Beau

A case report

Signalment:

• 11 year old • Male Castrated• Border collie

History

• 12/29/06 referring veterinarian noticed lymphadnopathy. Blood work was unremarkable and the urinalysis showed RBCs. He was placed on deramaxx for arthritis (per owners Beau was slowing down) and doxycycline.

• 1/8/07 Beau was not improving. Along with the lymphadnopathy he now had bruising on his abdomen. Lymph node biopsies : only showed lymphoid hyperplasia and panniculitis. Coag panel was normal although his platelet numbers had dropped from 314,000 to 171,000. Deramaxx was stopped.

• Beau continued to decline and was referred to NCSU-CVM 2/21/07.

PE

• Temp: 103.6• BCS: 4/9• Diffuse marked lymphadenopathy

CBC

• Normocytic normochromic nonregenerative anemia

• Lymphopenia• Monocytopenia

Lymph node aspirate

• > 50% Lymphoblast• Multinucleated lymph cells

Thoracic radiographs

• Sternal and tracheobronchial lymphomegaly

Ultrasound

• Infiltrative splenic disease

Ultrasound

• Diffuse lymphadenopathy

Stages of Lymphoma

• Stage I: Only one lymph node involved.• Stage II: Regional LNs, limited to one

side of diaphragm• Stage III: All peripheral LNs• Stage IV: All peripheral LNs plus spleen,

liver, and/or anterior mediastinum.• Stage V: Everything in stage IV plus

bone marrow involvement.

Staging Lymphoma

• The stage of the disease does not impact the response to chemotherapy.

• So stage II may not have a better prognosis than stage IV.

• The exception is stage V which has a poor response to chemotherapy.