barry bunin open science summit at the berkeley intl house 2010
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Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
CDD aids Collaborations
ResultNew leads reveal known drugs that reverse chloroquine resistance
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.© 2010 Collaborative Drug Discovery, Inc.
Yes We Can!
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
CDD Successfully Builds Collaborative Drug Discovery Communities
• DDT, 2009 (14: 261-270): • $1.89M Tuberculosis B&MGF Project• >5 Years CDD SaaS in the Cloud • Thousands of scientists engaged:
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
CDD Platform
• Modules:
• CDD Vault – Secure place for private data – private by default
• CDD Collaborate – Selectively share subsets of data
• Datasets:
• CDD Public – expanding public data sets
• published compounds
• data from community members
• vendor libraries
• Unique to CDD – simultaneously query your private data, collaborators’ data, & public data
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
CDD Database for Your Private Data
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups
Collaborator 1 Collaborator 2 Collaborator 4Collaborator 3
Consolidated CDD DB
Project A Project DPro
ject B
Company A
Project C
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared
CDD DB group 1
CDD DB group 2
CDD DB group 3
CDD DB group 4
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
New Types of Offerings for a Rapidly Changing Industry
• CDD Community: tap into global R&D via “crowd-sourcing”• CDD Alliance: better management of your collaborations• CDD Customize: fast, good, and cost-effective = agile
Use CDD Vault™, Collaborate™, Public™ for Global R&D Community
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
Acknowledgements
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
• Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia Office)
• Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo
• Moses Hohman, PhD (VP Software Development)
• Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard (magna cum laude, Physics)
• Sylvia Ernst, PhD (Senior Director Community Growth – Northwest Office)
• Accelrys-Scitegic, MDL
• Andrea Barry (Senior Director Business Dev – N. Carolina Office)
• Accelrys-Scitegic, MDL
• Kellan Gregory (Head Community Interests Group)
• Anna Spektor (Community Advocate, ex-IDBS)
• Eli Lilly & Co.
• Bill & Melinda Gates Foundation
• Initial TB pilot laboratories
• CDD Researcher Community
• 1000s of CDD collaborators from academia, foundations and industry
• ChemAxon Tools (under the hood)
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
• Start with Strong Mission & Values• Neglected disease and commercial disease are both core components
• Collaborative culture – share successes and failures, as much as possible
• Tap leading community expertise with industry focused process
• Do Groundbreaking Work• Revolutionary approaches to solving critical health problems
• Imagine what would be possible in an ideal world, practically implement
• Discover drugs while changing the nature of the game
• What if…you had a magic wand?
Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
Answers for Our Field
Archive, Mine, Collaborate© 2009 Collaborative Drug Discovery, Inc.
CDD Collaborative Drug Discovery, Inc.
Burlingame, CAwww.collaborativedrug.com
Barry A. Bunin, PhDCEO & President
Archive, Mine, Collaborate®