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TRANSCRIPT
28
1987
2016 9 10
1576 1241 78.7% 229 14.5%
23402262
1458 64.5% 839 37.1%662 29.3% 648 28.6% 399 17.6% 236 10.4%
MDMA 195 8.6% 187 8.3% 76033.6% 614 27.1% 319 14.1% 23710.5% 119 5.3% 70 3.1%
1209 53.4% 384 17.0%193 8.5% 126 5.6% 118 5.2% 101 4.5%
81 3.6% 2262 1164 11 791 68.0%
108 9.3% 74 6.4% 78 6.7% 198
43 43.9% 15 15.3%
- 101 -
20
1990
32000
2011
1970War on Drug 40
HIV
6
1987
2016
1.
38133 6964 82
1,323 1,576
2.
1) 2016 9 1
10 31 2
2) 2016 7
8
1)
2016 11 30 11
FAX
- 102 -
2017 1
3)
ICD-10
ICD-10 F1
ICD-10
2016
4)
13)
a b
c d e f MDMA g MDMA h i j k l
m ADHD Attention-Deficit / Hyperactive
disorder n o
5)
1 1
1
6
5% 1
- 103 -
:
ADHD
3.
A2016-002
1576
1241 78.7%1014
64.3%229 14.5%2340
382302
2302
2262
1. 2262
1) 1 2262
1637 72.4% 623 27.5%2 0.1%
10
12 0.5% 20 254 11.2% 30 62627.7% 40 723 32.0% 50 44319.6% 60 158 7.0% 70 462.0% 30 40
941 41.6%
532 23.5%
1126 49.8%
501 22.1%
890 39.3% 407
18.0%1443 63.8%
2) 2
1458 64.5% 83937.1% 662 29.3%
648 28.6% 39917.6% 236 10.4% MDMA 195
8.6% 187 8.3% MDMA165 7.3% 53
2.3% 612.7% ADHD 37 1.6%
210.9% 47 2.1%
3) 3
760 33.6%614 27.1%
319 14.1% 237 10.5%119 5.3% 70 3.1%
MDMA 21 0.9% 160.7% 3 0.1% MDMA 140.6% 13
0.6% ADHD 9 0.4%5
0.2%
- 104 -
4) 4
1209 53.4%384 17.0% 193
8.5% 126 5.6% 1185.2% 101 4.5% 81
3.6% 15 0.7%12 0.5%
9 0.4%MDMA 4 0.2% ADHD
4 0.2% 3 0.1%2 0.1% MDMA 1 0.0%
5) ICD-10 F1 5
ICD-10 F1F1x. 0 56
2.5% F1x. 1 176 7.8%F1x. 2 1295 57.3% F1x.
3 56 2.5% F1x. 4 20 0.9% F1x. 5
372 16.4% F1x. 6 291.3% F1x. 7
739 32.7% F1x. 840 1.8%
6) ICD-10 6
125955.7% ICD-10 F3 402 17.8%
F4325
14.4% F564 2.8% F6
251 11.1% F2227
10.0% F7 1315.8% F0
74 3.3% F974 3.3% F8
63 2.8%
2. 1 1164
1) 7 1 1164
912 78.4%251 21.6% 1 0.1%
10 2 0.2% 20 706.0% 30 266 22.9% 40 40034.4% 50 283 24.3% 60 11610.0% 70 27 2.3%
30 50 1
394 33.8%237
20.4%
671 57.6%
309 26.5%559 48.0%
190 16.3%740 63.6%
2) 8
1875
75.2% 50143.0% 320 27.5%
207 17.8% 17114.7% 98 8.4% MDMA 76
6.5% MDMA 73 6.3%68 5.8% 22 1.9%
19 1.6%ADHD 16 1.4% 14 1.2%
9 0.8% 3) 9
1464 39.9%
402 34.5%103 8.8% 77
6.6% 33 2.8%
- 105 -
31 2.7% MDMA9 0.8% MDMA 6 0.5%
4 0.3%3 0.3% ADHD
3 0.3% 2 0.2%2 0.2
4) 10
1791 68.0%
108 9.3%74 6.4%
78 6.7% 46 4.0% 282.4% 27 2.3%
4 0.3% ADHD 3 0.3%2 0.2% 1 0.1% MDMA
1 0.1%1 0.1%
5) ICD-10 F1 11
1 ICD-10 F1 F1x. 0 1
0.1% F1x. 1 46 4.0%F1x. 2 518 44.5% F1x.
3 4 0.3% F1x. 40 0.0% F1x. 5
163 14.0% F1x. 6 12 1.0%F1x. 7 595
51.1% F1x. 829 2.5%
6) ICD-10 12
1 604
51.9% F3184 15.8%
F2139 11.9% F4
12210.5% F6
113 9.7% F7 554.7% F0
44 3.8% F933 2.8% F5
29 2.5% F8 181.5% 3. 16
16 977
41885 54
27306 87
1) 13 6
p<0.00194.4% 92.6%
51.0% 57.0%
6p<0.001 42.4%40
30 6
p<0.00169.9% 72.4%
32.1%31.8%
p<0.001 46.3%16.5%
p<0.001 72.7%8.5%
p=0.00525.9% 25.9%
7.4%
p<0.001 48.6%9.2%
p=0.001 25.8%3.7%
- 106 -
p=0.011 81.5%53.7%
2) 14
4
44.4% 36.5%
50.0%
19.2% 3) 15
6
20.4%4.2%
3.4% p<0.00125.8%
24.1% 22.2%1.1%
p<0.00111.1%
0.3% 0.0%p<0.001
46.9%42.6% 0.7%
0.0% p<0.001
78.1%; 30.4%p<0.001
78.1%p<0.001
37.0%p<0.001
50.6%p<0.001
6
4) ICD-10 F1
16 F1x. 0
11.1% p=0.006 F1x. 123.2%
F1x. 280.5%
55.6% p=0.017 F1x. 3 9.3%
8.8%p<0.001 F1x. 5
30.1%2.9%
p<0.001 F1x. 6 5.6%
p=0.035 F1x. 7
21.1% p<0.001 F1x. 4 F1x.
8 6
5) ICD-10
17 F3 p=0.002 F4
p<0.001 F6p<0.001 F7 p<0.001F8 p=0.007
F3 26.5% 28.7%
F4
35.0% F6
26.4 F720.0%
F811.1%
10.3% F0
F2F5
F96
- 107 -
4.
1) 18 1 1164
98 9843 43.9% 15
15.3%12 12.2% 11 11.2%
5 5.1% 2) 19
9875 76.5% 23
23.5% 10 11.0% 20 30 30.6% 30 4040.8% 40 21 21.4% 50 6 6.1%
53 54.1%
2525.5%
50 51.0%
25 25.5%37 37.8%
2222.4%
76 77.6% 2) 20
7677.6% 65 66.3%
35 35.7%30 30.6% MDMA 27
27.6% MDMA 19 19.4%15 15.3% 11 11.2%
3 3.1% ADHD 3 3.1%3 3.1% 2 2.0%
3) 21
3636.7%
18 18.4%13 13.3% MDMA 4 4.1%
3 3.1%MDMA
2 2.0% ADHD1 1.0%
4) 22
4849.0%
26 26.5%22
22.4%19 19.4%
12 12.2% 5) ICD-10 F1 23
ICD-10 F1 F1x. 01 1.0% F1x. 1 7
7.1% F1x. 2 6970.4% F1x. 3 2 2.0%F1x. 4 1 1.0%F1x. 5 29 29.6% F1x.
7 1919.4% F1x. 8
1 1.0% F1x. 6
6) ICD-10 24
ICD-10 F319 19.4%
F6 1313.3% F4
12 12.2% F211
11.2% F8 6 6.1%F7 F9
- 108 -
5 5.1% F02 2.0% F5
5.
1) 25 2262
82.2 vs. 64.6, p<0.001
p=0.022
45.0% vs. 37.4%, p<0.001
21.5% vs. 26.0, p=0.033
42.3% vs. 59.2, p<0.001
33.7 vs. 46.5, p<0.001
19.5% vs. 16.2%, p=0.042
2) 26
55.8% vs. 75.4%,
p<0.001 33.7% vs. 41.4%, p<0.00125.0% vs. 33.2%, p<0.001 6.9%
vs. 10.0%, p=0.009 1.6% vs. 3.3%, p=0.008 16.2% vs. 19.4%, p=0.045
38.6 vs. 17.5%, p<0.0014.1% vs. 1.0%, p<0.001
1.4% vs. 0.4%, p=0.01914.2% vs. 5.7%, p<0.001 ADHD
2.3% vs. 0.8%, p=0.005
MDMA MDMA
3) 27
62 2200
p<0.001
23.8% vs. 33.1%
20.8% vs. 6.5% 4) 28
N=2262
p<0.001
44.8% vs. 64.3%24.0% vs. 8.2% 6.6%
vs. 3.5% 5) 29
148.0% vs.
55.8%, p<0.001
6.1% vs. 8.6%, p=0.025 8.9% vs.
- 109 -
13.3%, p=0.0011.3% vs. 0.4%, p=0.02817.6% vs. 5.0%, p<0.0016.8% vs. 2.6%, p<0.001 5.0%
vs. 2.0%, p<0.001
6) ICD-10 F1
30
ICD-10 F1
F1x. 0 3.2% vs. 1.6%, p=0.016 F1x. 1 11.8% vs. 2.8%, p<0.001 F1x. 2 60.8% vs. 52.7%, p<0.001 F1x. 3 3.1% vs. 1.7%, p=0.033 F1x. 4
1.4% vs. 0.3%, p=0.008 F1x. 82.6% vs. 0.7%, p=0.001
F1x. 513.3% vs. 20.4%, p<0.001 F1x. 7
28.0% vs. 38.6%, p<0.001
F1x. 6
7)
31 N=1259
vs.
F4
68.3% vs. 31.7% F562.5% vs.
37.5% F6 86.9% vs. 13.1% F7 94.7% vs. 5.3% F8 100.0% vs. 0.0% F9
95.9% vs. 4.1%
F016.2% vs. 83.8%
F221.1% vs. 79.9%
F3
51.2% vs. 48.8% 8) 6
32
ICD-10 6 N=1147
F2p<0.001 F4
p<0.001 F6p=0.015 F8 p<0.001
F2
F4
F6
F8
6.
1) 33
11204143
120 84
� 5654
2)
34
- 110 -
19 5SG 4 4
3)
35
93
3 4) 36
10129
27 15 5) ADHD 37
ADHD30
ADHD8
3 3 6) 38
5
2 22
1 2
1987
1
2 2016
14.5% 201416.4%
23401709 1
11641019
1.
2012
2012, 2013
16.3%2
2014 , 2015 23.7%
4.5% 2 3
4 1
2014 34.8% 6.4%5 2014
2
- 111 -
2010 , 2011
11
17.0%1
6.7%
42.2% 53.8% 2 1
68% 54 6
22
26 27
3.6%2 1 2.3%
5
3
4 7
5
2.
1 1164
98 8.4%1
8.4%
415.3%
- 112 -
77.6%
12.2%
22%
18.0% 116.3%
3.
2
41
2
1
ICD-10 F1
1
3
Andréasson et al, 1987
Khantzian & Albanese, 2008
Khantzian
- 113 -
Albanese 2008 Self-medication hypothesis
55.7%
4.
ADHD
1)
4
1
2)
3)
- 114 -
1980
4) ADHD 2007
5)
MSM
5.
- 115 -
20
39
1576
1241 78.7%229 14.5% 2340
2262
1209 53.4%384 17.0%
193 8.5% 126 5.6% 1185.2% 101 4.5%
81 3.6% 1 1164
98
4
55.7%
1. Okumura Y, Shimizu S, Matsumoto T: Prevalence,
prescribed quantities, and trajectory of multipleprescriber episodes for benzodiazepines: A 2-year cohort study. Drug and Alcohol Dependence 158:118-125, 2016.
Matsumoto T, Tachimori H, Takano A, Tanibuchi Y, Funada D, Wada K: Recent changes in the clinical features of patients with new psychoactive-substances-related disorders in Japan: Comparison of the Nationwide Mental Hospital Surveys on Drug-related Psychiatric Disorders undertaken in 2012 and 2014. Psychiatry and Clinical Neurosciences, 70: 560–566, 2016.
:
4808 19-23 2016 :
19(8) 1125-1136 2016
: 31(11) 1449-1454
11 2016 2.
: 15
2016.5.20 :
1002016.6.17
: 38
2016.9.10 :
? 51
2016.10.8 :
232016.11.27
.
()
1.
- 116 -
2.
3.
Andréasson, S., Allebeck, P., Engstrom, A., et al.1987 Cannabis and schizophrenia: a
longitudinal study of Swedish concepts. Lancet ii: 1483-1486.
Khantzian, E.J., Albanese, M.J. 2008Understanding addiction as self-medication: Finding hope behind the pain, Rowman & Littlefield Publishers, Ranham.
, , , 2013
, , , 2011
. 22
() , pp89-115.
, 2013
. 24
() , pp111-144.
2015
26
pp95-128
- 117 -
%1637 72.4623 27.5
2 0.110 12 0.520 254 11.230 626 27.740 723 32.050 443 19.660 158 7.070 46 2.0
941 41.6532 23.5
1126 49.8501 22.1890 39.3407 18.0
1443 63.8
1: N=2262
%1458 64.5839 37.1648 28.6187 8.353 2.3
MDMA 195 8.6MDMA 165 7.3
399 17.6662 29.3
61 2.7
21 0.9
236 10.4ADHD 37 1.6
47 2.1
2: N=2262
- 118 -
%1209 53.4
193 8.581 3.6
2 0.13 0.1
MDMA 1 0.0MDMA 4 0.2
101 4.5384 17.0
12 0.5
9 0.4
118 5.2
ADHD 4 0.215 0.7
126 5.6
4: N=2262
%F1x. 0 56 2.5F1x. 1 176 7.8F1x. 2 1295 57.3F1x. 3 56 2.5F1x. 4 20 0.9F1x. 5 372 16.4F1x. 6 29 1.3F1x. 7 739 32.7F1x. 8 40 1.8
5: ICD-10 F1 (N=2262)
F1
- 119 -
%1259 55.7
F0 74 3.3F2 227 10.0F3 402 17.8F4 325 14.4F5 64 2.8F6 251 11.1F7 131 5.8F8 63 2.8F9 74 3.3
6: ICD-10 (N=2262)
%912 78.4251 21.6
1 0.110 2 0.220 70 6.030 266 22.940 400 34.450 283 24.360 116 10.070 27 2.3
394 33.8237 20.4671 57.6309 26.5559 48.0190 16.3740 63.6
7: 1 N=1164
%875 75.2501 43.0320 27.598 8.422 1.9
MDMA 76 6.5MDMA 73 6.3
171 14.7207 17.8
19 1.6
9 0.8
68 5.8ADHD 16 1.4
14 1.2
8: 1 N=1164
- 120 -
%402 34.5464 39.9103 8.8
2 0.2MDMA 6 0.5MDMA 9 0.8
33 2.877 6.6
2 0.2
3 0.3
31 2.7
ADHD 3 0.34 0.3
25 2.1
9: 1 N=1164
%791 68.0108 9.327 2.31 0.1
MDMA 1 0.174 6.478 6.7
1 0.1
4 0.3
28 2.4
ADHD 3 0.32 0.246 4.0
10: 1 N=1164
%F1x. 0 1 0.1F1x. 1 46 4.0F1x. 2 518 44.5F1x. 3 4 0.3F1x. 4 0 0.0F1x. 5 163 14.0F1x. 6 12 1.0F1x. 7 595 51.1F1x. 8 29 2.5
11: 1 ICD-10 F1 (N=1164)
F1
- 121 -
%604 51.9
F0 44 3.8F2 139 11.9F3 184 15.8F4 122 10.5F5 29 2.5F6 113 9.7F7 55 4.7F8 18 1.5F9 33 2.8
12: 1 ICD-10 (N=1164)
n=418 n=85 n=54 n=27 n=306 n=87
294 65 51 25 156 50% 70.3 76.5 94.4 92.6 51.0 57.5
124 20 3 2 150 37% 29.7 23.5 5.6 7.4 49.0 42.5
2 0 2 0 2 3% 0.5 0.0 3.7 0.0 0.7 3.4
51 15 14 6 56 20% 12.2 17.6 25.9 22.2 18.3 23.0
136 24 26 15 89 30% 32.5 28.2 48.1 55.6 29.1 34.5
130 36 7 5 94 16% 31.1 42.4 13.0 18.5 30.7 18.4
83 8 5 1 37 13% 19.9 9.4 9.3 3.7 12.1 14.9
14 2 0 0 16 3% 3.3 2.4 0.0 0.0 5.2 3.4
2 0 0 0 12 2% 0.5 0.0 0.0 0.0 3.9 2.3
134 27 35 15 214 63% 32.1 31.8 64.8 55.6 69.9 72.4
92 14 25 9 103 22% 22.0 16.5 46.3 33.3 33.7 25.3
304 39 22 12 26 14% 72.7 45.9 40.7 44.4 8.5 16.1
69 22 14 2 39 21% 16.5 25.9 25.9 7.4 12.7 24.1
203 32 11 6 28 14% 48.6 37.6 20.4 22.2 9.2 16.1
68 15 2 6 79 17% 16.3 17.6 3.7 22.2 25.8 19.5
257 65 29 22 190 61% 61.5 76.5 53.7 81.5 62.1 70.1
p*
16.624 5
145.229 5
5
527.742
326.028 5
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
13: 1 6 N=977
10
20
30
40
50
60
70
N
977
977
df
68.769 5
84.068 30
977
977
977
977
2
19.653
977
977
136.330
p=0.005
p<0.001
p=0.001
p=0.011977 14.817 5
5
- 122 -
n=403 n=85 n=54 n=26 n=296 n=87
179 4 1 5 15 0% 44.4 4.7 1.9 19.2 5.1 0.0
147 72 8 1 29 9% 36.5 84.7 14.8 3.8 9.8 10.3
47 5 38 5 15 6% 11.7 5.9 70.4 19.2 5.1 6.9
1 0 0 0 0 0% 0.2 0.0 0.0 0.0 0.0 0.0
3 0 0 0 1 0% 0.7 0.0 0.0 0.0 0.3 0.0
7 0 0 0 1 0% 1.7 0.0 0.0 0.0 0.3 0.0
10 2 4 13 1 1% 2.5 2.4 7.4 50.0 0.3 1.1
3 1 1 1 216 9% 0.7 1.2 1.9 3.8 73.0 10.3
0 0 0 0 4 1% 0.0 0.0 0.0 0.0 1.4 1.1
2 0 2 0 13 61% 0.5 0.0 3.7 0.0 4.4 70.1
2 0 0 0 1 0% 0.5 0.0 0.0 0.0 0.3 0.0
2 1 0 1 0 0% 0.5 1.2 0.0 3.8 0.0 0.0
2 df p*
MDMA
MDMA
14: 6 1 N=951
ADHD
1595.210 55 p<0.001
n=418 n=85 n=54 n=27 n=306 n=8754 8 11 4 13 3
% 12.9 9.4 20.4 14.8 4.2 3.4108 7 13 6 9 1
% 25.8 8.2 24.1 22.2 2.9 1.132 1 3 3 1 0
% 7.7 1.2 5.6 11.1 0.3 0.06 2 0 1 9 1
% 1.4 2.4 0.0 3.7 2.9 1.1196 2 23 2 2 0
% 46.9 2.4 42.6 7.4 0.7 0.01 0 1 0 239 2
% 0.2 0.0 1.9 0.0 78.1 2.31 0 0 0 93 0
% 0.2 0.0 0.0 0.0 30.4 0.00 3 0 0 6 62
% 0.0 3.5 0.0 0.0 2.0 71.322 2 5 10 26 4
% 5.3 2.4 9.3 37.0 8.5 4.63 43 0 3 4 15
% 0.7 50.6 0.0 11.1 1.3 17.23 6 3 0 0 1
% 0.7 7.1 5.6 0.0 0.0 1.193 17 4 4 5 4
% 22.2 20.0 7.4 14.8 1.6 4.6
15: 1 6 N=977
5
5
5
5
5
95.458
33.799
4.034
282.591
675.900
2 df p*
27.465 5
5
5
5
34.294
77.257
p<0.001
p<0.001
p<0.001
p<0.001544.055
309.057
5
5
p<0.001
p<0.001
p<0.001
p<0.001
p<0.001
p=0.545
p<0.001
p<0.001
221.067
582.395
- 123 -
n=418 n=85 n=54 n=27 n=306 n=8712 8 0 3 23 4
% 2.9 9.4 0.0 11.1 7.5 4.68 5 8 3 71 16
% 1.9 5.9 14.8 11.1 23.2 18.4295 65 34 15 236 70
% 70.6 76.5 63.0 55.6 77.1 80.510 1 5 0 27 4
% 2.4 1.2 9.3 0.0 8.8 4.64 1 0 1 9 0
% 1.0 1.2 0.0 3.7 2.9 0.0126 13 13 6 9 6
% 30.1 15.3 24.1 22.2 2.9 6.94 3 3 0 2 2
% 1.0 3.5 5.6 0.0 0.7 2.388 12 8 3 7 5
% 21.1 14.1 14.8 11.1 2.3 5.72 2 0 0 4 0
% 0.5 2.4 0.0 0.0 1.3 0.0
16: 1 6 ICD-10 F1 N=977
60.895
5.345
p<0.001
p=0.375
p=0.006
p<0.001
p=0.017
p<0.001
5
5
5
5
5
5
5
5
2 df p*
16.158
87.097
F1x. 2
F1x. 3
F1x. 4
F1x. 5
F1x. 0
F1x. 1
ICD-10
F1x. 6
F1x. 7
*
F1x. 8
13.836
22.257
8.036
99.349
5
11.984
p=0.154
p<0.001
p=0.035
n=418 n=85 n=54 n=27 n=306 n=87192 47 21 13 238 64
% 45.9 55.3 38.9 48.1 77.8 73.68 2 0 0 12 1
% 1.9 2.4 0.0 0.0 3.9 1.136 6 3 4 19 5
% 8.6 7.1 5.6 14.8 6.2 5.768 11 11 4 81 25
% 16.3 12.9 20.4 14.8 26.5 28.741 12 4 1 107 20
% 9.8 14.1 7.4 3.7 35.0 23.010 1 1 0 13 2
% 2.4 1.2 1.9 0.0 4.2 2.328 6 3 3 61 23
% 6.7 7.1 5.6 11.1 19.9 26.428 17 1 0 12 5
% 6.7 20.0 1.9 0.0 3.9 5.712 1 2 3 12 9
% 2.9 1.2 3.7 11.1 3.9 10.321 3 0 0 9 4
% 5.0 3.5 0.0 0.0 2.9 4.6
17: 1 6 ICD-10 F1 N=977
F8 15.877 5 p=0.007
F9 5.717 5 p=0.335
F6 47.845 5 p<0.001
F7 32.982 5 p<0.001
4.280 5 p=0.510
F5 4.526 5 p=0.476
F4 84.893 5 p<0.001
92.454 5 p<0.001
F0 6.125 5 p=0.294
F3 18.442 5 p=0.002
F2
2 df p
%43 43.911 11.215 15.312 12.2
5 5.112 12.2
18: N=98
- 124 -
%75 76.523 23.5
10 1 1.020 30 30.630 40 40.840 21 21.450 6 6.1
53 54.125 25.550 51.025 25.537 37.822 22.476 77.6
19: N=98
%76 77.635 35.765 66.311 11.2
2 2.0MDMA 27 27.6MDMA 19 19.4
30 30.63 3.10 0.0
15 15.3ADHD 3 3.1
3 3.1
20: N=98
%13 13.318 18.436 36.7
MDMA 4 4.1MDMA 2 2.0
18 18.42 2.0
3 3.1
ADHD 1 1.01 1.0
21: N=98
- 125 -
%48 49.019 19.412 12.222 22.426 26.5
22: N=98
%F1x. 0 1 1.0F1x. 1 7 7.1F1x. 2 69 70.4F1x. 3 2 2.0F1x. 4 1 1.0F1x. 5 29 29.6F1x. 6 0 0.0F1x. 7 19 19.4F1x. 8 1 1.0
23: ICD-10 F1 (N=98)
F1
%54 55.1
F0 2 2.0F2 11 11.2F3 19 19.4F4 12 12.2F5 0 0.0F6 13 13.3F7 5 5.1F8 6 6.1F9 5 5.1
24: ICD-10 (N=98)
- 126 -
n=1003 n=1259824 813
% 82.2 64.6179 444
% 17.8 35.30 2
% 0.0 0.26 6
% 0.6 0.595 159
% 9.5 12.6264 362
% 26.3 28.8329 394
% 32.8 31.3220 223
% 21.9 17.774 84
% 7.4 6.715 31
% 1.5 2.5375 566
% 37.4 45.0261 271
% 26.0 21.5594 532
% 59.2 42.3215 286
% 21.4 22.7466 424
% 46.5 33.7162 245
% 16.2 19.5631 812
% 62.9 64.52262
2262
2262
2262
25: N=2262
10
20
30
40
50
60
70
2262 p<0.001
N
p=0.022
p<0.001
p=0.033
2262
2262
2262
p*2 df
86.936 2
14.746 6
18.461 2
2
1
1
1
1
1
6.821
64.282
0.531
38.225
4.141
0.607
p<0.001
p=0.466
p<0.001
p=0.042
p=0.436
2262
- 127 -
n=1003 n=1259
756 702% 75.4 55.8
415 424% 41.4 33.7
333 315% 33.2 25.0
100 87% 10.0 6.9
33 20% 3.3 1.6
90 105% 9.0 8.3
77 88% 7.7 7.0
195 204% 19.4 16.2
176 486% 17.5 38.6
10 51% 1.0 4.1
4 17% 0.4 1.4
57 179% 5.7 14.2
8 29% 0.8 2.3
20 25% 2.0 2.0
ADHD
p<0.001
p<0.001
p<0.001
p=0.009
p=0.008
p=0.594
p=0.532
p=0.045
p<0.001
p<0.001
p=0.019
p<0.001
p=0.005
p=0.989
MDMA
MDMA
26: N=2262
p*2 df
93.756 1
14.179
18.277
6.892
7.064
0.284
0.390
1
4.030
119.547
19.841
5.495
43.515
7.867
0.000
1
1
1
1
1
1
1
1
1
1
1
1
n=971 n=1229321 293
% 33.1 23.8374 386
% 38.5 31.4130 107
% 13.4 8.71 2
% 0.1 0.27 7
% 0.7 0.67 14
% 0.7 1.131 39
% 3.2 3.263 256
% 6.5 20.82 11
% 0.2 0.90 5
% 0.0 0.425 94
% 2.6 7.61 8
% 0.1 0.79 7
% 0.9 0.6
27: N=2200
2 df p*
MDMA
MDMA
152.826 12 p<0.001
ADHD
- 128 -
n=1003 n=1259645 564
% 64.3 44.885 108
% 8.5 8.642 39
% 4.2 3.10 2
% 0.0 0.22 1
% 0.2 0.10 1
% 0.0 0.11 3
% 0.1 0.250 51
% 5.0 4.182 302
% 8.2 24.03 9
% 0.3 0.70 9
% 0.0 0.735 83
% 3.5 6.61 3
% 0.1 0.26 9
% 0.6 0.751 75
% 5.1 6.0
MDMA
MDMA
28: N=22622 df p*
149.300 14 p<0.001
ADHD
n=1003 n=1259
560 604% 55.8 48.0
48 63% 4.8 5.0
86 77% 8.6 6.1
18 23% 1.8 1.8
4 16% 0.4 1.3
133 112% 13.3 8.9
50 221% 5.0 17.6
26 85% 2.6 6.8
20 63% 2.0 5.0
35 45% 3.5 3.6
28 50% 2.8 4.0
10 7% 1.0 0.6
1
83.628
20.695
29: N=2262
p<0.0011 13.800
0.057
5.045
0.003
4.844
1
1
1
1
11.010
p=0.228
p*
p 0.811
p=0.025
p=0.954
p=0.028
p=0.001
2 df
14.309
0.012
1
1
1
1
1
1
p<0.001
p<0.001
p<0.001
p=0.914
p=0.1272.334
1.456
1
- 129 -
n=1003 n=125916 40
% 1.6 3.228 148
% 2.8 11.8529 766
% 52.7 60.817 39
% 1.7 3.13 17
% 0.3 1.4205 167
% 20.4 13.314 15
% 1.4 1.2387 352
% 38.6 28.07 33
% 0.7 2.6
30: N=2262 ICD-10 F1
*
F1x. 8
p=0.668
p<0.001
p=0.001
20.910
0.184
28.654
ICD-10
F1x. 6
F1x. 7
F1x. 2
F1x. 3
F1x. 4
F1x. 5
F1x. 0
F1x. 1
2 df
5.786
p*
p=0.0161
p<0.001
p<0.001
p 0.033
p=0.008
p<0.001
1
1
1
62.513
14.966
4.550
7.039
1
1
1
1
1
11.887
N74 12 62
% 5.9 % 16.2 83.8227 48 179
% 18.0 % 21.1 79.9402 206 196
% 31.9 % 51.2 48.8325 222 103
% 25.8 % 68.3 31.764 40 24
% 5.1 % 62.5 37.5251 218 33
% 19.9 % 86.9 13.1131 124 7
% 10.4 % 94.7 5.363 63 0
% 5.0 % 100.0 0.074 71 3
% 5.9 % 95.9 4.1F9
F0
F2
F3
F4
F5
F6
31: N=1259
F7
F8
n=564 n=108 n=39 n=51 n=302 n=8340 7 1 0 13 1
% 7.1 6.5 2.6 0.0 4.3 1.2117 29 13 14 22 8
% 20.7 26.9 33.3 27.5 7.3 9.6177 24 16 18 108 34
% 31.4 22.2 41.0 35.3 35.8 41.0109 20 5 10 134 26
% 19.3 18.5 12.8 19.6 44.4 31.324 2 1 1 21 4
% 4.3 1.9 2.6 2.0 7.0 4.898 20 4 8 73 25
% 17.4 18.5 10.3 15.7 24.2 30.168 29 1 1 12 6
% 12.1 26.9 2.6 2.0 4.0 7.219 1 2 6 17 11
% 3.4 0.9 5.1 11.8 5.6 13.345 6 1 3 10 5
% 8.0 5.6 2.6 5.9 3.3 6.0
14.136
54.659
5
5
5
5
5
2 df p*
10.493
45.866 5
5 p=0.062
p<0.001
F0
F2
F3
F6
p 0.051
F4 p<0.001
F5 p=0.222
11.035
73.928
6.979
* 2
32: 6 N=1147
p 0.015
F9 p=0.131
F7 p<0.001
F8 p<0.00124.515
8.484
5
5
- 130 -
20414312084565434343017171614
766555443332211111111
33:
195
SG 4433211111
34:
- 131 -
933211
35:
1012927151110
98877653322222111111111111111
36:
- 132 -
3083321
37: ADHD
522222222111111111111111111
38:
- 133 -
1:
- 134 -
- 135 -
1 2442 1333 1184 1095 1016 907 868 818 81
10 7911 5212 5012 5014 4215 3516 3217 2818 2718 2718 2721 2622 2323 2224 2124 2124 2124 2128 2028 20
39: 20
- 136 -