BioMediTechA Source for

High Quality Research and Innovations

BioMediTech

Over 250 scientists in world-class basic and translational research• Tissue engineering and stem cell technology

• Biomaterials

• Sensor and actuator technologies

• Measurement and imaging technologies

• Biotechnology

• Immunology

• Cancer and mitochondrial research

• Systems biology

• Bioinformatics

• Computational methods in biomedicine

Joint institute of University of Tampere & Tampere University of Technology

Kauppi University Campus

Orig. http://www.pshp.fi/

BioMediTech• aims for excellence in

- education- basic research - translational research

• houses state-of-the-art laboratories and 200m2 GMP-level clean rooms

• EMEA approved GMP stem cell production unit

Aiming for Excellence

Example of Research Excellence

BioMediTech: world leader in stem cell based reconstructions of cranial bones

• 22 cases operated

• combination of biomaterials and stem cells differentiated from subcutaneous fat

2 months post op 28 months post op

• Nearly 20 M€ project funding for Human Spare parts program (2011-2015)• Development of tissue engineering products and supporting technologies • Tekes, Academy of Finland, Council of Tampere Region, EU

Tissue engineering at Regea

• Adult stem cells• Embryonic stem cells• iPSCs• Production in GMP and own

xenofree media

Cardiac, neural, opthalmological, soft and hard tissue applications

Adipose stem cells

Stem cells can be isolated from the patient’s own adipose tissue, differentiated in vitro and transplanted back into the host tissue rejections are avoided

S.Miettinen

Adipose stem cellsDifferentiate to....• Adipocytes• Osteocytes• Chondrocytes• Tendocytes

and also to• Neural cells?• (Cardio)myocytes?• Hepatocytes?• Epi/Endothelial cells?

Adapted from www.nationalacademies.org/stemcells, Wellen and Hotamisligil 2003, Hotamisligil 2006 by Bettina Lindroos

Adipose stem cells

Neurosurgery

Tampere University Hospital: Prof. Juha Öhman

Adipose stem cells and biomaterial

hASC, β- TCP