awardees & new class of young...scientific distinction in clinical research for his seminal...
TRANSCRIPT
SABCS Highlights New Komen Blogs
Congratulations to Komen BrinkerAwardees amp New Class of Young
Investigators
Komen recognized two renowned researchers with its highest honor the Brinker Awardsfor Scientific Distinction for their significant contributions to breast cancer research andmedicine
Lisa Coussens PhD Professor of Cell Developmental and Cancer Biology School ofMedicine at the Knight Cancer Institute at Oregon Health amp Sciences University receivedthe Brinker Award for Scientific Distinction in Basic Science for her significant contributionsto breast cancer research which have been essential in advancing our understanding ofthe role of the tumor microenvironment particularly immune cells in cancerdevelopment Read more about Dr Coussens
Eric Winer MD Professor of Medicine Harvard Medical School Senior Vice Presidentfor Medical Affairs Director Breast Cancer Program and Thompson Chair in BreastCancer Research at Dana-Farber Cancer Institute received the Brinker Award forScientific Distinction in Clinical Research for his seminal contributions in improving thetreatment of breast cancer and his devotion to applying the advances from clinical trials todaily practice which have helped to shape the standard of care and improve quality of lifefor breast cancer patients globally Read more about Dr Winer
From left Komen Chief Scientific Advisor Jennifer Pietenpol PhD Komen President and CEO
Paula Schneider Brinker Awards Recipients Lisa Coussens PhD and Eric Winer MD and
Komen Chief Scientific Advisor George Sledge MD at the Brinker Awards Reception
During the Brinker Awards Reception Komenrsquos new class of early-career investigatorswere also recognized and received Komen-embroidered laboratory coats Out of the 62research grants awarded in 2018 (totaling nearly $26M) 23 grants were awarded to early-career investigators - 9 of those investigators were coated by members of KomenrsquosAdvocates in Science (AIS) during the ceremony (pictured below)
From left Justin Balko PharmD PhD Subhamoy Dasgupta PhD Sandy Finestone PysD
Anne Meyn Rachel Freedman MD Shom Goel MD PhD Meryl Weinreb MA Jennifer
Geurriero PhD Darran OrsquoConnor PhD Patty Spears Kevin Roarty PhD Joe Taube PhD
Rebecca Watters PhD and Rebecca Seago-Coyle
Komen Hails Findings from KATHERINE Trial
In other SABCS news Komen hailed findings releasedby Roche from their KATHERINE clinical trial Thistrial shows patients with early stage HER2+ breastcancer who used T-DM1 (Kadcylareg) following surgeryrather than Herceptinreg which is the current standard ofcare are at lower risk of recurrence or death at 3 yearsafter treatment Read more about these practicechanging results
Komen Blogs on Early Career Investigators
Cutting-edge breast cancer research relies on the talent and dedication of researchers whocan bring new insights to our understanding of breast cancer Komen is committed tosupporting todayrsquos young scientists and clinicians who are the future of breast cancerresearch Since 1982 Komen has supported more than 1100 early career investigatorsYou can read more about the work of four of our early career investigators
Paula Bos PhD is investigating a new way to treat breast cancer that hasmetastasized to the brainRobert Faryabi PhD is using big data to find new ways to treat triple negativebreast cancer (TNBC)
Elizabeth Wellberg PhD is studying how obesity and metabolism impact breastcancer recurrenceJennifer Guerriero PhD is trying to improve treatment response in peoplediagnosed with TNBC by targeting the immune system
Komen Kudos
Komen Scholar Ingrid Mayer MD presented a plenary lecture focused on thelatest in endocrine therapy at the 2018 SABCSKomen Scholar Ann Partridge MD MPH received the AACR OutstandingInvestigator Award for Breast Cancer Research at the 2018 SABCSKomen Advocate in Science Patty Spears received the 2018 Komen North CarolinaTriangle to the Coast Spirit AwardKomen-funded investigator Lucile Adams-Campbell PhD was named a 2018Washingtonian of the YearKomen-funded investigator Geoffrey Shapiro MD PhD received the TATInternational Congress 2019 Honorary AwardKomenrsquos Big Data for Breast Cancer (BD4BC) Travel Scholarship was recentlyawarded to four Komen-funded grantees Omar Rahal PhD Jia Shen PhD XinLu PhD and Jason Herschkowitz PhD
Research Snapshots
Researchers including Komen-funded investigators Tracy Battaglia MDMPH (pictured left below) and Komen Scholar Julie Palmer ScD (pictured rightbelow) analyzed data from the Black Womenrsquos Health Study a study of 59000African-American women across the United States that started in 1995 Theirfindings published recently in Cancer Causes and Control show that African-American women with a low or high birth weight or born to older mothers may be atincreased risk of developing breast cancer This work highlights the importanceof research investigating why African-American women are more likely to die ofbreast cancer than white women More coverage of this work can be found here
The detection of circulating tumor DNA (ctDNA) is a promising way to potentiallymonitor treatment response and to predict metastatic progression In a recent NPJBreast Cancer publication Komen-funded investigator Gaorav Gupta MD (picturedbelow left) Komen Scientific Advisory Board member Lisa Carey MD (picturedbelow right) and colleagues developed a new blood test that can monitor changesin tumor mutations over time This test may be used to predict response to therapy inestrogen receptor-positive (ER+) metastatic breast cancer and it could help guidetreatment decisions for patients
People diagnosed with estrogenreceptor-positive (ER+) breast canceroften become resistant to standardtherapies In a new NatureGenetics publication funded in part byKomen Nikhil Wagle MD and teamshow that acquired mutationsin HER2contribute to treatmentresistance in patients with metastaticER+ breast cancer They demonstratedthat resistance could be reversed bycombining ER-directed therapies withthe irreversible HER2 inhibitor calledneratinib
Some tumor cells can spread todistant parts of the body where they liedormant or asleep These cells calleddisseminated tumor cells (DTCs) aredifficult to eliminate and can eventuallydevelop into metastatic tumors In
a Nature Cell Biology publicationKomen-funded investigator CandiceGrzelak PhD (pictured) CyrusGhajar PhD and colleagues showthat DTCs residing near bloodvessels are protected from the killingeffects of chemotherapy Theydemonstrate that targeting the areaaround blood vessels can sensitizebreast DTCs to chemotherapy and stopthe development of metastatic tumorsarising from DTCs More coverage onthis work can be found here
If you have a recent or upcoming publication on your Komen-funded research pleasenotify your Research Grants Manager or email us at researchprogramskomenorg Yourwork could be featured in the next newsletter
Komen in the News
News Medical Life Sciences New data from the TAILORx trial partially funded byKomen confirms that women of all races and ethnicities can safely follow theTAILORx recommendationsPost Online Media Two new studies both funded in part by Komen have developedPET imaging tools that can help identify those most likely to benefit from targetedtherapies such as PARP inhibitors
Research Resources
Komen funding has generated numerous publicly available resources intended to advanceresearch Our readers are encouraged to use the below resources so we can continue tomove toward our goal of saving lives
The Komen Tissue Bank (KTB) atthe Indiana University SimonCancer Center is the only repositoryin the world containing breast tissueand blood products from womenwho do not show evidence of breastcancer Please contact the KTBdirectly if you are interested in usingthese samples Read more fromresearchers who have used thisresource
TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences
Paula Schneider Brinker Awards Recipients Lisa Coussens PhD and Eric Winer MD and
Komen Chief Scientific Advisor George Sledge MD at the Brinker Awards Reception
During the Brinker Awards Reception Komenrsquos new class of early-career investigatorswere also recognized and received Komen-embroidered laboratory coats Out of the 62research grants awarded in 2018 (totaling nearly $26M) 23 grants were awarded to early-career investigators - 9 of those investigators were coated by members of KomenrsquosAdvocates in Science (AIS) during the ceremony (pictured below)
From left Justin Balko PharmD PhD Subhamoy Dasgupta PhD Sandy Finestone PysD
Anne Meyn Rachel Freedman MD Shom Goel MD PhD Meryl Weinreb MA Jennifer
Geurriero PhD Darran OrsquoConnor PhD Patty Spears Kevin Roarty PhD Joe Taube PhD
Rebecca Watters PhD and Rebecca Seago-Coyle
Komen Hails Findings from KATHERINE Trial
In other SABCS news Komen hailed findings releasedby Roche from their KATHERINE clinical trial Thistrial shows patients with early stage HER2+ breastcancer who used T-DM1 (Kadcylareg) following surgeryrather than Herceptinreg which is the current standard ofcare are at lower risk of recurrence or death at 3 yearsafter treatment Read more about these practicechanging results
Komen Blogs on Early Career Investigators
Cutting-edge breast cancer research relies on the talent and dedication of researchers whocan bring new insights to our understanding of breast cancer Komen is committed tosupporting todayrsquos young scientists and clinicians who are the future of breast cancerresearch Since 1982 Komen has supported more than 1100 early career investigatorsYou can read more about the work of four of our early career investigators
Paula Bos PhD is investigating a new way to treat breast cancer that hasmetastasized to the brainRobert Faryabi PhD is using big data to find new ways to treat triple negativebreast cancer (TNBC)
Elizabeth Wellberg PhD is studying how obesity and metabolism impact breastcancer recurrenceJennifer Guerriero PhD is trying to improve treatment response in peoplediagnosed with TNBC by targeting the immune system
Komen Kudos
Komen Scholar Ingrid Mayer MD presented a plenary lecture focused on thelatest in endocrine therapy at the 2018 SABCSKomen Scholar Ann Partridge MD MPH received the AACR OutstandingInvestigator Award for Breast Cancer Research at the 2018 SABCSKomen Advocate in Science Patty Spears received the 2018 Komen North CarolinaTriangle to the Coast Spirit AwardKomen-funded investigator Lucile Adams-Campbell PhD was named a 2018Washingtonian of the YearKomen-funded investigator Geoffrey Shapiro MD PhD received the TATInternational Congress 2019 Honorary AwardKomenrsquos Big Data for Breast Cancer (BD4BC) Travel Scholarship was recentlyawarded to four Komen-funded grantees Omar Rahal PhD Jia Shen PhD XinLu PhD and Jason Herschkowitz PhD
Research Snapshots
Researchers including Komen-funded investigators Tracy Battaglia MDMPH (pictured left below) and Komen Scholar Julie Palmer ScD (pictured rightbelow) analyzed data from the Black Womenrsquos Health Study a study of 59000African-American women across the United States that started in 1995 Theirfindings published recently in Cancer Causes and Control show that African-American women with a low or high birth weight or born to older mothers may be atincreased risk of developing breast cancer This work highlights the importanceof research investigating why African-American women are more likely to die ofbreast cancer than white women More coverage of this work can be found here
The detection of circulating tumor DNA (ctDNA) is a promising way to potentiallymonitor treatment response and to predict metastatic progression In a recent NPJBreast Cancer publication Komen-funded investigator Gaorav Gupta MD (picturedbelow left) Komen Scientific Advisory Board member Lisa Carey MD (picturedbelow right) and colleagues developed a new blood test that can monitor changesin tumor mutations over time This test may be used to predict response to therapy inestrogen receptor-positive (ER+) metastatic breast cancer and it could help guidetreatment decisions for patients
People diagnosed with estrogenreceptor-positive (ER+) breast canceroften become resistant to standardtherapies In a new NatureGenetics publication funded in part byKomen Nikhil Wagle MD and teamshow that acquired mutationsin HER2contribute to treatmentresistance in patients with metastaticER+ breast cancer They demonstratedthat resistance could be reversed bycombining ER-directed therapies withthe irreversible HER2 inhibitor calledneratinib
Some tumor cells can spread todistant parts of the body where they liedormant or asleep These cells calleddisseminated tumor cells (DTCs) aredifficult to eliminate and can eventuallydevelop into metastatic tumors In
a Nature Cell Biology publicationKomen-funded investigator CandiceGrzelak PhD (pictured) CyrusGhajar PhD and colleagues showthat DTCs residing near bloodvessels are protected from the killingeffects of chemotherapy Theydemonstrate that targeting the areaaround blood vessels can sensitizebreast DTCs to chemotherapy and stopthe development of metastatic tumorsarising from DTCs More coverage onthis work can be found here
If you have a recent or upcoming publication on your Komen-funded research pleasenotify your Research Grants Manager or email us at researchprogramskomenorg Yourwork could be featured in the next newsletter
Komen in the News
News Medical Life Sciences New data from the TAILORx trial partially funded byKomen confirms that women of all races and ethnicities can safely follow theTAILORx recommendationsPost Online Media Two new studies both funded in part by Komen have developedPET imaging tools that can help identify those most likely to benefit from targetedtherapies such as PARP inhibitors
Research Resources
Komen funding has generated numerous publicly available resources intended to advanceresearch Our readers are encouraged to use the below resources so we can continue tomove toward our goal of saving lives
The Komen Tissue Bank (KTB) atthe Indiana University SimonCancer Center is the only repositoryin the world containing breast tissueand blood products from womenwho do not show evidence of breastcancer Please contact the KTBdirectly if you are interested in usingthese samples Read more fromresearchers who have used thisresource
TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences
Elizabeth Wellberg PhD is studying how obesity and metabolism impact breastcancer recurrenceJennifer Guerriero PhD is trying to improve treatment response in peoplediagnosed with TNBC by targeting the immune system
Komen Kudos
Komen Scholar Ingrid Mayer MD presented a plenary lecture focused on thelatest in endocrine therapy at the 2018 SABCSKomen Scholar Ann Partridge MD MPH received the AACR OutstandingInvestigator Award for Breast Cancer Research at the 2018 SABCSKomen Advocate in Science Patty Spears received the 2018 Komen North CarolinaTriangle to the Coast Spirit AwardKomen-funded investigator Lucile Adams-Campbell PhD was named a 2018Washingtonian of the YearKomen-funded investigator Geoffrey Shapiro MD PhD received the TATInternational Congress 2019 Honorary AwardKomenrsquos Big Data for Breast Cancer (BD4BC) Travel Scholarship was recentlyawarded to four Komen-funded grantees Omar Rahal PhD Jia Shen PhD XinLu PhD and Jason Herschkowitz PhD
Research Snapshots
Researchers including Komen-funded investigators Tracy Battaglia MDMPH (pictured left below) and Komen Scholar Julie Palmer ScD (pictured rightbelow) analyzed data from the Black Womenrsquos Health Study a study of 59000African-American women across the United States that started in 1995 Theirfindings published recently in Cancer Causes and Control show that African-American women with a low or high birth weight or born to older mothers may be atincreased risk of developing breast cancer This work highlights the importanceof research investigating why African-American women are more likely to die ofbreast cancer than white women More coverage of this work can be found here
The detection of circulating tumor DNA (ctDNA) is a promising way to potentiallymonitor treatment response and to predict metastatic progression In a recent NPJBreast Cancer publication Komen-funded investigator Gaorav Gupta MD (picturedbelow left) Komen Scientific Advisory Board member Lisa Carey MD (picturedbelow right) and colleagues developed a new blood test that can monitor changesin tumor mutations over time This test may be used to predict response to therapy inestrogen receptor-positive (ER+) metastatic breast cancer and it could help guidetreatment decisions for patients
People diagnosed with estrogenreceptor-positive (ER+) breast canceroften become resistant to standardtherapies In a new NatureGenetics publication funded in part byKomen Nikhil Wagle MD and teamshow that acquired mutationsin HER2contribute to treatmentresistance in patients with metastaticER+ breast cancer They demonstratedthat resistance could be reversed bycombining ER-directed therapies withthe irreversible HER2 inhibitor calledneratinib
Some tumor cells can spread todistant parts of the body where they liedormant or asleep These cells calleddisseminated tumor cells (DTCs) aredifficult to eliminate and can eventuallydevelop into metastatic tumors In
a Nature Cell Biology publicationKomen-funded investigator CandiceGrzelak PhD (pictured) CyrusGhajar PhD and colleagues showthat DTCs residing near bloodvessels are protected from the killingeffects of chemotherapy Theydemonstrate that targeting the areaaround blood vessels can sensitizebreast DTCs to chemotherapy and stopthe development of metastatic tumorsarising from DTCs More coverage onthis work can be found here
If you have a recent or upcoming publication on your Komen-funded research pleasenotify your Research Grants Manager or email us at researchprogramskomenorg Yourwork could be featured in the next newsletter
Komen in the News
News Medical Life Sciences New data from the TAILORx trial partially funded byKomen confirms that women of all races and ethnicities can safely follow theTAILORx recommendationsPost Online Media Two new studies both funded in part by Komen have developedPET imaging tools that can help identify those most likely to benefit from targetedtherapies such as PARP inhibitors
Research Resources
Komen funding has generated numerous publicly available resources intended to advanceresearch Our readers are encouraged to use the below resources so we can continue tomove toward our goal of saving lives
The Komen Tissue Bank (KTB) atthe Indiana University SimonCancer Center is the only repositoryin the world containing breast tissueand blood products from womenwho do not show evidence of breastcancer Please contact the KTBdirectly if you are interested in usingthese samples Read more fromresearchers who have used thisresource
TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences
The detection of circulating tumor DNA (ctDNA) is a promising way to potentiallymonitor treatment response and to predict metastatic progression In a recent NPJBreast Cancer publication Komen-funded investigator Gaorav Gupta MD (picturedbelow left) Komen Scientific Advisory Board member Lisa Carey MD (picturedbelow right) and colleagues developed a new blood test that can monitor changesin tumor mutations over time This test may be used to predict response to therapy inestrogen receptor-positive (ER+) metastatic breast cancer and it could help guidetreatment decisions for patients
People diagnosed with estrogenreceptor-positive (ER+) breast canceroften become resistant to standardtherapies In a new NatureGenetics publication funded in part byKomen Nikhil Wagle MD and teamshow that acquired mutationsin HER2contribute to treatmentresistance in patients with metastaticER+ breast cancer They demonstratedthat resistance could be reversed bycombining ER-directed therapies withthe irreversible HER2 inhibitor calledneratinib
Some tumor cells can spread todistant parts of the body where they liedormant or asleep These cells calleddisseminated tumor cells (DTCs) aredifficult to eliminate and can eventuallydevelop into metastatic tumors In
a Nature Cell Biology publicationKomen-funded investigator CandiceGrzelak PhD (pictured) CyrusGhajar PhD and colleagues showthat DTCs residing near bloodvessels are protected from the killingeffects of chemotherapy Theydemonstrate that targeting the areaaround blood vessels can sensitizebreast DTCs to chemotherapy and stopthe development of metastatic tumorsarising from DTCs More coverage onthis work can be found here
If you have a recent or upcoming publication on your Komen-funded research pleasenotify your Research Grants Manager or email us at researchprogramskomenorg Yourwork could be featured in the next newsletter
Komen in the News
News Medical Life Sciences New data from the TAILORx trial partially funded byKomen confirms that women of all races and ethnicities can safely follow theTAILORx recommendationsPost Online Media Two new studies both funded in part by Komen have developedPET imaging tools that can help identify those most likely to benefit from targetedtherapies such as PARP inhibitors
Research Resources
Komen funding has generated numerous publicly available resources intended to advanceresearch Our readers are encouraged to use the below resources so we can continue tomove toward our goal of saving lives
The Komen Tissue Bank (KTB) atthe Indiana University SimonCancer Center is the only repositoryin the world containing breast tissueand blood products from womenwho do not show evidence of breastcancer Please contact the KTBdirectly if you are interested in usingthese samples Read more fromresearchers who have used thisresource
TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences
a Nature Cell Biology publicationKomen-funded investigator CandiceGrzelak PhD (pictured) CyrusGhajar PhD and colleagues showthat DTCs residing near bloodvessels are protected from the killingeffects of chemotherapy Theydemonstrate that targeting the areaaround blood vessels can sensitizebreast DTCs to chemotherapy and stopthe development of metastatic tumorsarising from DTCs More coverage onthis work can be found here
If you have a recent or upcoming publication on your Komen-funded research pleasenotify your Research Grants Manager or email us at researchprogramskomenorg Yourwork could be featured in the next newsletter
Komen in the News
News Medical Life Sciences New data from the TAILORx trial partially funded byKomen confirms that women of all races and ethnicities can safely follow theTAILORx recommendationsPost Online Media Two new studies both funded in part by Komen have developedPET imaging tools that can help identify those most likely to benefit from targetedtherapies such as PARP inhibitors
Research Resources
Komen funding has generated numerous publicly available resources intended to advanceresearch Our readers are encouraged to use the below resources so we can continue tomove toward our goal of saving lives
The Komen Tissue Bank (KTB) atthe Indiana University SimonCancer Center is the only repositoryin the world containing breast tissueand blood products from womenwho do not show evidence of breastcancer Please contact the KTBdirectly if you are interested in usingthese samples Read more fromresearchers who have used thisresource
TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
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TNBCtype is a tool that allows sub-typing of triple negative breast cancer (TNBC)using genomic data Komen Chief Scientific Advisor Jennifer Pietenpol PhD andher team at Vanderbilt University Medical Center developed this toolThe Metastatic Breast Cancer (MBC) Project (mbcprojectorg) led by KomenGrantee Nikhil Wagle MD is a patient-driven initiative that asks MBC patients toshare their cancer experiences medical records and tumor tissues to accelerateresearch discoveries The project released the first publicly accessible data set intocBioPortal with more to come and will soon be sharing raw data in the GenomicData Commons (GDC) The goal of this growing data set is to allow as manyresearchers as possible to make discoveries that accelerate our understanding ofMBC Find out more at mbcprojectorgdata-release
Thank You for Your Support
Komen Affiliates are working to address breast cancer every day in their localcommunities YOU can contribute to this work by participating in an Affiliate event such asa Race for the Cure More Than Pink Walk or Metastatic Breast Cancer (MBC)Event Over the past six years Komen Affiliates have hosted various MBCeventsconferences throughout the country to unite and support the MBC communitySeveral upcoming MBC eventsconferences will be held in the followinglocations Washington DC on Feb 23 San Diego CA on Mar 5 Independence OH onMar 9 and Portland OR on Mar 16 To learn more read a recent Komen blog on the KeyThemes of the 2018 MBC conferences And thank you for your continued support
Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
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Komen Scholar Alana Welm PhD at the More Than Pink Walk in Utah in November 2018
If you have recently participated in a Komen Affiliate or 3-Day event please send photosand a brief description to your Research Grants Manager or email usat researchprogramskomenorg Your photo may be featured in our next newsletter
Upcoming Research Conferences
Susan G Komen partners with other breast cancer organizations professional societiesand academic institutions to support and participate in a number of patient-focused
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences
meetings and scientific conferences each year Below is a list of meetings Komen supportsandor will have a presence at () as well as other conferences that may be of interest
Society of Surgical Oncology (SSO)s Annual Cancer Symposium - March 27-302019 San Diego CAAmerican Association of Cancer Research (AACR) Annual Meeting - March 29-April3 2019 Atlanta GAAmerican Society of Clinical Oncology (ASCO) Annual Meeting - May 31-June 42019 Chicago IL
Take Action
Like what yoursquore reading Wed love yoursupport
1 FIND your local Affiliate2 SIGN UP for a More Thank Pink
Walk 3-Day or Race for theCure event
3 VOLUNTEER at a local event4 Become an ADVOCATE5 Create a project to FUND-RAISE6 DONATE to our Mission
Connect with us Like subscribe and follow us to keep up with the latest breast cancernews inspirational stories and more
Copyright Acirccopy 2019 Susan G Komenreg All rights reserved
unsubscribe from this list update subscription preferences