basal ganglia physiological aspects
DESCRIPTION
Physiological functions of Basal Ganglia MBBS LectureTRANSCRIPT
![Page 1: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/1.jpg)
1
BASAL GANGLIA
Dr Raghuveer Choudhary
5/3/2012
![Page 2: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/2.jpg)
Basal Ganglia
![Page 3: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/3.jpg)
• Define basal ganglia and describe the parts
• Describe the main connections and functions
• Describe the function and the disorders of basal ganglia such as Parkinsonism and tremors
OBJECTIVES
![Page 4: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/4.jpg)
![Page 5: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/5.jpg)
Basal Ganglia
Anatomic considerations-
Group of subcortical Grey nuclear masses at base of cerebral hemisphere, on each side of brain.play an essential role in control of movements.
![Page 6: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/6.jpg)
![Page 7: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/7.jpg)
Where are the basal ganglia?
![Page 8: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/8.jpg)
![Page 9: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/9.jpg)
![Page 10: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/10.jpg)
![Page 11: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/11.jpg)
• Caudate nucleus + putamen=Neo Striatum(major input center).
• Putamen +Globus pallidus = Lenticular nucleus.– Caudate nucleus- comma shaped band of gray
matter,head, body & tail.Head continuous with putamin, tail ends with close relation of amygdaloid body.
– Putamen - outer part of lenticular nucleus, seperated from pallidum by white fibrous band, it is dark in color compared to pale pallidum.
– Globus pallidus- Inner region of lenticular nucleus, divided into GP externa & GP interna by internal lamina of white matter.
![Page 12: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/12.jpg)
Subthalamic body of Luys- biconvex mass of grey matter located in midbrain, just below the thalamus.
Substantia nigra- sheet of neurons containing dark pigment neoromelanin present ventral to the crus cerebri in midbrain,divided into –
Pars compacta- dopaminergic and cholinergic neurons.Pars reticulata GABAergic neurons.
Globus pallidus referred as- palaeostriatum,Caudate N & Putamin- neostriatum.
![Page 13: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/13.jpg)
The internal capsule lies within borders formed by the thalamus, caudate N & lenticular nucleus(P+G.P=lens shaped).This is a crucial area for passage way for all nerve fibers connecting cerebrum with rest of CNS.
![Page 14: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/14.jpg)
BG dysfxnSlow, inefficient actions, rigidity, bradykinesia, unwanted movement
![Page 15: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/15.jpg)
Connections• BG has multiple connections with other parts of CNS-
cerebral cortex, cerebellum, thalamus,reticular formation, mid brain.
• They are imp. Centres of coordination, in control of automatic associated movements.
• Corpus striatum(C+P) is responsible for initiation and inhibition of gross intentional body movements that are unconsciously performed in normal person.
• Also provide muscle tone – so that exact movements can be performed,hand work- requiring coordinated effort of entire arm & trunk for hand to be able to perform.
![Page 16: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/16.jpg)
Connections
• Caudate nucleus • Putamen
• Globus pallidus – output leaves
receive input
![Page 17: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/17.jpg)
![Page 18: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/18.jpg)
Connections
• Connections of striatum
– Caudate nucleus & putamen – input
– Receive afferent - cerebral cortex, intralaminar thalamic nuclei, subs nigra
– Efferent – globus pallidus, subs nigra
• Connections of globus pallidus
– 2 segments – GPi & GPe– GPi& subs nigra – output– Receive afferent – striatum,
subthalamic nucleus– Efferent
• GPe – subthalamic N• GPi– thalamus (VA,VL,CM)
– motor areas
![Page 19: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/19.jpg)
![Page 20: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/20.jpg)
![Page 21: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/21.jpg)
• The corticostriatal projections arise from neurons from in layer V of cortex& appear to use glutamate as its excitatory NT.
• The striatum then influences neurons in VL, VA nucleui of thalamus by- 2 pathways.
![Page 22: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/22.jpg)
![Page 23: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/23.jpg)
Basic Circuit of Basal Ganglia
Neostriatum
Gpi/SNpr
Cerebral Cortex
VA/VL thalamus
+
+
Gpe
Subth
+
![Page 24: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/24.jpg)
Direct and Indirect- fig.In direct pathway- striatum projects-i segment of GP & pars R of SN.
This projection is inhibitory, NT are GABA,subatance P.Gpi +SNr project to VA/VL of thalamus, this is also inhibitory(GABA).The VA /VL send excitatory connection to prefronatal, premotor & supplementary area of cortex.
![Page 25: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/25.jpg)
![Page 26: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/26.jpg)
• This input to cortex influences motor planning, affects discharge of corticospinal, corticobulbar neurons.
• Pars reticulata also influences eye movementsby projection to superior colliculus.
• Direct pathway appears to function as follows-– Neurons in striatum have little background
activity,activated from input of cortex.– In contrast Gpi has high level of background
activity.– Striatum is inhibitory to Gpi, but pallidial neurons
themselves are inhibitory to VA,VL N , therefore activation of striatum disinhibits the thalamus- i.e excites these neurons and their target neurons in MOTOR CORTEX .
![Page 27: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/27.jpg)
![Page 28: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/28.jpg)
Indirect pathway
Striatum –to exter. Segment of GP which projects to SN- this inturn projects back to Gpi.In this pathway pallidial neurons in Gpe are inhibited by- GABA& enkephalin.GABA & enkephalin disinhibit neurons neurons of STN.
The STN neurons become more active as disinhibition.Release Glutamate in int. seg of GP.This transmitter excites neurons of VA/VL Thalamic N.The pallidal action is inhibitory, activity of thalamic N decreases, as does that of cortical neurons.
![Page 29: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/29.jpg)
![Page 30: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/30.jpg)
• Thus the direct & indirect pathways have opposing actions.
• An increase in either one of these pathways – leads to imbalance in motor control.
• It influences increase/ decrease in motor output of cortex.
• Neurons of SN (pc)- project to striatum• (3rd circuit)Dopamine is the neurotransmitter.• This has an excitatory effect on Direct and• Inhibitory action on indirect pathway.
– Both actions facilitate activity in C.Cortex.– This circuit is imp. Functionally.
![Page 31: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/31.jpg)
![Page 32: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/32.jpg)
![Page 33: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/33.jpg)
![Page 34: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/34.jpg)
34
Nolte 13-6
IE
Forebrain: Basal Motor Nuclei
•Motor loop: ipsilateral
•Substantia nigra interconnected with striatum (e.g., nigrostriatal proj.)•Subthalamus reciprocally interconnected with GP
•Gpi: major lentiform output (-) to motor thalamus• Basal-motor nuclei (-) tonic (spont.) activity of motor thalamus, and thus modulate CST outputs: BMN modulate contra movement
•M. cort. areasstriatumGpithalamus (VA/VL)M. cort areas
CST
contra
loop
Motor cortical areas Motor cortical areas
loop
IE++
+
-
+
--
-
-DIRECT PATHWAY
INDIRECT PATHWAY
![Page 35: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/35.jpg)
Direct Indirect
Pathway Striatum (-) GPi, SNr
Striatum (-) GPe (-) STN (+) GPi
Effect on BG output
GPi, SNr inhibited GPi stimulated
Effect on Thalamus
Stimulated Inhibited
Effect on movement
Initiated Inhibited
Malfxning Parkinson’s bradykinesia
Huntington’s Chorea
![Page 36: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/36.jpg)
![Page 37: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/37.jpg)
Putamin circuit-execution of movements
• Principal role of BG in motor activity is– skilled movements performed subconsciously-
• Writing letters of alphabet• Cutting paper with scissor• Hammering nails, shooting basketball.• Passing throwball, shoveling dirt• Vocalisation, controlled movements of eyes.
– Damage in putamin circuit-• Damage in GP-ATHETOSIS(writhing movements).• Lesion in subthalamus- HEMIBALLISMUS(flialing of
whole limb)• Lesion in putamin- CHOREA(flicking movmet in
hand,face)• Damage in SN- PARKINSONISM(TRA/D).
![Page 38: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/38.jpg)
![Page 39: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/39.jpg)
![Page 40: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/40.jpg)
![Page 41: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/41.jpg)
![Page 42: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/42.jpg)
![Page 43: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/43.jpg)
![Page 44: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/44.jpg)
![Page 45: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/45.jpg)
![Page 46: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/46.jpg)
Caudate circuit-cognitive control
• Thinking process using sensory input & memory in information (stored).
• Motor activity occur as result of – thoughts generated.
• Efferents end in accessory motor regions in premotor & supplementary areas-concerned in putting together sequential patterns of movement lasting for seconds/ don’t excite muscle movements. For e.g person seeing a lion.
• Without thinking for long, respond immediately to achieve complex goal.
![Page 47: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/47.jpg)
• Another imp. Function is change timing & scale the intensity of movements.– How rapidly movement is to be performed.– How large the movement will be.
• In patients of severe lesion in BG- timing & scaling is lost.
• Example is – writing alphabet ‘a’.• This is function of BG along with cerebral cortex.• In lesion of post. Parietal cortex-
– Centre for spatial coordination for motor control of all parts of body & relation of body its parts with surrounding.
![Page 48: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/48.jpg)
Fig showsperson lacking
lt.post.parietal cortex draw the face of human being,
proper proportion for rt. Side ignoring lt.
side(rt. Field of vision), avoid using
rt.hand, arm not aware of existance.
![Page 49: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/49.jpg)
![Page 50: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/50.jpg)
Basal Ganglia Connections
•Circuit of connections– cortex to basal ganglia to
thalamus to cortex– Helps to program automatic
movement sequences (walking and arm swinging or laughing at a joke)
•Output from basal ganglia to reticular formation–reduces muscle tone–damage produces
rigidity of Parkinson’s disease
![Page 51: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/51.jpg)
• The general effect of BG excitation is of inhibitory (-) signals to bulboreticular facilitatory(+),
• and excitatory(+) signals to bulboreticular inhibitory(-) areas.
• When BG are not functioning adequately-– Facilitatory areas(+) become overactive.– Inhibitory areas(-) become underactive.– Resulting in Rigidity throughout body.
![Page 52: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/52.jpg)
Metabolic considerations
• Metabolism is unique.– The structures have a high O2 consumption.– Copper content of substantia nigra & locus
ceruleus is particularly High.– In Wilson’s disease, genetic autosomal
recessive disorder, plasma level of copper binding protein ceruloplasmin is- LOW.
– Chronic copper intoxication and severe degeneration of Lenticular nucleus take place.
![Page 53: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/53.jpg)
![Page 54: Basal Ganglia Physiological aspects](https://reader034.vdocument.in/reader034/viewer/2022051322/5408ab21dab5ca07028b4664/html5/thumbnails/54.jpg)