bilcare research optima services
TRANSCRIPT
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Research Solution
• Bilcare Research offers a comprehensive packageof research solution for drugs and packagingmaterials, components and systems to support allyour manufacture and new product developmentactivities.
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BilcareOptimaTM
* Sensitivity Profiling of solid dosage formulations
and
* Scientific Identification of Optimum Packaging
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Applications of BilcareOptimaTM
New formulations Bottles Blister Alu-Alu Alu-Strips Double Packs
Optimum packaging
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Product Parameters for Sensitivity
Profiling
• Hygroscopicity
• Degradation – Physical
– Chemical
• Drug release properties (DT and Dissolution)
• Mechanical properties (Hardness / Friability)
• Photosensitivity as a function of RH & Temperature
• Gas liberation tendency
• Dimensional aspects (Film Thinning)
All are studied under various conditions and identify the factors affecting
the degradation and its threshold values.
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Identification of Optimum
Packaging Solution
Determine barrier requirements of package through mathematical modeling Moisture barrier requirements Light Barrier requirements Gas barrier requirements Dimensional requirements
Thinning profile through simulation software Defining Film structure
BilcareOptima is a professional service for customers to optimize the formulation
and determine optimum packaging.
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Dimensional Aspects
• Thinning Profile on cavity formation using FEM software
• % Maximum, Minimum and Average thinning
• 3 D modeling of the blister Design using Solid work software
• Determination of Strip Area and blister area
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Benefits of Bilcare OptimaTM
• Formulation sensitivity profiling
• Reduce analytical resource loading
• Shorten package development time
• Start stability test without worry
• End of over-packaging
• Long-term saving on materials
• Prevent under-packaging
• Prevent after sales quality issues
• Optimum packaging solutions