An Elemental Change in How We Treat Disease

Cellular Degeneration Underlies Biological Aging2

Dementia

Diabetes Type 2

Sarcopenia

Nephropathy

Alzheimer’s Disease

Hypertension

Cardiovascular disease

Atherosclerosis

CANCER

Arthritis

Cataracts

Cellular Degeneration

Macular Degeneration

These are all symptoms of cellular Aging!

Disease, Function and Operating Systems3

Are You Ready for the Future?4

The Consequences of not Upgrading5

5 billionMore than 99 percent of all species,

amounting to over five billion species, that ever lived on Earth are extinct

99%

1%

What is normal?

How we used to Die7

Mortality record from London,

1665

Causes of death8

Causes of death in 2010, USA

Survivors(%) by Age, England & Wales, Males

1925

2010

1975

1850

9

Death Rates From Diseases of Aging, England & Wales 2013

Cancer

Lung Disorders

Heart Disease

Alzheimer’s

Diabetes

Data source: Office of National Statistics

11

The Brain on Aging11

87-Year-old Ventricles expand as gray matter shrinks; executive function declines

27-Year-old Ventricles holding cerebro-spinal fluid are narrow in the young

Source: 2011 Gizmodo Brain Image images courtesy of Oregon Brain Aging Study, Portland VAMC and Oregon Health & Science University

VENTRICLES

Why treat biological aging?

Increased Global Lifespan will Increase the Burden of the Diseases of Aging13

Young Children and Older People as a percentage of global population, %

Age <5

Age 65+

188%351%

1004%

65+ 85+ 100+

change in world`s 65+ population by 2050

• By 2050 more older people than children

• More people at extreme old age

Diseases of aging:

Heart diseaseDiabetes

Alzheimer’s Cancerothers

Current translation process for drugs is highly inefficient and costly and produces products that fail to work for many patients

14

Cost to develop a new drug, $B

Novel drug per $B R&D spentAnti-Depressants

Asthma

Diabetes

Arthritis

Alzheimer

Drug Efficacy

- drug does not work

62%

60%

57%

50%

30%

Cancer 25%

Decreased efficiency of investments in R&D

Increased costs on R&D Low efficacy of non-personalised drugs01 02 03

Why Gene Therapy?

Healthy Lifespan And Gene Therapy 16

Field Mouse1 Calorie Restriction3

Gene Therapy4

knockout effects GH IGF1 TSHor over express FGF21

Source: 1. Ashley Cohen, 2. wiki media commons, 3. Jeff Miller/University of Wisconsin-Mad ,

6-8 months

60 months26-30 months12-18 months

Lifespan

Lab Mouse2

What is Gene Therapy17

Therapy Administered Easily & Efficiently

Carrier Reaches Target Cell & Releases TherapyDeliver Gene to Create

Target Protein

What are BioViva’s Therapies?

BioViva’s Targets19

Lengthening Telomeres

Reverse Atherosclerotic

Plaques

Clear Miss-Folded

Proteins

Remove Senescent

Cells

Strengthen Muscles

Boost the Immune System

Increase Cell Signaling

BioViva‘s Telomerase Inducing Gene Therapy20

Resets genome to a youthful

state

Wiki Telomere Microglia Neurons

Side effects

Increased the cellular division

or stem cells

BioViva‘s Myostatin Inhibiting Gene Therapy 21

Side effects

Increased muscle mass

Decrease white fat

StaminaInsulin

sensitivity

What is the Future of Genetic Cures?

Given Like Immunizations23

Enhancement vs Preventative MedicineScheduled Gene-Boosting TherapiesTreat people before they need invasive treatments !

Source: Centers for Disease Control and Prevention's Public Health Image Library (PHIL)

Future Consequences of Gene/Genomic Engineering 24

Organ Regeneration Intelligence

Radiation Resilience

Better Vision

Cosmetic

Digital Interface

Physical Enhancement

Nutritional

Autoimmune Disorders

Congenital

Scientific Advisory Board25

Dr. Bill Andrews PhD is the President and CEO of Sierra Sciences

Ali Fallah PhD molecular medicine and the Co-founder & CEO at Mede Bioeconomy

Top Experts In The Field

Aubrey de Grey, PhD. Chief Science Officer and the gerontologist who researched and Co- Founded SENS Research Foundation

George Church is Professor of Genetics at Harvard Medical School and Director of PersonalGenomes.org

Matt ScholzCEO of Immusoft

John Schloendorn, PhD founded Gene And Cell Technologies in 2013 and serves as its CEO

26

Change the paradigm of what we consider is normal01

02

03

04

05

06

Symptoms of aging (Cancer, Alzheimer’s, Heart disease etc) are caused by the biological aging 

We are learning how we can change /reverse the rate at which we ageBioViva is working on therapies to do this now

Gene therapy offers both preventative/regenerative careNew therapies will more than pay for themselves.

What Will You do With Yours?

The Most Important Currency is Time

BioViva USA Inc.The Cure is in the Helix of Humanity

www.BioViva-Science.com