bioinformatics oppertunity

8/13/2019 Bioinformatics Oppertunity

1/36

(insight in to the IT Companies)K.P.Mishra (Director, URC Allahabad )

Brijesh Singh Yadav(Senior Research Associate &Head Bioinformatics Research)United Research Center, UIT Campus Allahabad,

E-mail: [email protected]

Career in Bioinformatics


2/36

What is Bioinformatics? Bioinformatics is the application of

computer technology and statistics to

the management of biological

information.

In the past decade bioinformatics has

become an integral component of

research and development in biologicalsciences.

The need for bioinformatics stems from

a fundamental change that is taking

place in biology.


3/36

Bioinformatics Is aMerging of Disciplines


4/36

Core of BioinformaticsTDQAAFDTNIVTLTRFVMEQGRKARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLV

sequence 3D structure protein functions

Properties and evolution of genes, genomes, proteins, metabolicpathways in cells

Use of this knowledge for prediction, modelling, and design


5/36

Need ofbioinformatics

Data growth is exponential

Difficult to understand life without BI

Detection of new diseases

BI tools allow to save expr. Expend.

Rational Drug design

Computer-aided vaccine design


6/36

Need of bioinformatics


7/36

Need of bioinformaticso t

Handle the

growth of

information.

Knowledgediscovery.

Globalizing

theresearch.

Data

visualizatio

n.


8/36

Need of bioinformaticso t


9/36

BIOINFORMATICSDEVELOPMENTS IN INDIA Department of Biotechnology created in 1986

Bioinformatics programme started ever since

Biotechnology Information System Network (BTISnet) in 1987.

BTISnet today has 65 institutions and universities. Emphasis on infrastructure creation and human resource

development.

Biotechnology in India has greatly benefited from the capacity

building in Bioinformatics Dedicated virtual private network connecting the major centres

sharing of data as well as computing resources.


10/36

Bioinformatics Facilitiesin India


11/36

Two forms of initiatives are in operationalTwo forms of initiatives are in operationalTwo forms of initiatives are in operational

Two forms of initiatives are in operational

Short-Term Training

Nationwide trainingsand workshops

Presently around 100organised per year in

seven defined areas

More than 10000trainedso far

Long-Term Training

Advanced DiplomaCoursesin five universities

M.Sc., M.Tech., Ph.D.courses

in Bioinformatics

Educational Activities ofIndia in Bioinformatics


12/36

Integration ofBioinformaticsBiotechnology Collaborative effort

RFP (Request for Proposals) in

following areas: Parasitic diseases

Agro-biotech

Herbal medicine

BioPhara Development

Clinical Data management


13/36

In-house softwaredevelopment1. GeneScan, GenEvolve, PROCOR

2. PLHOST

3. APSSP (Protein structureprediction), MHCBN

4. PCR: s/w for setting PCR reactions5. LOOPSEARCH, CONFPLOT

6. VirGen, CE, AVIS

7. Micro array analysis (Avadis),Genome annotation (Acuris),

Oligonucleotide probe design(Sarani)

8. BioSuite

JNU, DelhiIGIB, DelhiIMTECH, ChandigarhDevi Ahilya

UniversityBose Institute,

KolkattaUniversity of Pune,

Pune

Strand Genomics,BangaloreTCS, Hyderabad

These efforts needs to be strengthened withHuman resource development


14/36

Bioinformatics Market

Global Bio-Informatics Market 1.2bn In 2004Overall Market Size Projected to reach USD 1.7 bnby 2006Indian Bioinformatics Market has touched USD22Million in 2004Indian Bioinformatics is growing at the rate of40% per annum

(Source: CII)


15/36

Market share of differentSegments of Bioinformatics Genomic 50%

Proteomics 20%

Chemoinformatics 19% Pharmacogenomics 15%


16/36

Advantages for India Strong IT capabilities

R & D strength in Modern biology

Highly trained manpower inbiotechnology and Bioinformatics

Rich Biodiversity

Diverse ethnic population

Strong Biotechnology Infrastructure Wide Networking of Institutions and

Scientists.

Industrial enterprise.

HHBIO


17/36

The Role of IT inBioinformatics

1. Electronic Data Capture2. Data Mining3. Data Warehousing

4. Data Visualization5. Customized Software


18/36

Indian IT Companies Indian IT companies such as Tata Consultancy

Services (TCS), Cognizant Technologies,Infosys, Wipro, and Satyam have already set up

their bioinformatics divisions.

TCS, for instance, is entering the bio-informaticsmarket with its indigenously developedcomputing platforms and applications within this

year. The company is nurturing a 40-memberteam that is working on developing bio-informatics software solutions.


19/36

Indian IT CompaniesCont.. A database application, specially created for the

bioinformatics segment is in the pipeline. TCS is alsolooking at developing bio-informatics softwareapplications in collaboration with biotech and pharma

companies.

Satyam's Center of Excellence has identified Data

warehousing and Datamining as a key initiative area inthe field of bio-informatics since the field is an emergingdomain where data warehousing and dataminingtechniques and concepts are used extensively fordeciphering complex patterns and to correlate and

analyze the vast volumes of data generated.


20/36

Indian Pharma Companies Pharmaceutical companies too, are making

moves into the bioinformatics arena. GVKBiosciences, Dr. Reddy's Laboratories, Biocon,

Astra Zeneca, Ranbaxy, Biological E, andNicholas Piramal are some of the names thathave either opted for the joint venture route orhave tied up with start-up companies.


21/36

people required by aIndustries Computer Programmer, who develop

software tool and application for

biotechnology and life science

companies.A good Programmerhaving knowledge ofHTML, XMLSAS-CGICGI between web and

databaseBuild HTML page tointerfaceKnow DNA analysisprograms

Understand:Basic MolecularBiologyHow a networkworksHow databasesare structured


22/36

People required by aIndustries cont.. People with a background in life sciences

who are the end user of such programs andpackages and they use these tools to

translate the information into tangibleproducts such as new molecules, drugs,enzymes etc.

They can conduct their R&D program moreeffectively if they are cross-trained in

computing skills. They can also be business analysts for life

science companies.


23/36

Skills needed for the Desing of Experiments Using Bioinformatics

Systems

Administration/Networking

2%

General Computer Sciences

7%

Artificial Intelligence

3%Advanced algorithms

Data Structures

8%

Biochemistry

10%

Biophysics

6%

Structural Biology

7%

Genetics

11%

Molecular Biology

12%

Evolution

7%

Statistics

12%

Mathematics

6%

Computational Chemistry

6%

Software Engineer ing

3%


24/36

What Is a Bioinformatics

Company Like? Consists of Biologists, Computer Scientists,Mathematicians and Marketing people.

Bioinformatics companies should expect

revenues in a few million dollars only. Only those companies who are able to adapt

and innovate will survive.

A great deal of competition exists in the field.

For any new company offering bioinformaticsservices or products, proof of concept, will beessential. This means that a nascent companywill need to demonstrate its ability beforegetting business.


25/36

Areas of opportunity in India Bioinformatics

Vaccines, dignostics and therapeutics

Biomedical devices, instruments and

sensors Bioartificial organs using tissue

engineering and stem cells

Clinical trial and contract research

Agriculuture

disease and pest resistant,drought and salinity tolerant seeds and

plants

Biofertilisers and Biopesticides


26/36


27/36

Job opportunities inBioinformatics Postgraduates and,Doctorates

Bachelordegrees / 3year diplomaholders 3) Degree

with one yearcourse incomputers

Qualification Experience Job Title

Formal Training andunderstanding marketrequirement ofBioinformatics

Sound knowledge inMolecular Biology andprogramming

Good typing speed,Knowledge in molecularBiology and computerapplication

Group leaders /Sr. Executives /Scientists/Faculties

System AnalystTechnical Asst./Programmer /

COs / DEOs


28/36

Major Research Areas inBioinformaticsResearch Activities [%]

Gene Analysis

Prot. Struc. Pred.

Prot Design & Folding

Macr. Modelling

Evol. Biol.

Struc-Func Studies

Mech. of Dis.

Data Mining Stud


29/36

Business Opportunities in BI Software development

Web servers development

Train manpower in Field of BI

Database management

Rational Drug design

Develop Diagnostic kits

Assist user in Vaccine development Consultant to Biotech Companies


30/36

Outsourcing Model inTechnology BusinessesOutsourcing has developed as an

important concept in today'sbusiness.

1) Focus on core strength - theopportunity cost of adding a newsegment of services to an existing

business is high. Companies preferto not diverge from their focus on theircore competencies, and staycompetitive.


31/36


32/36

Outsourcing cont. 5) Improve service delivery to

customersthe company can dictateto the outsourcing partner the

timelines it is required to meet. 6) Reduce cost and timethe time

spent otherwise on planning anddevelopment is saved and better

utilized to managing the existingresources.

7) Expand service portfoliocompanies can extend their serviceswithout having to invest on building inhouse capabilities


33/36

Outsourcing Inspite of a tremendous increase in

demand, the US educational stream hasnot significantly increased the

production of scientific workforce. As a result cost of research has gone

higher.

Many companies are realizing that they

can get their research done abroad, atcheaper cost, without any compromisein quality.

In clinical trials for example, GSK

(Glaxo smith Kline) has announced thatit will shift 30% of its clinical trials to


34/36

The Ultimate Goals of Bioinformatics is

to:Implement LaboratoryInformation Management

Systems

14%

Design experiments using

bioinformatics

9%

Provide training and

assistance in the use of

bioinformatics software

tools

10%

Use existing software for

bioinform atics analyses

10%

Discover new insights or

hypotheses in molecular

genetics or evolutionary

processes

10%Research new

technologies (algorithms,

principles, models,

databases) to ascertain

their potential for

bioinform atic analysis

11%

Develop software for

bioinformatics applications

12%

Implement web-interfaces

for bioinformatics

applications/data bases

12%

Create & maintain

laboratory research

databases

12%


35/36

Bioinformatics Jobs searchengines Medzilla(Biotech,Medical,etc job listings)

BioSpace (job listings)

BioView (job listings)

Bio online Carrier Center Symbios Career Service

(Biotech,MedDevice,Pharm )

Genomics ,Bioinformatics and

Biocomputing Jumping pills Biotech jobs

NEE-HOW Bioresource Finder jobs

JobsScience

http://www.bhrc.ca/


36/36
http://images.google.co.in/imgres?imgurl=http://www.wondercliparts.com/thanks/graphics/thanks_graphics_06.gif&imgrefurl=http://www.unp.co.in/f6/congratsssssss-ronny-ji-10-000-posts-hogiaaaaa-20152/&usg=__1CQw57KeLTz_XEXfmKlWgkKn9cA=&h=300&w=300&sz=126&hl=en&start=15&tbnid=8PkxgX0XndQguM:&tbnh=116&tbnw=116&prev=/images%3Fq%3Dthanks%26gbv%3D2%26hl%3Den%26sa%3DGhttp://images.google.co.in/imgres?imgurl=http://www.wondercliparts.com/thanks/graphics/thanks_graphics_06.gif&imgrefurl=http://www.unp.co.in/f6/congratsssssss-ronny-ji-10-000-posts-hogiaaaaa-20152/&usg=__1CQw57KeLTz_XEXfmKlWgkKn9cA=&h=300&w=300&sz=126&hl=en&start=15&tbnid=8PkxgX0XndQguM:&tbnh=116&tbnw=116&prev=/images%3Fq%3Dthanks%26gbv%3D2%26hl%3Den%26sa%3DG

bioinformatics oppertunity

Documents