benzodipyrazoles: a new class of potent cdk2 inhibitors

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2005 Pyrazole derivatives Pyrazole derivatives R 0180 Benzodipyrazoles: A New Class of Potent CDK2 Inhibitors. — The synthesis of the title compounds, e.g. (VIII), is accomplished using a solution-phase protocol ame- nable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. — (D'ALESSIO*, R.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 5, 1315-1319; Dep. Chem., Nerviano Med. Sci., Nerviano, I-20014 Milano, Italy; Eng.) — H. Haber 28- 129

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Page 1: Benzodipyrazoles: A New Class of Potent CDK2 Inhibitors

2005 Pyrazole derivatives

Pyrazole derivativesR 0180 Benzodipyrazoles: A New Class of Potent CDK2 Inhibitors. — The synthesis of

the title compounds, e.g. (VIII), is accomplished using a solution-phase protocol ame-nable to rapid parallel expansion and suitable to be scaled-up in view of possible lead development. — (D'ALESSIO*, R.; et al.; Bioorg. Med. Chem. Lett. 15 (2005) 5, 1315-1319; Dep. Chem., Nerviano Med. Sci., Nerviano, I-20014 Milano, Italy; Eng.) — H. Haber

28- 129

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