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transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation BC Kidney Days October 5, 2017

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Page 1: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

BC Transplant

BC Transplant Update

Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation

BC Kidney Days October 5, 2017

Page 2: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

BC Transplant

BC Transplant provides oversight for all aspects of organ donation and transplantation across BC. Provincial scope and model of

care is unique in Canada.

Page 3: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

BCT Operational Goals

Increase organ donation

Reduce the number of patients on the transplant wait list

Improve how we deliver care to patients and donor families

Page 4: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Work underway across the continuum of care

Page 5: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

transplant.bc.ca/medications

Page 6: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Work underway across the continuum of care

“In a time of great sadness and grief, we are able to provide a silver lining to families by facilitating what becomes the gift of life.” “I have the privilege to work with real life heroes—people and families who are going through some of the most difficult times of their lives and yet are still so thoughtful, generous, and intent on helping others.

Page 7: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Public awareness and partnerships

Page 8: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Poll question!

From 2014-2016, what was the growth in deceased donor referrals from hospitals to BC Transplant?

a. 15%

b. 84%

c. 145%

d. 192%

Page 9: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

BCT Referrals (2012-2016)

124

180 178

321

437

0

100

200

300

400

500

2012 2013 2014 2015 2016

Referrals

Page 10: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Poll question!

What is the growth in transplants since 2012?

a. 12%

b. 27%

c. 38%

d. 45%

Page 11: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Number of transplants is increasing

306

95

326

422 423

70 67 69 95 97 90

130 107 113 95

0

50

100

150

200

250

300

350

400

450

2012 2013 2014 2015 2016

Transplants Deceased donors Living donors

Page 12: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Donation and Transplant Stats

2015 2016 2017 (to Oct 1)

Heart 19 28 16

Kidney – deceased donor 161 173 181

Kidney – living donor 110 95 70

Liver – deceased donor 76 74 61

Liver – living donor 3 0 0

Liver-Kidney 3 1 0

Pancreas, pancreas-kidney, pancreas islet

15 12 4

Lung 35 40 43

TOTAL 422 423 376

Exceeded 2016!

Exceeded 2016!

Page 13: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Summary of Stats – October 1, 2017

99 deceased donors

66 living donors

376 transplanted

4,544 patients followed post transplant

≈ 625 people in BC currently waiting for transplant

1,157,735 people have registered their decision for organ donation

Page 14: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Page 15: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

# of deceased donors is climbing

07 08 09 10 11 12 13 14 15 16

British Columbia

Kidney donors

0

2

4

6

8

10

12

14

16

18

20

22

07 08 09 10 11 12 13 14 15 16

per m

illio

n po

pula

tion

British Columbia

Canada

All donors

Year

Page 16: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Deceased Kidney Donors

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

07 08 09 10 11 12 13 14 15 16

Perc

ent

Other

Aboriginal

Asian Indian

Asian

Caucasian

Race

07 08 09 10 11 12 13 14 15 16

A

AB

B

O

Blood type

Distribution of deceased kidney donors Deceased kidney donors with at least one kidney used for transplant in BC in the given year. Kidney donors from OOP are included.

Year

Page 17: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Kidney transplants by donor type

All

0

50

100

150

200

250

300

07 08 09 10 11 12 13 14 15 16

Num

ber

of T

rans

plan

t

Year

Total kidney transplants by donor type Patients received a kidney during the given year, including multi-organ transplants and pediatrics.

Deceased Donor

Living Donor

Page 18: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Wait times by blood type

0

20

40

60

80

100

120

2009 2010 2011 2012 2013 2014 2015 2016

Wait times by blood type

A AB B O

Median wait time (in months) from dialysis to transplant for adult deceased donor kidney transplants by blood type (first kidney transplant) Adult patients received a deceased donor kidney in the given year. Simultaneous multi-organ transplants and retransplants are excluded.

Mon

ths

Page 19: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Wait times by blood type and age

0

20

40

60

80

100

120

140

2012 2013 2014 2015 2016

Mon

ths

AABBO

0

20

40

60

80

100

120

140

2012 2013 2014 2015 2016

Mon

ths

AABBO

Recipient age < 60 Recipient age >= 60

Page 20: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Most patients are transplanted within 5 years of listing

40% of patients waitlisted in 2000 were transplanted within 5 years with ~35% still waiting after 5 years 80% of patients waitlisted in 2011 were transplanted within 5 years with ~ 7% still waiting after 5 years

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

02 03 04 05 06 07 08 09 10 11

Status: 5 years on wait list

Died

Removed

Transplanted - DD

Transplanted - LD

Transplanted - OOC

Waiting

Page 21: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

How long do people spend on the kidney wait list?

0%

10%

20%

30%

40%

50%

60%

70%

80%

90%

100%

07 08 09 10 11 12 13 14 15 16

Perc

ent

Year

5+ yr4-<5 yr3-<4 yr2-<3 yr1-<2 yr<1 Year

Proportion of people waiting for 2+ years has decreased

Page 22: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

HSP Transplants in BC

Year Out-of-Province Donor BC Donor Total

2014 2 2 4 2015 10 2 12 2016 11 7 18 2017 (Sep 30) 10 3 13 Total 33 14 47

Page 23: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

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Living Kidney Donation – BC still leads the country

0

10

20

30

40

50

60

70

80

07 08 09 10 11 12 13 14 15 16

Num

ber

Donor type

Biologically Related

Biologically Unrelated

Paired Donation

0

5

10

15

20

25

30

07 08 09 10 11 12 13 14 15 16

per m

illio

n po

pula

tion

British Columbia

Canada

Donor per million population

Year

Page 24: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Poll question!

What kind of transplant has the best outcomes for a person whose kidneys have failed?

a. A pre-emptive living donor kidney transplant (before dialysis)

b. A living donor kidney transplant after starting dialysis

c. A deceased donor kidney transplant

Page 25: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Patient and graft survival

Patient and graft survival among first kidney transplants, by donor type Patients who received a kidney in BC from 2000 to 2015, including pediatrics. Simultaneous multi-organ transplants and retransplants are excluded.

50%

55%

60%

65%

70%

75%

80%

85%

90%

95%

100%

0 1 2 3 4 5 6 7 8 9 10

Perc

ent

Patient survival

0 1 2 3 4 5 6 7 8 9 10

Transplants - - all

Deceased donor

Living donor

Graft Survival

Years post-transplant

Page 26: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Transplant First

Page 27: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

transplant.bc.ca

Transplant First

Videos for recipients and donors • English • Mandarin Chinese • Punjabi* • Cantonese*

* Coming soon

Page 28: BC Transplant Update D...transplant.bc.ca BC Transplant BC Transplant Update Leanne Appleton, Provincial Executive Director Dr. David Landsberg, Physician Lead, Transplantation306

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BC Transplant