May 2012

Axsun Technologies Inc.

Swept Laser based OCT Subsystems

Outline

• Axsun Overview

• Axsun Technology and Manufacturing

• Axsun Swept Laser Engine products

• Product Roadmap

• Images

• Summary

Axsun Technologies Inc.

• A wholly owned subsidiary of Volcano

Corporation (Nasdaq: VOLC)

• Founded in 1998, located in Billerica, MA

• Producing more than ten thousand

optical engines annually into Telecom,

Industrial Spectroscopy and Medical

Imaging applications

• Unique tunable MEMS and optical

integration technology

• Telecom and Industrial products have

strong synergy with Medical Imaging

• 115 employees

• 104 Issued Patents

AXSUN MODULE ASSEMBLY FACILITY

Optical Engine

5

MEMs Technology and

Manufacturing Platform

High Capacity, Automated

Manufacturing

The Axsun Platform – Unique Devices,

Assembly, and Products

Unique Devices Optical Bench Optical Engine

Module

Complete Subsystem

The Axsun Platform – Unique Devices,

Assembly, and Products

Unique Devices Optical Bench Optical Engine

Module

Complete Subsystem

The Axsun Platform – Unique Devices,

Assembly, and Products

Unique Devices Optical Bench Optical Engine

Module

Complete Subsystem

The Axsun Platform – Unique Devices,

Assembly, and Products

Unique Devices Optical Bench Optical Engine

Module

Complete Subsystem

10

Swept Source OCT

Axsun Swept Laser Technology

and Performance

Optical Coherence Tomography OCT Techniques

1. Time-domain OCT

2. Frequency-domain OCT • Spectral-domain OCT

• Swept-source OCT

Swept-Source OCT advantages

– Enables balanced and polarization diverse detection

schemes

– Longer Wavelengths, such as 1060 and 1300 nm, enable

deeper penetration into tissue

– Increased imaging depth range from slower signal roll-off

– High SNR and Resolution in a compact, rugged package

#11

SSOCT

#12

Axsun MEMs External Cavity Tunable Laser

14 mm

SOA

Tunable FP Filter

Laser Cavity

Gain Output

Optical

Fiber

Fiber

Reflector

Lens Lens

Micro-Electro-Mechanical System

(MEMS) Tunable Filter

Tethered

Membrane

Filter Assembly

Wafer Scale Processing

HR Coated

Flat Mirror

Electrode Gap

Optical Cavity

HR Coated Curved

Mirror on Tethered

Membrane

Si

#13

V

MEMS Fabry-Perot Filter Structure

Micro-Optical Bench Packaging Platform

#14

SOA gain chip

Output Fiber pigtail

LIGA alignment structure

Si micro lens

MEMS tunable filter

Micro-optical bench

x

y

z

Micro-

lens

fiber

Enables the most compact, highest

speed tunable laser for OCT

Axsun Swept Laser

Performance

Axsun Laser Tuning Range (Bandwidth)

#16

BW > 110 nm BW > 100 nm

Axsun Laser Coherence Length

#17

Operating conditions:

– l ~ 1060 nm

– 110 nm tuning

range

– 100 kHz scan rate

Axsun’s slow signal rolloff enables longer imaging depth

range than competitive swept lasers and Spectral Domain

OCT systems

SNR over Imaging Depth

#18

Slow SNR rolloff enables

longer imaging depth

range

Ref:

Benjamin Potsaid, Bernhard Baumann,

David Huang, Scott Barry, Alex E. Cable,

Joel S. Schuman, Jay S. Duker, and

James G. Fujimoto, "Ultrahigh speed

1050nm swept source / Fourier domain

OCT retinal and anterior segment imaging

at 100,000 to 400,000 axial scans per

second," Opt. Express 18, 20029-20048

(2010)

1060 47kHz

InGaAs Camera 850nm 91kHz

CMOS Camera Axsun 1060nm

100kHz Engine

Axsun OCT Engine

Current products

OCT system with Axsun SS Laser +

Axsun Data Acquisition Board

#21

Swept Laser

20

80

50

50

Balanced

Receiver

Variable Delay

10

90

Clock

Clock interferometerDAQ Board

Sweep

Trigger

Signal

1060 nm OCT “Engine”

Probe

Axsun OCT products

#22

Axsun Swept Laser OEM Engine Axsun Camera Link DAQ Board

Axsun Swept Laser Benchtop

Engine Axsun Swept Laser Engine with

integrated DAQ

Axsun OCT Engine Specifications 1310 Swept

Source

1060 Swept

Source

Output Power

(Average) (mW) 18 15

lTuning Range (nm) 1250-1360 980 – 1100 nm

Sweep Rate (kHz) 50 100

Coherence Length (Round

Trip PL, mm) 13 10

K-Clock Depth (Std, mm) 5 3.7

K-Clock Frequency (MHz) 130 330

Balanced Detector Optional Optional

Demonstrated Sensitivity *

(dB) 105 102

Power Supply (vDC) +12 +12

Size (OEM, mm) 114 x 177 x 58 114 x 177 x 58

#23

Highlights:

• High output power (15-18 mW with back trace blanking)

• > 100 nm tuning range (for imaging resolution < 8 µm (1060) or 15 µm (1310) )

• > 10 mm long coherence length (for imaging depth > 5 mm)

• 50–100 kHz scan rates (for fast data acquisition)

• Compact, reliable, and mass-manufacturable

• Low noise (RIN < 120dBc/Hz)

-60

-40

-20

0

20

40

60

80

100

120

0.001 0.01 0.1 1 10 100 1000 10000

dB

Reference Power (uW)

Sensitivity for 2.5 mW sample power

Noise

Signal

SNR

SNR + Loss

OCT System Performance

#24

Operating conditions:

– l ~ 1060 nm

– 110 nm tuning range

– 100 kHz scan rate

– System includes

Axsun BD and DAQ

Shot Noise Limited

sensitivity of 102dB .

Axsun OCT Product

Roadmap

Product Plans

• Axsun’s Core Technology provides distinct advantages in

size, speed, imaging depth range and reliability for our OCT

Engine Products

• In 2012 and beyond, Axsun will build on our technology lead

in Swept Laser Subsystems

– Higher speed, wider bandwidth Swept Laser Engines

– Data Acquisition/Image Processing

• Our value added subsystem products will speed TTM and

allow our OEM customers to focus on their applications

26 Confidential

OCT Product Roadmap – Next Gen Lasers

• 150nm 100kHz 1310nm Engine

– High resolution Anterior segment

imaging

– Endoscopic cancer detection

– Enables higher resolution and

speed

– Targeting similar coherence length to our 100nm 50kHz 1310 laser (12-

15mm) – We can provide equivalent resolution

at 4X speed and 3x Imaging depth of

our competitors

27 Confidential

Wider Tuning BW

100nm

150nm （10kHz)

Possibilities for Swept Laser

• In addition to higher speed and wider

bandwidth we can provide other

variations on our swept laser

• Longer coherence length for deep

imaging

– May require some tradeoffs in speed and

resolution

OCT Product Roadmap- System Capabilities

• 2 Channel PCIe based DAQ Board – Specifically designed to work seamlessly

with Axsun 100 and future 200kHz sources

– 2 Channel 500MSPS 12-bit DAQ – 1024-2048 samples per A scan

– Xlinx Virtex 6 FPGA gives added signal

processing capability – Image processing (FFT, Pol. Mixing Windowing)

– Image compression

– Multiple high speed data interfaces – Ethernet, GBE, RS232, PCI

– In house expertise to provide custom

algorithms

– Quick turn customization capability will be

a differentiator and speed TTM for our

customers

29 Confidential

500MSPS PCI DAQ

x8 PCIe

Bra

cket

Cut

out

regi

on (

end

view

)

4GTXs

8 GTXs

DSP

TI ADC

TI ADC

BracketMtg Hole

MaximADC

Virtex-6Xilinx

XC6VLX130T-1FFG784C

+ Aavid374324B60023G(27x27x10mm)

spring-clip

anchor

Flash

FRAM

LED

StandoffMtg Hole

(on Engineand heatsink)

Engine PCB Outline

PHY

1Gb

PHY

PHY

JTAG1 J6

QSFP cageMolex 0747500021

Module

AvagoAFBR-79Q4Z

PCB Bracket

Strut

Mtg HoleStrut

CLOCK LOGIC

12V SUPPLY FILTER,

DIGITAL VOLTAGE REGULATORS

(5VD, 3.3VD, 2.5V, 1V)

ANALOGVOLTAGE

REGULATORS(6V, 5VA, 3.3VA

-5V)

SATA

J1

SATAJ2

PowerJ3

USBJ4

MBJ5

0.124

SDRAM

SMA J10

Hand-pieceJ11

RJ-45J9

(R/A)

COMJ7

7.000”

4.376”

FAN J16

AUX

J15

F/O

J8

JTAG J12J14

J13

Customer Input for DAQ

• Preferred interface (PCIEx)

• Signal Processing

– FFTs, Windowing, Filtering, other signal

processing commands

– Does customer want to program their

algorithms

• Other needs

Axsun OCT Real World

Imaging Examples

Enhanced Depth Imaging with Axsun SL

Engine

• SSOCT Imaging of the

entire Anterior Segment,

Kitasato University

showing dynamic

accomodation(1)

• Full Anterior Segment

Imaging using fast

Optical Switching – Univ.

of Luebeck (2)

32

1. Biomedical Optics Express Vol 1, Issue 5, Nov. 2010

2. ARVO Meeting, May 2011

12mm

OCT Images of Anterior Segment at 1310 nm

#33

OCT image of

an eye after

corneal

transplantation

OCT image of anterior

eye chamber after

corneal transplantation

Images courtesy of Nicolaus Copernicus University, Torun, Poland

World Class Retinal Imaging

Image Courtesy of

Topcon

(Healthy Subject)

#34

Retinal Images with 1060nm Axsun

Swept Laser Engine

#35

Images published by Kyoto University and Tokyo Medical and Dental University

Retinal/AS Images with 1060nm

Axsun Swept Laser Engine

#36

Ultrahigh speed 1050nm swept source / Fourier domain OCT retinal and anterior segment imaging at 100,000 to

400,000 axial scans per second 13 September 2010 / Vol. 18, No. 19 / OPTICS EXPRESS 20029

Images Generated by Massachusetts Institute of Technology RLE 1

Cornea displacement and ONH Imaging • Eye displacement with

Swept Laser OCT

– Sample data from NCU

Poland using OCT to

measure Intraocular

pressure with an air puff

system (1)

• Volumetric Optic Nerve

Head Imaging with High

Speed OCT

– Simon Fraser University (2)

37

Dynamic

measurement of

corneal

displacement

from an air-puff

(NCU- Optics

Express)

1. Optics Express Vol 19, Issue 15, July 2011

2. Biomedical Optics Express Vol.2, #9 August, 2011

Real Time High Speed Volumetric Imaging using

Compressive Sampling OCT (High Speed Optic

Nerve Head Imaging with the Axsun 1060nm Swept

Laser) – Simon Fraser University

Doppler Imaging with Axsun SL Engine

• Retinal Blood flow with 200kHz Axsun SSOCT demonstrated by MIT(1)

• Doppler OCT blood flow measurement data from Duke University (2) – Axsun 1060nm SSOCT

demonstrated a more than 60% improvement in Doppler dynamic range over SDOCT

38

MIT Retinal Blood Flow with 200kHz Doppler OCT

1. Biomedical Optics Express Vol 2, Issue 6, May 2011

2. Biomedical Optics Express Vol.2, #8 August, 2011 High Velocity Doppler OCT retinal blood flow

comparison of Axsun 1060 SSOCT vs 830nm SDOCT

Summary

• Axsun’s Core Technology provides distinct

advantages in size, speed, imaging depth range

and reliability for our OCT Engine Products

• Researchers and OEMs are building a large body

of impressive clinical data showing advantages

from the use of Swept Laser OCT

• Axsun’s Swept Laser OCT Engine products are

leading the way in the next generation of OCT

imaging systems