bbepp alg folder en expertise folder sept16

Contact our business development team at [email protected]

Mrs. Muriel Dewilde, Mob. +32 477 75 62 35, [email protected]. Frederik De Bruyn, PhD, Mob.+32 484 40 44 25, [email protected] Mr. Hendrik Waegeman, PhD, Mob. +32 479 56 20 61, [email protected]

Bio Base Europe Pilot PlantRodenhuizekaai 1 • B-9042 Gent (Desteldonk), BelgiumTel +32 (0)9 335 70 01 • Fax +32 (0)9 335 70 02

Why more than 100 companies already teamed up with Bio Base Europe Pilot Plant Save time and money thanks to our unique combination of equipment and expertise:

Equipment: A broad variety of state-of-the-art technical solutions is available at diff erent scales, including:• Fermentation scale up to 15 m3

• Gas fermentation facilities• A wide range of DSP unit operations from bench-top to multi ton scale• Combination of fermentation and Ex proof downstream processing• …Broad expertise: Scale-up is our core business! Our operational team of engineers, operators and technicians combines decades of experience and technological know-how and guarantees a fast and effi cient scale-up, resulting in faster learning curves and shorter time to market.

Independence: Bio Base Europe Pilot Plant is an independent facility. We have no industrial shareholders and operate in full confi dentiality.

Flexibility: We design the project outline to your needs and fl exibly build up process lines that can be operated 24/7.

Transparency: A close communication throughout the project ensures a seamless technology transfer in both directions. We welcome your presence at our facilities during the trials, the experience gainded is yours!

Quality management systems: ISO9001, FSSC22000 as from 1st half of 2017.

Global player: Bio Base Europe Pilot Plant collaborates with companies and research institutes from all over the world (Europe, Asia and The Americas). We assisted many key players in the biobased economy with their developments and managed to build up a vast network.

Accelerating your biobased innovationPROCESS DEVELOPMENTSCALE-UP CUSTOM MANUFACTURING Kilogram to Multi Ton Scale

www.bbeu.org

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EXPERIENCE

As an open innovation pilot and demonstration facility, Bio Base Europe Pilot Plant is open for collaboration with companies, research institutes and other partners active in the biobased economy.

At Bio Base Europe Pilot Plant, your processes are in the competent hands of highly trained engineers, process operators and technicians. Our team stands for a vast amount of know-how on both a scientific and technical level. Combined with decades of experience in scale-up and operating industrial equipment, our engineers translate your lab scale process into a viable industrial process.

We work in 24/7 operations if necessary. A confidential and close communication throughout the project as well as your presence at our facilities during the trials ensure a seamless technology transfer in both directions.

In addition, we can operate as a one-stop-shop, converting renewable feedstocks into sustainable products all under one roof.

PRODUCTSBio Base Europe Pilot Plant is an open innovation pilot and demonstration facility for process development, scale-up and custom manufacturing of biobased products and processes from lab to multi ton scale. A wide and flexible spectrum of modular unit operations combined with a team of highly trained and experienced engineers, process operators and technicians facilitates the translation of biobased laboratory processes into viable industrial processes. Bio Base Europe Pilot Plant has successfully performed 200 projects for more than 100 companies.

Pretreatment PurificationBiocatalysis

Fermentation

Green Chemistry

REFINED PRODUCT

BIOMASS

Bio Base Europe Pilot PlantThe gateway to industrial production

Process Development

Biomass Pretreatment

Purification and Product Recovery

Scale up

Biocatalysis

Green chemistry

Custom Manufacturing

Fermentation

Gas Fermentation

• Concept design• Fermentation optimization• Downstream process (DSP) development and

optimization• Bench-top feasibility trials• Techno-economic assessment

(in-house model)

Mechanical, physico-chemical, solvent-based and enzymatic pretreatment of biomass feedstocks

e.g. acid hydrolysis, organosolv

Centrifugation, depth and cross flow filtration, evaporation, ion exchange, crystallization, solvent

extraction, drying, etc.

• Production of bulk bio-products up to multi ton scale

• 24/7 operations• Quality control• Food grade production• ISO9001 and FSSC22000:

as of 1st half of 2017

Batch, fed-batch, chemostatFermentation with: bacteria, yeast, fungi

Aerobic and anaerobic fermentationsEx proof fermentations

Scales ranging from shake flask to 2x15m3. e.g. chemicals, industrial enzymes, food ingredients,

cosmetics, fuels, flavours and frangrances

High pressure 10L gas fermenter. Auxiliary equipment for strict anaerobic cultivation

and gas premixing. Gaseous feedstocks: industrial off-gas, syngas,

methane…

• Feasibility and optimization trials in scaleable equipment

• Equipment available at different scales: bench-top, 100 kg, ton and multi ton scale

• First series compounds for application trials• Demonstration of technology at larger scale• Generation of pilot data incl. mass- and energy

balances

Enzymatic conversions in aqueous and two-phase systems, immobilization of enzymes

e.g. oligosaccharide synthesis, glycoside synthesis

Chemical conversion, extraction, solvent evaporation, crystallization in Ex proof and corrosion resistant

reactors up to 5m3.

TECHNOLOGIES

OUR OFFER

AN INDEPENDENT STATE-OF-THE-ART

PILOT AND DEMONSTRATION FACILITY

FOR BIOBASED PRODUCTS AND PROCESSES

Examples of biobased products

produced at Bio Base Europe

Pilot Plantbiosurfactants

specialty carbohydratesenzymes biochemicals

biofuels

biobased building blockssolvents

flavours and fragrances

protein concentrates

organic acids esters

nutraceuticals

food ingredients

biocolourants

cosmetics

WIDE and FLEXIBLE spectrum of modular

unit operations

Team of highly trained and experienced

engineers and operators

Successful scale-up

of your process

EXPERIENCE

Fermentation

Green Chemistry

REFINED PRODUCT

BIOMASS

Process Development

Scale up

Biocatalysis

Green chemistry

Fermentation

Gas Fermentation

(in-house model)

methane…

balances

reactors up to 5m3.

TECHNOLOGIES

OUR OFFER

biofuels

nutraceuticals

food ingredients

biocolourants

cosmetics

unit operations

Successful scale-up

of your process

EXPERIENCE

Fermentation

Green Chemistry

REFINED PRODUCT

BIOMASS

Process Development

Scale up

Biocatalysis

Green chemistry

Fermentation

Gas Fermentation

(in-house model)

methane…

balances

reactors up to 5m3.

TECHNOLOGIES

OUR OFFER

biofuels

nutraceuticals

food ingredients

biocolourants

cosmetics

unit operations

Successful scale-up

of your process

BIOMASS PRETREATMENT

BIOMASS PRETREATMENT BIOCATALYSIS FERMENTATION GREEN CHEMISTRY PRODUCT RECOVERY AND PURIFICATION

BIOMASS PRETREATMENT

For more information: please visit www.bbeu.org

For questions, please call +32 9 335 70 01 or send an email to [email protected]

Equipment overview:Reactors for chemical pretreatment of biomass:These reactors are suitable for acid (H2SO4, HCl…), alkaline (NaOH, ammonia…), sulfite, organosolv and other types of pretreatment∂ Benchtop, 2 L (ATEX, glass lined, pressurized)∂ 1 x 85 L (ATEX, glass lined, pressurized)∂ 1 x 500 L (ATEX, glass lined, pressurized)∂ 1 x 1000 L (ATEX, glass lined, pressurized)∂ 1 x 5400 L (ATEX, glass lined, pressurized)

Reactors for enzymatic hydrolysis of biomass:∂ Lab scale hydrolysis∂ 1 x 500 L∂ 1 x 1000 L∂ 2 x 4000 L∂ 2 x 5000 L∂ 4 x 8000 L∂ 3 x 50 000 L

Reaction vessels for slurries with high solids contents

Auxiliary equipment:Milling∂ Dry milling: roller crusher, knife mill, hammer

mill, cutting mill, pin disk mill∂ Wet milling: pulper (2000 L), inline mixer, inline

colloid mixerThermal treatment∂ Direct steam injection∂ Jet cooking with holding tubeDewatering and concentration equipment∂ Filter press∂ Decanter centrifuge∂ Screw press∂ Falling film three-effect evaporator, 5 t/h water

evaporation∂ Wiped film evaporators, 2 kg/h and 150 kg/h

water evaporation

What we offer:∂ Mechanical, thermal, physico-chemical and

enzymatic pretreatment of biomass feedstocks∂ Logistics and storage:

• Truck (un)loading docks• Bulk solid biomass storage (55 t silo, 3x90 t bunkers)• Liquid storage (vessels up to 125 m³)• Dedicated areas for IBC storage • Chemicals storage• Refrigerated storage room, freezers

∂ A wide spectrum of modular operation units

Expertise:Experience in treating the following lignocellulosic raw materials:∂ Agro-industrial side streams: paper pulp, spent

grains, bagasse, press cakes, stillage...∂ Agronomic by-products: corn stover, corn cobs,

husk, fiber, stems, leaves, verge grass…∂ Dedicated energy crops: miscanthus, poplar…

BIOCATALYSIS

Equipment overview:Process vessels for aqueous reactions:∂ 1 x 500 L∂ 1 x 1000 L∂ 2 x 4000 L∂ 2 x 5000 L∂ 4 x 8000 L∂ 3 x 50 000 L

Process vessels for solvent-based reactions:∂ 1 x 2 L (ATEX)∂ 1 x 7 L (ATEX)∂ 1 x 85 L (ATEX)∂ 1 x 500 L (ATEX)∂ 1 x 1000 L (ATEX)∂ 1 x 5400 L (ATEX)

Reaction vessels for suspensions with high solids contents

Auxiliary equipment:∂ Fermenters of different sizes to produce the

biocatalyst (see fermentation brochure)∂ A variety of downstream purification equipment

to purify the product of interest from the reaction mixture (see product recovery and purification brochure)

What we offer:∂ Scale-up and demonstration of biocatalytic

processes∂ Process development and optimization∂ Custom manufacturing∂ Single enzyme or whole cell biocatalyst systems∂ Immobilization of enzymes and whole cells∂ Aqueous and solvent based reactions∂ Enzyme or whole cell biocatalyst production

through bacterial, yeast or fungal fermentation

Expertise:BBEPP’s team of process and R&D engineers has built up a significant track record in production of biocatalysts and in biocatalytic conversions at lab and pilot scale. The team has demonstrated various aqueous and solvent based reactions at an industrially relevant scale.

FERMENTATION

Equipment overview:(An)Aerobic fermenters:batch, fed-batch, continuous∂ 4 x 7 L∂ 2 x 10 L∂ 1 x 50 L∂ 4 x 150 L∂ 2 x 1500 L∂ 1 x 4500 L∂ 2 x 15000 L

Anaerobic fermenters:∂ 1 x 85 L (ATEX)∂ 1 x 500 L (ATEX)∂ 1 x 1000 L (ATEX)∂ 1 x 5400 L (ATEX)

Gas fermenters, feed CO, CO2, H2:∂ 1 x 10 L (ATEX)

Auxiliary equipment:∂ Analytical capabilities: HPLC, GC, fast bio-

chemistry analyzer, off gas analysis and data logging

∂ Equipment for biomass separation: centrifuges, decanter, plate filters, filter press, membrane filtration

∂ Biomass pretreatment equipment for second generation bioproducts (see Biomass pretreatment brochure)

∂ A variety of downstream processing equipment to recover and purify the product of interest from the fermentation broth (see Product Recovery and Purification brochure)

What we offer:∂ Scale-up and demonstration of fermentation

processes∂ Batch, fed-batch and continuous (with or

without cell recycle) fermentations∂ Experience with bacterial, yeast and fungal

systems∂ Process development and optimization∂ Custom manufacturing∂ Examples of products: industrial enzymes, fine

and bulk chemicals, biofuels, biochemicals, bioplastics, biosurfactants, biosolvents, nutraceuticals, food ingredients, bioflavours...

Expertise:Our team combines over 50 years of fermentation experience. We can rely on fermentation experts with academic and industrial backgrounds. This combination makes our expertise unique.

GREEN CHEMISTRY

Equipment overview:Glass lined, pressure proof and corrosion resistant reactors, coupled to a condenser and vacuum pump.

Properties:∂ Pressures up to 8 bar ∂ Temperatures up to 200°C. ∂ Vacuum down to 20 mbara

Reactor volumes (ATEX):∂ 1 x 2 L∂ 1 x 7 L∂ 1 x 85 L∂ 1 x 500 L ∂ 1 x 1000 L∂ 1 x 5400 L

Auxiliary equipment (ATEX):∂ Filter dryer (1900 L)∂ Conical dryer (980 L)∂ Bag filter∂ Filter press∂ Basket centrifuge (40 kg)∂ Continuous liquid-liquid extraction column 6 L/h

GREEN CHEMISTRY

What we offer:ATEX compliant installation and expertise for chemical processes: ∂ Solvent evaporation and condensation∂ Zoning of the operational area to ATEX zone 2∂ Explosion protection on all electrical equipment:

ExII2G T3∂ N2 inertisation and blanketing∂ Pressure proof from -1 to 8 bar

Types of processes: ∂ Chemical synthesis reactions∂ Chemical conversion reactions∂ Chemical hydrolysis∂ Extractions

Expertise:ATEX zoning challenges the possibilities and freedom of operation. However, our team of experienced engineers and operators can always find a safe and workable approach. Our team is ready to bring your product to the next level.

Examples:∂ Functionalisation of biopolymers and oligosaccharides∂ Esterification of fatty acids∂ Synthesis of oleochemicals∂ Chemical synthesis of biosurfactants∂ …

PRODUCT RECOVERY AND PURIFICATION

For questions, please call +32 9 335 70 01 or or contact [email protected]

The equipment overview below gives an idea of the variety of modular operation units we have available to perform your purification and product recovery processes. However, this list is not complete. If you are looking for specific equipment not listed below, do not hesitate to contact us.

Equipment overview:Centrifugation ∂ High speed disc stack centrifuges, 500 L/h and 3 m3/h∂ Screw decanter centrifuge, 750 kg/h∂ Basket centrifuges, 10 kg and 40 kg∂ Inverting filter centrifuge, up to 50 kg of product per cycle∂ Ex proof disc stack centrifuge 500 L/h

Membrane Filtration:∂ Cross-flow membrane filtration units for Micro, Ultra

& Nanofiltration ∂ Different membrane types: spiral wound, hollow fiber,

ceramic

Filtration:∂ Dead-end filtration such as plate and frame filters,

candle filter∂ Filter presses∂ Rotary vacuum drum filter, basket filter

Ion exchange and adsorptionColumns for ion exchange, adsorption or activated carbon treatment∂ 3 x 30 L resin∂ 4 x 800 L resin∂ 2 x 2000 L resin

Crystallization∂ Various reactors from 50 L to 4 m³ for cooling

crystallization and evaporation crystallization∂ Crystallization line up to 1000 t/y equipped with

crystallizer 4 m³, inverted basket centrifuge, crystal dryer∂ Continuous cooling crystallization unit 50 L∂ Benchtop crystallizer 2000 ml

Evaporation∂ Continuous evaporation units from liter to ton scale ∂ Falling film three-effect evaporator, 5 t/h water

evaporation∂ Wiped film evaporators, 2 kg/h and 150 kg/h∂ Spinning cone evaporator, up to 50 kg/h water

evaporation∂ Batch evaporation reactors for both water and

solvent based distillation

Extraction∂ Filter dryer 1900 L (ATEX) for solvent extraction and

solids drying∂ Karr column (6 L/h) for countercurrent liquid-liquid

extraction∂ Glass lined reactors, 500 to 5400 L for solid-liquid

and liquid-liquid extractions

Chromatography∂ GRACE bench scale preparative chromatography unit∂ Columns up to 500 L for batch chromatography

Drying∂ Continuous sludge dryer, 5 kg/h∂ Vacuum tray dryer, 150 L filling volume∂ Conical dryer, 980 L (ATEX)∂ Filter dryer, 1900 L (ATEX) ∂ Drying oven, 2000 L ∂ Access to freeze- and spray drying facilities∂ Spray dryer, 3 kg/h water evaporation∂ Lyophilizer, 8 kg water per drying cycle

Various∂ Multipurpose process tanks up to 8000 L∂ Storage and process buffer tanks up to 50 m3

∂ Homogenizer, cell disruptor, 10 L/h and 100 L/h (rental)

∂ Access to a wide range of rental equipment

What we offer:∂ Expertise in development, scale-up and

demonstration of product recovery and purification processes

∂ A broad range of processing equipment for aqueous and solvent based applications

∂ Flexibility in setting up dedicated process lines∂ …

www.bbeu.org

bbepp alg folder en expertise folder sept16

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