bionanoimaging
TRANSCRIPT
An unexpected journey to a wonderful world
Presented By: Mehdi SoleymaniGoloujeh
Supervisor: Dr. A. Barzegar
Medical Nanotechnology DepartmentTabriz University of Medical Sciences
Presentation Layout:
Introduction
Classifications
New approaches
Future trends
Conclusions
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
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Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
Introduction to Bionanoimaging
Introduction
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Bionanoimaging
An unexpected journey to a wonderful world
Nowadays we use in cancer detection,molecular imaging, MRI & US
Some facilities and materials are prerequisite to reach our goals
So we should classify these materials to study them easily
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
Introduction to Bionanoimaging
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Medical Nanotechnology Department
Classifications
Bionanoimaging
QDs
UICAMNPs
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Medical Nanotechnology Department
Quantum Dots
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QUANTUM DOTS• Emission of photons under excitation, which are visible• Emission depends on size not on the material
“Size Matters”
• Smaller the dot –
• Larger the dot – red end of spectrum
• They can also be tuned beyond visible light to IR or UV
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Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
Quantum dots (QDs) are incredibly small particles. They range between 2
to 10 nanometers in diameter, which is equivalent to 50 atoms
The colour light that a quantum dot emits is directly related to its size;
smaller dots appear blue, larger ones more red.
Quantum dots are a "semiconductor nano-crystal
A quantum dot as this: tiny pieces of matter with unique properties,
including the ability to emit light at very specific wavelengths. Sort of like
microscopic pieces of glitter that glow green, red, or blue depending on their
size.
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The smaller the nanoparticle, the higher the energy difference between the valence band
and conduction band, which results in a deeper blue color. For a larger nanoparticle, the
energy difference between the valence band and the conduction band is lower, which shifts
the glow toward red.
Quantum dots are very, very tiny particules on the order of a nanometer in size. They are
composed of a hundred to a thousand atoms. These semiconductor materials can be made
from an element, such as silicon or germanium, or a compound, such as CdS or CdSe.
These tiny particles can differ in color depending on their size. Below is a collection of CdSe
quantum dot nanoparticles that different in size as a result of how long they were allowed to
form in the synthersis reaction
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Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
MEDICAL IMAGING
The quantum dots (QD) can be injected to asubject, and then be detected by exciting themto emit light
Source: Department of immunology, University of Toronto
Solutions of CdSe QD’s of different diameter
CdSe nanoparticle (QD) structureSource: Laurence Livermore Laboratories
Imaging of QD’s targeted on cellular structures
Nano Letters 2008., Vol. 8, pp3887-3892
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Medical Nanotechnology Department
QD LOCALIZATION OF A TUMORA. It is possible to overlap X-ray images with infrared images to localize a tumor. The X-rayimages give the images an anatomical context, while the infrared images detect the QD’semission, which correlates to the tumor location (see B.)
Annu. Rev. Biomed. Eng. 2007. Vol. 9, pp. 257–288
B. C. 560-QD-Streptadivin targets and images In-vitrobreast cancer cells having the IgG factor characteristicof chemotherapy responsive cells
Nature Biotechnology 2003. Vol. 9, pp. 41-46
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Medical Nanotechnology Department
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Medical Nanotechnology Department
Mehdi Soleymani Goloujeh
Medical Nanotechnology Department
ULTRASOUND CONTRAST AGENTS
Ultrasound is currently a well-established technology enabling real-time imaging of the human body
Traditional ultrasound, however, has its own limitation including increase in
attenuation with increasing insonating frequency, yielding low resolution of thickerstructures, and thus prohibiting deeper scans
A possible solution to overcoming the issues of deep scans and achieving improved
resolution is the use of contrast agents (CA) for ultrasound imaging [25, 26]. The
ultrasound imaging contrast agents (UICA) can be classified into liposomes, polymeric
nanosomes, and these are further classified according to the type of ultrasound agentencapsulated in them.
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MAGNETIC NANOPARTICLES
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Medical Nanotechnology Department
Paramagnetic
Super-paramagnetic Iron Oxide(SPIO)
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Passive Targeting Active Targeting Cell Tracking Magnetic Relaxation Switching(MRS)
Applications:
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Medical Nanotechnology Department
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New approaches
New Developments
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Medical Nanotechnology Department
New approaches
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Future trends
Science-fictionJules Verne Stories
Imaginations
Insights Documents
Experiences
Thoughts
C O O H
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50 µm
Fe3O4 NPs
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Conclusions
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Medical Nanotechnology Department
Conclusions
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