basal forebrain components - schizophrenia - limbic connections - sanjoy sanyal

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BASAL FOREBRAIN COMPONENTS AND LIMBIC CONNECTIONS Dr Sanjoy Sanyal Professor and Course Director, Neuroscience

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This is the PowerPoint version of the Video created by Dr Sanjoy Sanyal, Professor and Course Director of Neuroscience. The components of Basal Forebrain are described, followed by the Meso-limbic and Meso-cortical Pathways. Then their role in Drug Addiction and Schizophrenia are explained. Finally the Hypothalamic, Hippocampal Formation, Septal Areas and Amygdala Connections are demonstrated graphically. YouTube video has been embedded after Slide number 13, which contains a running commentary by the author on a formalinized juman brain specimen. It describes what has bee mentioned in the preceding slides. This is purely for educational purposes and no copyright infringement is intended. Tags: Basal Forebrain, Mesolimbic, Mesocortical, Drug Addiction, Schizophrenia, NAc Pathway, Hippocampal Formation, Septal Areas, Amygdala, Sanjoy Sanyal, Professor, Neuroscience,

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Page 1: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

BASAL FOREBRAIN COMPONENTS AND

LIMBIC CONNECTIONS

Dr Sanjoy Sanyal

Professor and Course Director, Neuroscience

Page 2: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Basal Forebrain Components OF-PFC: Orbito-Frontal Pre-Frontal Cortex Septal Areas:

Cortical Areas: Para-terminal Gyrus (Adjacent to Lamina Terminalis) and Sub-callosal (Under Rostrum of Corpus Callosum)

Subcortical Nuclei: Between Septum Pellucidum and Anterior Commissure (Lateral, Medial, Posterior Nuclei)

Ventral Striatum: Nucleus Accumbens + Olfactory Tubercle (Cells of Calleja)

Ventral Pallidum: Substantia Innominata; Including Nucleus Basalis of Meynert

Anterior Hypothalamus: Pre-Optic Area

Page 3: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Orbito-Frontal PFC

Page 4: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Septal Areas and Connections

Page 5: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Ventral Striatum

Includes Nucleus Accumbens under Striatum (Fusion of Head of Caudate Nucleus with Putamen)

Also includes Olfactory Tubercle (Part of Allocortex containing Cells of Calleja in Anterior Perforated Substance)

Page 6: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Nucleus Accumbens

Page 7: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Ven

tral P

allid

um

Page 8: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Nucleus Basalis of Meynert

Page 9: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Ventral Striato-pallidal Tract

Olfactory Cortex / OF-PFC / Hippocampus

Ventral Striatum (Nucleus Accumbens +

Olfactory Tubercle)

Ventral Pallidum (Substantia innominata, which

includes Nucleus Basalis of Meynert)

Dorso-medial (Medio-Dorsal) Nucleus of

Thalamus

Page 10: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Septal Areas and Connections

Page 11: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Meso-Limbic / Meso-Cortical Tract

Page 12: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Meso-Limbic / Meso-Cortical Tract

Page 13: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Schizophrenia and Reward Pathway

Page 14: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Hypothalamic Afferents

Page 15: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Hypothalamic Efferents

Page 16: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Limbic Connections

Page 17: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal
Page 18: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Hippocampal Formation Connections

Page 19: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal
Page 20: Basal Forebrain Components - Schizophrenia - Limbic Connections - Sanjoy Sanyal

Amygdala Connections