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Proudly introducing “The Harrington Project for Discovery & Development” Bridging the Valley of Death Baiju R. Shah, CEO, BioMotiv The Harrington Project for Discovery & Development TEDxCLE April 4, 2014

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Page 1: Baiju Shah

• Proudly introducing

• “The Harrington Project for Discovery &

Development”

Bridging the Valley of Death

Baiju R. Shah, CEO, BioMotiv

The Harrington Project for Discovery & Development

TEDxCLE

April 4, 2014

Page 2: Baiju Shah

1

More Money…Fewer Medicines

1

Source: Diagnosing the decline in pharmaceutical R&D efficiency (2012); Burrill & Company analysis for PhRMA (2008)

$ Bns, R&D

New Drugs

Page 3: Baiju Shah

2Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008

The Valley of Death

Page 4: Baiju Shah

Developing New Medicines

Late

Clin

ica

l

Early C

linic

al

Pre

-Clin

ical

Pro

duct

Dis

covery

Page 5: Baiju Shah

To Heal. To Teach. To Discover.

Developing New Medicines

Late

Clin

ica

l

Early C

linic

al

Pre

-Clin

ical

Pro

duct

Dis

covery

Page 6: Baiju Shah

Opportunity for Innovation

“There’s never been a time where we’ve had

a greater outpouring of discoveries about the

nature of disease. And yet paradoxically,

the ability to turn that information into

clinical applications seems to have

slowed down. If there was ever a time when

we need to figure out how to take this

wonderful scientific opportunity and apply the

most bold, audacious principles of innovation

to make those products happen, it is now.”

Dr. Francis Collins

NIH Director

Page 7: Baiju Shah

To Heal. To Teach. To Discover.

Bridging the Valley of Death

Late

Clin

ica

l

Early C

linic

al

Pre

-Clin

ical

Pro

duct

Dis

covery

Valley of Death

Page 8: Baiju Shah

To Heal. To Teach. To Discover.

7

Accelerating Breakthrough Discoveries into Medicines

Nonprofit For-Profit

Breakthrough

Medicines

Harrington

Discovery

Institute

Innovation

Center

Research Institutions and

Disease Foundations

BioMotiv

Page 9: Baiju Shah

To Heal. To Teach. To Discover.

8

Current Technologies

THP

Page 10: Baiju Shah

To Heal. To Teach. To Discover.

Bridging the Valley of Death

Source Image: “Translational Research: Crossing the Valley of Death,” Nature, June 11, 2008