguez, A. M., 146, 151 Domino, E. F., 170,208,305,

307

AUTHOR INDEX

Dorcus, R. M., 2, 25 Douglas, C. G., 1

Doull,]., 169, 170,204 Dreisback, R. H., 319,343 Dren, A. T., 170,208 Driscoll, P., 293-309 DuBois, K. P., 169, 170, 180,

202,204,313,343 Dubowski, K. M., 31, 54 Dutta, S. N., 156, 193,208

Edelwejn, Z., 188, 198,204 Eger, E. I., 271,288 Elder,]. H., 409, 423 Ellin, R. 1., 188,204 Ellinwood, E. H., 378, 395 Elliott, H. W., 188, 190,204 Elsberry, D., 226, 228, 229,

230, 237, 262 Engen, T., 59, 60, 74 Erdmann, W. D., 188, 196,

201, 204 Erickson, R. W., 170,207 Estes, W. K., 110, 125 Evans, H. L., 57, 237, 238,

348,398,399,427 Eyl, T. B., 320,343

Faff,]., 188, 198,204 Falb, A., 188,204 Fang, H. C. H., 392, 393 Farhi, L., 68, 72 Farkas, I., 173, 174, 194,203,

244, 261 Farr, A. L., 335, 343 Farrer, D. N., 409, 423 Feldman,]. N., 380, 395 Fernandes, G., 330, 337, 343 Ferster, C. B., 352, 369 Fibiger, H. C., 194, 204 Finesinger,]. E., 170,207 Firemark, H., 188, 189,204 Fischman, M. W., 375-399 Fischman, V. S., 377,395 Fitz-Gerald, F., 378, 395 Fleisher,]. H., 187, 188,204,

205 Fleming, D. E., 167, 204

AUTHOR INDEX

Florio, V., 185,204 Fonnum, F., 170, 171,204 Forbes, A., 442 Forbes, W. H., 71, 72 Fournier, E., 197,204 Frankenhaeuser, M., 172,

173, 174,209,308 Fraser, D. A., 285, 288 Frontali, N., 190, 192, 193,

202,211 Fudema, J. J., 197, 208 Fulkerson, W., 320, 344 Fulton,J. F., 430, 435 Fulton, W. B., 2, 26 Funderburk, W. H., 191,204 Furchtgott, E., 319, 343

Gage,J. C., 285, 288 Gage, M. 1., 56,150,152,

210 Gaines, T. B., 249, 261 Gates, A. H., 345 Gatti, G. L., 155-215 Gaultier, M., 196,204 George, M. E., 146, 151 German, W.J., 430, 435 Gershon, S., 197,204,213 Ghent, L., 430,435 Giachetti, A., 194, 204 Gibbons, R.J., 184, 186,206,

212, 398 Gilbert,J. R., 285, 288 Glees, P., 430, 434 Glow, P. H., 172, 173, 174,

185,191,192,194,195, 205,208

Godovikov, N. N., 156,206 Goldbaum, T. R., 146, 151 Goldberg, A. M., 179,206,

330,344 Goldberg, M. E., 197,205 Goldberg, S. R., 352, 363, 370 Goldman, B. D., 290 Goldsmith,J. R., 14,25 Golikov, S. H., 156, 194,205 Goodman, 1., 319, 344 Goodnow, R. E., 8, 25 Gorski, R. A., 290 Gothert, G., 5, 25

Goy, R. W., 290 Goyo, K., 433, 435 Grandjean, E., 305, 307 Grandstaff, N. W., 1-27, 55,

58,73,75,145,150,441, 443

Grant, C. A., 430, 431, 434 Graybill, F. A., 327, 343 Green, C. S., 409, 423 Green, D. M., 74 Gregory, M., 13,25 Groll-Knapp, E., 5, 21,23,25 Grose, S. A., 352, 358, 359,

361,362,370,371,372, 373,374

Guerra, M., 194,204 Gunn,J. H., 352, 369 Gurd, M. R., 352, 369 Gurina, E. 1., 188,205 Guttormsen, D. M., 170, 171,

204

Haagen-Smit, A. J., 63, 71 Hadick, D. G., 179, 180,207 Hagan, E. C., 172,205 Hagerman, D., 312, 343 Haggard, H. W., 285, 288 Haider, M., 5, 21,23,25 Hake, D. F., 359 Haldane, J. B. S., 1 Haldane,J. S., 1,25,105,125 Hall, C. S., 333, 343 Hall, G. H., 305, 307 Halperin, M. H., 2, 5,26 Halpern, M., 379, 393, 394 Hamilton, H. C., 319, 343 Hanna, M. G., Jr., 285, 288 Hanninen, H., 130, 151 Hannon,J. P., 112, 125 Hanson, H. M., 257, 261 Hardy, D. F., 198,205 Harned, B. K., 319, 343 Harr, J. R., 248, 249, 261 Harris, C. N., 54 Harris, L. W., 187, 188,204,

205 Harris, W., 378,395 Harrison, J. M., 427 Hartemann, F., 308

449

Hauck, H., 5, 21,23,25 Haun, C. C., 146,151 Haverlack, B. J., 379, 393,

394 Havlena, J., 319, 344 Hawkins,J. E., Jr., 402, 403,

407,410,412,416,423, 424

Hayes, W.J.,Jr., 249, 261 Haymaker, W., 312, 343 Head, H., 61,71 Hearst, E., 382, 395 Heath, D. F., 156,205 Heffner, H., 409, 423 Heinig, P., 4, 26, 30, 47, 51,

53,54,55,61,69,72,146, 151

Heise, G. A., 195,205 Heller, A., 156,210 Henderson, Y., 1,285,288 Herd,J. A., 351-374 Herrmann, A. A., 30, 33, 34,

47,53,54,55,61,69,70, 72,145, 151

Herrnstein, R. J., 7, 26 Hicks, L. B., 434,435 Hicks, S. P., 312, 343 Hinners, R. G., 131,151 Hobbiger, F., 156, 188, 189,

205,206 Hodge, H. C., 248, 261 Hodgkin, A., 442 Hoffer, B. J., 437 Hoffield, D. R., 319, 343 Hoffman, L. J., 234, 236 Hohn, R., 352,370 Holland, G., 60 Holmes,J. H., 197, 198,207 Holmstedt, B., 156, 171, 187,

206 Holz, C., 359 Horton, R.J. M., 437 Horvath, S. M., 5, 21,22,23,

25,61,65, 71 Hosko, M.J., 4, 26, 29-60,

61,69,70,72,145,151 Howatt, W. F., 298, 307 Hrdina, P. D., 198,206,262 Hrdina, V., 188,201,214 Hrub~s, V., 294, 295, 297,

298,299,306,307

450

Hunt, R., 439 Hunter, D., 430, 435 Hurwitz, D. A., 115, 725 Hurwitz, L.J., 431,435

Imparato, B., 54,54 Isbell, M. 01.,54,54

Jager, K. W., 219,237 Jakl, A., 188,207,214 James, D., 244, 267 Janku, I., 164,206 Jarvik, M. E., 195,202, 293,

307 Jenner, P. M., 172,205 Jensen, S., 429, 435 Jernelov, A., 429, 435 Jex,J. R., 4, 26 Johanssen, G., 307,308 John, E. R., 166,203,206 Johnson, B. L., 58, 129-153,

262, 440 Johnson, H. E., 197,205 Johnson, M. K., 197,207,206 Johnsson, L. G., 402, 403,

407,410,412,423,424 Jones, L. G., 352, 357,370 Jones, W. I., 172,205 Jovic, R., 187,206

Kabachnik, M. 1.,156,206 Kagan, I. S., 156,207, 244,

267 Kaita, A. A., 179,206 Kalant, H., 184, 186,206,

212, 398 Kapp, B. S., 195,209 Karas, G. G., 225, 226, 227,

228, 229, 230, 233, 234, 237,244,267,262

Karczmar, A. G., 156, 198, 206

Karle, F. j., 284, 288 Kasirsky, G., 392, 393,395 Kaswan,J., 142,757 Katsunuma, H., 320

Kelleher, R. T., 72,152, 351-374,445

Keller, C., 195,205 Kemeny, T., 244, 267 Kennedy, F. S., 429, 435 Kety, S. S., 431,432,433,435 Khairy, M., 244, 267 Khramova, E. A., 188,206 Knelson, j. H., 298, 307 Koch, R., 295, 306 Koehler, W., 224, 237 Koelle, G. B., 156,206 Koester, A. G., 194,203 Konorski, j., 373 Koob, G. F., 112, 725 Korolev, A. A., 172,209 Kowalska, M., 373 Kramer, j. C., 377,395 Kraybill, H. F., 156,206,

248,267 Krijnen, C.J., 199,206 Kumer, S., 442 Kuhnen-Clausen, D. M., 190,

206 Kulp, R. A., 141,757

Landaw, S. A., 14,25 Langman, J., 319, 343 Lasagna, L., 352, 370 Lashley, K. L., 245, 267 Laties, V. G., 7,23,26, 57,

60,74,126,142,757,153, 254, 256, 267, 262, 284, 288, 352, 370

Lattal, K. A., 244, 267 Laughlin, N., 195,205 Laverty, R., 114, 725 Lawther, P.J., 146,757 Le Blanc, A. E., 184, 186,

206, 212, 398 Lecorsier, A., 196, 204 Leibowitz, S. F., 193 Lenz, W., 312,343 Leong, B. K.J., 265-291, 289 Levshunova, M. E., 194,205 Levy, E., 2, 26 Lewis,J. A., 62, 77 Ling, G. M., 198,206, 262 Linyuchev, M. N., 188,206

AUTHOR INDEX

Lippmann, M., 285, 288 Littlefield, D. C., 377,395 Loewi, 0., 442 Lofroth, G., 320, 343 Long, K. R., 234, 236 Longo, V. G, 185, 187, 198,

204,206 Loomis, T. A., 188,207 Lovitt, D., 62, 77 Lowe, M.J., 312,343 Lowy, K., 425, 426 Lowry, O. H., 335, 343 Luke,J. L., 31, 54 Lundberg, G. D., 379, 393,

394 Lynch, G. S., 194,204 Lynch, W. T., 172,207 Lyon, W. S., 320,344

MacEwen,J. D., 146,757 Mackenzie, W. F., 146,757 Mackworth,.1. F., 10, 13,22,

23, 26 Mackworth, N. H., 13,26,

62,72 Maland,J. B., 226,227,228,

233, 234, 23~ 244,262 Malorny, G., 5, 25, 294, 304,

305,307 Margules, D. L., 192,207 Masterton, B., 409, 423 Matsumoto, H., 433, 435 Mayer, 0.,160,170,171,

189,190,207 McCarron, M., 379, 393, 394 McCormick, R., 379, 392,

393,394 McFarland, R. A., 2, 5, 7, 21,

26, 105, 725 McGaugh,.1. L., 245, 267 McMahon, E. M, 380,395 McMillan, D. E., 382, 395 McPhillips,.1 . .1., 172, 207 Medved, L. I., 156,207, 244,

267 Meeter, E., 180,207 Meier, G. W., 105, 725 Mellender,j. W., 29-60 Metcalf, D. R., 197, 198,207

AUTHOR INDEX

Metzler,]., 19,26 Michaelis, M., 170,207 Michalek, H. M., 155-215 Michelson, M.]., 156,206 Michon,]. A., 140, 142,151 Mick, D. L., 234, 236 Mikulka, P., 4, 26, 30, 47, 51,

53,54,55,61,69,72,146, 151

Miller, G. R., 187,204 Miller,] M., 402, 403, 409,

410,412,423,424 Miller, R. W., 433, 435 Milosevic, M. P., 155-215 Mirsky, A. F., 228, 237 Mitra, P., 198,207 Miyama, T., 320 Mogenson, G.]., 114,125 Monteleone, P. N., 146, 151 Moody, D. B., 403, 414, 423 Moore, C. M., 193,208 Morrison, C. F., 305, 307 Morrison, G., 198,209 Morse, W. H., 7, 26,152,

351-374 Moshkin, E. A., 188,205 Mosteller, F., 8,25 Maya, F., 312, 343 Muallen, M., 271,288 Munson, E. S., 271,288 Murakami, U., 320, 343 Murphy, S. D., 172, 203 Myrsten, A. L., 307, 308

Nachmansohn, D., 187, 198, 206

Nahas, G. G., 114, 126 Nair, V., 313, 343 Narotsky, R., 431, 434 National Academy of Sciences,

30,54 Natoff, I. L., 156,207 Neal, M.]., 271, 288 Neir, A., 308 Neuhaus, G., 196,201 Nettesheim, P., 285, 288 Newton, P. E., 29-60 Niarfeix, M., 308 Niven,].]., 2, 5, 26

Norseth, T., 345 NRC Committee on Effects of

Atmospheric Contaminants on Human Health and Welfare, 62, 72

O'Brien, R. D., 156,207 O'Donnell, R. D., 4, 5, 26,

30,47,51,53,54,55,61, 69,72, 145, 146, 151

O'Hanlon,]. F., 5, 21, 22, 23, 25,58,61-75,103,262, 263,289,307,308,344, 345,346,349,427,437, 443

Olds,], 106,125 Olds, M. E., 106, 125 Olin,]. S., 114, 125 Oliverio, A., 305, 307 Oliverio, O. 0., 190, 193,

207,208 Olsen, D. A., 78, 103 O'Neal,]. D., 32, 54 Oswald, I., 397 Overstreet, D. H., 172, 173,

174, 179, 180, 185, 186, 192,194,195,203,208, 209

Overton, D. A., 110, 125, 185,208

Parkes, D. C., 173,202 Passo, S. S., 114, 126 Pearson, D. W., 193, 194,

203,208 Pearson, R. D., 402, 406, 416,

417,418,424 Pebay-Peyroula, F., 196,204 Pepler, R. D., 62, 72 Permutt, S., 68, 72 Perovic, L., 113,125 Peters, D. A. V., 198,206,

262 Peterson,] E., 4, 26, 29-60,

61,69,70,72,75,145,151, 309, 424, 443

Petrinovich, L., 245, 261 Pickens, R., 378, 395

451

Pincus, I. ].,379,393,394 Piontkovsky, I. A., 319, 343 Post, B., 307, 308 Prabhu, V. S., 197,208 Pradhan, S. N., 156, 193,208 Pribram, K. H., 430 Prick,].]. G., 430, 435 Priestley,]. G., 1, 25 Prim, M. M., 409, 423 Proctor, C. D., 197,208 Punte,C. L., 131,151

Quadagne, D. M., 290

Ramsey,] M., 3, 8, 26 Randall, R.], 335, 343 Ravizza, R., 409,423 Ray, A. M., 3, 26, 130, 145,

151 Razumova, M. A., 194,205 Rech, R. H., 282, 288 Regan, M.]., 271,288 Reizen, M. S., 320, 343 Renault, P. F., 376, 395 Reske,] A., 290 Revusky, S. H., 243, 261 Reynolds, G. S., 185,203,212 Rhodes, L. E., 167,204 Richardson, A.], 172, 173,

174,185,191,192,194, 195,205,208

Richterich, R., 296, 307 Ridlon, S. A., 197,208 Riggs, H. E., 266, 288 Riopelle, A.]., 56, 213, 214,

291,348,349,437 Risso, M., 200, 208 Roberts, M., 249, 262 Robinson,], 249, 262 Robinson, S. M., 115, 125 Robson,]. M., 271, 288 Rockwell, T. H., 3, 26, 130,

145, 151 Rodier, P., 319,343 Rodkey, F. L., 32, 54 Rokaw, S. N., 54, 54 Root, W. S., 69, 72 Roschina, L. F., 194,208

452

Rose, S., 172, 173, 174, 185, 191,192,194,195,205

Rosebrogh, N.]., 335, 343 Rosecrans,J. A., 170,208 Rosen, C. G., 429, 435 Rosenberg, P., 188, 208

Rosenberger, P. B, 406, 423 Rosie, N., 155-215 Roth, L.J., 188, 189,204

Roughton, F.J. W., 2, 5, 26, 65,70, 77

Rozengart, E. V., 156,206 Rozengart, V.]., 156,205,

206

Ruch, T. C., 430, 435 Rudo, F. G., 271,287 Rugh, R., 312,343 Rumbaugh, C. L., 392, 393 Rump, S., 188, 198, 204

Russek, M., 114, 725 Russell, R. W., 156, 172, 173,

174,179,180,185,186, 192,194,195,207,203,

208, 270

Ryan, L. C., 172, 179, 180, 209

Rybolovlev, R. S., 188,205 Rylander, R, 294, 305, 307

Saidman, L.J., 271, 288 Salerno, P R., 169, 170,204

Sanders, A. F., 78, 703

Sandler, B. E., 225, 226, 227, 228,229,230,233,237, 244,267,262

Sandler, R., 226, 227, 228, 234,237

Santolucito,]. A., 198, 209,

309 Sargent, F., 77, 72 Satrapinsky, Y. F., 188,206

Sayers, R. R., 2, 26 Scanlan, R. L., 392, 393 Schmiedeberg, 0., 442 Schnakenberg, D. D., 112,

725 Schneider, A. M., 195,209

Schoenfeld, R. I., 397,437 Schulte,]. H., 2, 22, 26, 53,

55, 61, 72

Schuster, C. R., 73, 185,209, 211,308,370,375-399, 436,441

Sebesse, S., 5, 25 Segal, D. S., 172, 173, 174,

179,185,192,194,195, 209, 270, 213

Segall, H. D., 392, 393 Selivanova, A. T., 156, 188,

194, 205, 209

Semagin, V. N., 319, 343 Semmes,J., 430, 435 Setzer,J. V., 129-153,440 Severinghaus, J. W., 271, 288 Shaw, F. H., 197,204,213 Shepard, R. N., 19,26 Sherman, W. M., 195,209

Sherrington, C. S., 442 Shigan, S. A., 172, 209

Shore, P. A., 114, 725 Shryne,J.,290 Shults, W. D., 320, 344 Siggins, G. R., 437 Sikov, M. R., 319, 344 Simon, G., 173, 174, 194,203 Simon, W., 429-437 Singhal, R. L., 198,206, 262

Sivian, L. D., 409, 423 Skinner, B. F., 110, 725, 352,

369, 402,423 Sloof, .J. L., 430, 435 Slusher, M. A., 114, 726 Small, H., 345 Smith, B. E., 312, 343 Smith, C. B., 355, 370 Smith,J. L., 1 Smith, P. W., 172, 179, 180,

209 Smith, R. M., 218, 234, 237 Smithberg, M., 320, 330,343,

344 Snyder, S. H., 114, 726 Sobotka, T. J., 173, 174, 198,

199,203,209,210,213,

214,262, 346, 347, 349, 395,396,397,426,435, 436

Soltysik, S., 238, 373 Sonne, A. E. H., 430, 435 Sosa,.J. M., 431, 435 Sparber, S. B., 330, 344

AUTHOR INDEX

Spiotta, E.J., 245, 262 Spyker, D. A., 330, 344, 433,

435,437 Spyker,J M., 311-349, 439 Spynu, E. I., 156, 207, 244,

267 Squire, L. R., 193, 209

Stamm,J. S., 430 Stavinoha, W. B., 172, 179,

180,189,203,209

Stebbins, W. C., 126,291, 401-427, 445

Stecher, O. 0.,157,209

Steele, B. J., 355,369 Stein, L., 113, 726, 192,207,

209

Steinsland, O. S., 114, 726 Stembridge, V. A., 146,757 Stevenson, D. E., 249,262 Stevenson,J. A. F., 114,725 Stewart, R. D., 4, 26, 29-60,

61,69,70,72,145,757, 443

Stewart, R. L., 284, 288 Stewart, W. C., 170,270

Stickney,]. C., 105, 106, 112, 115, 726

Stokinger, H. E., 285, 288 Stupfel, M., 305, 307 Surgeon General, 29, 55 Sussman, D. E., 244, 262 Suzuki, T., 320, 345 Swallow, M., 431, 435 Swedish National Institute of

Public Health, 430, 435 Swensson, A., 321,344, 345 Swets,J. A., 74,139,757

Tagiuri, R., 8, 25 Takeuchi, T., 430, 433, 435 Taniere, C., 308 Tanikella, T. K., 199,202

Tanner, W. P., 139, 757 Tansy, M. F., 392, 393,395 Tatter, D., 379, 393,394 Taussig, H. B., 312, 344 Taylor, H. M., 402, 424 Taylor, K. M., 114, 725 Teal,J. S., 392, 393

AUTHOR INDEX

Teichner, W. H., 55, 56, 77-104,443

Terrace, H. S., 290 Teuber, H. S., 430, 435 Thacore, V. R., 397 Theodore,j., 4, 5,26,30,47,

51,53,54,55,61,69,72, 145,146,757

Thomas, A. A., 146, 757 Thomas, N. C., 187,204

Thompson, T., 376, 395 Thomsen, C. E., 248, 262 Thorpe, E., 249, 262 Tolman, E. C., 224, 237 Triolo, A.j., 197,270 Tschirgi, R. D., 166,206

Ts'o, T. O. T., 74, 239, 265-291,373,396,425, 437,445

Tune, G. S., 13,25, 105, 726

Ulfvarsson, U., 321, 344, 345 Ungar, G., 180,270

U. S. Department of Health Education and Welfare, 105, 726

Usdin, E., 158, 190,270

VanBuren,]. M., 228, 237 Vane,]. R., 382, 395 Van Gelder, G. A., 217-239,

244,267,262,288,319, 344,440

VanLiere, E.j., 105, 106, 112,115,726

VanNote, W., 244, 262 Varagic, V., 113, 725 Vasquez, B. j., 172, 173, 174,

179, 192, 194, 195,209

Vernot, E. H., 146,757 Verster, deB. F., 170,207 Villee, C. A., 312, 343 Vincent, N. M., 319,344

Vojvodic, V., 188, 189,205, 206

Vukovich, R. A., 197,270

Wagner, H., 5, 21,23,25 Wald, G., 442 Walker, A. I. T., 249, 262 Wallace, R. A., 320, 344 Waller, M., 7, 26, 356,370

Waller, P. F., 356, 370 Wands, R., 57, 58, 72, 103,

151,213,289,373,374, 425,427

Wanner, H. U., 305, 307

Warburton, D. M., 172, 173, 174,179,185,192,193, 194, 195, 198,205, 209,

270,213 Waszak, M., 308 Watson, R. H., 172, 173, 174,

209

Webster, R. L., 319,343 Webster, W., 319, 343 Weigand, G. E., 2, 25 Weiland, N. G., 402, 406,

416,417,418,424 Weinstein, S., 430, 435 Weinstein, S. A., 106, 109,

110, 112, 725, 726 Weiss, B., 7,23,26, 59, 60,

127, 142, 757, 152,153, 156, 27~ 213, 243,254, 256,267, 262, 284,288, 345,352,370, 427, 429-437

Weiss, T., 195,203

Welford, A. T, 434, 435 Wenzel, B. M., 166,206 Werboff,]., 319, 344 Wertheim, G. A., 3, 4, 5, 16,

21,25,29,30,33,34,47, 48, 50, 51,52, 53, 54,54, 61,69,77,130,145,147, 149, 750

Westbrook, W., 245, 267

453

White, S. D., 409, 423 Wilbur, E. H., 244, 267 Wilcos, K. R., jr., 320, 343 Wilkinson, R. T., 23, 26, 62,

72 Wills,j. H., 187, 188, 196,

204,270

Wilson, C. E., 167,204

Wilson,]. G., 322, 344 Wilson, W. A., 430, 435 Winer, B. j., 67, 72, 322, 327,

344 Winfield, D. L., 245,262 Winter, j. C., 211,212,291,

374 Wise, C. D., 113, 726 Witoslawski,]. ].,257,267 Wohlfromm, M., 312,343 Wood,]. M., 429, 435 Wood, R. W., 290, 397, 426 Woodrow, H., 138, 140, 757 Woods,j. H., 185,209,211,

395, 396, 398 Woolsey, C. N., 430, 435 World Health Organization,

156,270

Xintaras, C., 27, 55, 58, 129-153,263,440

Yamamoto, I., 156 Yamamura, H. I., 188,205,

207 Yant, W. P., 2, 26 Yoshino, K., 345 Young, S., 142,757

Zaidi, I. H., 392, 393, 395 Zaugolnikov, S. D., 188,205 Zawolkow, G. A., 179, 185,

186,203

Zimmerman,]., 185,209, 211,384,395

Zweig, M., 114, 726

SUBJECT INDEX

acclimatization physiological after hypoxia, 110 in smokers after CO exposure, 70

acetaldehyde and swimming performance, 305-306

acetylcholine levels after anticholinesterase drugs, 157,170-171 and avoidance acq uisition, 210 and behavioral depression, 156-157 and demeton, 180 determination of, 160 and paraoxon and atropine, 187 and tolerance mechanisms, 179

acrolein and swimming performance, 305-306

acuity increase hearing and drugs, 427 visual and COHb levels, 56

adrenaline excretions and cigarette smoking, 308

aging damage after methylmercury, 341 nervous changes, 431 studies in chimpanzee, 437

air pollution and cognitive and perceptual motor abilities,

62 alcohol

effects on behavior, 153, 319 driving readiness task, 56 Flanagan coordination test, 57

aldrin effect of prenatal exposure, 319 low dose and depressing conditioned re­

flexes, 244 allowable dail y intake

and overt clinical toxicity, 429-430 alternation behavior

and difference in tolerance rate, 173

ammonIa

and swimming performance, 305-306 amphetamine

and behavior, 7, 23-24, 113 differences in behavioral performances, 282 and environmental circumstances, 352 history of development of abuse, 377 lethality, 252 mult. FI/FR, 355-356 necrotizing angiitis, 379, 393 rodents, 397-398 symptoms in animals, 377-378

in humans, 395 tolerance to, 185

Amthauer intelligence test effects of CO on, 5

animals (experimental) and control rate of responding, 282 manipulation and hypertension, 374 mice, strain 129/SvS1, 321,324

A/Jax,321 monkey, Cercopithecus aethiops, 403

Erythrocebus patas, 403 Macaca arctoides, 403 Macaca fasicularis, 403 Macaca mulatta, 403 Macaca nemestrina, 403 Papio papio, 403 Rhesus, 131,375 Squirrel, 353

quail, Coturnix coturnix japonica, 250 rat, albinos, 298, 301

Long-Evans, 106 Sprague-Dawley, 287 Wistar, 158,245,250,254

sheep, domestic, 219 antibiotics, see also neomycin, kanamycin

and behavior, 427 and irreversible hearing impairment, 402

455

456

anticholinesterase drugs, acetylcholine levels, 157, 170-171

duration of tolerance, 214 human behavioral studies, 213 interaction with other compounds, 197

intoxication, main symptoms, 156, 158-159 muscarinic components, 187 nicotinic components, 187 relearning, 163 specific and non specific changes in be­

havior, 191 poisoning, prevention and therapy, 196

antimuscarinic agents, see also atropine, scopo­lamine

and behavior, 195 arithmetic tests

effects of CO, 2, 10 Flanagan, description, 35

effects of CO, 45 arousal

level, interaction subject-experimenter, 10, 22

after CO exposure, 10, 14, 22 and difficulty, interest and duration of the

task, 22 in EEG after CO exposure, 305

arterial oxygen pressure index of tissue hypoxia, 69

atropine effects on blood pressure and heart rate, 368 paraoxon, and brain acetylcholine levels,

187 variation in behavioral performances, 282

automobile driving effects of cigarette smoking, 308 effects of CO, 3, 130, 145

automobile exhaust effects on psychological and psychomotor

tests, 2 autonomic functions

and response of the organism, 373 aversiveness

of a drug, 398-399 of a noise, 427

avoidance, see operant techniques azacytidine

after prenatal exposure, 319

BAL prophylactic agent and methylmercury In­

toxication, 344-345

SUBJECT INDEX

barbiturates after prenatal exposure, 319

Beard-Wertheim time discrimination test, see

time discrimination behavior

alternation and difference in tolerance rate, 173

amphetamine, 7, 23-24, 113 antibiotics, 427 anti muscarinic agents, 195 carbon disulfide, 130 carboxyhemoglobin, 18-19, 23, 36, 39,

41-42,50-54 compensatory after brain damage, 430 diazoxide, 373-374 environmental determinants, 351 extra or intracranial events, 266 facilitation and DFP, 193

and physostigmine, 193-194 halogenated hydrocarbons, 57 maternal-offspring, 325 muscarinic agonists, 193 nitroglycerine, 373-374 noise, 417 nonspecific changes, 191 of progeny, 315 recovery and parameters of the schedule, 167 specific changes, 191

behavioral adaptation and hypoxia, 109-111 consequences depending upon age of ex­

posure during pregnancy, 319 depression and acetylcholine levels, 156-157

and cholinesterase activity, 156-157 differences in performances and drugs, 282 human studies and anticholinesterases, 213 of the monkey and chlorpromazine, 152 output and facilitating effects, 156 parameters and nicotine, 305 schedules and sheep, 221 sciences and quantification of toxic effects,

284 subtle abnormalities and their appearance,

313 techniques, considerations about, 262

limitations in industrial toxicology, 283 recovery after intoxication, 283 and toxic effects, 283 utilities in industrial toxicology,

282 teratology, definition, 313

SUBJECT INDEX

behavioral (cont.)

test, sensitivity of, 164, 166-167 toxicity and individual differences, 277-278

blind controls importance of, 101-102

blood cholinesterase levels after ruelene, 234 dieldrin levels, 249, 254 glucose after methamphetamine, 389 insulin after methamphetamine, 389 lead analysis, 238-239 mercury, threshold levels, 348

blood-brain barrier and anoxia, 189 and anticholinesterases, 180 and obidoxime, 188 and organophosphorus, 189 permeability of, 188-189 and pralidoxime, 188 and quaternary compounds, 188-190

blood pressure and atropine and methyl atropine, 368-369 and chlorpromazine, 363 description of the method, 356-359 and diazoxide, 373-374 and I-epinephrine, 363 during FR, 359-360 influence of the schedule on, 371 and motor behavior, 371 and nitroglycerine, 373-374 and Pavlovian conditioning experiment, 371 and phentolamine, 363 and Sidman avoidance, 373 and "situation" of the experiment, 373

blood samples determination of, 64 hematocrit levels after CO exposure, 65, 72,

151-152 hemoglobin levels after CO exposure, 65 plasma protein levels after CO exposure, 65

body weight and cigarette smoking, 302

CO exposure, 123 hypoxia, 112, 123

gain after methylmercury prenatal exposure, 332

obesity and underweight after methyl­mercury, 339-340

of pregnant mice after methylmercury, 349 of the second generation offspring after

methylmercury, 346

brain functional capacity of, 432

brain amine analysis

457

after chronic methamphetamine adminis­tration, 393-394

brain cholinesterase activity and anticholinergic drugs, 167-171 and behavioral depression, 156-157 determination of, 160 after methylmercury prenatal exposure, 346 and tacrine, 171

brucella abortus antigen, 337-338

cannabis tolerance to, 185

capillaries and morphologic ear changes, 425

carbamates, see also neostigmine, physo­stigmine

and organismic factors, 199 carbon dioxide

and respiratory alkalosis, 109, 114 carbon disulfide

effects on behavior, 130 carbon monoxide, see CO carboxyhemoglobin

behavior, 18-19, 23, 36, 39, 41-42, 45, 50-54

concentration after CO exposure, 2-7, 13-14

in smokers and nonsmokers, 66 determination of 31-32,296-297 and dichloromethane, 58 levels after cigarette smoking, 298, 301 physical symptoms of, 57 and visual acuity, 56

catecholamine levels and hypoxia, 112-115

cell counting system and degree of cell loss, 436 density, 436 repair, 436

central and peripheral factors and behavior, 191-193 and cholinergic agonists, 193-196

central cholinergic system and drive modulation, 195 and response suppression, 195

chlordiazepoxide differences in behavioral performance, 282

458

chlorinated hydrocarbon pesticides, see aldrin, DDT, dieldrin, endrin

chlorpromazine effect on blood pressure, 363 effect on I-epinephrine, 363 effects on monkey's behavior, 152 effects on mull. FljFR, 355-356 effects on time discrimination, 142, 145 in errorless discrimination learning, 291 and interval between injection and trials,

164 and the parameters of the schedule, 167 after prenatal exposure, 318-319

choline acetyl transferase after methylmercury prenatal exposure, 335

cholinesterase determination and methylmercury prenatal exposure, 335

cigarette smoking and adrenal excretions, 308 automobile driving, 308 and carboxyhemoglobin, 298, 301 and control, difficulties about, 309 reduction of performance, 301 respiratory frequency, 296-298

inhibition, 303, 305 shuttle-box, 302-304 swimming endurance, 299-301 symptoms, rat, 296, 299, 302-303 and weight, 302

Clean Air Act, 130 CO

and acclimatization of smokers, 70 Amthauer intelligence test, 5 arithmetic test, 2, 10 arousal in EEG, 305 auditory time discrimination, 145 automobile driving, 3, 130, 145 avoidance responding, 305 Beard-Wertheim time discrimination, 35,

45,48, 50-51 body weight, 123 carboxyhemoglobin levels, 2-7, 13-14, 66 cigarette smoking, 301 cortical negative variation, 5, 58 Crawford collar and pin test, 4, 45, 53 Crawford screw test, 4 digit span test, 10 and discrimination test, 2 display experiment, 9 driving readiness task, 56 Flanagan arithmetic test, 45, 53

SUBJECT INDEX

CO (cont.)

Flanagan coordination test, 45, 53 Flanagan inspection test, 45, 53 food intake, 106, 122 hand steadiness test, 45, 53 heart rate, 69 hematocrit levels, 65,151-152 learning,S Marquette time estimation, 41-42, 45, 53 minute ventilatory volume, 69 and monitoring task, 67-70 psychomotor test, 5 reaction time, 3-4 response blocking, 87-93 self-paced digit keying, 99-101 sleep and EEG, 5 spatial perception task, 19 spontaneous running activity, 304 spontaneous sand digging in hamster, 304 stimulation of monosynaptic reflexes, 305 swimming performance, 304 tachistoscopic presentation, 5 theory of signal detection, 85-87 time discrimination, 146, 150 and time estimation, 3-5, 27, 39, 41, 51-53,

145-146 time perception, 29 time replication, 4

tracking test, 4 vigilance task, 5-6,10-11 visual cognitive task, 82-88 visual evoked responses, 4, 57-58

cochlea kanamycin and nerve degeneration, 409 potentials of, and DDT, 426 principles of hearing for frequency, 409

cochlear histopathology and kanamycin, 409 and neomycin, 411, 414 and noise exposure, 422

cognitive tests orthorater, 56 and perceptual-motor abilities, air pollution,

62 self-paced digit keying, 98

effects of CO, 99, 101 spatial, 18, 19

effects of CO, 19 visual, description, 80-81

effects of CO, 82-88 computers, 258, 260, 285-286

SUBJECT INDEX

conditioned reflexes and low dose of aldrin, 244

conditioned suppression paradigm, see operant techniques

constriction of spiral vessels and hearing loss, 402

coordination tests Flanagan coordination test, description, 35

effect of alcohol on, 57 of CO on, 45, 53

hand steadiness test, description, 35 effect of CO, 45, 53

tracking test, perceptual, 16-27 effect of CO on, 4

of hypoxia on, 2 cortical tissue

amount of, and motor and sensory function, 430

Crawford collar and pin test, see psychomotor test

Crawford screw test, see psychomotor test cross-fostering

definition of, 315 effect on growth, 332

on survival, 328 cross-sectional method, 314 cycle, 4,000 dip, 424

DDT and auditory signal detection, 233 cochlear potentials, 426 maze, 244 problem solving, 244 running time in a straight alley, 244 visual form discrimination learning, 244

degeneration of nerve fibers after kanamycin, 409

noise exposure, 422 synapses after 6-hydroxydopamine, 437

delayed response and dieldrin, 244

demeton and avoidance extinction, 173 brain acetylcholine levels, 180 and serial problem solving, 173

deprivation and satiation changes in DRL, 386

DFP acetylcholine levels after, 170-171 and avoidance acquisition, 177, 179

DFP (cont.)

chronic treatment with, 174-17 5 and facilitation of behavior, 193 female rat's receptivity, 198 muscarinic receptors, 180 obidoxime, 189 shuttle-box avoidance, 164-165 TMB4,191

diazoxide effect on behavior, 373-374 effect on blood pressure, 373-374

dichloromethane and COHb level, 58

dieldrin auditory signal detection, 230-232 blood levels of, 249, 254 death of animals, causes of, 249 delayed response, 244 DRL,255 EEG of sheep, 228 extinction of avoidance, 222-223 FI, sheep, 235

quails, 252-253 rats, 251-252

FR, sheep, 235 heart rate, 223-224 learning of detour problem, 244 maze, detour, 225-226

Lashley III, 247-248 V-visual discrimination, 226-227

running time in a straight alley, 244 slow wave EEG, 239 symptoms in mammals, 219

of toxicity in sheep, 222

459

differential reinforcement of low rates (DRL), see operant techniques

difficulty of the task and arousal level, 22

digit span test effect of CO on, 10

diisopropylfluorophosphate, see also DFP, 157-158

discrimination after CO exposure, 2 after hypoxia, 2 "impossible", 138-140

display experiment effects of CO exposure, 9 method, 7-8

dose effect on survival after prenatal exposure,

328

460

dose (cont.)

levels, effects of drug and behavior, 244 response curve and anticholinesterase,

161-162 driving readiness task

effects of alcohol on, 56 CO exposure on, 56

drug abuse, problems about, 375 effects and duration of the task, 22-23

and extensive training, 220 and postnatal maternal effect, 332 prolonged and cumulative aftereffects, 243 and sensitivity of self-initiated DRL, 392 and training, 214

orally administered and digestive system In

sheep, 237-238 uptake and time of its greatest effect, 23

duration action of, and physostigmine, 163

and DFP, 164-165 and neostigmine, 163 and paraoxon, 164-165

of response latency, display experiment, 8-9 of task, 22-23

and arousal level, 22 of tolerance, 396

with anticholinesterase drugs, 214

ear hair cells, after kanamycin, 409

neomycin, 414 noise exposure, 422

EDTA prophylactic agent and methylmercury in­

toxication, 344 electrical self-stimulation, see operant tech­

niques electroencephalographic record (EEG)

arousal after CO, 305 cortical negative variation and CO,S, 58 and dieldrin on sheep, 228 of sleep and CO, 5 slow wave and dieldrin, 239 of visual negative responses and CO, 4,

57-58 emotionality

after ionizing radiation exposure, 319 after prenatal exposure of psychotropic

drugs, 318

"end spurt" performance after CO exposure, 73

SUBJECT INDEX

and the difficulty of the task, 73 endrin

low doses and manipulation of objects, 244 environmental

circumstances and amphetamine lethality, 252

contaminants, criticism, 199-200 sensitivity of operant techniques, 257 and sensory effects, 426

determinants of behavior, 351 enzyme reactivators (oximes), see obidoxime,

pralidoxime, TMB4 EOCT

effects on FR, 274, 276, 279, 281-282 individual differences, 278-279, 281 pathological investigation after, 276-277 and sexual behavior, 277 and testicular atrophy, 288-289

I-epinephrine and chlorpromazine, 363

phentolamine, 363 effects on blood pressure, 363

FR,363 errorless discriminative learning, see operant

techniques ethacrynic acid

reversible hearing loss, 426 ethylene oxide, cyclic tetramer of, see EOCT eye

closure in a cat and loss of cells, 436-437 movement and CO exposure, 96-97, 104 problems after methylmercury, 339

facilitating effects and behavioral output, 156

filters and HCN of the smoke Cambridge, 295 charcoal, 296

fixed-interval (FI), see operant techniques fixed-response (FR), see operant techniques Flanagan coordination test, see coordination

tests Flanagan inspection test

description, 35 effects of CO on, 45, 53

food intake effect of CO, 106, 122

hypoxia, 106, 112, 122

SUBJECT INDEX

food intake (cont.)

effect of (cont.)

methamphetamine, 382

tolerance to anticholinesterases, 172 variation in tolerance rate and, 173

fostering definition, 315

effects on growth, 332

on survival, 327

growth

inn uenee of maternal endocrine changes after methylmercury, 349

after methylmercury exposure, 332

halogenated, see also halothane and methoxynurane

hydrocarbons, effects on behavior, 57 solvents, halothane and methoxynurane, 267

halosubstituted vinyl phosphorus esters

effect on open field, 173 halothane

effects on mull. FRjCRF punishment, 269~271

individual differences and, 271

relative potency of, 271~272

hand steadiness test, see coordination tests HCN of the smoke

Cambridge filter, 295 charcoal filter, 296 determination, 295

hearing

differential acuity in, 415 normal and auditory thresholds detection,

408 principles of, and cochlea, 409 reaction time in, 414~415

signal detection, sheep, 229

effects of DDT, 233 dieldrin, 230~232

lead, 235 ruelene, 233~234

thresholds in monkeys, 403, 408 effects of kanamycin, 415~416

effects of neomycin, 409, 411, 414

hearing loss and antibiotics, 402 constriction of spiral vessels, 402

hearing loss (cont.)

delayed, 414 ethacrynic acid, 426 intense sound, 402 permanent after noise exposure, 422 quinidine, 426 quinine, 402, 426 recovery of, 417 rock and roll music, 42S~426

heart rate

461

during avoidance signal presentation, 373 FR, 359~360

description of recording, monkey, 356~359

sheep, 221 determination, sheep, 222 effects of atropine and methyl atropine on,

368~369

CO exposure, 69 dieldrin, 223~224

neostigmine, 369

the schedule, 371

vagal activity, 369 heat exposure

and monitoring task, 62

high-altitude syndrome, 115

hilarity and CO exposure, 75

horizontal surface

description, 336 effects of prenatal methylmercury exposure

on, 337

6-hydroxydopamine degeneration of synapses, 437

hypertension and manipulation of the animal, 374

and noise, 427

hypoxia body weight, 112, 123 catecholamine levels, 112~ 115

conditioned suppression paradigm, 11 O~ 111, 126~127

discrimination, 2 food intake, 106, 112, 122 intensity of the stimulation, 108, III

monitoring task, 62 neurohumors, 114

physiological acclimatization, 110 rate of responding, 1 07 ~ 108, III

reaction time, 2 respiratory alkalosis, 109, 111, 113

tracking test, 2

462

imipramine

and errorless discrimination learning, 291 immune

reaction after methylmercury, 337-339 type reaction and tolerance mechanisms, 180

inclined plane description, 336 effects of prenatal methylmercury exposure

on, 336-337 individual differences

and behavioral toxicity, 277-278 due to training, 290 after EOCT, 278-279, 281 after halothane, 271 and marijuana inhalation, 308-309 after methoxyflurane, 271 and nicotine uptake, 308-309 and toxic reactions, 284

industrial toxicology and limitations of behavioral techniques, 283 and no-effect levels, 265 utilities of behavioral techniques, 282

inhalation exposure and prevention, 267 of smoke, 294-298 of the vapor of a drug, 284-285

insulin effects of acute methamphetamine, 389

intensity of the shock and avoidance, 211 of the stimulation and hypoxia, 108

interaction maternal-fetal, 317 maternal-offspring, 317 subject-experimenter and the arousal level,

10,22 interest of the task

and arousal level, 22 interresponse times (IRT)

and CO exposure, 119, 122 dieldrin, 255-256

intersignal interval (lSI) and CO exposure, 82, 84 definition, 78

intravenous catheters description, 377

isolation behavior due to, 325

kanamycin, 406 cochlear histopathology after, 409

SUBJECT INDEX

kanamycin (cant.) effects on auditory thresholds detection, 408

on differential acuity, 416 on reaction time to sensory stimulation,

414-415 hair cell of the ear, 409 nerve degeneration of the cochlea, 409

kyphosis after methylmercury prenatal exposure, 339

lead effects on auditory signal detection, 235 prenatal exposure, 311-312, 319

and visual discrimination, 319 learning

ability and prenatal methylmercury ex­posure, 319

and ionizing radiation, 319 and CO exposure, 5 of a detour problem and dieldrin, 244 discrimination and tolerance to an-

ticholinesterase, 172 paradigm, 110 and stimulus control (sheep and goat), 238

lesion compensation mechanisms, 186

lethality amphetamine and environmental circum­

stances, 252 dieldrin, causes of, 249 methamphetamine, and causes in human,

379 in monkeys, 397

methylmercury prenatal exposure, 332, 341-342

life style of drug abusers, 376 litters

abortion of, after methylmercury exposure, 347

eating of, after methylmercury exposure, 346 longitudinal research

and long-term and delayed effects, 314 LSD

effect on motor activity, 346-347

manipulation of objects and low doses of endrin, 244

marijuana and inhalation, individual differences in,

308-309

SUBJECT INDEX

maze detour task, sheep, 226

effects of dieldrin, 226-227

Lashley III, 246-247 effects of dieldrin, 247-248

learning ability, effect of prenatal adminis­tration of psychotropics, 318-319

retention of learning, and DDT, 244 Y -visual discrimination, sheep, 226

effects of dieldrin, 226-227 meprobamate

after prenatal exposure, 318-319 methamphetamine

acute lethal doses of, 379-380 blood glucose and insulin of, 389 clinical reports about, 376 and DRL, 386-387, 389, 391 food and water intake, 382 FR,382 hypoglycemia, 380 intake by human, 398 IRT, 385-386, 388-389 lethality, in abusers, 379

causes, in monkeys, 397 differences between human and animals,

379 precautions to avoid, 379

necrotizing angiitis, 396 self-initiated DRL, 388-389, 392 stereotypy, 397 tolerance, 382-384

to the lethal effect, 389, 391 ultrastructural changes, 393 withdrawal of, 391

symptoms of, 391,396-397 methoxyflurane

effects of mull. FR/CRF punishment, 269-271

individual differences, 271 relative potency of, 271-272

methylatropine effects on blood pressure and heart rate, 368

methylmercury and BAL, 344-345 binding and resin, 345 cholinesterase determination after, 335 earliest clinically detectable symptoms, 430 and EDT A, 344 eye problems after, 339 in fish; risks for a pregnant or nursing

mother, 347

463

methylmercury (cont.)

and neurological damage in adults, 348 and growth, 332 and horizontal surface, 337 immune reaction after, 337-339 and inclined plane, 336-337 IP administration versus oral, 347 kyphosis after, 339 milk level of, 345 mortality after, 332, 341-342 and nervous tissue, 430 neurological deficits, 335-337 neuromuscular deficits, 332, 341 obesity after, 339-340 and open field, 333 and penicillamines, 345 physical defects at birth, 331 placental barrier, 320 postnatal development, 322-342 prenatal development, 320-322

exposure, 320-342 prophylaxis, 344-345 sexual behavior after, 349 shuttle-box, acquisition of, 346 specificity for certain cell types, 437 survival after exposure, 327-328 and swimming test, 333-335 symptoms, neurologic, 335, 337,341 threshold levels in blood, 348 underweight after, 339-340 and vertical grid, 337 weight gain, 332

of the offspring of the second generation, 346

of pregnant mice, 349 when to study deficits after, 346

monitoring task description, 65, 93 effects of c6, 94-96

with nonsmokers, 67 -69 with smokers, 67,70

and heat exposure, 62 parameters affecting, 62, 73

monosynaptic reflexes stimulation of, and CO exposure, 305

monotony and monitoring task, 62, 73

motivation and central cholinergic system, 195 effects of CO exposure, 149 influence on behavioral tests, 23

464

motor activity effect of LSD on, 346-347

muscarinic agonists and behavior, 193 components In anticholinesterase intoxi­

cation, 187 receptors, sensitivity after DFP, 180

role of, 186

necrotizing angiitis in amphetamine abusers, 379, 393 after methamphetamine intoxication, 396

neomycin, 406-407 cochlear histopathology after, 411, 414 effects on auditory thresholds detection, 409,

411 hair cell of the ear, 414

role of peripheral fibers in the effects of, 426 neostigmine

and dose-response curve in a shuttle-box, 161-162

effect on FR, 369 on heart rate, 369

neurohumors hypoxia and the release of, 114

neurological deficits after methylmercury exposure, 335-337,348

neuromuscular deficits after methylmercury prenatal exposure, 332

neuron redundancy and damage measures, 437

nicotine and behavioral parameters, 305 effects in human, 307-308 stimulant effect of, 304 and swimming performance, 301 uptake, individual variation in, 308-309

nicotinic components and anticholinesterase intoxication, 187

nitro compounds and human headaches, 374

nitrogen dioxide, 263 nitroglycerine

effect on behavior, 373-374 effect on blood pressure, 373-374

no-effect levels and industrial toxicology, 265

noise behavioral changes, 417 cochlear histopathology, 422

SUBJECT INDEX

noise (cont.)

degeneration of nerve fibers, 422 frequency and impairment, 417 hair cell of the ear, 422 hearing loss, 417, 422 hypertension, 427 industrial, 424 method of exposure to, 407-408 octave band, 407 protective regulation in USA, 426 tissue damage, 425 versus ototoxic drugs, 416-417

obidoxime and acetylcholine levels, with paraoxon,

170-171 and blood brain barrier, 188 and DFP, 189 and paraoxon, 189

observation of the animals usefulness of, 289

Occupational Health and Safety and preemployment· audiogram in industry,

130,425 open field

description, 333 effects of halosubstituted vinyl phosphorus

esters, 173 of prenatal methylmercury exposure, 333

operant techniques avoidance

acquisition and acetylcholine levels, 210 DFP, 177, 179 methylmercury, 346 paraoxon, 177, 179, 182 parathion, 177, 179 tolerance, 73

behavior, and parathion and low casein diet, 173-174

tolerance, 173 extinction of, and demeton, 173

and dieldrin, 222-223 responding, and low CO concentration,

305 conditioned suppression paradigm

description, 110-111 effects of hypoxia on, 126-127

DRL description, 255, 384 effects of dieldrin on, 255

SUBJECT INDEX

operant techniques (cont.)

DRL (cont.)

effects of methamphetamine on, 386-387, 389, 391

self-initiated, description, 384-385 drugs' effects, sensitivity of, 392 effects of deprivation and satiation, 386 effects of methamphetamine on,

388-389, 392 electrical self-stimulation

description, 106 effects of CO, 115-122 effects of hypoxia, 106-109

errorless discrimination learning, 291

FI

effects of chlorpromazine and imipramine on, 291

description, 250-251, 253 effects of dieldrin, quails, 252-253

rats, 251-252 sheep, 235

effects of phentolamine, 371 effects of scopolamine, 212

FR dcquisition of, 278-279 blood pressure and heart rate during,

359-360 chain of, and tolerance, 172 chlorpromazine, 363 description, 274, 353, 381

of training, 278 dieldrin and sheep, 235 EOCT, 274, 276, 279, 281-282 methamphetamine, 382 neostigmine, 369 phel)tolamine, 363 tolerance to anticholinesterase, 172

mult. FRjCRF punishment description, 268 effects of halothane, 269, 271 effects of methoxyflurane, 269, 271

mult. FR/FI food, description, 353 effects of amphetamine, 355-356 effects of chlorpromazine, 355-356 pattern of responding, 354 shock, description, 353

shuttle-box, rat, description, 158-159,302 effects of acute injection of an­

ticholinesterases, 161-166 chronic injection of anticholinesterases,

174-176

operant techniques (cont.)

shuttlebox (cont.)

extinction of, 302

465

effects of cigarette smoking on, 302-304 sheep, description, 221

extinction of, 221 effects of dieldrin on, 222-223

Sidman avoidance schedule blood pressure in, 373

organismic factors and organophosphates and carbamates, 199

organogenesis mice, 317

organophosphates, see also DFP, paraoxon, parathion

brain acetylcholine levels, 170 cochlear potentials, 426 interactions with other pesticides, 198 neurophysiological systems, 198 organismic factors, 199 tolerance, 172

ototoxic drugs versus noise, 416-417

ozone, 263

parameters influencing the physical defects at birth, 331 of the schedule and chlorpromazine, 167

and recovery of the behavior, 167 paraoxon

brain acetylcholine levels, 167-170 with atropine, 187 with obidoxime, 170-171

cholinesterase activity, 169 chronic treatment with, 174-175 dose-response curve in shuttle-box, 161-162 effects on avoidance acquisition, 177, 179,

182 and obidoxime, 189 and pralidoxime, 189

parathion and avoidance acquisition, 177-179 and low casein diet, 173-174

pathological changes after chronic methamphetamine,

392-393 investigation after EOCT, 276-277

pattern of behavior and blood pressure and heart rate, 371 in mult. FI/FR food versus shock, 354

466

Pavlovian conditioning blood pressure during, 371

penicillamines prophylactic agent and methylmercury m­

toxication, 345 perception

after CO exposure,S physostigmine

and avoidance acquisition, 177, 179 and brain acetylcholine levels, 170 and dose-response curve in a shuttle-box,

161-162 and facilitation of behavior, 193-194

phentolamine and behavior, 370-371 effect on blood-pressure, 363 effect on I-epinephrine, 363 effect on FR, 363 on Fl, 371

placental barrier and protection of the fetus, 312

polyphagia after chronic methamphetamine, 384

postnatal development after methylmercury, 322-342 effects, direct and indirect, 315

induced by the mother, 314, 332 of pesticides, 199 versus prenatal exposure, 330

"poverty of reserve" and neural loss, 431

pralidoxime and blood brain barrier, 188 and central depressant effect, 188 and paraoxon, 189 and sarin, 187

prenatal, see also methylmerucry development after methylmercury, 320-322 effects, direct and indirect, 315

of pesticides, 199 exposure and azacytidine, 319

barbiturates, 319 chlorpromazine, 318-319 lead, 311-312, 319 meprobamate, 318-319 methylmercury, 320-342 psychotropic drugs, 318 radiation, 311-312 reserpine, 318-319 sodium bromide, 319

exposure and toxicity, 311 presbycusis, 424

problem solving effects of DDT on, 244

of demeton, 173

SUBJECT INDEX

prophylactic agents, see BAL, EDTA, peni­cillamines

prophylaxis after methylmercury exposure, 344-345

psychological tests effects of automobile exhaust on, 2

psychomotor tests Crawford collar and pin test, description, 35

effect of CO on, 4, 45, 53 Crawford screw test, effect of CO, 4

effects of CO on,S automobile exhaust on, 2

psychotropic drugs prenatal exposure, effect on maze learning,

318-319

quinidine gluconate and monkey's hearing, 402 hearing loss, 426

quinine and reversible or permanent hearing loss,

402,426

radiation effects after prenatal exposure, 311-312 ionizing, effects on behavior, 319

rate of error costs and tolerance, 185,211-213 of responding, and amphetamine, 382-383

drug effects on, 356 hypoxia, 107-108, 111 individuality of the animal, 282

ratio increase in FR, and blood pressure and heart

rate, 360 reaction time

effects of CO, 4 effects of hypoxia, 2 in the Marquette time estimation test, 34,

42, 45 multiple-choice, effects of CO, 3 to sensory stimulation, 414-415

effects of kanamycin on, 415 reactivator (enzyme)

and brain changes, 187

SUBJECT INDEX

reactivator (enzyme (cont.)

protection given when used alone, 187 rebound

effect and anticholinesterase intoxication, 195

from an insult in the young or old organism, 431

receptor sensitivity and tolerance mechanism, 180, 186

regulation of exposure of workmen, 265 reinforcing properties of a drug, 398-399 relearning

after anticholinesterase intoxication, 163 of form discrimination, and dieldrin, 244

reserpine after prenatal exposure, 318-319

resin

and methylmercury binding, 345 respiratory

alkalosis and carbon dioxide, 109, 114 hypoxia, 109, 111,113

frequency during cigarette smoking, 296-298

inhibition during cigarette smoking, 303, 305

minute ventilatory volume and CO, 69 response

enhancing effects of anticholinesterases, 194 modulating systems, 192-193 suppression and cholinergic system, 195

response blocking definition, 78 effect of CO on, 87-93

rock and roll music and hearing loss, 425-426

ruelene, 219 and auditory signal detection task, 233-234 and blood cholinesterase levels, 234

running time in a straight alley and DDT, 244 and dieldrin, 244

salicylate and anorexia, 427 effects on monkey's hearing, 402 and reversible hearing loss, 402, 426

sarin and pralidoxime, 187

scopolamine differences in behavioral performance, 282

scopolamine (cont.)

and FI, 212 tolerance to, 185

sensitivity of operant techniques and environmental contaminants, 257

sensitization phenomena, 163 sensory effects

and environmental contaminants, 426 sexual behavior

effects of EOCT on, 277 methylmercury, 349

female rat's receptivity and DFP, 198 and potency in rats, 290 testicular atrophy and EOCT, 288-289

sheep behavioral schedule with, 221

467

digestive system and oral drug adminis­tration, 237-238

usefulness of, 235 shuttle-box, see operant techniques signal detection theory, 12

CO exposure, (3, 86-87 CO exposure, d', 85, 87 and index of response criterion «(3), 79 and index of sensitivity to stimulation (d'),

79 and "stimulus rating procedure," 74

"silent damage," 431 sleep deprivation

effects on monitoring tasks, 62 society concern

and deleterious effect of self-administration of drug, 376

sodium bromide after prenatal exposure, 319

spontaneous running activity and low CO concentration, 304

spontaneous sand digging in hamster and low concentration of CO, 304

statistical model for analyzing survival data, 326

stimulant effect of nicotine in human, 307-308 versus depressant effects, 308

stimulation intensity of, and hypoxia, 108 monosynaptic reflexes of cat after CO ex­

posure, 305 stimulus control

and sheep or goat learning, 238 substitute systems

and tolerance mechanisms, 180

468

susceptibility of the developing nervous system, 433

swimming endurance, description, 298

effects of cigarette smoking, 299-301 performance and acetaldehyde, 305-306

acrolein, 305-306 ammonia, 305-306 CO, 304 nicotine, 301

test, description, 333-334 effects of prenatal methylmercury ex­

posure, 333-335 symptoms after

amphetamine, animals, 377-378 human, 395

anticholinesterase intoxication, 156, 158-159

carboxyhemoglobin, 57 cigarette smoking, 296, 299, 302-303 EOCT,273 dieldrin, mammalian, 219

sheep, 222 methamphetamine, 380, 384, 3'91 methylmercury, 430

neurological effects, 335, 337, 341 withdrawal of methamphetamine, 391,

396-397 synapses

evaluation of the number of, 437 and 6- hydroxydopamine, 437

tacrine and brain cholinesterase activity, 171

teratology principles of, 316-317

threshold behavioral determination

242-243 of toxicity,

limit of a new chemical, and behavioral tech­niques, 266

toxic levels, difficulties about, 431 time between the injection and the beginning

of the trials effects of chlorpromazine, 164

time discrimination

auditory, effects of CO on, 145 Beard-Wertheim test, description, 34

effects of CO on, 36, 45, 48, 50-51

SUBJECT INDEX

time discrimination (cont,) behavior and chlorpromazine, 142-145 in monkeys, 131-137

acquisition threshold of, 138-142 effects of CO exposure on, 146-150

visual, effects of lead prenatal exposure, 319 time estimation

Marquette test, description, 34 effects of CO on, 41-42,45 reaction time in, 34, 42, 45

task, effects of CO on, 145-146 of ten- and thirty-second, description, 34

effects of CO on, 3-5, 27, 39-41, 51-53, 146

time replication task effects of CO on, 4

tinnitus, 426 tissues

damage in high noise environment, 425 differentiation and time of exposure, 317,

328, 330 TMB4

and DFP, effect on behavior, 191 tolerance

to amphetamine, 185 to anticholinesterase drugs and behavior,

172,174-175,177,179 and duration, 214, 396

behavioral versus physiological, 181-186 to cannabis, 185 criticism about experiments on, 199 different rates of, depending upon situation,

173 to fenitrothion, 172 general concept about, 179-180 to lethal effect of methamphetamine, 389,

391 to methamphetamine, 382-384 to organophosphates, 172 to scopolamine, 185 versus tachyphylaxis, 398

tracking tests, see coordination tests training

effects upon drug, 214, 220 individual differences due to, 290

variability of the behavior results discrepancies about, 244-245

SUBJECT INDEX

vascular changes and behavioral responses, 374 after chronic methamphetamine, 392

vertical grid description, 333 effects of prenatal methylmercury exposure,

333 vigilance

definition, 61

vigilance (cant.)

task, visual, 5, 21 duration of, 22-23 performance after CO, 5-6, 10-11

water intake effect of methamphetamine on, 382 and tolerance to anticholinesterase, 172 variation in tolerance rate and, 173

469