biomedical sciences - springer · 2012-04-27 · biomedical sciences spring 2012 - title selection...

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S.I. Ahmad, Nottingham Trent University, UK (Ed.)

Neurodegenerative DiseasesNo back cover text.

More on www.springer.com/978-1-4614-0652-5Online orders shipping within 2-3 days.

2012. XXXII, 390 p. 71 illus. (Advances in ExperimentalMedicine and Biology, Vol. 724) Hardcover978-1-4614-0652-5

▶149,95 €

A. Alonso, Instituto Nacional de Toxicologia y CienciasForenses, Madrid, Spain (Ed.)

DNA Electrophoresis Protocols forForensic GeneticsForensic DNA profiling procedures are mainlybased on high resolution and high throughputcapillary electrophoresis separation and detectionsystems of PCR amplicons obtained from DNAgenomic markers with different inheritance patterns.In DNA Electrophoresis Protocols for ForensicGenetics, expert researchers in the field detail many ofthe protocols and methods which are now commonlyused to perform forensic DNA profiling. It includesprotocols for profiling of autosomal STRs, Y-STRs,X-STRs, autosomal SNPs, INDELS, Y-SNPs, mtDNA-SNPs, and mtDNA hypervariable regions HV1 andHV2 . Protocols for molecular identification of non-human species and mRNA profiling for body fluididentification are also included. Written in the highlysuccessful Methods in Molecular Biology™ seriesformat, chapters include introductions to theirrespective topics, lists of the necessary materialsand reagents, step-by-step, readily reproduciblelaboratory protocols, and key tips on troubleshootingand avoiding known pitfalls.

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2012. XIII, 394 p. 70 illus., 44 in color. (Methods in MolecularBiology, Vol. 830) Hardcover978-1-61779-460-5

▶109,95 €

L. Antkiewicz-Michaluk, Polish Academy of Sciences,Krakow, Poland; H. Rommelspacher, Charité-UniversityMedicine, Berlin, Germany (Eds.)

Isoquinolines And Beta-Carbolines As Neurotoxins AndNeuroprotectantsNew Vistas In Parkinson's Disease Therapy

This book summarizes, for the first time, the resultsfrom behavioral, neurochemical and molecularexperiments, which demonstrate a wide spectrum oftetrahydroisoquinolines (TIQs) and beta-carbolines(BCs) effects - from their rather mild neurotoxicactions to the important neuroprotective andantiaddictive properties. Additionally, the recentresults of experimental studies in vivo have alloweda much better understanding and simultaneouscomparison of the neurochemical and molecularmechanisms underlying the neuroprotective andneurotoxic actions of endogenous TIQs and BCs andhave pointed to the possibility of their therapeuticapplications in neurodegenerative diseases such asParkinson's disease.The specific topic, IsoquinolinesAnd Beta-Carbolines As Neurotoxins AndNeuroprotectants – New Perspectives In Parkinson'sDisease Therapy, was chosen in light of accumulatingneurobiological evidence indicating that, in additionto exogenous neurotoxins (e.g., 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP]),endogenous compounds may play an importantrole in the most common neurodegenerativedisorders (e.g., Parkinson's disease). Two groupsof amine related compounds, which appearedchemically like MPTP, were detected in humanbrain and cerebrospinal fluid (CSF): BCs andTIQs. These are heterocyclic compounds formedendogenously from phenylalanine/tyrosine(TIQs) and tryptophan, tryptamine, and 5-hydroxytryptamine (BCs), respectively, and exerta wide spectrum of psychopharmacological andbehavioral effects. The TIQs and BCs may bind totheir own high affinity sites on neuronal membranesassociated with or located close to the receptors ofneurotransmitters. Research on TIQs and BCs isstimulated also by their possible role in pathologicalconditions, especially parkinsonism and alcoholism.Recently, clinical interest has been spurred by theirrole as neuroprotective, and even neurorestorative,anticonvulsant and antiaddictive, substances.


2012. X, 177 p. 34 illus., 3 in color. (Current Topics inNeurotoxicity, Vol. 1) Hardcover978-1-4614-1541-1

▶139,95 €

R. Baron, University of Utah, Salt Lake City, UT, USA (Ed.)

Computational Drug Discoveryand DesignDue to the rapid and steady growth of availablelow-cost computer power, the use of computersfor discovering and designing new drugs is becominga central topic in modern molecular biology andmedicinal chemistry. In Computational DrugDiscovery and Design: Methods and Protocolsexpert researchers in the field provide key techniquesto investigate biomedical applications for drugdevelopments based on computational chemistry.These include methods and techniques from bindingsites prediction to the accurate inclusion of solventand entropic effects, from high-throughput screeningof large compound databases to the expanding areaof protein-protein inhibition, toward quantitativefree-energy approaches in ensemble-based drugdesign using distributed computing. Written in thehighly successful Methods in Molecular Biology™series format, chapters include introductions totheir respective topics, reference to software andopen source analysis tools, step-by-step, readilyreproducible computational protocols, and keytips on troubleshooting and avoiding knownpitfalls. Thorough and intuitive, Computational DrugDiscovery and Design: Methods and Protocols aidsscientists in the continuing study of state-of-the-artconcepts and computer-based methodologies.


2012. XVII, 628 p. 110 illus., 17 in color. (Methods inMolecular Biology, Vol. 819) Hardcover978-1-61779-464-3

▶124,95 €

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J.D. Blom, University of Groningen, Netherlands; I.E.C.Sommer, University Medical Centre Utrecht, Netherlands(Eds.)

HallucinationsResearch and Practice

Hallucinations continue to fascinate peoplethroughout the world. The mere possibility ofperceiving things that are not there is the stuff thatcampfire tales are made of. It is one thing to be in adream state, to be asleep and to conjure up people,scenes, and landscapes that do not actually exist, butit is quite another to hallucinate: to be wide awake,and yet hear that ethereal music, see those costumedfigures strolling by, smell the roses that used togrow in your grandfather’s garden, feel his handupon your shoulder, sense his presence somewherenear -- and to be the only one able to experienceit.In this book, 44 international neuroscientificexperts join forces to present a state-of-the-art overview of hallucinatory phenomena, rangingfrom visual, auditory, olfactory, gustatory, and bodilyhallucinations to less well-known phenomena suchas synaesthesias, musical hallucinations, hallucinatedpain, autoscopic phenomena, phantom sensations,sensed presences, and compound hallucinationsattributed to djinns. Additional sections deal with theconceptual, phenomenological, and neuroscientificaspects of those phenomena, and offer an updateon contemporary treatment possibilities rangingfrom pharmacotherapy to electroconvulsive therapy,transcranial magnetic stimulation, cognitive-behavioral therapy, and self-help groups.This bookis essential reading for neuroscientists, neurologists,psychiatrists, general physicians, psychologists,historians of science, and philosophers professionallyinvolved in the diagnosis, treatment, and scientificstudy of hallucinations.Jan Dirk Blom, M.D., Ph.D.,is the Director of the Psychiatric Residency TrainingProgramme of the Parnassia Bavo Group in TheHague, and holds a position as Assistant Professorof Psychiatry at the University of Groningen.IrisE.C. Sommer, M.D., Ph.D., is Professor of Psychiatryat the University Medical Center Utrecht and theRudolf Magnus Institute of Neuroscience, Utrecht,the Netherlands.


2012. XVII, 424 p. 72 illus., 60 in color. Hardcover978-1-4614-0958-8

▶149,95 €

G. Castoria, University of Naples, Italy; A. Migliaccio,University of Naples, Italy (Eds.)

Advances in Rapid Sex-SteroidActionNew Challenges and New Chances in Breast andProstate Cancers

Rapid actions of sex steroids play a critical role inmediating the biological outcome of target tissues.This book reviews the importance of these non-genomic effects in initiation and progression of breastand prostate cancers.Particular emphasis is placed ondiscussing how rapid steroid actions not only impactdisease development and response to conventionaltherapies for these two types of cancers, but have alsoled to the identification of potential new therapeutictargets and treatment possibilities for cancer patients.The book reviews the fundamental basis of targetdevelopment and the current status of these studies,which are providing valuable insights in key areasof breast and prostate cancers.Particular emphasis isplaced on discussing how rapid steroid actions notonly impact disease development and response toconventional therapies for these two types of cancers,but have also led to the identification of potential newtherapeutic targets and treatment possibilities forcancer patients. The book reviews the fundamentalbasis of target development and the current status ofthese studies, which are providing valuable insights inkey areas of breast and prostate cancers.



▶139,95 €

M. Chatterjee, Jadavpur University, Kolkata, India; K. Kashfi,City University of New York Medical School, New York, NY,USA (Eds.)

Cell Signaling & Molecular Targetsin CancerThe abnormal behavior of all cancer cells regardlessof cancer type is irregular cell signaling pathwayactivity. A mechanistic approach dealing with afundamental and molecular view based signalingcascade are exciting and dynamic areas of cancerresearch. This book illuminates what we know, howwe know and what remains to be discovered in thisregard. The book explore and identify not only thekey compounds of cell signaling pathway but also theinteraction between them, the cross-talk. This bookbring together up-to-date summaries of the signalingcomponents that are likely to be used in diagnosis,prognosis and novel target for pharmaceuticalintervention and therapeutic development andhighlight the importance of molecular approachto clinical cancer research. A lot clinical trials andoutcome are promising.The translation of recentadvance in the knowledge of intracellular signalinginto the generation of innovative molecular targetedcancer therapy are essential features of this book.Goals are manifold such as, resensitise chemoresistanttarget, capitalize on different mechanism of actionand gain an advantage in the identification of bestcombination of drugs to induce clinically relevantresponse. The expert review compile in this bookis an invaluable resource for graduate researcherand established scientist working in cell biology,pharmacy, experimental and molecular therapeuticsand molecular medicine.


2012. XI, 328 p. 53 illus., 43 in color. Hardcover978-1-4614-0729-4

▶139,95 €




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C.-H. Chen, University at Albany, NY, USA

Activation and DetoxificationEnzymesFunctions and Implications

There are many advances that have been madein the past decades towards the understanding offunctions and implications of activation enzymesand detoxification enzymes. An organized, conciseoverview is needed for the readers who are initiallyexposed to this important subject, particularly forstudents and researchers in the areas of biomedicalsciences, biochemistry, nutrition, pharmacology andchemistry. This book is intended to serve this purposeas an introduction to the subject. Furthermore, majortopics in the book, excluding catalytic reactions andstructural properties, may have interest to otherreaders who have knowledge of basic sciences andunderstanding enzyme related information. The bookdiscusses subjects associated with foreign compoundmetabolizing enzymes with emphasis on biochemicalaspects, including lipophilic foreign compounds,phase I and phase II enzymes, catalytic properties,reactive intermediates, biomedical and biochemicaleffects, genetic polymorphisms, enzyme inducibility,enzyme modulation for health benefits, dietary relatedenzyme modulators, and structural characteristics ofenzyme inducers.


2012. XIV, 177 p. 41 illus., 3 in color. Hardcover978-1-4614-1048-5

▶139,95 €

A. Chouker, Klinikum Großhadern, München, Germany (Ed.)

Stress Challenges and Immunityin SpaceFrom Mechanisms to Monitoring and PreventiveStrategies

Stress of either a psychological or a physical naturecan activate and/or paralyse humans’ innate or

adaptive immunity. However, adequate immunityis crucial to the maintenance of health on earth andin space. During space flight, human physiology andhealth are challenged by complex environmentalstressors (confinement, gravitation, oxygen tension,radiation) which might be at their most pronouncedduring lunar or interplanetary missions. This bookadopts an interdisciplinary approach in seeking toidentify the impact of living conditions in spaceon the adaptation of the immune system. Whileother publications have addressed the physiologicalchanges that occur during space flight, to the authors’knowledge this is the first book specifically to analyzethe complex interaction of living conditions in space,the immune system, and astronauts’ health. It isexplained how such analysis of the consequences ofstress for the immune system may help in preventing,diagnosing, and counteracting immune-relatedalterations in health on earth as well as in space.


2012. XIII, 469 p. 74 illus., 50 in color. Hardcover978-3-642-22271-9

▶179,95 €

N. Curtis, Royal Children's Hospital Melbourne, Parkville,Australia; A. Finn, University of Bristol, Bristol, UnitedKingdom; A.J. Pollard, University of Oxford, Oxford, UnitedKingdom (Eds.)

Hot Topics in Infection andImmunity in Children VIIINo back cover


2011. XIII, 212 p. 29 illus., 18 in color. (Advances inExperimental Medicine and Biology, Vol. 719) Hardcover978-1-4614-0203-9

▶139,95 €

G. Darai, Universität Heidelberg; M. Handermann,Universität Heidelberg; H.-G. Sonntag, Universität

Heidelberg; L. Zöller, Institut für Mikrobiologie derBundeswehr, München (Eds.)

Lexikon derInfektionskrankheiten desMenschenErreger, Symptome, Diagnose, Therapie undProphylaxe

Obwohl bei der Bekämpfung derInfektionskrankheiten einige Erfolge zu verzeichnensind, erkranken weiterhin weltweit jedes Jahrmehrere Millionen Menschen an Malaria,Hepatitis B oder Tuberkulose. Die Prävalenzder infektiösen Darmerkrankungen ist aufgrundfehlender Verfügbarkeit sauberen Trinkwassersund mangelhafter hygienischer Verhältnissein vielen Regionen der Erde ungebrochenhoch. Neue Varianten von Influenzaviren oderEnterohämorrhagischen E. coli verursachenschwere Ausbrüche. Darüber hinaus ist dieAntibiotikaresistenz bei zahlreichen Erregern aufdem Vormarsch und stellt die Medizin teilweisevor Probleme wie in der präantibiotischen Ära.Aktuelle Kenntnisse über die Infektionskrankheitensind daher mehr denn je unerlässlich. Die vierteAuflage des Lexikon der Infektionskrankheitendes Menschen trägt dem mit neuen Kapitelnbeziehungsweise aktuell überarbeiteten Beiträgen zuTop-Themen der Infektiologie, wie Bioterrorismus,Hightech in der Infektiologie, Influenzavirus A/H1N1/2009, Nosokomiale Infektionen, NeueInfektionserreger mit pandemischem Potential,Reiseimpfungen oder Neu-Delhi Metallo-Beta-Laktamase-1 (NDM-1) und andere CarbapenemasenRechnung. Neu sind zudem Übersichtskapitel zuinfektionsbedingten Krankheitsbildern, die durchmehrere Erreger verursacht werden können, wieEndokarditis, Meningitis/Enzephalitis, Pneumonie,Harnwegsinfektionen oder Sepsis. Ergänztwird das Werk durch die neuen geographisch-epidemiologischen Karten zur Verbreitung relevanterInfektionserreger. Ausführliche Angaben überdie neueste Schlüsselliteratur, die nationalenReferenzzentren, die Expertenlaboratorien undaktuelle Web-Adressen zu weiterführendenInformationen komplettieren die vierte Auflage.zur Verbreitung relevanter Infektionserreger.Ausführliche Angaben über die neuesteSchlüsselliteratur, die nationalen Referenzzentren, dieExpertenlaboratorien und aktuelle Web-Adressen zuweiterführenden Informationen komplettieren dievierte Auflage.


2012. XVIII, 979 S. 30 Abb. Mit CD-ROM. Hardcover978-3-642-17157-4

▶186,87 €





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A. Destexhe, CNRS, Gif sur Yvette, France; M. Rudolph-Lilith,CNRS, Gif sur Yvette, France

Neuronal NoiseNeuronal Noise combines experimental, theoreticaland computational results to show how noise isinherent to neuronal activity, and how noise can beimportant for neuronal computations. The bookcovers many aspects of noise in neurons, with anemphasis on the largest source of noise: synapticnoise. It provides students and young researcherswith an overview of the important methods andconcepts that have emerged from research in this area.It also provides the specialist with a summary of thelarge body of sometimes contrasting experimentaldata, and different theories proposed to explore thecomputational power that various forms of "noise"can confer to neurons.


2012. XVIII, 458 p. 203 illus., 1 in color. (Springer Series inComputational Neuroscience, Vol. 8) Hardcover978-0-387-79019-0

▶149,95 €

Th.J. Dougherty, AstraZeneca Pharmaceuticals LP, Waltham,MA, USA; M.J. Pucci, Achillion Pharmaceuticals, New Haven,CT, USA (Eds.)

Antibiotic Discovery andDevelopmentThis volume covers major aspects of the antibioticdiscovery and development process. The contributors,a group of highly experienced individuals in bothacademics and industry, include chapters on thehistorical perspectives of antibiotic discovery, theneed for new antibiotic compounds,strategiesfor screening for new antibiotics, sources ofnovel synthetic and natural antibiotics, discoveryphases of lead development and optimization, andcandidate compound nominations into development.Significant attention is given to existing antibiotics,their resistance mechanisms, and new efforts to

overcome resistance within these classes. Beyonddiscovery, the book covers the studies to prepare forIND submission and NDA filings. This book walksthe reader through virtually all aspects of antibioticdiscovery, which has never been done before in asingle reference.With the alarming rise in antibioticresistance and the increasing view that a crisis maybe looming in infectious diseases, there are strongsigns of renewed emphasis in antibiotic research. Thepurpose of the book is to offer a detailed overviewof all aspects of the problem posed by antibioticdiscovery and development.



▶399,00 €

H. Duifhuis, University of Groningen, The Netherlands

Cochlear MechanicsIntroduction to a Time Domain Analysis of theNonlinear Cochlea

The field of cochlear mechanics has receivedincreasing interest over the last few decades. In themajority of these studies, researchers use linearsystems analysis or linear approximations of thenonlinear (NL) systems. Even though it has beenclear that the intact cochlea operates nonlinearly,lack of tools for proper nonlinear analysis, andwidely available tools for linear analysis still leadto inefficient and possibly incorrect interpretationof the biophysics of the cochlea. An example is thepresumption that a change in cochlear stiffnessat hair cell level must account for the observedchange in tuning (or frequency mapping) due toprestin application. Hypotheses like this need tobe addressed in a tutorial that is lucid enough toanalyze and explain basic differences. CochlearMechanics presents a useful and mathematicallyjustified/justifiable approach in the main part of thetext, an approach that will be elucidated with clearexamples. The book will be useful to scientists inauditory neuroscience, as well as graduate students inbiophysics/biomedical engineering.


2012. XIV, 261 p. 66 illus. Hardcover978-1-4419-6116-7

▶139,95 €

J.-B. Fan, Illumina, Inc., San Diego, CA, USA (Ed.)

Next-Generation MicroRNAExpression Profiling TechnologyMethods and Protocols

The rapid pace of microRNA (miRNA) researchcontinues to drive the advances of techniquesfor miRNA expression profiling, and innovativetechnologies that are more sensitive, specific,quantitative, and that are compatible with a widerange of biospecimens have been developedduring the past few years. In Next-GenerationMicroRNA Expression Profiling Technology:Methods and Protocols, expert researchers in thefield contribute detailed examinations of the mostcurrent approaches being used today. This volumeincludes comprehensive coverage of methodologiesthat have been developed for miRNA profiling, aswell as next-gen sequencing technology, miRNAdatabases, and specialized applications, such ascancer studies and miRNA-based non-invasivebiomarker development. Written in the highlysuccessful Methods in Molecular Biology™ seriesformat, chapters feature introductions to theirrespective topics, lists of the necessary materials andreagents, step-by-step, readily reproducible laboratoryprotocols, and tips on troubleshooting and avoidingknown pitfalls. Authoritative and cutting-edge,Next-Generation MicroRNA Expression ProfilingTechnology: Methods and Protocols provides an idealguide for novices and experts alike who are seeking toutilize these powerful technologies.


2012. XI, 341 p. 64 illus., 11 in color. (Methods in MolecularBiology, Vol. 822) Hardcover978-1-61779-426-1

▶109,95 €





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L. Feuk, Rudbecklaboratoriet, Uppsala, Sweden (Ed.)

Genomic Structural VariantsMethods and Protocols

The completion of a consensus draft sequencefor the human genome was the starting point formore thorough investigations of individual genomevariation. The development of array-based strategiesmade it possible to look at our genome in new waysand for new types of variation to be discovered andcharacterized. Characterization of copy numbervariation and other forms of structural geneticvariation has highlighted the complexity of humangenetic variation and also provided significantinsight into the evolution and dynamic nature ofour genome. Genomic Structural Variants: Methodsand Protocols provides an in-depth description ofthe developments in our understanding of structuralgenetic variation and its implications for humandisease, from the introduction of microarrays upto current state-of-the-art sequencing strategies.It covers the major technologies used for researchand diagnostics as well as web-based resources forvariation data, and it then goes into depth regardingspecific regions of the genome that differ in variationcontent. Specific patient groups where copy numbervariation has been shown to be of great importanceare highlighted, and implications for both pre-nataland standard diagnostics are described. Written inthe highly successful Methods in Molecular Biology™series format, chapters contain introductions to theirrespective topics, lists of the necessary materials andreagents, step-by-step, readily reproducible laboratoryprotocols, and notes on troubleshooting and avoidingknown pitfalls. Authoritative and accessible, GenomicStructural Variants: Methods and Protocols providescomplete comprehensive coverage of this burgeoningfield.



▶109,95 €

R.W. Finberg, University of Massachusetts, Worcester, MA,USA; R. Guharoy, UMassMemorial Health Care, Worcester,MA, USA

Clinical Use of Anti-infectiveAgentsA Guide on How to Prescribe Drugs Used to TreatInfections

This book is an overview of the clinicalapproach to the use of anti-infective agents. A briefdescription of the drugs used to treat infections isfollowed by an analysis of approaches to diseasescaused by different organisms (bacteria, fungi, andviruses). The final section consists of a series ofcases in which the authors outline the rationale forthe use of each drug in a clinical setting. A set ofappendices provide dosing recommendations for oraland parenteral administration as well as a list of druginteractions for commonly used anti-infective drugs. For students of pharmacology and medicalstudents, the illustrative cases describing how toapproach patients, as well as organisms, are includedalong with a brief discussion of clinical approachesto making a diagnosis and treating a patient withan infection. The book is intended as anintroduction for pharmacy students interested inapplying their knowledge of drugs to patients, and fornurse practitioners, medical students, residents, andpracticing physicians, who need to understand thebasic principles of treating patients with infections.


2012. XI, 181 p. 63 illus. Hardcover978-1-4614-1067-6

▶99,95 €

D.A. Frank, Dana-Farber Cancer Institute, Boston, MA, USA(Ed.)

Signaling Pathways in CancerPathogenesis and TherapySince the 1940s, the treatment of advanced cancerhas been based on administering maximal dosesof non-specifically toxic drugs in the hope thatcancer cells would be killed more effectively thannormal cells. While this is occasionally successful,for most common cancers only a minority of patientsexperience any meaningful benefit. Unfortunately,nearly all treated patients experience toxicities, whichrange from unpleasant to life threatening. In recentyears, however, our understanding of the molecularunderpinnings of cancer has increased enormously. We now have a much deeper understanding ofhow intracellular signaling pathways that controlcritical cellular functions can become subverted bythe genetic alterations arising in a cancer cell. Infact, we are now in a position to use this knowledgeto design rational targeted therapeutic approachesthat hold the promise of much greater efficacy withfewer side effects. In this volume, oncologists andscientists from academia, government, and industryhave come together to provide insight into strategiesto modulate signaling pathways, which are currentlybeing translated from the laboratory to the clinic. These advances will hopefully usher in a new era inthe treatment of cancer patients, and thus the goalof this volume is both to inform those interested inthis field, and to inspire further contributions in thiscutting edge area.


2012. VIII, 148 p. 13 illus., 12 in color. Hardcover978-1-4614-1215-1

▶99,95 €




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J.E. Green, National Cancer Institute, Bethesda, MD, USA; Th.Ried, National Cancer Institute, Bethesda, MD, USA (Eds.)

Genetically Engineered Mice forCancer Researchdesign, analysis, pathways, validation and pre-clinical testing

Technological advances in manipulating the mousegenome has led to the development of sophisticatedgenetically-engineered models of human cancerthat recapitulate many molecular, biologic andhistologic features of human tumors. This bookprovides an overview of the design considerationsand technical approaches used to generate theseimportant models of human cancer. These modelsare designed to recapitulate molecular aberrationsin target organs known to drive human cancers. State-of-the-art methods to analyze genome andtranscriptome alterations in these models andparticular relationships to human cancers arepresented. Mouse-human comparisons of tumorpathologies are exemplified. Criteria for selectingrelevant models for preclinical studies that mightbe translatable to the treatment of human cancersare discussed. The topics presented in this bookwill be invaluable to both newcomers to the field aswell as established investigators who use genetically-engineered mouse models to study the development,progression and treatment of cancer.


2012. XX, 632 p. 75 illus., 47 in color. Hardcover978-0-387-69803-8

▶169,95 €

M. Hayes, Teagasc, Dublin, Ireland (Ed.)

Marine Bioactive CompoundsSources, Characterization and Applications

This book aims to bring together the areas ofmacroalgal taxonomy with strategies and methodsused to characterise marine bioactive compounds.In addition, it looks at the importance of correct

taxonomic characterization. It also describesapplications of bioactive compounds from the marineenvironment and discusses how marine bioactivecompounds represent a major market application infood and other industries. It provides examples ofbioactive compounds isolated from marine resources. Examples are given as to how bioactive compoundshave been used in functional food formulations andpharmaceutical applications, and how they alterbiological activity to provide therapeutic benefits,nutritional values and health protection. It looks atthe screening process for identification of bioactivemolecules including computing methods for efficientin silico analysis, and describes different productionmethods used for bioactive compound isolation andidentification. Furthermore, this book provides aninsight into the market opportunities that exist for theidentification and commercialization of new marinebioactive compounds. It also highlights regulations inthe US, Europe, Japan and China regarding health ornovel food claims for functional food products.


2012. XII, 229 p. 34 illus., 8 in color. Hardcover978-1-4614-1246-5

▶149,95 €

T.L. Jackson, University of Michigan, Ann Arbor, MI USA (Ed.)

Modeling Tumor VasculatureMolecular, Cellular, and Tissue Level Aspects andImplications

To profoundly understand biology and harness itsintricacies for human benefit and the mitigation ofhuman harm requires cross-disciplinary approachesthat incorporate sophisticated computational andmathematical modeling techniques. These integrativestrategies are essential to achieve rapid and significantprogress in issues, in health and disease, which spanmolecular, cellular and tissue levels. The use ofmathematical models to describe various aspects oftumor growth has a very long history, dating backover six decades. Recently, however, experimentaland computational advances have improved ourunderstanding of how processes act at multiple scalesto mediate the development of tumor vasculatureand drive the advancement of cancer. This bookwill showcase the development and utilization ofnew computational and mathematical approaches toaddress multiscale challenges associated with tumorvascular development.



▶139,95 €

S. Jacobson, Tufts University, Boston, MA, USA; E.M. Marcus,University of Massachusetts, MA, Worcester, USA

Neuroanatomy for theNeuroscientist Neurology, more than any other system of medicine,is rooted in the firm knowledge of basic sciencematerial (i.e., the anatomy, physiology, and pathologyof the nervous system). This material enablesstudents to readily arrive at diagnoses and to applytheir knowledge to solving problems in clinicalsituations. Neuroanatomy for the Neuroscientistgives neuroscientists the tools to teach this materialat levels appropriate for students at several levels ofstudy, including undergraduate, graduate, dental, andmedical school. The text also provides an updatedapproach to lesion localization in neurology, utilizingthe techniques of computerized axial tomography(CT scanning), magnetic resonance imaging (MRI),and magnetic resonance angiography (MRA).Multiple illustrations demonstrating the value of thesetechniques in clinical neurology and neuroanatomicallocalization have been provided.


2011. XXIV, 404 p. 260 illus., 98 in color. Hardcover978-1-4419-9652-7

▶149,95 €

Y. Karamanos, Université d'Artois, Arras, France (Ed.)

Expression Profiling inNeuroscienceTranscriptomics and proteomics, studying theprofile of the expression of nucleic acids andproteins respectively, are increasingly applied togain a mechanistic insight into a wide spectrumof investigation, and the use of expressionprofiling studies for the central nervous systemand brain function aids in the understandingof neurodegenerative disorders and tumor





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development mechanisms. In Expression Profilingin Neuroscience, expert researchers provide a surveyof the most commonly used approaches in thefield and scan the different ways of studying thecentral nervous system/brain environment throughexpression profiling. The first part addresses thegene expression profiling of the brain at a largescale or to a specific cell type such as blood-brainbarrier endothelium. Then, the second part describesthe protein expression studies and the differenttechnologies applied. Written for the popularNeuromethods series, chapters include correspondingbackground information, tested laboratory protocols,and step-by-step methods for reproducible laboratoryexperiments. Detailed and authoritative, ExpressionProfiling in Neuroscience presents the state-of-the-arttechniques necessary to expand research further intothis vital area of study.


2012. XIII, 284 p. 55 illus., 33 in color. (Neuromethods, Vol.64) Hardcover978-1-61779-447-6

▶94,95 €

M. Kaufmann, Private Universität Witten/Herdecke gGmbH,Germany; C. Klinger, Private Universität Witten/HerdeckegGmbH, Witten, Germany (Eds.)

Functional GenomicsMethods and Protocols

Over the last decade Life Science has undergone anaccelerated evolution, culminating in the -omics eracharacterized by the development of a multitude ofhigh throughput methods that are becoming moreroutinely applied in biochemistry labs. In FunctionalGenomics: Methods and Protocols, Second Editionexpert researchers in the field detail many of themethods which are now commonly used for studiesin the life sciences focusing on the dynamic aspectsof the transcriptome, proteome and metabolome,respectively.Written in the highly successful Methodsin Molecular Biology™ series format, chapters includeintroductions to their respective topics, lists of thenecessary materials and reagents, step-by-step,readily reproducible laboratory protocols, andkey tips on troubleshooting and avoiding knownpitfalls.Authoritative and practical, FunctionalGenomics: Methods and Protocols, Second Editionseeks to aid scientists in establishing or extendingtechnologies and techniques in their laboratories.


2012. XV, 418 p. 73 illus., 13 in color. (Methods in MolecularBiology, Vol. 815) Hardcover978-1-61779-423-0

▶109,95 €

A. Kuchment, Scientific American, New York, NY, USA

The Forgotten CureThe Past and Future of Phage Therapy

“Bacteriophages have the potential to stop many ifnot most life threatening, drug resistant bacterialinfections. The Forgotten Cure is a non-stop, coverto cover read.” James D. Watson, Nobel Laureate “Alively tale of killer viruses, superbugs and a magicalcure that has all the twists of a cold-war spy novel.” –George Hackett, Newsweek magazine “A marvelous,jargon-free historical account of the genesis, theups-and-downs, and the current renaissance ofphage therapy. The Forgotten Cure ranks at thelevel of Judson’s Eighth Day of Creation.” SankarAdhyaNational Institutes of HealthThe ForgottenCure: How a Long Lost Treatment Can Save Lives inthe 21st Century Before the arrival of penicillin inthe 1940s, phage therapy was one of the few weaponsdoctors had against bacterial infections. It saved thelife of Hollywood legends Tom Mix and ElizabethTaylor before being abandoned by Western science.Now, researchers and physicians are rediscoveringthe treatment, which pits phage viruses againsttheir natural bacterial hosts, as a potential weaponagainst antibiotic-resistant infections.“The ForgottenCure” traces the story of phages from Paris, wherethey were discovered in 1917; to Tbilisi, Georgia,where one of phage therapy’s earliest proponentsdied at the hands of Stalin; to the Nobel podium,where prominent scientists have been recognized forbreakthroughs stemming from phage research. Today,a crop of biotech startups and dedicated physicians isracing to win regulatory approval for phage therapybefore superbugs exhaust the last drug in the medicalarsenal. Will they clear the hurdles in time?


2012. XVI, 131 p. 6 illus. Hardcover978-1-4614-0250-3

▶19,95 €

Th. Liehr, Universitätsklinikum Jena, Germany

Small Supernumerary MarkerChromosomes (sSMC)A Guide for Human Geneticists and Clinicians

Human beings normally have a total of 46chromosomes, with each chromosome present twice,apart from the X and Y chromosomes in males. Somethree million people worldwide, however, have 47chromosomes: they have a small supernumerarymarker chromosome (sSMC) in addition to the 46normal ones. This sSMC can originate from any oneof the 24 human chromosomes and can have differentshapes. Approximately one third of sSMC carriersshow clinical symptoms, while the remaining twothirds manifest no phenotypic effects.This guiderepresents the first book ever published on this topic.It presents the latest research results on sSMC andcurrent knowledge about the genotype-phenotypecorrelation. The focus is on genetic diagnostics as wellas on prenatal and fertility-related genetic counseling.A unique feature is that research meets practice:numerous patient reports complement the clinicalaspects and depict the experiences of families livingwith a family member with an sSMC.


2012. XX, 220 p. 64 illus., 5 in color. Hardcover978-3-642-20765-5

▶44,95 €

A. Lorence, Arkansas State University, Jonesboro, AR, USA(Ed.)

Recombinant Gene ExpressionStudies related to recombinant gene expressionhave brought new advance such as the emergenceof the “omics” technologies. While Escherichiacoli, Sacharomyces cerevisiae and insect cellscontinue to be the dominant production platformsof recombinant proteins. In Recombinant GeneExpression: Review and Protocols, Third Edition,expert researchers in the field detail many of themethods now commonly used to study recombinant





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gene expression. These include methods andtechniques for bacteria, lower eukaryotes, fungi,plants and plant cells, and animals and animalcells. Written in the highly successful Methods inMolecular Biology™ series format, chapters includeintroductions to their respective topics, lists of thenecessary materials and reagents, step-by-step,readily reproducible laboratory protocols, andkey tips on troubleshooting and avoiding knownpitfalls. Authoritative and practical, RecombinantGene Expression: Review and Protocols, ThirdEdition seeks to aid scientists in the further study ofthis crucially important research into recombinantgene expression.


2012. XVI, 649 p. 105 illus. (Methods in Molecular Biology,Vol. 824) Hardcover978-1-61779-432-2

▶124,95 €

P.B. Luppa, TU München; H. Schlebusch, Universität Bonn(Eds.)

POCT - PatientennaheLabordiagnostikPOCT („Point of care testing“) - PatientennaheLabordiagnostik. Dabei handelt es sich umLaboruntersuchungen, die nicht in einemZentrallabor, sondern direkt am Patienten, z.B.im Operationssaal, in einer Ambulanz oder amNotfallort durchgeführt werden. Die Untersuchungenerfolgen mittels einfacher Messsysteme und liefernein schnelles Ergebnis. Besondere Bedeutung hatPOCT in der Anästhesie, Intensivmedizin undNotfallmedizin, da hier die rasche Verfügbarkeit vonMessergebnissen und damit die schnelle adäquateund zielgerichtete Behandlung des Patientenbesonders wichtig ist. Mit den verschiedenenVerfahren können z.B. die Blutgerinnung,Thrombozytenfunktion, Blutglucose, Elektrolyte,Herzinfarktmarker und Liquorbestandteile bestimmtwerden. Das Werk gibt einen Überblick überdie wichtigsten Analyseverfahren und derenklinische Anwendung sowie Informationen, u.a.zu medizinischer und wirtschaftlicher Bedeutungvon POCT, Methodik, Organisation und Trendsfür die Zukunft. Die Inhalte orientieren sich anden Richtlinien der Bundesärztekammer. Die 2.Auflage wurde komplett aktualisiert und wichtigeThemen, wie Kosten und Erlöse noch stärkerberücksichtigt. Das Buch richtet sich an alle, diePOCT bereits durchführen oder zukünftig einführenmöchten: Ärzte aller Fachbereiche in Klinik oder

Praxis, Assistenzpersonal,Verantwortungsträger inKliniken, Krankenhausverwaltungen.


2012. XVIII, 386 S. 56 Abb. Softcover978-3-642-20171-4

▶37,34 €

L. Luzi, Università degli Studi di Milano, Italia (Ed.)

Cellular Physiology andMetabolism of Physical ExerciseThe book covers areas of cellular physiologyand metabolism that are of interest to scientistsinvolved in research in diabetes and metabolicdiseases. Some chapters of the book are specificallyresearch-oriented, as all the authors are activelypracticing either bench or clinical research in the area.Nonetheless, since the work is fully comprehensive ofthe discipline, it is also suitable for university classesof graduate and undergraduate students. In particular,the book discusses classical aspects of cellularphysiology and the metabolism of physical exercise,as well as novel topics like exercise in transplantationand exercise in beta-cell failure, which mark thefrontiers of research in sport-related sciences andresearch. Exercise physiologists, biologists andphysicians are the specific professional and academictargets of this work. The team of authors togetherwith the editor are world-renowned experts in thefield of physiology and metabolism applied to sportsciences.


2012. XX, 180 p. 50 illus. in color. Hardcover978-88-470-2417-5

▶139,95 €

C. López-Larrea, Hospital Universitario Central de Asturias,Oviedo, Spain (Ed.)

Self and NonselfIn 1960 Sir Frank Macfarlane Burnet received theNoble Prize in Physiology and Medicine. He titled hisNobel Lecture “Immunological Recognition of Self”emphasizing the central argument of immunologicaltolerance in “How does the vertebrate organismrecognize self from nonself in this the immunologicalsense—and how did the capacity evolve.” The conceptof self is linked to the concept of biological selfidentity. All organisms, from bacteria to higheranimals, possess recognition systems to defendthemselves from nonself. Even in the context of thelimited number of metazoan phyla that have beenstudied in detail, we can now describe many of thealternative mechanism of immune recognition thathave emerged at varying points in phylogeny. Twodifferent arms—the innate and adaptive immunesystem—have emerged at different moments inevolution, and they are conceptually different.The ultimate goals of immune biology includereconstructing the molecular networks underlyingimmune processes.


2012. XXII, 318 p. 35 illus., 22 in color. (Advances inExperimental Medicine and Biology, Vol. 738) Hardcover978-1-4614-1679-1

▶149,95 €

C. López-Larrea, Hospital Central de Asturias, Oviedo, Spain(Ed.)

Sensing in NatureBiological systems are an emerging discipline thatmay provide integrative tools by assembling thehierarchy of interactions among genes, proteins andmolecular networks involved in sensory systems.The aim of this volume is to provide a picture, ascomplete as possible, of the current state of knowledgeof sensory systems in nature. The presentation in this





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book lies at the intersection of evolutionary biology,cell and molecular biology, physiology and genetics.Sensing in Nature is written by a distinguished panelof specialists and is intended to be read by biologists,students, scientific investigators and the medicalcommunity.



▶149,95 €

N. Maurits, University Medical Center Groningen, TheNetherlands

From Neurology to Methodologyand BackAn Introduction to Clinical Neuroengineering

In today’s hospitals, the gap between technologyand medicine constantly needs to be bridged, bothby physicians and engineers. By taking a uniqueclinical neuroengineering approach, From Neurologyto Methodology and Back off ers a translationalstudy of neurology and technology, spanningtraditionally distinct focuses. The fundamentaltopics covered range from basic concepts such assampling and simple statistical measures via Fourieranalysis to source localization. Providing clinicallyrelevant context and introduce technical concepts,the neurological diseases presented range fromepilepsy, brain tumors and cerebrovascular diseasesto tremor, MS and neuromuscular diseases. All topicsare presented in a true clinical neuroengineeringapproach.Each chapter begins with one or morepatient cases for inspiration. Each case is thenpresented to illustrate a working example ofa distinct neurodiagnostic technique, and themathematical and physical principles underlyingthese techniques are explained. Finally, the authorreturns to the patient, and examines how thepresented technology can help provide a diagnosisfor each case.From Neurology to Methodology andBack serves as an upper-undergraduate/graduatelevel guide for those interested in a translationalapproach between the fields of medicine andtechnology in neuroengineering. Neurologistsand residents in neurology, medical engineers,medical students, biomedical engineers and students,technical medicine students or students of other

interdisciplinary fields will therefore all find this bookuseful.


2012. XV, 285 p. 131 illus., 86 in color. Hardcover978-1-4614-1131-4

▶59,95 €

D.W. McCandless, Rosalind Franklin University, Chicago, IL,USA

EpilepsyAnimal and Human Correlations

Correlation is a vital element in epilepsy research,especially given the condition’s notorious resistanceto treatment. With a current ‘rate of translation’estimated at between seven and nine years, and atranslation ‘success rate’ of below 50 per cent, thereis room for improvement in the correlative researchexploring this intractable condition.Epilepsy: Animaland Human Correlations offers judiciously selectedmaterial with clear correlative relevance. Arrangedaccording to animal studies and related studies inthe human population, each chapter covers clinicaldescription, neurophysiology, neurochemistry,neuropathology, and treatment attempts. The humanchapters have an additional section detailing studiesbased on counterpart animal studies, as well ascovering promising further research suggested byanimal results. The book includes a clear statement ofthe rationale for future human clinical investigationsbased on animal results. The chapters cover animaland human studies related to both simple andcomplex partial seizures. It covers typical as wellas atypical seizures, and includes material on someseizure disorders which resist neat classification.Studies conducted in the primate population receivecareful attention About the Author: The workof Dr. David W. McCandless spanned over 35years of laboratory research into basic mechanismsof various metabolic encephalopathies. He wasthe Founding Editor of the journal MetabolicBrain Disease (Springer), now in its 27th year. Dr.McCandless served on the faculty or research staffat The University of Vermont College of Medicine,NIH-NINCDS, University of Texas Medical School atHouston, and The Chicago Medical School, and wasa visiting professor at Washington University Schoolof Medicine. Most recently, he served as the John J.Sheinin Professor of Anatomy in the Department ofCell Biology and Anatomy at The Chicago MedicalSchool, Rosalind Franklin University, North Chicago,IL, USA. About the Author: The work of Dr. DavidW. McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolic

encephalopathies. He was the Founding Editor ofthe journal Metabolic Brain Disease (Springer),now in its 27th year. Dr. McCandless served on thefaculty or research staff at The University of VermontCollege of Medicine, NIH-NINCDS, University ofTexas Medical School at Houston, and The ChicagoMedical School, and was a visiting professor atWashington University School of Medicine. Mostrecently, he served as the John J. Sheinin Professorof Anatomy in the Department of Cell Biologyand Anatomy at The Chicago Medical School,Rosalind Franklin University, North Chicago, IL,USA. About the Author: The work of Dr. David W.McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor ofthe journal Metabolic Brain Disease (Springer),now in its 27th year. Dr. McCandless served on thefaculty or research staff at The University of VermontCollege of Medicine, NIH-NINCDS, University ofTexas Medical School at Houston, and The ChicagoMedical School, and was a visiting professor atWashington University School of Medicine. Mostrecently, he served as the John J. Sheinin Professorof Anatomy in the Department of Cell Biologyand Anatomy at The Chicago Medical School,Rosalind Franklin University, North Chicago, IL,USA. About the Author: The work of Dr. DavidW. McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor ofthe journal Metabolic Brain Disease (Springer),now in its 27th year. Dr. McCandless served on thefaculty or research staff at The University of VermontCollege of Medicine, NIH-NINCDS, University ofTexas Medical School at Houston, and The ChicagoMedical School, and was a visiting professor atWashington University School of Medicine. Mostrecently, he served as the John J. Sheinin Professorof Anatomy in the Department of Cell Biologyand Anatomy at The Chicago Medical School,Rosalind Franklin University, North Chicago, IL,USA. About the Author: The work of Dr. David W.McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor of thejournal Metabolic Brain Disease (Springer), now inits 27th year. Dr. McCandless served on the faculty orresearch staff at The University of Vermont Collegeof Medicine, NIH-NINCDS, University of TexasMedical School at Houston, and The Chicago MedicalSchool, and was a visiting professor at WashingtonUniversity School of Medicine. Most recently, heserved as the John J. Sheinin Professor of Anatomyin the Department of Cell Biology and Anatomyat The Chicago Medical School, Rosalind FranklinUniversity, North Chicago, IL, USA. Epilepsy: Animaland Human Correlations offers judiciously selectedmaterial with clear correlative relevance. Arrangedaccording to animal studies and related studies inthe human population, each chapter covers clinicaldescription, neurophysiology, neurochemistry,neuropathology, and treatment attempts. The humanchapters have an additional section detailing studiesbased on counterpart animal studies, as well ascovering promising further research suggested byanimal results. The book includes a clear statement ofthe rationale for future human clinical investigationsbased on animal results. The chapters cover animaland human studies related to both simple andcomplex partial seizures. It covers typical as well



springer.com 11

as atypical seizures, and includes material on someseizure disorders which resist neat classification.Studies conducted in the primate population receivecareful attention About the Author: The workof Dr. David W. McCandless spanned over 35years of laboratory research into basic mechanismsof various metabolic encephalopathies. He wasthe Founding Editor of the journal MetabolicBrain Disease (Springer), now in its 27th year. Dr.McCandless served on the faculty or research staffat The University of Vermont College of Medicine,NIH-NINCDS, University of Texas Medical School atHouston, and The Chicago Medical School, and wasa visiting professor at Washington University Schoolof Medicine. Most recently, he served as the John J.Sheinin Professor of Anatomy in the Department ofCell Biology and Anatomy at The Chicago MedicalSchool, Rosalind Franklin University, North Chicago,IL, USA. About the Author: The work of Dr. DavidW. McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor ofthe journal Metabolic Brain Disease (Springer),now in its 27th year. Dr. McCandless served on thefaculty or research staff at The University of VermontCollege of Medicine, NIH-NINCDS, University ofTexas Medical School at Houston, and The ChicagoMedical School, and was a visiting professor atWashington University School of Medicine. Mostrecently, he served as the John J. Sheinin Professorof Anatomy in the Department of Cell Biologyand Anatomy at The Chicago Medical School,Rosalind Franklin University, North Chicago, IL,USA. About the Author: The work of Dr. David W.McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor of thejournal Metabolic Brain Disease (Springer), now inits 27th year. Dr. McCandless served on the faculty orresearch staff at The University of Vermont Collegeof Medicine, NIH-NINCDS, University of TexasMedical School at Houston, and The Chicago MedicalSchool, and was a visiting professor at WashingtonUniversity School of Medicine. Most recently, heserved as the John J. Sheinin Professor of Anatomyin the Department of Cell Biology and Anatomyat The Chicago Medical School, Rosalind FranklinUniversity, North Chicago, IL, USA. The chapterscover animal and human studies related to bothsimple and complex partial seizures. It covers typicalas well as atypical seizures, and includes material onsome seizure disorders which resist neat classification.Studies conducted in the primate population receivecareful attention About the Author: The workof Dr. David W. McCandless spanned over 35years of laboratory research into basic mechanismsof various metabolic encephalopathies. He wasthe Founding Editor of the journal MetabolicBrain Disease (Springer), now in its 27th year. Dr.McCandless served on the faculty or research staffat The University of Vermont College of Medicine,NIH-NINCDS, University of Texas Medical School atHouston, and The Chicago Medical School, and wasa visiting professor at Washington University Schoolof Medicine. Most recently, he served as the John J.Sheinin Professor of Anatomy in the Department ofCell Biology and Anatomy at The Chicago MedicalSchool, Rosalind Franklin University, North Chicago,IL, USA. About the Author: The work of Dr. DavidW. McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolic

encephalopathies. He was the Founding Editor ofthe journal Metabolic Brain Disease (Springer),now in its 27th year. Dr. McCandless served on thefaculty or research staff at The University of VermontCollege of Medicine, NIH-NINCDS, University ofTexas Medical School at Houston, and The ChicagoMedical School, and was a visiting professor atWashington University School of Medicine. Mostrecently, he served as the John J. Sheinin Professorof Anatomy in the Department of Cell Biologyand Anatomy at The Chicago Medical School,Rosalind Franklin University, North Chicago, IL,USA. About the Author: The work of Dr. David W.McCandless spanned over 35 years of laboratoryresearch into basic mechanisms of various metabolicencephalopathies. He was the Founding Editor of thejournal Metabolic Brain Disease (Springer), now inits 27th year. Dr. McCandless served on the faculty orresearch staff at The University of Vermont Collegeof Medicine, NIH-NINCDS, University of TexasMedical School at Houston, and The Chicago MedicalSchool, and was a visiting professor at WashingtonUniversity School of Medicine. Most recently, heserved as the John J. Sheinin Professor of Anatomyin the Department of Cell Biology and Anatomyat The Chicago Medical School, Rosalind FranklinUniversity, North Chicago, IL, USA.


2012. XV, 532 p. 60 illus., 2 in color. Hardcover978-1-4614-0108-7

▶169,95 €

R. Milner, The Scripps Research Institute, La Jolla, CA, USA(Ed.)

AstrocytesMethods and Protocols

Ever since their discovery more than 150 yearsago, astrocytes have proved to be something of anenigma. Only in the last 10-15 years has it becomeclear that astrocytes are multifunctional versatilecells that play key roles in a multitude of diverseprocesses in the CNS. Astrocytes: Methods andProtocols provides scientists with a comprehensiveguide to many techniques used for astrocyte cellculture, as well as more specialized approachesfor studying astrocyte functions, both in vitro andin vivo. Key cellular, molecular and biochemicaltechniques are used to study the many and variedfunctions of this fascinating cell. Written in thehighly successful Methods in Molecular Biology™series format, chapters include introductions to theirrespective topics, lists of the necessary materialsand reagents, step-by-step, readily reproduciblelaboratory protocols, and key tips on troubleshooting

and avoiding known pitfalls. Authoritative andpractical Astrocytes: Methods and Protocols seeksto aid scientists and researchers looking to use morespecialized techniques to examine astrocyte function.


2012. XIV, 575 p. 113 illus., 40 in color. (Methods inMolecular Biology, Vol. 814) Hardcover978-1-61779-451-3

▶124,95 €

R.H. Morse, New York State Department of Health, Albany,NY, USA (Ed.)

Chromatin RemodelingMethods and Protocols

Chromatin is of central importance to gene regulationin eukaryotes. Reflecting this singular role forchromatin, numerous approaches have evolvedin the laboratory over the past three decades tostudy chromatin structure and its alterations.Methods of investigating chromatin remodeling,whether in changes in nucleosome structure orposition with respect to the incorporated DNA orin histone modifications, have progressed rapidlyover the recent years. In Chromatin Remodeling:Methods and Protocols, expert researchers contributechapters which include methods for investigatingchromatin remodeling in vitro and in vivo, inyeast, plants, and mammalian cells, and at localand global levels. Both gene-specific and genome-wide approaches are covered, and in recognitionof the increasing prevalence of the latter type ofstudy, the final two chapters focus on bioinformatic/computational approaches to analyzing genome-wide data on chromatin structure. Written in thehighly successful Methods in Molecular Biology™series format, the chapters include introductions totheir respective topics, lists of the necessary materialsand reagents, step-by-step, readily reproduciblelaboratory protocols, and tips on troubleshootingand avoiding known pitfalls. Comprehensive andessential, Chromatin Remodeling: Methods andProtocols serves as a key source of clear techniques aswell as a collection of chapters that can inspire futuretechniques in this vital field of study.


2012. XII, 453 p. 83 illus., 5 in color. (Methods in MolecularBiology, Vol. 833) Hardcover978-1-61779-476-6

▶109,95 €




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Y. Okada, National Institute for Physiological Sciences,Okazaki, Japan (Ed.)

Patch Clamp TechniquesFrom Beginning to Advanced Protocols

Channels and transporters are multi-functionalproteins that mediate substrate transport and signaltransmission and simultaneously act as regulatorsfor other proteins and biosensors for environmentalmaterials. Patch clamping is an epoch-makingtechnique that allows researchers to perform real-timemeasurements of electrogenic channel/transporterfunctions at the single/multiple molecular level.This book describes not only the conventional patchclamp techniques but also their newly developedvariations or applications, such as perforated patch,slice patch, blind patch, in vivo patch, imaging patch,smart patch, and automated patch clamping. Thesepatch clamp techniques are now essential and areextensively used across the life sciences and in relatedindustries. With plain and practical descriptions ofpatch clamping and how to carry it out, especiallyfor beginners, the book also shows how widely andexquisitely the patch clamp techniques can be appliedby expert electrophysiologists. This work serves as auseful guide for young researchers and students intraining and laboratory courses as well as for seniorresearchers who wish to extend their repertoire oftechniques.

More on www.springer.com/978-4-431-53992-6Due: May 31, 2012

2012. XII, 439 p. 157 illus. (Springer ProtocolsHandbooks) Hardcover978-4-431-53992-6

▶109,95 €

V. Orgogozo, CNRS UMR7592, Université Paris VII, Paris,France; M.V. Rockman, New York University, New York, NY,USA (Eds.)

Molecular Methods forEvolutionary GeneticsWe are entering a particularly fruitful periodin evolutionary genetics, as rapid technological

progress transforms the investigation of geneticvariation within and between species. MolecularMethods for Evolutionary Genetics is a collectionof advanced molecular biology protocols andgeneral overviews intended to represent the essentialmethods currently bringing evolutionary geneticsto fruition. Divided into six thematic sections, thisvolume covers methods for characterizing genomes,diverse approaches to enrich DNA for subsets of thegenome prior to sequencing, and state-of-the-artprotocols for sampling genetic variation for geneticmapping studies and population genetic studies(RAD sequencing, Sequenom, microarrays, etc.).The volume concludes by focusing on methods tostudy candidate genes, from obtaining their sequencesand analyzing their transcripts to experimentallymanipulating their activities in vivo. Written in thehighly successful Methods in Molecular Biology™series format, chapters contain introductions to theirrespective topics, lists of the necessary materialsand reagents, step-by-step, readily reproduciblelaboratory protocols, and notes on troubleshootingand avoiding known pitfalls. Authoritative andaccessible, Molecular Methods for EvolutionaryGenetics serves as a rich resource to biologistsinterested in evolution, whether they be specialists orbeginners in molecular biology.


2011. XVI, 503 p. 81 illus., 4 in color. (Methods in MolecularBiology, Vol. 772) Hardcover978-1-61779-227-4

▶109,95 €

J.M. Parry, Lyndhurst, UK; E.M. Parry, Lyndhurst, UK (Eds.)

Genetic ToxicologyPrinciples and Methods

The evaluation of potential mutagenic activityis a critical step in the assessment of the safetyof both new and pre-existing chemical types. InGenetic Toxicology: Principles and Methods, expertcontributors help to satisfy the demand for educationin this tremendously important area of study. Thevolume covers three basic areas: the scientific basisof the discipline, the methodologies of the main testassays, and the application of the methods, all aimedprimarily at scientists in the safety departments of theindustries working with both natural and syntheticchemicals. Written in the highly successful Methodsin Molecular Biology™ series format, chapters includeintroductions to their respective topics, lists of thenecessary materials and reagents, step-by-step,readily reproducible laboratory protocols, and tips ontroubleshooting and avoiding known pitfalls. Intuitiveand cutting-edge, Genetic Toxicology: Principles and

Methods provides crucial support to both laboratoryworkers in providing quality information on theappropriate application of techniques and to studydirectors in their assay selection and protocol designin this vital field.


2012. XVI, 433 p. 114 illus., 46 in color. (Methods inMolecular Biology, Vol. 817) Hardcover978-1-61779-420-9

▶109,95 €

J. Peccoud, Virginia Bioinformatics Institute, Blacksburg, VA,USA (Ed.)

Gene SynthesisMethods and Protocols

The de novo fabrication of custom DNA molecules isa transformative technology that significantly affectsthe biotechnology industry. Basic genetic engineeringtechniques for manipulating DNA in vitro openedan incredible field of opportunity in the life sciences.In, Gene Synthesis: Methods and Protocols expertresearchers in the field detail many of the methodswhich are now commonly used to fabricate DNA .These include methods and techniques for theassembly of oligonucleotide, cloning of synthonsinto larger fragments, protocols and softwareapplications, and educational and biosecurity impactsof gene synthesis. Written in the highly successfulMethods in Molecular Biology™ series format, thechapters include the kind of detailed descriptionand implementation advice that is crucial for gettingoptimal results in the laboratory. Thorough andintuitive, Gene Synthese: Methods and Protocols aidsscientists in understanding all the different stagesof a complex gene synthesis process, while refiningtheir understanding of gene synthesis and determinewhat part of the process they can or should do in theirlaboratory and what parts should be contracted to aspecialized service provider.



▶109,95 €





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X. Peng, Texas A&M Health Science Center, Temple, TX, USA;M. Antonyak, Department of Molecular Medicine, CornellUniversity, Ithaca NY (Eds.)

Cardiovascular DevelopmentMethods and Protocols

Congenital heart disease is the leading cause ofinfant death and affects approximately one inevery 100 babies born in the United States. Thestudy of cardiovascular development has acquirednew momentum in last twenty years due to theadvancement of modern molecular biology andnew available equipments and techniques. InCardiovascular Development: Methods and Protocolsexpert researchers in the field in the field detail manyof the methods which are now commonly used inthe field of cardiovascular development research.These include methods and techniques for usingdifferent organisms for cardiovascular developmentalresearch, using cell and molecular biology methodsto study cardiovascular development, as well as otheravailable techniques for cardiovascular developmentresearch. Written in the highly successful Methods inMolecular Biology™ series format, chapters includeintroductions to their respective topics, lists of thenecessary materials and reagents, step-by-step,readily reproducible laboratory protocols, andkey tips on troubleshooting and avoiding knownpitfalls.Authoritative and practical, CardiovascularDevelopment: Methods and Protocols seeks toaid scientists in understanding new state-of-the-art techniques in the field of cardiovasculardevelopment research including in vivo imaging andBioinformatics.


2012. XIV, 341 p. 64 illus., 41 in color. (Methods in MolecularBiology, Vol. 843) Hardcover978-1-61779-522-0

▶109,95 €

J. Reichrath, The Saarland University Hospital, Homburg,Germany; S. Reichrath, Universitätsklinikum des Saarlandes,Homburg, Germany (Eds.)

Notch Signaling in Embryologyand Cancer.



▶149,95 €

M.G. Rossmann, Purdue University, West Lafayette, IN, USA;V.B. Rao, Catholic University of America, Washington, D.C.,USA (Eds.)

Viral Molecular MachinesA biological organism can be viewed as a collectionof molecular machines well integrated to functionas a self-replicating unit. One of the principal goalsin biology is to be able to fully understand themechanisms of an organism in atomic detail. Virusesoffer the best opportunities to achieve this goal.Written by leaders in the respective fields, this bookexamines a variety of viral molecular machines, usingthe best examples from bacteriophages and animalviruses, many causing infectious diseases of publichealth importance. Beginning with the viral entryinto a host cell, the book takes the reader throughreplication of the genome, assembly of structuralcomponents, genome packaging and maturation intoan infectious virion. The book conveys the state of theart knowledge of the topic generated by combiningX-ray crystallography, high resolution electronmicroscopy, molecular genetics, biochemistry, andsingle molecule biophysics. Viral Molecular Machinesis not only a “must-have” book for virologists but itwill also be broadly useful for molecular biologists inacademia and industry as well as an educational tool

for teaching graduate and upper level undergraduatestudents.


2012. XIV, 687 p. 221 illus., 192 in color. (Advances inExperimental Medicine and Biology, Vol. 726) Hardcover978-1-4614-0979-3

▶199,95 €

J.M. Sanches, Technical University of Lisbon, Portugal; A.F.Laine, Columbia University, NY, USA; J.S. Suri, BiomedicalTechnologies, Inc., Denver, CO, USA and Idaho StateUniversity (Affiliated), Pocatello, ID, USA (Eds.)

Ultrasound ImagingAdvances and Applications

Ultrasound Imaging: Advances andApplications presents some of the recent advancesin Ultrasound imaging technology covering severalorgans and techniques in a Biomedical Engineering(BME) perspective. The focus of the book is in thealgorithms, methodologies and systems developedby multidisciplinary research teams of engineersand physicians for Computer-Aided Diagnosis(CAD) purposes.Cardiovascular and Cancer, themost common life-threatening diseases in westerncountries, are two of the most important topicsfocused in the book. However, other advanced issuesare also presented such as Intravascular Ultrasound,3D US and Ultrasound in Computer-Aided Surgery(CAS). Some chapters are direct contributions frommedical research groups where Ultrasound has alsoreceived great attention in the last decade. By this,new techniques based on Ultrasound were introducedin the clinical practice for diagnosis and therapeutics,mainly in hospital facilities.



▶149,95 €





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N.W. Schultheiss, Boston University, Boston, MA, USA;A.A. Prinz, Emory University, Atlanta, GA, USA; R.J. Butera,Georgia Institute of Technology, Atlanta, GA, USA (Eds.)

Phase Response Curves inNeuroscienceTheory, Experiment, and Analysis

Neuronal phase response curves (PRCs) summarizethe relationship between the timing of inputswithin a neuron’s spike cycle and the consequentshifts in output spike timing. The form of aneuron’s PRC reflects its mechanism of spikeinitiation or excitability as well as other influencesof membrane conductances on synaptic integration. PRCs are efficient encapsulations of the input-output processing of individual neurons to singleperturbations and are powerful devices for theprediction and interpretation of patterned neuronalnetwork activity including synchronizationphenomena in connected networks or populationsreceiving shared input. Thus, application of phaseresponse analysis to neural systems targets theinterface of neural computation at the cellular andnetwork levels, one of the most critical and expansivegaps in our understanding of the brain. This volumesurveys the diversity of applications of phase responseanalysis by many of the prominent theoreticians andexperimentalists in the Computational Neurosciences. Readers will find a thorough introduction to thefoundational concepts underlying phase responseanalysis, advanced techniques for accurate estimationof neuronal PRCs, and impactful illustrations of boththe cellular underpinnings of the phase responseproperties of neurons and the power of phaseresponse analysis to explain network behavior. Throughout the book, the authors use phase responseanalysis to elucidate a number of neural systemsthat are current foci of exciting research in theComputational Neurosciences and are at the forefrontof our advancing grasp of the complex mechanisms ofbrain function and dysfunction.


2012. XIII, 518 p. 170 illus., 32 in color. (Springer Series inComputational Neuroscience, Vol. 6) Hardcover978-1-4614-0738-6

▶169,95 €

B. Shapiro, The Pennsylvania State University, UniversityPark, PA, USA; M. Hofreiter, University of York, UK (Eds.)

Ancient DNAMethods and Protocols

Research into ancient DNA began more than 25years ago with the publication of short mitochondrialDNA sequence fragments from the quagga, an extinctrelative of the zebra. Ancient DNA research reallygained momentum following the invention of PCR,which allowed millions of copies to be made of thefew remaining DNA molecules preserved in fossilsand museum specimens. In Ancient DNA: Methodsand Protocols expert researchers in the field describemany of the protocols that are now commonly usedto study ancient DNA. These include instructionsfor setting up an ancient DNA laboratory, extractionprotocols for a wide range of different substrates,details of laboratory techniques including PCRand NGS library preparation, and suggestions forappropriate analytical approaches to make senseof the sequences obtained. Written in the highlysuccessful Methods in Molecular Biology™ seriesformat, chapters include introductions to theirrespective topics, lists of the necessary materials andreagents, step-by-step, readily reproducible laboratoryprotocols, and key tips on troubleshooting andavoiding known pitfalls. Authoritative and practical,Ancient DNA: Methods and Protocols seeks to aidscientists in the further study of ancient DNA and themethodological approaches in ancient research.


2012. XII, 247 p. 26 illus., 12 in color. (Methods in MolecularBiology, Vol. 840) Hardcover978-1-61779-515-2

▶94,95 €

J. Siepmann, University Lille Nord de France, Lille, France;R.A. Siegel, University of Minnesota, Minneapolis, MN, USA;

M.J. Rathbone, Griffith University, Southport, QLD, Australia(Eds.)

Fundamentals and Applications ofControlled Release Drug DeliveryThis authoritative book covers the fundamentalsrelating to the science and technology of drugdelivery. The book is written at a level that isunderstandable to those entering the field andwho are not familiar with its common phrases orcomplex terms. It is a book that provides a simpleencapsulation of concepts and expands on themusing a building block approach to each subject,starting at a basic level and building to extend thereaders knowledge and application of the subject. In each chapter the basic concept is explained assimply and clearly as possible without a great dealof detail, then in subsequent sections additionalmaterial is introduced in order to build up thereader’s understanding and comprehension of thesubject matter. The book comprises several Parts. The first part covers the fundamentals of drugdelivery, the second covers delivery materials, thethird deals with delivery systems (both temporaland spatial) and the fourth introduces the readerto some clinical applications of drug delivery. Thebook ends with a future outlook chapter in whichprospects for the field are envisioned. This bookwill be indispensible to scientists interested in thescience and technology of drug delivery and beessential for those developing delivery systemsdesigned to improve the clinical performance of adrug. Professor Juergen Siepmann is Professor ofPharmaceutics at the College of Pharmacy, UniversitéLille Nord de France, Lille, France. He studiedpharmacy and received his doctoral degree fromthe Freie Universitaet Berlin, Berlin, Germany, in1999. His research focuses on the elucidation of theunderlying mass transport phenomena in controlleddrug delivery systems. Prof. Siepmann is reviewseditor of the International Journal of Pharmaceuticsand president of APGI (French Association ofPharmaceutical Technology). Since 2010 he is headingthe INSERM (French National Institute of Health andMedical Research) research group “Controlled DrugDelivery Systems and Biomaterials”. Ronald A. Siegel,Sc.D., is Professor of Pharmaceutics and BiomedicalEngineering at the University of Minnesota. Hereceived his doctoral degree from MIT under thedirection of Prof. Robert Langer in 1984, and taughtat the University of California, San Francisco until1998, when he moved to Minnesota. ProfessorSiegel is Fellow of the Controlled Release Society(CRS), the American Association of PharmaceuticalScientists, and the American Institute of Medicaland Biological Engineering. He was president ofCRS from 1997-1998. His present research interestsinclude hydrogels, block polymers, microfabricatedsensors and drug delivery systems, and mathematicalmodeling of transport. Michael J. Rathbone isAssociate Professor of Pharmaceutics at the Schoolof Pharmacy, Griffith University, Australia. Dr.Rathbone’s research interests are in the modifieddelivery of bioactives to the mouth, polymericdelivery systems and long acting veterinary drugdelivery systems. He is a Fellow of the ControlledRelease Society (CRS) and received the CRSDistinguished Service Award in 2006. He has editedor co-edited many books in the fields of modified



springer.com 15

release drug delivery, oral mucosal drug delivery andveterinary drug delivery.


2012. XIII, 592 p. 156 illus., 33 in color. (Advances in DeliveryScience and Technology) Hardcover978-1-4614-0880-2

▶169,95 €

C. Stanford, University College London, UK; R. Tannock,University of Toronto, ON, Canada (Eds.)

Behavioral Neuroscience ofAttention Deficit HyperactivityDisorder and Its TreatmentThe Behavioral Neuroscience of Attention DeficitHyperactivity Disorder reviews the latest discoveriesin research of ADHD. There is a strong emphasison translational science, with preclinical approachessuggesting new directions for development ofnew treatments. Individual chapters describehow neuroimaging, neuroendocrine, genetic andbehavioral studies use powerful research tools thatare offering a completely new understanding of thefactors that increase vulnerability to ADHD. Theclinical impact of co-morbid problems, especiallyobesity and substance misuse, are highlighted andexplain what such problems can tell us about theetiology of ADHD, more generally. Reviews of thepharmacology of established drug treatments forADHD justify an exciting novel theory for theirtherapeutic actions and address questions aboutthe effects of their long‑term use. This volume isaimed at both clinicians and basic scientists, who areinterested in ADHD, giving students and establishedresearchers an overview of the current status of thefield and insight into topics that will be prominent inthe future.


2012. XIV, 433 p. 18 illus., 10 in color. (Current Topics inBehavioral Neurosciences, Vol. 9) Hardcover978-3-642-24611-1

▶149,95 €

M.E. Symonds, University of Nottingham, Nottingham, UK(Ed.)

Adipose Tissue BiologyIn conjunction with the obesity “epidemic” in thedeveloped world there has been an exponentialincrease in academic and medical interest in adipose

tissue. Consequently, the intricacies and new insightsinto adiposity have provided some of the mostexciting recent advances in science. At the sametime, the ability of fat to grow at an almost unlimitedcapacity means that our ability to combat the risein global obesity remains very challenging. So withthe clear need to further understand the causes ofexcess adipose tissue growth, this book is designedto provide a comprehensive insight into currentperspectives and challenges in adipose tissue biology.In <i>Adipose Tissue Biology</i>, scientists andclinicians discuss adipocyte precursors, differentiationand growth, brown and white adipose tissue, gender,inflammation, dietary and genetic determinants of fatmass, together with evolutionary and developmentalaspects of adiposity. It should therefore providea comprehensive guide and essential reading fordoctors, healthcare workers and scientists who areeither new to or established within the field – enjoy!


2012. VI, 413 p. 42 illus., 24 in color. Hardcover978-1-4614-0964-9

▶149,95 €

L.W. Tari, Trius Therapeutics, San Diego, CA, USA (Ed.)

Structure-Based Drug DiscoveryThe last decade has seen the confluence of severalenabling technologies that have allowed proteincrystallographic methods to live up to their truepotential. Taken together, the numerous recentadvances have made it possible to tackle difficultbiological targets with a high probability of success:intact bacterial ribosomes have been structurallyelucidated, as well as eukaryotic trans-membraneproteins like the potassium channel and GPCRs. It isnow possible for medicinal chemists to have access tostructural information on their latest small moleculecandidates bound to the therapeutic target withindays of compound synthesis, allowing structureguided ligand optimization to occur in "real time".Structure-Based Drug Discovery presents an arrayof methods used to generate crystal structures ofbiological macromolecules, how to leverage thestructural information to design novel ligands anew,and how to iteratively optimize hits and convertthem to leads. Written in the successful Methods inMolecular Biology™ series format, chapters includeintroductions to their respective topics, lists of thenecessary materials and reagents, step-by-step, readilyreproducible protocols, and notes on troubleshootingand avoiding known pitfalls. Authoritative and easilyaccessible, Structure-Based Drug Discovery aims toprovide scientists interested in adding SBDD to their

arsenal of drug discovery methods with well-honed,up-to-date methodologies.


2012. IX, 385 p. 130 illus., 5 in color. (Methods in MolecularBiology, Vol. 841) Hardcover978-1-61779-519-0

▶109,95 €

R.-F. Wang, Baylor College of Medicine, Houston, TX, USA(Ed.)

Innate Immune Regulation andCancer ImmunotherapyThere has been major growth in understandinginnate immune signaling, inflammation, immunesuppression and cancer immunotherapy. Innateimmune regulation and cancer immunotherapyhighlights emerging research about the underlyingmechanisms of innate immunity and signalingregulation, inflammation and immune suppressionthat promote or inhibit cancer development andprogression, and offers novel ideas and strategies todevelop therapeutic cancer drugs or cell therapy bymanipulating or blocking these negative signalingpathways and generating potent antitumor immunity. Recent studies have identified key innate immunereceptors or sensors, novel signaling moleculesand immune regulatory molecules that controlimmune responses, inflammation and immunesuppression in cancer and other diseases. Majorprogresses in understanding of tumor antigens,immune suppressive molecules and cell populationand novel vaccine strategies bring therapeutic cancervaccines and drugs in realty. With chapters writtenby internationally recognized contributors, thisbook provides essential introduction and guidefor immunologists, basic, translational and clinicalcancer researchers.Features of this book:Offers themost recent development from basic science toclinical application of cancer immunotherapy, thusserving useful guide for immunologists, and cancerresearcher and oncologists. Identify key immunesignaling molecules and cell populations that dampenimmune responses against cancer, thus providingnovel strategies to develop therapeutic cancer vaccinesand drugs.


2012. X, 478 p. 39 illus., 32 in color. Hardcover978-1-4419-9913-9

▶149,95 €






16 springer.com

R.O. Williams III, University of Texas, Austin, TX, USA; A.B.Watts, University of Texas, Austin, TX, USA; D.A. Miller,Hoffmann-La Roche, Inc., Nutley, NJ, USA (Eds.)

Formulating Poorly Water SolubleDrugsA pharmaceutical scientist’s approach towardsolubility enhancement of a poorly water-solublemolecule typically includes detailed characterizationof the compound’s physiochemical properties, solid-state modifications, advanced formulation design,non-conventional process technologies, advancedanalytical characterization, and specialized productperformance analysis techniques. The scientist mustalso be aware of the unique regulatory considerationspertaining to the non-conventional approaches oftenutilized for poorly water-soluble drugs. One facedwith the challenge of developing a drug productfrom a poorly soluble compound must possessat minimum a working knowledge of each of theabovementioned facets and detailed knowledgeof most. In light of the magnitude of the growingsolubility problem to drug development, this isa significant burden especially when consideringthat knowledge in most of these areas is relativelynew and continues to develop. There are numerousliterature resources available to pharmaceuticalscientists to educate and provide guidance towardformulations development with poorly water-solubledrugs; however, a single, comprehensive reference islacking. Furthermore, without access to a vast journallibrary, the detailed methods used to implement theseapproaches are not available. The objective of thisvolume is therefore to consolidate within a single textthe most current knowledge, practical methods, andregulatory considerations pertaining to formulationsdevelopment with poorly water-soluble molecules.


2012. XII, 646 p. 188 illus., 135 in color. (AAPS Advances inthe Pharmaceutical Sciences Series, Vol. 3) Hardcover978-1-4614-1143-7

▶199,95 €

J.C. Wright, DURECT Corporation, Cupertino, CA, USA; D.J.Burgess, School of Pharmacy, University of Connecticut,Storrs, CT, USA (Eds.)

Long Acting Injections andImplantsLong acting injections and implants improvetherapy, enhance patient compliance, improvedosing convenience, and are the most appropriateformulation choice for drugs that undergo extensivefirst pass metabolism or that exhibit poor oralbioavailability. An intriguing variety of technologieshave been developed to provide long acting injectionsand implants. Many considerations need to go intothe design of these systems in order to translate aconcept from the lab bench to actual therapy fora patient. This book surveys and summarizes thefield. Topics covered in Long Acting Injectionsand Implants include the historical development ofthe field, drugs, diseases and clinical applicationsfor long acting injections and implants, anatomyand physiology for these systems, specific injectabletechnologies (including lipophilic solutions,aqueous suspensions, microspheres, liposomes,in situ forming depots and self-assembling lipidformulations), specific implantable technologies(including osmotic implants, drug eluting stentsand microfabricated systems), peptide, protein andvaccine delivery, sterilization, drug release testingand regulatory aspects of long acting injections andimplants.This volume provides essential informationfor experienced development professionals butwas also written to be useful for scientists justbeginning work in the field and for others whoneed an understanding of long acting injectionsand implants. This book will also be ideal as agraduate textbook.Dr. Jeremy Wright is a PrincipalEngineer at the DURECT Corporation in Cupertino,California. He has over 30 years of experience in thedevelopment of drug delivery systems. He has beena key contributor to the development of implantableosmotic systems for veterinary and human use(DUROS®) and is currently involved in research anddevelopment of injectable depot systems. Dr. Wrightis the inventor on over 50 patents. Dr. Diane J.Burgess is Distinguished Professor of Pharmaceutics,at the University of Connecticut. Her research effortsfocus on gene and drug delivery and she has over140 refereed publications. Dr. Burgess was the 2010President of the Controlled Release Society (CRS),the 2002 President of the American Association ofPharmaceutical Scientists (AAPS) and is a CRS, AAPSand an American Institute for Medical and Biological

Engineering (AIMBE) fellow. She is editor of theInternational Journal of Pharmaceutics.


2012. XV, 557 p. 146 illus., 46 in color. (Advances in DeliveryScience and Technology) Hardcover978-1-4614-0553-5

▶169,95 €



Spring 2012 – Title Selection BIOMEDICAL SCIENCES Ahmad Neurodegenerative Diseases

Alonso DNA Electrophoresis Protocols for Forensic Genetics

Antkiewicz-Michaluk Isoquinolines And Beta-Carbolines As Neurotoxins And Neuroprotectants

Baron Computational Drug Discovery and Design

Blom Hallucinations

Castoria Advances in Rapid Sex-Steroid Action

Chatterjee Cell Signaling & Molecular Targets in Cancer

Chen Activation and Detoxification Enzymes

Chouker Stress Challenges and Immunity in Space

Curtis Hot Topics in Infection and Immunity in Children VIII

Darai Lexikon der Infektionskrankheiten des Menschen

Destexhe Neuronal Noise

Dougherty Antibiotic Discovery and Development

Duifhuis Cochlear Mechanics

Fan Next-Generation MicroRNA Expression Profiling Technology

Feuk Genomic Structural Variants

Finberg Clinical Use of Anti-infective Agents

Frank Signaling Pathways in Cancer Pathogenesis and Therapy

Green Genetically Engineered Mice for Cancer Research

Hayes Marine Bioactive Compounds

Jackson Modeling Tumor Vasculature

Jacobson Neuroanatomy for the Neuroscientist

Karamanos Expression Profiling in Neuroscience

Kaufmann Functional Genomics

Kuchment The Forgotten Cure

Liehr Small Supernumerary Marker Chromosomes (sSMC)

Lorence Recombinant Gene Expression

Luppa POCT - Patientennahe Labordiagnostik

Luzi Cellular Physiology and Metabolism of Physical Exercise

http://www.springer.com/biomed/neuroscience/book/978-1-4614-0652-5�

http://www.springer.com/biomed/human+genetics/book/978-1-61779-460-5�


http://www.springer.com/biomed/pharmaceutical+science/book/978-1-61779-464-3�


http://www.springer.com/biomed/cancer/book/978-1-4614-1763-7�


http://www.springer.com/biomed/human+physiology/book/978-1-4614-1048-5�


http://www.springer.com/biomed/immunology/book/978-1-4614-0203-9�

http://www.springer.com/biomed/medical+microbiology/book/978-3-642-17157-4�

















http://www.springer.com/biomed/book/978-3-642-20171-4�


López-Larrea Self and Nonself

López-Larrea Sensing in Nature

Maurits From Neurology to Methodology and Back

McCandless Epilepsy

Milner Astrocytes

Morse Chromatin Remodeling

Okada Patch Clamp Techniques

Orgogozo Molecular Methods for Evolutionary Genetics

Parry Genetic Toxicology

Peccoud Gene Synthesis

Peng Cardiovascular Development

Reichrath Notch Signaling in Embryology and Cancer

Rossmann Viral Molecular Machines

Sanches Ultrasound Imaging

Schultheiss Phase Response Curves in Neuroscience

Shapiro Ancient DNA

Siepmann Fundamentals and Applications of Controlled Release Drug Delivery

Stanford Behavioral Neuroscience of Attention Deficit Hyperactivity Disorder and Its Treatment

Symonds Adipose Tissue Biology

Tari Structure-Based Drug Discovery

Wang Innate Immune Regulation and Cancer Immunotherapy

Williams III Formulating Poorly Water Soluble Drugs

Wright Long Acting Injections and Implants

http://www.springer.com/biomed/immunology/book/978-1-4614-1679-1�










http://www.springer.com/biomed/molecular/book/978-1-61779-522-0�


http://www.springer.com/biomed/virology/book/978-1-4614-0979-3�












biomedical sciences - springer · 2012-04-27 · biomedical sciences spring 2012 - title selection...

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