autologous stem cells and transplantation process

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Autologous Adult Stem cells and Transplantion

Process

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Website : www.stemgenn.com | Email : [email protected] | Phone : +91 9910596674

Autologous Adult Stem cells and Transplantion Process

Autologous or Adult stem cells (ASCs) are the "multipotent" cells which are found throughout the body.

These cells do not involve embryos and is less controversial as compared to pluripotent cells.

Their ability to differentiate is more limited than pluripotent cells but is vast nonetheless.

The NIH’s site provide a list of around 4500 ASC trials as compared with 27 for embryonic stem cells and 21 for induced pluripotent stem cells.

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Recent announcements of new stem cell treatments usually involve ASCs, such as there was news that a toddler born without a trachea received a new one made from her own adult stem cells. Due to which now all the attention of researchers has been grabbed by ASC’s both here in India and abroad. Today’s, Physicians routinely offer treatments involving ASC's transplantation to their patients which can be performed in their clinics.Autologous adult stem cells, used to treat a variety of conditions and are harvested from the patient, processed, and returned to the same patient.

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Treatable diseases using autologous stem cells

The diseases which are being treated nowadays using autologous stem cells mostly related to damage or destruction of bone marrow which includes diseases such as non-Hodgkin's lymphoma and Hodgkin's lymphoma, leukemia, multiple myeloma, and aplastic anemia.

Restoration of bone marrow is being done that has been damaged by total body radiation and high doses of chemotherapy used for cancer treatment.

Apart from above diseases, these cells have also been used for the treatment of diabetes, Parkinson's disease, sickle cell disease, and thalassemia.

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Source of stem cells and the process of transplantation

The source of stem cells used in transplants can be :

Autologous stem cells - Patient receives stem cells from his own blood.

Allogeneic stem cells - Patient receives stem cells from a donor.

*The donor used in an allogeneic stem cell transplant can be the patient's identical twin, sibling, family member or an unrelated donor.

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For Autologous transplants physicians usually collect the stem cells from the peripheral blood rather than the bone marrow cells.

The growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood.

*G-CSF is a protein that is produced naturally in the body.

The blood is removed from a vein and passed through a machine that separates the stem cells. The machine then returns the remaining blood through a needle in the person's arm or through a central venous catheter. This way of collecting stem cells is called apheresis.

In adults, most autologous transplants use stem cells from blood. In a child, the decision whether to use cells from the bone marrow or the blood depends on the size of the child.

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Advantages of adult stem cells over autologous transplantations

In an autologous stem cell transplant procedure, the body recognizes the self- cells and does not lead to a condition known as Graft-versus-Host Disease (GVHD).

Treatment process does not require immunosuppressant's and histocompatibility matching.

The process of finding a donor for stem cell treatment is not required as the stem cells are taken from the patient itself.

Autologous blood is readily available, and immune reconstitution is more rapid than after allogeneic.

Autologous transplants are relatively safe procedures, with low rates of complications and infections compared with other type of transplants.Treatment related mortality rate is 2% to 3% in patients in most of the studies.

http://www.wdxcyber.com/gvhd.html

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Disadvantages of adult stem cells over autologous transplantationsApart from having a lot of benefits as compared to other types of transplantations, Autologous stem cells have some disadvantages as well:

Stem cells after transplantation may get infected with tumor cells and contribute to relapse of the tumor condition.

Autologous transplants cannot be used for genetic or acquired diseases in which the hematopoietic cells are injured or defective.

Prior treatment with certain chemotherapy drugs or with radiation therapy to the spine or pelvis may reduce the number of stem cells that can be collected for an autologous transplant in certain cases.

Possible marrow injury leading to myelodysplasia (Either from prior chemotherapy or transplant regimen).

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Stemgenn Therapeutics is one of the centre where stem cells are being used for the treatment of various life threatening diseases.It is the leading Cell therapy & Regenerative medicine services company that supports the development and commercialization of cellular therapies and stem cell research. Stemgenn provides cGMP-compliant cell manufacturing and consulting services that address regulatory, financial, technical, process, training and quality system strategies. Services include a full spectrum of support and consulting related to process and product development, validation, due diligence evaluations, tissue collection, processing, and storage, product manufacturing, distribution and transportation.


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Why StemGenn Therapeutics?

• As Stem cell have inherent properties to self renew and differentiation into other cell types. They are multi potent and found within our body.

• No side effects: as it's found in patient's own tissues or blood, chances of rejection and infection is negligible.

• World class clinicians and experts from Regenerative Medicine.

• Cost Effectiveness: autologous stem cell transplant is very much affordable.

• Non- Surgical Procedure & convenient.• Proven Results.


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For more detail:

Email: [email protected] Mob : +91 9811011690 W: StemGenn.com

mailto:[email protected]

http://StemGenn.com/

autologous stem cells and transplantation process

Health & Medicine