biomaterials: biological origin or application?biomaterials: biological origin or application?...

$: Biomaterials: biological origin or application?Biomaterials: biological origin or application? Andrés Vercik Grupo de Nanotecnologia, Biomateriais e Dispositivos (\nanobiodev) Faculdade$
Biomaterials: biological origin or application?

Andrés Vercik

Grupo de Nanotecnologia, Biomateriais e Dispositivos (www.usp.br\nanobiodev)

Faculdade de Zootecnia e Engenharia de Alimentos

Universidade de São Paulo


Motivation


Science Accuracy

Precision

Concept

Words

Terms

Names

Example: Stent

• Intravascular stent

• Stented heart valve

• Stent-graft

• Stent-valve


Example: dislocation


Roots: multiple meanings

nano

• Nanotechnology

• Nanostructure

• Nanomaterials

Nanostructured material

Bio

• Biopolymers

• Bioceramics

• Biomaterials

• Biomedical materials


XII SBPMat – Symposium H

Sym posium H

New Trends in Biom aterials and Nanom aterials Applied to Biosystem s

Scope:The symposium will provide a platform for discussing current advancements and future trends in biomaterials for

biomedical and dental applications and nanomaterials applied to biosystems. Through the synergistic approach of applied

chemistry and physics, material science, electronics, mechanical engineering, biochemistry and medicine, this

symposium about biomaterials includes how the deeper insight into biological events and its interplay with

nanotechnology may support the development of a generation of novel materials, micro-nano-devices and molecular

level approaches suited to solve relevant biomedical problems both for therapy and diagnostics. New materials also play

an important role in veterinary, agriculture, biotechnology, smart packaging, food industry and natural environment. The

subject matter of the symposium reflects the wide range and transdisciplinary nature of research in materials science

and engineering applied to biological systems. The symposium will provide an excellent opportunity to meet and

establish collaboration with large number of experts with several specializations including engineering, basic sciences,

pharmacists, medical and dental professionals, etc.

Session Topics:

Biomaterials in constructing tissue substitutes

Synthetic scaffolds as extracellular matrices

Bioinspired and biomimetic materials

Anti-infective biomaterials

Adhesive biomaterials

Biomaterials for cardiovascular applications, vascular grafts and embolic devices

Biomaterials for cancer therapy

Biomaterials for orthopedic and ophthalmic applications

Controlled Release

Biomaterials in dental applications

Materials applied to Agriculture, smart packaging

Biodegradable Polymers, Polymers from Renewable Resources and Hydrogels

Nanotoxicology and Nanoecotoxicology

Sensors and Biosensors

Tentat ive List I nvited Speakers:Mitsuo Niinomi, Institute for Materials Research Biomaterials Science, Japan

Thierry Gloriant, Institut National des Sciences Appliquées - INSA, France

Yannis Missirlis, University of Patras, Laboratory of Biomechanics and Biomedical Engineering, Greece

Garrett B. McGuinness, Dublin City University, Centre for Medical Engineering, Research, Ireland

Ketul C. Popat, Colorado State University, USA

Pedro L. Granja, Instituto de Ciências Biomédicas, Portugal

Jonny Blake, Imperial College, UK

Alexander L. Yarin, University of Illinois, USA

Sym posium organizers:Carlos Roberto Grandini, Universidade Estadual Paulista "Júlio de Mesquita Filho", Bauru, Brasil

Ana Paula Rosifini Alves Claro, Universidade Estadual Paulista "Júlio de Mesquita Filho", Guaratinguetá, Brasil

Rossana Mara da Silva Moreira Thiré, Universidade Federal do Rio de Janeiro/COPPE, Brasil

dow nload


Different

Words

Same

Phenomena


Biomaterials Biomaterials

Biomaterials

Talk outline

• Definitions of bio-things

• Examples of bio-things (to make us change our minds)

• Let’s try a new definition?

• Rules of the game


Accuracy - Definitions

Biosensor (IUPAC 1999)

“a self-contained integrated device,

which is capable of providing specific

quantitative or semi-quantitative

analytical information using a biological

recognition element (biochemical

receptor) which is retained in direct

spatial contact with an electrochemical

transduction element”

D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No.

12, pp. 2333-2348, 1999.

Biomaterials (Williams 1999)

“a material intended to interface with

biological system to evaluate, treat,

augment or replace any tissue, organ, or

function of the body”

The Williams dictionary of biomaterials. University

Press, 1999.



Biosensor Biomaterials


Biological

Element Transducer Sense

Biological

System Material

Evaluate Treat

Augment Replace


Biosensor (IUPAC 1999)

“a self-contained integrated device,

which is capable of providing specific

quantitative or semi-quantitative

analytical information using a biological

recognition element (biochemical

receptor) which is retained in direct

spatial contact with an electrochemical

transduction element”

D. R. Thévenot et al. Pure Appl. Chem., Vol. 71, No.

12, pp. 2333-2348, 1999.

Biomaterials (Williams 2009)

“a substance that has been engineered

to take a form which, alone or as part of

a complex system, is used to direct, by

control of interactions with

components of living systems, the

course of any therapeutic or diagnosis

procedure, in human or veterinary

medicine”

D. F. Williams, Biomaterials 30 (2009) 5897-5909.


Concept of Biological System (element)

Biomaterials community vision There are many more living things


1999

1999

2009

Is it a biomaterial?

• Titanium

• Steel

• Silicon

• Gold

• Silver

• Collagen

• Cellulose

• Gelatin

• Chitosan

• Wood


Application? Origin?

Neurons on silicon

Nanoelectronic scaffolds Is it a biomaterial?

Scaffold Yes

Biosensor No


B. Tian et al., Nature Materials 11 (2012) 986-994

Energy harvesting


Biofuel cell


A. Zebda et al., Nature Communications DoI: 10.1038/1365.

A. Zebda et al., Scientific Reports 3: 1516 (2013) 1-5

D. Leech et al., Electrochimica Acta 84 (2012) 223–234

M. Holzinger et al., Electrochimica Acta 82 (2012) 179–190

J. Ma, Y. Sahai / Carbohydrate Polymers 92 (2013) 955–975

Biodegradable electronics


M. Irimia-Vladu et al., Materials today 15 (2012) 340-346.

Theragnostics


P. Rai et al., Advanced Drug Delivery Reviews 62 (2010) 1094–1124


Biomaterial (Natural or synthetic)

• Titanium

• Steel

• Silicon

• Gold

• Silver

Natural Material

• Collagen

• Cellulose

• Gelatin

• Chitosan

• Wood


Application? Origin?


Yes

Application

No

Origin


Let’s try a definition

• a substance that has been engineered

• alone or as part of a complex system

• is used to do something (direct…)

• control of interactions with components of living systems

• therapeutic or diagnosis procedure, in human or

veterinary medicine

• Intended to work in intimate spatial contact with a

biological system


Biomaterial

“a material intended to interface with a

biological system”


Biomaterial

“an engineered substance that, alone or as part

of a complex system, is devised to interface (or

to work) in intimate (spatial) contact with a

biological system, by controlling their (mutual)

interactions”


Interactions

Material on biology

• Toxicity

• Rejection

• Necropsy

• Induction

• Activity

Biology on material

• Cell or protein adhesion

• Corrosion

• Interference


Rules of the game: Foul

Yes! No!



Thank you!

When I use a word, it

means what I choose it

to mean, neither more

nor less

biomaterials: biological origin or application?biomaterials: biological origin or application?...

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