baiju shah
TRANSCRIPT
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• Proudly introducing
• “The Harrington Project for Discovery &
Development”
Bridging the Valley of Death
Baiju R. Shah, CEO, BioMotiv
The Harrington Project for Discovery & Development
TEDxCLE
April 4, 2014
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1
More Money…Fewer Medicines
1
Source: Diagnosing the decline in pharmaceutical R&D efficiency (2012); Burrill & Company analysis for PhRMA (2008)
$ Bns, R&D
New Drugs
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2Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008
The Valley of Death
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Developing New Medicines
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
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To Heal. To Teach. To Discover.
Developing New Medicines
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
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Opportunity for Innovation
“There’s never been a time where we’ve had
a greater outpouring of discoveries about the
nature of disease. And yet paradoxically,
the ability to turn that information into
clinical applications seems to have
slowed down. If there was ever a time when
we need to figure out how to take this
wonderful scientific opportunity and apply the
most bold, audacious principles of innovation
to make those products happen, it is now.”
Dr. Francis Collins
NIH Director
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To Heal. To Teach. To Discover.
Bridging the Valley of Death
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
Valley of Death
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To Heal. To Teach. To Discover.
7
Accelerating Breakthrough Discoveries into Medicines
Nonprofit For-Profit
Breakthrough
Medicines
Harrington
Discovery
Institute
Innovation
Center
Research Institutions and
Disease Foundations
BioMotiv
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To Heal. To Teach. To Discover.
8
Current Technologies
THP
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To Heal. To Teach. To Discover.
Bridging the Valley of Death
Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008