basic concepts of immunology scott barnum, ph.d

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Basic Concepts of Immunology Scott Barnum, Ph.D.

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Basic Concepts of Immunology Scott Barnum, Ph.D. Immunology is Important to You as a Future Clinician Because:. 1.Failure of the immune system to cope with infection/trauma is the reason for many patient visits. 2.Immunological status of your patients dictates treatment decisions. - PowerPoint PPT Presentation

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Page 1: Basic Concepts of Immunology Scott Barnum, Ph.D

Basic Concepts ofImmunology

Scott Barnum, Ph.D.

Page 2: Basic Concepts of Immunology Scott Barnum, Ph.D

Immunology is Important to Youas a Future Clinician Because:

1. Failure of the immune system to cope with infection/trauma is the reason for many patient visits

2. Immunological status of your patients dictates treatment decisions

3. Need to protect yourself and your staff from infection

Page 3: Basic Concepts of Immunology Scott Barnum, Ph.D

Immune System Components

Cells and Organs: thymus, spleen, lymph nodes, stem cells and precursors, T and B cells, macrophages (MØ), neutrophils (PMN), dendritic cells (DC), mast cells and others

Humoral/Soluble: antibody, cytokines, complement, acute phase proteins, enzymes, antimicrobials, etc.

Page 4: Basic Concepts of Immunology Scott Barnum, Ph.D

Innate Versus Adaptive Immunity

Page 5: Basic Concepts of Immunology Scott Barnum, Ph.D

Innate Immune Mechanisms of Protecting the Host

Page 6: Basic Concepts of Immunology Scott Barnum, Ph.D

Innate Immune Mechanisms of Protecting the Host

Phagocytosis

Inflammation

Page 7: Basic Concepts of Immunology Scott Barnum, Ph.D

How Does the Innate Immune SystemRecognize Infection?

• Via Pathogen Associated Molecular Patterns (PAMPs)

• Specific receptors recognize microbial components (LPS, lipoproteins, peptidoglycan, ssRNA etc)

• These receptors are termed Pattern Recognition Receptors (PRRs)

• Examples of PRRs include: Collectins, CRP and Toll-like receptors

Page 8: Basic Concepts of Immunology Scott Barnum, Ph.D

Toll-like Receptors (TLRs)

Page 9: Basic Concepts of Immunology Scott Barnum, Ph.D

Adaptive Immunity

Active Immunity -

Passive Immunity -

Humoral Immunity -

Cell-mediated Immunity -

Page 10: Basic Concepts of Immunology Scott Barnum, Ph.D

Adaptive Immunity- mediated by lymphocytes

Page 11: Basic Concepts of Immunology Scott Barnum, Ph.D

Adaptive ImmunityCardinal Features

Specificity -

Diversity -

Memory -

Self-Limiting Response -

Recognition of Self vs. Non-self -