baiju shah
TRANSCRIPT
• Proudly introducing
• “The Harrington Project for Discovery &
Development”
Bridging the Valley of Death
Baiju R. Shah, CEO, BioMotiv
The Harrington Project for Discovery & Development
TEDxCLE
April 4, 2014
1
More Money…Fewer Medicines
1
Source: Diagnosing the decline in pharmaceutical R&D efficiency (2012); Burrill & Company analysis for PhRMA (2008)
$ Bns, R&D
New Drugs
2Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008
The Valley of Death
Developing New Medicines
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
To Heal. To Teach. To Discover.
Developing New Medicines
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
Opportunity for Innovation
“There’s never been a time where we’ve had
a greater outpouring of discoveries about the
nature of disease. And yet paradoxically,
the ability to turn that information into
clinical applications seems to have
slowed down. If there was ever a time when
we need to figure out how to take this
wonderful scientific opportunity and apply the
most bold, audacious principles of innovation
to make those products happen, it is now.”
Dr. Francis Collins
NIH Director
To Heal. To Teach. To Discover.
Bridging the Valley of Death
Late
Clin
ica
l
Early C
linic
al
Pre
-Clin
ical
Pro
duct
Dis
covery
Valley of Death
To Heal. To Teach. To Discover.
7
Accelerating Breakthrough Discoveries into Medicines
Nonprofit For-Profit
Breakthrough
Medicines
Harrington
Discovery
Institute
Innovation
Center
Research Institutions and
Disease Foundations
BioMotiv
To Heal. To Teach. To Discover.
8
Current Technologies
THP
To Heal. To Teach. To Discover.
Bridging the Valley of Death
Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008