ayurceuticals – marriage of traditional knowledge & … such alternative medicines. the uk...

Ayurceuticals – Marriage of Traditional knowledge & Modern Science

Dr. Shefaali Thanawala

Senior Medical Advisor

Plethico Pharmaceuticals Ltd.

www.plethico.com

- the seven steps towards Advaita

6th Nutra India Summit WTC, Mumbai 17th February 2011

1. Marriage

2. Latest headlines

3. Some exceptional contributions

4. The seven steps for bonding of Ayurveda and modern science

5. Ayurceuticals - preaching through practice

6. The way forward

Overview


Union of two persons who establish and enjoy - legal, social, emotional, economical, spiritual, religious and fruitful relationship

Marriage


The CDC report published on January 28, 2011, Drug-Induced Deaths More Common Than Alcohol- or Firearm-Related Fatalities. It included those

• attributable to acute poisoning by drugs (drug overdoses) and • deaths from medical conditions resulting from chronic drug use (MMWR Morb

Mortal Wkly Rep. 2011;60:60-61)

Latest Headlines: imbalanced approach


The news posted on Feb 03, 2011, A ban on the sale of Ayurvedic and other herbal medicines will take effect across Europe from May 1 following a EU directive introduced as a response to growing concern over adverse effectsof such alternative medicines.

The UK MHRA Press release on Feb 11, 2011, People warned over adulterated herbal weight loss pill – test results reveal twice the prescribed dose of banned pharmaceutical ingredient


Striking balance??

Oh, East is East, and West is West, and never the twain shall meet,Till Earth and Sky stand presently at God's great Judgment Seat;

• AYUSH• TKDL • GTP • API: Part I (vol I-VII – medicinal herbs) & Part II (Ayurvedic generic

formulations)

• Research• Work of numerous researchers on herbal / Ayurvedic medicinal

plants • taxonomy & identification • safety • efficacy • other studies in the analytical area

• Work on application of Reverse Pharmacology• Work on correlating Prakriti with pharmacogenomics

Some exceptional contributions


• Evidence based medicine - clinical decisions formally supported by data, preferably derived from prospectively designed, randomized, controlled clinical trials

• Explosion of scientific knowledge which continues to intensify with time

• Science-based technology

Enrichment through the technology advancements:• Human genomics • Internet Medicine• Globalization of healthcare systems

1st step: Learning modern medicine – the language of present times


- Harrison’s Principles of Internal Medicine, 17th E; part I, introduction to clinical medicine

ComprehensibleTherapeutic effect of herbs / medicinal plants

Still incomprehensible - numerous theorems • Agni• Svabhavoparam Vaada - apoptosis – Charak Samhita Su. Sthanam 16• Nidaan panchak • Vyaadhi chikitsa sootrani • Shadvirechanashatashritiya Adhyaya – Charak Smahita Su. Sthanam 4

Many more....

2nd step: Understanding the language of Ayurveda


• Correlating the Ayurvedic disease descriptions with Evidence of modern medicine

• Several examples • Madhumeha – diabetes mellitus

• Rajayakshma – Tuberculosis

• Jalodar – Ascites

• Asthi Bhagna – Fractures

• Grahani / Atisaar / Amlapitta – GI disorders

Many more....

3rd step: Correlating the two sciences


• Application of reverse pharmacology: Reconfirming the claims and clinical results of Ayurvedic therapeutics through modern research modalities

• Experimental research models• Robust designed clinical trials• Numerous such examples available; most well studied –

Curcuma longa (1200+), Withania somnifera (350+), Allium sativum (3500+)!!

4th step: Conceptualization of Ayurceuticals -Simplifying & translating complex ancient wisdom


• Checking the possibility of commercialization of most appropriate prescriptions in terms of –

Availability Support through trans-disciplinary scientific expertise Cost effectiveness Feasibility of manufacturing through stringent GMP observance

• Compliance with regulatory standards• Effective marketing – speaking the language of modern

consumer / patient / physician

5th step: Developing Ayurceuticals -Evidence based product from Ayurveda


6th step: Expanding horizons - Going beyond products

Synergizing the sciences for stronger and more effective health care solutions

• Effective interpretation and utilization of Unique Ayurvedic principles

• Health maintenance• Dietetics• Rejuvenation• Panchakarma Therapies

• Logical application of modern principles to Ayurceuticals• Responsibility of claims substantiation through clinical trials• Applying pharmacovigilance


both the sciences reaching that state of unity –Advaita; so that –

• the boundaries merge

• strengths multiply / enhance, and

• limitations disappear

7th step: Striking the balance - for eternal concord


Examples from Plethico – taking one step at a time… • Ruthex• Travisil Neo

• METHEXMethi – The Aahar dravya praised by Ayurveda

Included in Shaaka Varga in Bhavaprakash Nighantu


Ayurceuticals – preaching through practice

Approx 400 research references on pubmed on Trigonella foenum-graecum with very strong evidence on –

Antihyperglycemic activity1

Antihyperlipidemic activity 1

Antiatherosclerotic effect2

Strong antioxidant activity3

Also serves as dietary fiber (galactomannan –mucilage isolated from Methi seeds) 1-2

Ayurceuticals: Preaching through practiceMethex


1) J Clin Biochem Nutr. 2008 Nov;43(3):167-74

2) Phytother Res. 2009 May;23(5):725-30

3) Eur J Pharmacol. 2008 Feb 26;581(1-2):216-25.

Indications: • Excellent supplement for patients suffering from

diabetes, CHD and / or hypercholesterolemia - India• maintaining the NORMAL blood sugar and cholesterol

levels – DSHEA USA• As adjuvant in diabetes mellitus & hypercholesterolemia

– THMPD -EU

Advantages: Safe and effective product based on sound principles of AyurvedaSimpler and faster regulatory approvals in regulated markets

Ayurceuticals: Preaching through practiceMethex


Ayurceuticals – the way forward

Stakeholders:

• Academia

• Research scientists

• Clinicians

• Industry

• Regulatory authorities

• Policy makers

Challenges ahead:

• Ayurconcepts

• Ayuresearch

• Ayurtherapies

• Ayurceuticals

• Ayurtrials / Ayurvigilance

• in support of Ayurswasthya


Oh, East is East, and West is West, and never the twain shall meet,

Till Earth and Sky stand presently at God's great Judgment Seat;

But there is neither East nor West, Border, nor Breed, nor Birth,

When two strong men stand face to face,

tho' they come from the ends of the earth!

- Rudyard Kipling

To conclude


Yoga Ratnakara – Prathama Adhyaya

Charak Samhita – Sutra Sthaanam

Bhava Prakash Nighantu - Methika

Āshwalāyana Gŗhyasūtra - 1-7-19 (http://www.vedah.com/org/literature/marriage/marriage.asp)

Active principles identification and dose determination; Vaidya A. et al; USP-IP 6th Ann meeting; Feb 2007

Reverse Pharmacology and Systems Approaches for Drug Discovery and Development; Bhushan Patwardhan, Ashok D. B.Vaidya, Mukund Chorghade, Swati P. Joshi; Current Bioactive compounds, 2008

Traditional medicine-inspired approaches to drug discovery: can Ayurveda show the way forward? ; Bhushan Patwardhan,Raghunath Anant Mashelkar; Drug Discovery Today Volume 14, Numbers 15/16 August 2009

www.ccras.nic.in/

http://www.ccras.nic.in/Golden_Tiangle/20081011_Golden_Tiangle_status.htm

www.indianmedicine.nic.in/

http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON108745

Bibliography


http://www.vedah.com/org/literature/marriage/marriage.asp�

http://www.ccras.nic.in/�

http://www.ccras.nic.in/Golden_Tiangle/20081011_Golden_Tiangle_status.htm�

http://www.indianmedicine.nic.in/�

http://www.mhra.gov.uk/NewsCentre/Pressreleases/CON108745�

Dr. Shefaali Thanawala

email: [email protected]

[email protected]

Thank you


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