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BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
BINF705 Research Ethics Fall 2015
Introduction to Ethics
Jeff Solka Ph.D.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Syllabus - I
Instructor - Jeff Solka, 540-809-9799 (Cell), [email protected]
Office Hours - By Appointment
Schedule - Monday 7:20 pm - 8:35 pm Ocaquan Rm. 304B
Texts Francis L. Macrina, Scientific Integrity: Text and Cases in
Responsible Conduct of Research (Paperback), 4th Edition 2014.
Course Structure Each class meeting will consist of a brief lecture followed by class discussions based on reading assignments, professor presented case studies, and student presented case studies.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Syllabus - II Course Description This course will examine the moral dilemmas
that currently face researchers. A particular emphasis will be placed on those issues associated with the use of computers in general and their application in bioinformatics in particular. Some of the topics to be discussed will include the fundamentals of ethics, scientific reporting and ethics, interpersonal relationships within a research setting, ethics and peer review, ethics and whistle blowing, relationships with funding agencies, animal research, human research, fraud, intellectual property, and improper use of computer equipment.
Grading - Grades will be based on a class presentation and class participation.
Breakdown Class Participation (25%), Class Presentation (50%), Takehome Midterm (12.5%), Takehome Final (12.5%)
Attendance will be taken and used to helps ascertain course participation.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Course Schedule Online Schedule
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
An Example Ethical Question - I
What level of physical persuasion is allowed in order to obtain information from enemy combatants?
We are not considering this as a legal question. What does the Geneva Convention say?
We are not considering this as a sociological question. What would most Americans allow.
We are asking what would be the best course of action. This is an ethical question.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
An Example Ethical Question - II
Is it ok to ask a student to write a paper based on your research and allow the student to be the first author solely based on the fact that the student wrote the paper even though the student made no contribution to the research in any manner?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Processing Ethical Questions
Do we attack these questions with our heart?
Do we attack these questions with our mind?
Do we attack these questions based on historical legal practices?
Do we attack these questions based on historical religious practices?
What methods would work the best (i.e. produce the best outcomes)?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Western Based Ethical Reasoning
Teleological Approach Also know as the Consequentialist Approach
Deontological Approach
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Teleological Approach
Focuses on the consequences of an action in order to determine the morality of that action.
pg. 25 of Macrina One determines the morality of an act based on
whether the consequences of that act are considered good or bad.
Best example of a teleological theory is utilitarianism Jeremy Bentham (1748-1832) John Stuart Mill (1806-1873) One must sum up the good and bad consequences of any
particular action. Must consider the interest of everyone (not just you
personally).
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Teleological Approach and Catbert
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Teleological Approach and Faked Research
Suppose that you are going to fake the results of a paper
Benefits you (prestige, publication, higher salary) Hurts others (others try to duplicate your faked results,
people might actually die if your faked results have impacts with regards to clinical trials.)
What would a teleological argument say?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Teleological Approach and the Case of the Escaped Mental Patient
A former student of mine has escaped from a mental hospital.
He shows up at GMU waving a scalpel and wants to know my home address?
Do you give him my home address or do you lie?
Isn’t lying wrong as we illustrated on the previous slide?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
What Are We Weighing When We Consider Teleological Arguments?
Happiness
Unhappiness
Mill
PleasurePain
Benthan
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Problems With Utilitarianism
Hard to Employ How Can We Calculate the Consequence of Our Actions
(Even a Simple One) Slippery Slope
Suppose there is a patient with Lymphoma that is producing a substance of tremendous value in the treatment of AIDS.
He refused to allow us to obtain any blood samples from him.
Might not utilitarianism argue that we should kill him and divide his blood supply/tissues among the various research labs?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Deontology Approaches
Does not depend exclusively on the consequences of an action to determine its morality.
Moderate (consequences and other things)
Extreme (consequences can’t come into the equation) Immanuel Kant (1724-1804)
Macrina pg. 27
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Immanuel Kant
Categorical imperative Various equivalent formulations of this idea One formulation
“act only on that maxim through which you can at the same time will that it should become a universal law.”
So we decide upon an act if we wish to take that same law into account in every situation.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Categorical Imperative and Fraudulent Scientific Results
Let’s reconsider the case of our fraudulent scientific results.
Do we want it to become a universal law that it is ok to fake your results?
This would stop the advancement of science.
No one would desire such a law to be universally applied.
Do we want it to be a universal law that you can never fake your results?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Alternative Formulation of Kant’s Treatise
“act in such a way that you always treat humanity whether in your own person or in the person of any other ,never simply as a means but always at the same time as a end.”
Implies a certain respect for people. Does it say that we never use a person as a means to
an end? How about a doctor treating a patient.
The doctor uses the patient as a means to make a living. What is the “end” in this case? What would be an example of treating a patient without
any “end” for the patient in mind.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Critical Thinking and the Case Study Approach
Become familiar with the codes that govern scientific behavior.
How do we apply these codes.
Case studies are designed to help us learn to think critically.
Critical thinking Identifies issues and evidence related to a problem, thereby
allowing defensible conclusions to be made. (Macrina pg. 29)
There may be alternate solutions to a particular problem.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Four Psychological Processes That Are Consistent With Behaving Morally
Bebeau et al., Moral Reasoning in Scientific Research
Moral Sensitivity
Moral Reasoning
Moral Commitment
Moral Perseverance (or Moral Implementation)
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Moral Sensitivity
What actions are possible?
Who would be affected?
How would the actions be regarded by the affected parties?
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Moral Reasoning
What course of action is morally right (or fair, or just, or good)?
These considerations prescribe a set of potential courses of action.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Moral Commitment
A decision is made to do what is morally right
Moral values are awarded priority above and beyond other personal values.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Moral Perseverance (or Moral Implementation)
Implementation of the moral course of action decided upon.
Potential obstacles may need to be overcome in the pursuit of this goal.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Interplay Between the Steps
The four steps can influence one another although they can in some sense be independent.
A person might be good at one of the steps but not the others.
Discussing various cases with one another can help us hone our skills and learn to recognize the various steps in the process.
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
The Problem With Case Studies
It is difficult to simulate the moral perseverance step in our case study discussions.
The true measure in this case is determined by what an individual actually does.
Sometimes presenters can indicate their true intentions at the end of a case study (i.e. their unwillingness to implement the prescribed course of action)
BINF705 RESEARCH ETHICS FALL 2015 SOLKA - INTRODUCTION
Discussion Questions
What are some of the moral values that are unique to the conduct of scientific research?
Should scientists be accountable for their choice of research pursuits if their published results are used for evil purposes by others?
Do you believe that some kinds of scientific research should be forbidden? If you do, provide examples?
Do scientists have a moral obligation to explain the implications of their research to society?