Abstract — WCN 2013No: 1506Topic: 3 — StrokeBedside dysphagia screening after acute stroke: Incidence,screening, and clinical outcomes

J.A.S. Vatanagul, C.P.V. Gallemit. Internal Medicine, Perpetual SuccourHospital, Cebu City, Philippines

Background: Dysphagia is a common finding in the clinical setting ofa patient with acute stroke, which can give rise to a risk of aspiration,pulmonary infections, fluid depletion, and malnutrition. Therefore,early identification of dysphagia is crucial to avoid these adversehealth consequences.Objectives: To determine the incidence and clinical outcomes ofacute stroke patients with dysphagia admitted at a tertiary hospitalin Cebu City from December 2011 to July 2012.Study design: Prospective, single center, descriptive study.Materials and methods: The study population included all patientsaged 18 years old and above admitted during the study period due toan acute stroke, whether an ischemic infarct or hemorrhage whounderwent dysphagia screening test within 24 h of admission andwith no previous documented dysphagia. Patients who passed thescreening test were fed orally and those who failed were insertedwith nasogastric tube for feeding and oral medications.Results: A total of 74 patients with acute stroke admitted at a tertiaryhospital in Cebu City from December 2011 to July 2012 were enrolled inthis study. Out of the total 74 respondents, 38 patients passed thedysphagia screening test and 36 patients failed. Eight (22%) of the 36patients developed pneumonia, and only one patient died of pneumonia.Conclusion: Early identification of dysphagia with a simple andinexpensive bedside screening procedure can certainly decrease therisk of pneumonia to develop among patients who have failed thedysphagia screening test, as well as reduce mortality and overallhealthcare expenditure.

doi:10.1016/j.jns.2013.07.807

Abstract — WCN 2013No: 1510Topic: 3 — StrokeCerebral venous sinus thrombosis (CVST): Study of four Filipinopatients and literature review

J.A.S. Vatanagul, I.A. Rulona. Internal Medicine, Perpetual SuccourHospital, Cebu City, Philippines

Research design: Case series study.Background: Cerebral venous sinus thrombosis (CVST) is rare, withestimated 3–4 cases per million annual with the introduction ofvenography. Most cases of cerebral venous sinus thrombosis are dueto hypercoagulability. Other important risk factors include pregnancy,primary antiphospholipid syndrome, and hereditary thrombophilias.Objective: To present four Filipino patients with radiologically-provencerebral venous sinus thrombosis (CVST) and discuss their demograph-ic, etiologic and clinical characteristics and clinical outcomes.Methods: A retrospective and descriptive analysis of the medicalrecords of four patients with CVST, who were admitted to a singletertiary hospital.Results: Four patients were identified with a mean age of 36.25 yearsold. The youngest patient was 22 years old. All of the patients werewomen. Two of the cases had previous use of oral contraceptives.The most frequent clinical manifestations were headache as seen inall patients (100%), dizziness (50%), vomiting (25%), motor weakness(50%) and seizures (25%). Three patients (75%) presented withthrombophilia — protein C deficiency.

Cranial CT scan revealed subarachnoid hemorrhage in 50% of thepatients while parenchymal hemorrhage was present in the other 2cases. Superior sagittal sinus (50%) and transverse sinus (50%) werethe most common locations. All cases received oral anticoagulationwith warfarin. All patients were discharged stable and without anyneurologic deficits and adverse outcomes.Conclusions: Venous sinus thrombosis may present to the physician ina number of clinical presentations. Early recognition of the conditionand investigation of appropriate therapy probably reducemortality andmorbidity.

doi:10.1016/j.jns.2013.07.808

Abstract — WCN 2013No: 1515Topic: 3 — StrokeExpression profile of microRNAs in the peripheral lymphocyte ofacute stroke patients

H. Zhaoa, P. Liua, R. Wanga, X. Liua, X. Wub, C. Xuc, X. Jia, L. Gaoc,Y. Luoa. aCerebrovascular Diseases Research Institute, Xuanwu Hospitalof Capital Medical University, Beijing, China; bDepartment of Neurology,The First Affiliated Hospital of Liaoning Medical University, Jinzhou,China; cDepartment of Neurology, Xuanwu Hospital of Capital MedicalUniversity, Beijing, China

MicroRNAs (miRs) profile of whole blood in acute stroke patients hasbeen reported, but the profiling of peripheral lymphocyte has not beencharacterized. Since the key role of immunity and inflammation instroke pathology, we currently profiled peripheral lymphocyte miRs ofacute stroke patients and healthy persons with Agilent humanmicroarray. We identified 70 down-regulated and 35 up-regulatedmiRs (N2-fold change) in lymphocyte by differential analysis. Next, 7deregulated miRs (miR-99a,−99b,−181c,−181d,−212,−424, and−532-5p) were selected randomly and detected in patients' plasma byqRT-PCR, and we found their trends were just the same as theircounterparts in peripheral lymphocyte. Pathway analysis indicated 58significantly changed KEGG pathways targeted by the deregulatedmiRNAs including MAPK pathway, ubiquitin mediated proteolysis andfocal adhesion pathways concerning molecular mechanisms of cellapoptosis and inflammation response. Moreover, a miRs-mRNAsnetwork was created based on bioinformatics analysis of pathwaysrelated with immune cell proliferation, chemotaxis and adhesion,presenting 22 critical miRs and their 139 targets to visualizehypothetical interactions. Taken together, except for profiling miRs oflymphocyte in acute stroke patients, we also showed that somemiRs inlymphocyte might be related with plasma miRs, and further provideimportant miRs as therapeutic targets of regulation of lymphocytefunction in acute stroke patients.

doi:10.1016/j.jns.2013.07.809

Abstract — WCN 2013No: 1537Topic: 3 — StrokeCirculating beta-antithrombin glycoform increases during theacute ischemic cerebrovascular event

A.M. Garciaa, M. de la Morena-Barriob, J. Corralb, J. Iniestaa,A. Miñanob. aNeurology, Reina Sofia Hospital, Spain; bCentro Regionalde Hemodonación, Servicio de Hematología y Oncología Médica,Hospital Morales Meseguer, Universidad de Murcia, Murcia, Spain

Despite control of thrombin is crucial in the development ofatherothrombosis, antithrombin, the main endogenous inhibitor of

Abstracts / Journal of the Neurological Sciences 333 (2013) e152–e214e202