ay2020 details of application for master’s degree-2€¦ ·...

Details of Application for Master’s degree by Students Expected to

Complete the Master Course of the Graduate School of Medical Sciences in 2020

１．Requirements for awarding degrees Students should acquire 30 credits or more within a period of 2 years or longer, and pass the Master's thesis

review and final examination. However, for those who have made excellent achievements, the academic

period of attendance can be 1 year.

２．About submission of application documents Please submit the following documents to the student affairs office of GSMS by the deadline.

※Please refer to Attachment 1 “Deadline of Application for Master’s degree in AY 2020”.

◎Documents to be submitted

The documents can be downloaded from the website of GSMS.

http://www.medphas.kumamoto-u.ac.jp/en/medgrad/gakunai/sinsei/

For Current Students→Degree application Interim review

（1） Check sheet ・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（2） Application Form for master’s Degree ・・・・・・ 1 copy

（3） Master's Thesis ・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy ［No bookbinding required］

（4） Abstract of Master’s Thesis ・・・・・・・・・・・・・・ 2 copies ［A4］

（5） Resume ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

◎Please send the author name and the title of the Thesis with the sending title “Application for Master’s

degree: XXXX (name of applicant)” via e-mail to the following address without attaching anything

Address：[email protected]

３．Submit to Student Affairs Office, Graduate School of Medical Sciences (Medical Education & Library Building 3F)

４．Public Presentation Schedule ※Please refer to Attachment 2 ” Degree Application Schedule”

（1） First Review

Documentary examination will be conducted at the educational committee on the third Wednesday and the

Faculty meeting on the fourth Wednesday (this may be changed depending on circumstances).

（2） Public Presentation

The date and place, and examiners will be announced after the first review.

（3） Second Review

Conducted at a faculty meeting on the fourth Wednesday of the month (this may be changed depending on

Master

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circumstances). The result of the review will be announced after the second review.

５．Note

（1） The Public Presentation will have 20 minutes of presentation and 10 minutes of discussion.

（2） Submit the Thesis and Abstract to all the examiners one week prior to the public presentation (review).

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Documentation Guidelines

１．Application Form for master’s Degree

（1） Please sign and seal. (Foreigners may use their signatures instead of a seal.)

（2） The Academic advisor’s signature and seal are required.

（3） Please write candidate’s names of examiners.

The Chief examiner must select a professor from the GSMS.

An academic advisor, an introductory advisor, coauthors of Thesis, and advisors who belong to the same

department of applicant are not permitted to be examiners.

２．Master's Thesis

（1） Language should be Japanese or English.

（2） If the title of the Thesis is Japanese, an English translation should be provided along with the Japanese;

if English, Japanese should be provided with the English.

（3） The paper should be A4 size, vertical, horizontal, and the margin should be 25mm on both sides.

（4） Make the font size about 10.5 to 12 points.

（5） A table of contents should be prepared according to the order below. Figures and tables should be

appropriately inserted.

1） Summary （Within 1 page）

2） List of Abbreviations

3） Background and Objective of Study

4） Method

5） Results

6） Discussion (including bibliography)

7） Conclusion

8） Acknowledgments

9） References

10） The meeting list related to this paper

（6） The paper shall be printed color double-sided,

The submission in permanent binding is not required.

３．Abstract of Master’s Thesis

（1） Please keep it simple and easy to understand in 2 pages of A4 size

（2） As the sample below shows, it is recommended in principle that the abstract to be divided into 5 parts;

objective, method, results, discussion, and conclusion.

（3） Please do not use of abbreviations as much as possible. In case of using abbreviations, please write the

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words in full followed by the abbreviation in parentheses, when you use an abbreviation for the first time.

Example: Duchenne muscular dystrophy (DMD). However, this does not apply to abbreviations widely

recognized in medical science and biology (for instance: DNA, ATP).

（4） The titles recorded in the Master’s Thesis and the abstract should be corresponded every single word and

phrases, including either capital or small letter as well as italic letter.

４．Resume

（1） Prepare the margins: top 25 mm, bottom 15 mm, left 25 mm, right 15 mm.

（2） The size of the text should be 10 point.

（3） Please sign and seal. (International Students may use their signatures instead of a seal.)

（4） The resume should be no more than one page.

（5） Kana over name to indicate pronunciation.

（6） International Students shall enter their nationality.

（7） Please state your educational background starting from graduation of bachelor’s degree of the University.

※Please provide the exact date of graduation, which stated on the graduation certificate etc.

（8） If there in no applicable business career, please enter “none”.

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※Submit the thesis using this check sheet as the cover.

Check sheet (Master’s Thesis)

Name of the applicant

Student number

Affiliation

Contact 1 (mobile phone)

Contact 2 (Affiliation)

Email address (valid address)

Confirm the following documents before you submit them, and check the box ( □ ) for each document.

※Please be sure to submit documents in hard copy.

Documents Number Confirmation items

□ Application Form for Master’s Degree 1

copy

□Signed and stamped by yourself. □Signed and stamped by the Academic advisor. □The Chief examiner must select a professor

from the GSMS. □Examiner candidates do not include co-

authors.

□ Master's Thesis 1

copy □The title matches abstract.

□ Abstract of Master’s Thesis 2

copies □The title matches Master’s Thesis.

□ Resume 1

copy

□Academic background is listed from graduation of bachelor’s degree.

□The date of submission is described. □Signed and stamped by yourself.

□

Send the author name and the title of the Thesis (in Japanese and English) with the sending title “Application for Master’s degree: XXXX (name of applicant)” via e-mail to the following address without attaching anything. Address：[email protected]

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Year/Month/Day

To the Dean of the Graduate School of Medical Sciences

Application Form for Master’s Degree I hereby apply for the Master’s Thesis. Applicant Name FAMILY First Middle Seal （Signature）

I agree with the application for the examination of Master's thesis

by（Applicant name） FAMILY First Middle . Academic advisor Name 山田一郎 Seal （Signature） Please write candidate’s names for examiners.

Head of examiners Professor ◯◯ ◯◯

Examiner Professor △△ △△

Examiner Professor □□ □□

Examiner Professor ◇◇ ◇◇

*An academic advisor, an introductory advisor, coauthors of Thesis, and advisors who belong to the same department of applicant are not permitted to be examiners.

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Master's Thesis

Cytotoxic T lymphocyte recognition of HIV-1-specific epitopes in HIV-1-

infected Thais and Japanese

(日本人およびタイ人の HIV-1 感染者において認識されている

HIV-1 特異的細胞傷害性 T細胞エピトープの解析)

Name (FAMILY First Middle)

Graduate School of Medical Sciences Kumamoto University

(Master’s Course)

Academic advisor：Professor ○○ ○○

September 2020

※If the Thesis is written in English, its title should be English with a Japanese translation provided in

parentheses; if it is in Japanese, its title should be Japanese with an English translation provided in parentheses.

※Centering

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Cytotoxic T lymphocyte recognition of HIV-1-specific epitopes in HIV-1-infected Thais and

Japanese

(日本人およびタイ人の HIV-1 感染者において認識されている

HIV-1 特異的細胞傷害性 T 細胞エピトープの解析)

Graduate School of Medical Sciences Kumamoto University (Master’ Course)

FAMILY NAME First name Middle name

（Academic advisor：Professor ○ ○ ○ ○ ）

［Purpose］HIV-1（ヒト免疫不全ウイルス）特異的な細胞傷害性 T 細胞（CTL）エピトープを同定することは

、AIDS（後天性ヒト免疫不全症候群）の病態やワクチン開発など様々な研究のために必須である。これまで

に HIV-1 clade B 感染者において比較的多数の clade B 特異的 CTL エピトープが同定されているのと対照

的に、それ以外の non-clade B 特異的 CTL エピトープは報告が少なく、clade E においては全くない。そこ

で、アジア人に高頻度にみられるヒトリンパ球抗原（HLA）である HLA-A*1101 に拘束される clade B 特異

的 CTL エピトープの同定を行い、さらにこれを用いて東南アジアにおいて主なサブタイプである clade E に特異的な CTL エピトープの同定を試み、clade E ウイルスに対する CTL の認識を解析した。［Methods］（１）はじめに、リバースイムノジェネティクス法によって、日本人の HIV-1 clade B 感染者で認識

されている 4 種の HLA-A*1101 拘束性 clade B 特異的 CTL エピトープを同定した。（２）これらと既知の 4種の HLA-A*1101 拘束性 clade B CTL エピトープを用いて、clade E の CTL エピトープを同定することを試

みた。まず、タイ人の clade E 感染者の末梢血単核球を、clade B CTL エピトープ部位に相当する clade Eペプチドで刺激することによって特異的 CTL を誘導できるか調べた。（３）さらに、誘導された clade E CTLが clade B ペプチドを認識するか、clade B CTL が clade E ペプチドを認識するか調べることによって、CTLエピトープが clade 間で共通（cross-clade）に認識されるか、あるいは clade 特異的に認識されるか解析した

。［Results］Pol 由来の 3 種の CTL エピトープは、タイ人の clade E 感染者でも認識されている

cross-clade CTL エピトープであった。また、3 種の CTL エピトープ部位に相当する clade B、clade E ペプチ

ドは、それぞれが日本人の clade B 感染者、タイ人の clade E 感染者で認識されている clade 特異的 CTLエピトープであった。HIV-1 clade E 感染 T 細胞におけるこれらの CTL エピトープの抗原提示能を明らかに

するために、それぞれ 3 種の cross-clade CTL および clade E 特異的 CTL が clade E ウイルスに感染し

た CD4+ CXCR4+細胞を認識するか観察した。その結果、これらの CTL エピトープを認識する CTL は clade E ウイルスに感染した標的細胞を特異的に傷害したことから（図１）、6 種の CTL エピトープは clade E ウイ

ルス感染細胞の細胞内でプロセッシングされ抗原提示されていることが示された。

Abstract of Master’s Thesis Sample

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［Include charts that can explain the contents of the study in a summarized manner, or figures that are

considered most important in the study.］

figure１ Cytolysis of target cells infected with HIV-1 clade E by three cross-clade epitope-specific CTL and three clade E epitope-specific CTL. A. Expression of HIV-1 p24 and HLA-A*1101 antigens in HIV-1 clade E infected cells. 721.221-CD4-A*1101 cells were infected with HIV-1 clade E clone p93JP-NH1. Uninfected cells and infected cells were analyzed for HLA-A*1101 expression on target cells by staining with a p24-specific mAb and anti-HLA-A11 mAb. 95% of cells were p24-positive and approximately 30% of p24-positive cells showed downregulation of HLA-A*1101. B. Cytolysis of HIV-1 clade E infected cells by HIV-1 specific CTL. Infected 721.221-CD4-A*1101 cells (closed bar) and uninfected 721.221-CD4-A*1101 cells pulsed with (shaded bar) or without (open bar) the corresponding peptide were used as target cells. Cytolytic activities of three cross-clade epitope-specific CTL clones (Pol424-432-34, Pol894-903-14 and Pol675-683-5E-3) and three clade E epitope-specific CTLs for these target cells were examined. The Gag 263-272-specific, HLA-A*2402-restricted CTL clone Gag 263-272-3 was used as a negative control. The specific lysis of this clone for C1R-A*2402 cells pulsed with (dotted bar) and without (open bar) the corresponding epitope peptide was also examined. ［日本語説明でも可］［Discussion］本研究によって、すでに明らかにされている HIV-1 CTL エピトープを用いて、他の clade のエ

ピトープを同定する事が可能である事が示された。この事は、clade E, C のように未だほとんど明らかにされ

ていない CTL エピトープ同定をより効率的におこなえる事を示している。しかしながら、本研究では、変異

性の高い Env 領域に対しての CTL エピトープの同定は不可能であった。今後、Env 領域内のエピトープを

用いて、変異性の高い領域での CTL エピトープの同定がどの程度可能かを明らかにする必要がある。［Conclusion］本研究において、HIV-1 clade B 特異的 CTL エピトープを利用したこの解析法は、clade E 特

異的 CTL エピトープを決定するためにきわめて有効であることが示され、この既知の clade B CTL エピトー

プを利用する方法を用いて、ほとんど解明されていない clade E CTL エピトープの同定が可能となった。

3.3 96.7

31.4 64.0

0.5 4.1

HLA-A*1101

HIV

-1 p

24

Uninfected

Infected with HIV-1 clade E virus

A B

specific lysis (%)0 20 40 60 80 100

Pol424-432-specific CTL clone (E/T ratio = 4:1)

Pol894-903-specific CTL clone (E/T ratio = 4:1)

Gag349-359-9S-specific bulk CTLs (E/T ratio = 4:1)

Nef84-92-2F6F-specific bulk CTLs (E/T ratio = 3:1)

Pol675-683-5E-specific CTL clone (E/T ratio = 2:1)

Gag263-272-specific, HLA-A*2402-restricted CTL clone (E/T ratio = 2:1)

Pol313-321-specific bulk CTLs (E/T ratio = 4:1)

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履歴書 Resume

Name

Kana pronunciation FAMILY NAME First name Middle name

Female

Date of birth

September 25, 1981

Nationality

Myanmar

Present address

Honjo 1-1-1, Chuo-ku, Kumamoto-shi Kumamoto, JAPAN

Educational Background

2019/6/30 Graduate: Bachelor of Medicine and Bachelor of Surgery, University of Medicine, Yangon, Myanmar 2019/10/1 Enrolled: Graduate School of Medical Sciences, Kumamoto University (Master’s couese)

2020/9/30 Expect to complete the above course

Business Career None

The above statement is true and correct

2020/Month/Day Name Kyu Kyu Maung Seal （Signature）

※When the name is written in kanji, spelling in Latin letters is unnecessary.

※Please fill in from university graduation

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【令和2年度】医学教育部博士課程・修士課程学位論文審査申請期限 Deadline of Application for Doctoral degree or Master’s degree in AY 2020

申請者は各自提出締め切りを確認し、期限に間に合うよう、申請をしてください。申請区分ごとの申請要項等は別に定められています。申請資格や提出物などは、必ずそちらを確認してください。

【医学教育部ウェブサイト】学生教職員へのお知らせ > 学位申請・中間審査について http://www.medphas.kumamoto-u.ac.jp/medgrad/gakunai/sinsei/

The deadline or period of degree application in this year are as follows. Please refer to these deadlines, make sure to submit the required documents before the due date. In addition, the application guidelines for each category are specified separately. Please make sure to confirm the Assessment Criteria, Detail of Application, Application Form, etc.

【Website of GSMS】 For Current Students > Degree application, Interim review http://www.medphas.kumamoto-u.ac.jp/en/medgrad/gakunai/sinsei/ ＜博士課程4年生及び3年生（甲）/ 4th and 3rd year Doctoral Course ‘甲’＞

事前審査申請締切 Deadline of application of Preliminary review

本審査提出締切 Deadline of Submission

令和2年 9月修了希望者 For graduation in September 2020

令和2年 5月18日（月） May 18 (Mon), 2020

令和2年 6月 5日（金） June 5 (Fri), 2020

令和３年 3月修了希望者 For graduation in March 2021

令和2年11月20日（金） November 20 (Fri), 2020

令和2年12月21日（月） December 21 (Mon), 2020

※通常の修了期以外(6 月・12 月)の修了を希望する場合は、修了予定月の 3 ヶ月以上前に医学教務担当まで申し出ること。 * Students who prefer to complete in June or December shall inform to student affairs office by 3-month notice.

＜令和元年度単位修得退学者（甲（遡及）） / For withdrawal in 2019 ‘甲(遡及)’＞単位修得退学後、1年以内の方が対象です。You can apply for doctoral degree as ‘甲(遡及)’ if it within one year after you complete coursework without degree.

事前審査申請締切 Deadline of application of Preliminary review

本審査提出締切 Deadline of Submission

令和元年 9月単位修得退学者 For withdrawal in September 2019

令和2年 5月18日（月） May 18 (Mon), 2020

令和2年 6月 5日（金） June 5 (Fri), 2020

令和2年 3月単位修得退学者 For withdrawal in March 2020



＜論文博士・乙 / Doctoral Dissertation ‘乙’＞事前審査申請締切

Deadline of application of Preliminary review 本審査提出締切

Deadline of Submission 令和2年度中に学位を取得する場合 For receiving a doctor's degree in AY 2020



＜修士課程/ Master’s Course＞ ※修士課程の場合、事前審査はありません。 * In Master’s Course, there is no Preliminary review.

提出締切 Deadline of Submission

令和2年 9月修了希望者 For graduation in September 2020

令和2年 6月 8日（月） June 8 (Mon), 2020

令和3年 3月修了希望者 For graduation in March 2021

令和2年12月 9日（水） December 9 (Wed), 2020

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【Attachment 1】

Schedule

By 5 p.m. 【Doctoral Course】＊

May 18, 2020 Deadline of Application ◎Submissions can be accepted for Preliminary review at anytime before the deadline. （To Student Affairs office of GSMS）

　

May 25, 2020 Preliminary reviewby Committee Professors

Return the documents for revision◎After preliminary review, the documents will be back

to you. Please revise the places which pointed out by

committee, and prepare for the formal submission.

By 5 p.m. 【Doctoral Course】June 5, 2020 Deadline of formal submission

for Doctoral degree（To Student Affairs office of GSMS）

By 5 p.m. 【Master Course】June 8, 2020 Deadline of Application

for Master's degree（To Student Affairs office of GSMS）

June 17, 2020 Educational committee ◎We officially receive your application and arrange

examiners for final defense.(Public presentation)

Jun 24, 2020 Faculty meeting=First Review=

　　◎Your examiners are decided.

June 26, 2020 ～ As soon as the examiner and schedule of public presentation is confirmed,we will inform it by email.◎Bring a thesis and abstract to your examiners

in person promptly.

July 1, 2020 ～ Public Presentation (Doctoral Course)July 31, 2020 Public Presentation (Master’s Course)

August 26, 2020 Faculty meeting=Second Review=

◎Deliberation your result: pass or fail

Around the early We will announce you result by emailSeptember ◎In accordance with the notification, please submit

necessary data and documents before you graduate.

On September 25, 2020 Completion Ceremony (expected)

＊Including students expected to complete earlier

Degree Application Schedule(For Students who Expected to Complete in September 2020)

Degree Applicant Committee・Faculty Meeting

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【Attachment 2】

Schedule

By 5 p.m. 【Doctoral Course】＊

November 20, 2020 Deadline of Application ◎Submissions can be accepted for Preliminary review at anytime before the deadline. （To Student Affairs office of GSMS）

　

November 26, 2020 Preliminary reviewby Committee Professors

Return the documents for revision◎After preliminary review, the documents will be back

to you. Please revise the places which pointed out by

committee, and prepare for the formal submission.

By 5 p.m. 【Master Course】＊

December 9, 2020 Deadline of Application for Master's degree

（To Student Affairs office of GSMS）

By 5 p.m. 【Doctoral Course】December 21, 2020 Deadline of formal submission

for Doctoral degree（To Student Affairs office of GSMS）

December 25, 2020 Educational committee ◎We officially receive your application and arrange

examiners for final defense.(Public presentation)

January 6, 2021 Faculty meeting=First Review=

　　◎Your examiners are decided.

January 13, 2021 ～ As soon as the examiner and schedule of public presentation is confirmed,we will inform it by email.◎Bring a thesis and abstract to your examiners

in person promptly.

January 27, 2021 ～ Public Presentation (Doctoral Course)February 5, 2021 Public Presentation (Master’s Course)

February 18, 2021 Faculty meeting=Second Review=

◎Deliberation your result: pass or fail

Around the end of We will announce you result by emailFebruary ◎In accordance with the notification, please submit

necessary data and documents before you graduate.

On March 25, 2021 Completion Ceremony (expected)

＊Including students expected to complete earlier

Degree Application Schedule(For Students who Expected to Complete in March 2021)

Degree Applicant Committee・Faculty Meeting

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【Attachment 2】