BioPAT® MFCSSCADA Software for Bioprocess Management

BioPAT® MFCS/win is the world standard for supervisory bioprocess control and data acquisition. It is a feature -rich, GAMP category 4 software package – based on over 25 years of experience and more than 3,000 installations worldwide. This software is capable of supporting you in the most demanding research and production environments.

BioPAT® MFCS

Features – Scalable software for almost all biopro-

cess applications

– Fully user configurable and upgradeable with specific modules

– Proven record over 25 years of software development

– Installation, configuration, validation & engineering services

– Central platform for realtime data and historians of process, analytical and sampling data

Benefits– Reduced training efforts and improved

data consistency

– Unique customization level and flexible investment costs

– Reliable and robust system performance

– Technologically and economically optimized solutions

– Full transparency and accessibility for advanced process control and under-standing

ApplicationsReliable data acquisition, monitoring and control

– for upstream and downstream unit operations

– from shake flask to large-scale bioreactors

– for single-use to reusable bioreactors

CO2 LacGlc

AutomationBioPAT® MFCS/win allows you to mirror each step of your process by selection of customized recipes complying to the ANSI/ISA-88.01 standard for computerized batch control. Semi or fully-automatic opera-tions, state or time-dependent transitions enable organized and structured batch pro-cessing as well as flexible manufacturing.

Chemometrics ToolboxThe BioPAT® MFCS/win DoE module transfers your design into a specific recipe and thus allows a reliable and seamless integration of DoE procedures into existing control strategies. The BioPAT® MFCS/win MVDA module automatically pre-formats and transfers historical data sets of multiple batch processes to BioPAT® SIMCA which leads to a quick and reliable interpretation of batch results. The BioPAT® MFCS/win OPC HDA Server ensures real-time and historical data transfer to BioPAT® SIMCA-online for early fault detection and isolation.

TrainingSartorius provides different levels of train-ings which are designed to ensure that each course participant has a proper understand-ing of the theoretical subject matter and acquires the necessary hands-on, practical skills. The ultimate aim and purpose is to enable, technicians and specialists working in R&D or production to perform their work safely and efficiently.

ConnectivityBioPAT® MFCS/win provides flexible device connectivity, true interoperability with major third-party products and control features which are second to none. Besides user-programmable or customized synoptic interfaces BioPAT® MFCS/win fully supports the OPC technology. „Plug & play“ commu-nication to analytical instruments, real-time data input for MES systems or alarm & event notification on multimedia devices simplify your automation tasks.

Your Choice for Customized Features

Service & SupportOur team of experienced service engineers has been involved in a number of successful projects world-wide. Expertise gained through long term cooperation with phar-maceutical and biotech companies has been used to develop and refine a comprehensive range of services including computer system validation (CSV) as well as qualification of automated process equipment.

ValidationBioPAT® MFCS/win supports all require-ments to achieve full compliance with 21 CFR Part 11. That means that your pro-cess can be evaluated, reviewed, approved and archived without a single sheet of paper and without the possibility to falsify process data and signatures. However, if required, all information can be printed and signed handwritten.

DCU & MFCSOur key platform to automation of fermen-tation and filtration systems is based on the use of the flexible Digital Control Unit (DCU), which is specifically tailored for bioprocess applications. When combined with BioPAT® MFCS/win this solution pro-vides the most cost-effective and flexible platform for small to medium scale research and pilot plant applications.

NetworkBioPAT® MFCS/win can easily be integrated with network security into an existing architecture by distributed operator work-stations. If required the SCADA environ-ment can also be isolated from your company‘s network. Not only the strong expertise of our IT engineers but also the use of the latest Windows® or Citrix® terminal server solutions allow for closing any security vulnerability.

Which software is right for me?

BioPAT® MFCS is provided in three versions:

The new BioPAT® MFCS 4 is our most recent software development for reliable data acquisition and effective trend monitoring.

In contrast BioPAT® MFCS/win is a feature- rich, GAMP category 4 software package with preconfigured modules enabling plug-and-play setup of advanced SCADA functionalities.

Choose Support Pack 2015 if you use the latest Microsoft® Windows® operating systems or if you want to integrate the Chemometrics Toolbox into your existing BioPAT® MFCS/win system. Support Pack 2015 is a comprehensive software upgrade for BioPAT® MFCS/win which ensures process safety and robustness.

www.sartorius-stedim.com/biopatmfcs

Learn more about the new BioPAT® MFCS and download a free demo version:

SYNCHRONIZED

PATSOLUTIONS

Microsoft® and Windows® are registered trademarks of Microsoft Corporation, USA.

Features MFCS 4Support Pack 2015 MFCS/win 3.0

Windows® 7 • • •

Windows® 8/8.1 • •

Windows® Server 2008 R2 • • •

Windows® Server 2012 R2 • •

Number of supported process units up to 24 up to 16 up to 16Minimum data storage interval 0.5 s 1 s 1 sDatabase management Microsoft®

SQLMicrosoft® Access

Microsoft® Access

Data acquisition and storage • • •

Supervisory control •* • •

Process value alarms •* • •

Configuration management •* • •

Sample data management •* • •

Calculations •* • •

Data export to Microsoft® Excel • • •

Advanced reporting •* • •

Advanced charting •* • •

Integrated Design of Experiments (DoE)** •* •

Integrated Multivariate Data Analysis (MVDA)** •* •

Recipe control according to ISA-88.01 •* • •

Replication manager •* • •

21 CFR Part 11 compliance •* • •

Terminal server edition •* • •

OPC DA server •* • •

OPC AE server •* • •

OPC HDA server •* •

OPC DA client •* • •

Validation support •* • •

Advanced service & support • (1st year) •

Training •* • •

• included • optional available * available soon ** powered by UMETRICS

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Sales and Service ContactsFor further contacts, visit www.sartorius-stedim.com

EuropeGermanySartorius Stedim Biotech GmbHAugust-Spindler-Strasse 1137079 Goettingen

Phone +49.551.308.0Fax +49.551.308.3289

Sartorius Stedim Systems GmbHRobert-Bosch-Strasse 5 – 7 34302 Guxhagen

Phone +49.5665.407.0Fax +49.5665.407.2200

FranceSartorius Stedim FMT S.A.S.ZI des PaludsAvenue de Jouques – CS 9105113781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.845619

Sartorius Stedim France SASZI des PaludsAvenue de Jouques – CS 7105813781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.846545

AustriaSartorius Stedim Austria GmbHModecenterstrasse 221030 Vienna

Phone +43.1.7965763.18Fax +43.1.796576344

BelgiumSartorius Stedim Belgium N.V.Leuvensesteenweg, 248/B1800 Vilvoorde

Phone +32.2.756.06.80Fax +32.2.756.06.81

HungarySartorius Stedim Hungária Kft.Kagyló u. 52092 Budakeszi

Phone +36.23.457.227Fax +36.23.457.147

ItalySartorius Stedim Italy S.p.A.Via dell’Antella, 76/A50012 Antella-Bagno a Ripoli (FI)

Phone +39.055.63.40.41Fax +39.055.63.40.526

NetherlandsSartorius Stedim Netherlands B.V.

Phone +31.30.60.25.080Fax +31.30.60.25.099

filtratie.nederland@sartorius-stedim.com

PolandSartorius Stedim Poland Sp. z o.o.ul. Wrzesinska 7062-025 Kostrzyn

Phone +48.61.647.38.40Fax +48.61.879.25.04

Russian FederationLLC “Sartorius ICR”and LLC “Biohit”Uralskaya str. 4, Lit. B199155, Saint-Petersburg

Phone +7.812.327.5.327Fax +7.812.327.5.323

SpainSartorius Stedim Spain, S.A.U.Avda. de la Industria, 32Edificio PAYMA28108 Alcobendas (Madrid)

Phone +34.902.110.935Fax +34.91.358.96.23

SwitzerlandSartorius Stedim Switzerland AGRingstrasse 24 a8317 Tagelswangen

Phone +41.52.354.36.36Fax +41.52.354.36.46

U.K.Sartorius Stedim UK Ltd.Longmead Business CentreBlenheim Road, EpsomSurrey KT19 9 QQ

Phone +44.1372.737159Fax +44.1372.726171

UkraineLLC “Biohit”Post Box 440 “B”01001 Kiev, Ukraine

Phone +380.44.411.4918Fax +380.50.623.3162

AmericaUSASartorius Stedim North America Inc.5 Orville Drive, Suite 200Bohemia, NY 11716

Toll-Free +1.800.368.7178Fax +1.631.254.4253

ArgentinaSartorius Argentina S.A. Int. A. Ávalos 4251 B1605ECS Munro Buenos Aires

Phone +54.11.4721.0505 Fax +54.11.4762.2333

BrazilSartorius do Brasil Ltda Avenida Senador Vergueiro 2962 São Bernardo do Campo CEP 09600-000 - SP- Brasil

Phone +55.11.4362.8900Fax + 55.11.4362.8901

MexicoSartorius de México S.A. de C.V.Circuito Circunvalación Poniente No. 149Ciudad Satélite53100, Estado de MéxicoMéxico

Phone +52.5555.62.1102Fax +52.5555.62.2942

Asia|PacificAustraliaSartorius Stedim Australia Pty. Ltd.Unit 5, 7-11 Rodeo DriveDandenong South Vic 3175

Phone +61.3.8762.1800Fax +61.3.8762.1828

ChinaSartorius Stedim Biotech (Beijing) Co. Ltd.No. 33 Yu’an RoadAirport Industrial Park Zone BShunyi District, Beijing 101300

Phone +86.10.80426516Fax +86.10.80426580

Sartorius Stedim (Shanghai) Trading Co. Ltd3rd Floor, North Wing, Tower 1No. 4560 Jinke RoadZhangjiang Hi-Tech Park Pudong DistrictShanghai 201210, China

Phone +86.21.68782300Fax +86.21.68782332 | 68782882

Sartorius Stedim Biotech (Beijing) Co. Ltd.Guangzhou Representative OfficeUnit K, Building 23Huihua Commerce & Trade BuildingNo. 80 Xianlie Middle RoadGuangzhou 510070

Phone +86.20.37618687 | 37618651Fax +86.20.37619051

IndiaSartorius Stedim India Pvt. Ltd.#69/2-69/3, NH 48, JakkasandraNelamangala Tq562 123 Bangalore, India

Phone +91.80.4350.5250Fax +91.80.4350.5253

JapanSartorius Stedim Japan K.K.4th Fl., Daiwa Shinagawa North Bldg.8-11, Kita-Shinagawa 1-chomeShinagawa-ku, Tokyo, 140-0001 Japan

Phone +81.3.4331.4300Fax +81.3.4331.4301

MalaysiaSartorius Stedim Malaysia Sdn. Bhd.Lot L3-E-3B, Enterprise 4Technology Park MalaysiaBukit Jalil57000 Kuala Lumpur, Malaysia

Phone +60.3.8996.0622Fax +60.3.8996.0755

SingaporeSartorius Stedim Singapore Pte. Ltd.1 Science Park Road, The Capricorn, #05-08A,Singapore Science Park IISingapore 117528

Phone +65.6872.3966Fax +65.6778.2494

South KoreaSartorius Korea Biotech Co., Ltd.8th Floor, Solid Space B/D, PanGyoYeok-Ro 220, BunDang-GuSeongNam-Si, GyeongGi-Do, 463-400

Phone +82.31.622.5700Fax +82.31.622.5799

www.sartorius-stedim.com

Sales and Service ContactsFor further contacts, visit www.sartorius-stedim.com

EuropeGermanySartorius Stedim Biotech GmbHAugust-Spindler-Strasse 1137079 Goettingen

Phone +49.551.308.0Fax +49.551.308.3289

Sartorius Stedim Systems GmbHRobert-Bosch-Strasse 5 – 7 34302 Guxhagen

Phone +49.5665.407.0Fax +49.5665.407.2200

FranceSartorius Stedim FMT S.A.S.ZI des PaludsAvenue de Jouques – CS 9105113781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.845619

Sartorius Stedim France SASZI des PaludsAvenue de Jouques – CS 7105813781 Aubagne Cedex

Phone +33.442.845600Fax +33.442.846545

AustriaSartorius Stedim Austria GmbHModecenterstrasse 221030 Vienna

Phone +43.1.7965763.18Fax +43.1.796576344

BelgiumSartorius Stedim Belgium N.V.Leuvensesteenweg, 248/B1800 Vilvoorde

Phone +32.2.756.06.80Fax +32.2.756.06.81

HungarySartorius Stedim Hungária Kft.Kagyló u. 52092 Budakeszi

Phone +36.23.457.227Fax +36.23.457.147

ItalySartorius Stedim Italy S.p.A.Via dell’Antella, 76/A50012 Antella-Bagno a Ripoli (FI)

Phone +39.055.63.40.41Fax +39.055.63.40.526

NetherlandsSartorius Stedim Netherlands B.V.

Phone +31.30.60.25.080Fax +31.30.60.25.099

filtratie.nederland@sartorius-stedim.com

PolandSartorius Stedim Poland Sp. z o.o.ul. Wrzesinska 7062-025 Kostrzyn

Phone +48.61.647.38.40Fax +48.61.879.25.04

Russian FederationLLC “Sartorius ICR”and LLC “Biohit”Uralskaya str. 4, Lit. B199155, Saint-Petersburg

Phone +7.812.327.5.327Fax +7.812.327.5.323

SpainSartorius Stedim Spain, S.A.U.Avda. de la Industria, 32Edificio PAYMA28108 Alcobendas (Madrid)

Phone +34.902.110.935Fax +34.91.358.96.23

SwitzerlandSartorius Stedim Switzerland AGRingstrasse 24 a8317 Tagelswangen

Phone +41.52.354.36.36Fax +41.52.354.36.46

U.K.Sartorius Stedim UK Ltd.Longmead Business CentreBlenheim Road, EpsomSurrey KT19 9 QQ

Phone +44.1372.737159Fax +44.1372.726171

UkraineLLC “Biohit”Post Box 440 “B”01001 Kiev, Ukraine

Phone +380.44.411.4918Fax +380.50.623.3162

AmericaUSASartorius Stedim North America Inc.5 Orville Drive, Suite 200Bohemia, NY 11716

Toll-Free +1.800.368.7178Fax +1.631.254.4253

ArgentinaSartorius Argentina S.A. Int. A. Ávalos 4251 B1605ECS Munro Buenos Aires

Phone +54.11.4721.0505 Fax +54.11.4762.2333

BrazilSartorius do Brasil Ltda Avenida Senador Vergueiro 2962 São Bernardo do Campo CEP 09600-000 - SP- Brasil

Phone +55.11.4362.8900Fax + 55.11.4362.8901

MexicoSartorius de México S.A. de C.V.Circuito Circunvalación Poniente No. 149Ciudad Satélite53100, Estado de MéxicoMéxico

Phone +52.5555.62.1102Fax +52.5555.62.2942

Asia|PacificAustraliaSartorius Stedim Australia Pty. Ltd.Unit 5, 7-11 Rodeo DriveDandenong South Vic 3175

Phone +61.3.8762.1800Fax +61.3.8762.1828

ChinaSartorius Stedim Biotech (Beijing) Co. Ltd.No. 33 Yu’an RoadAirport Industrial Park Zone BShunyi District, Beijing 101300

Phone +86.10.80426516Fax +86.10.80426580

Sartorius Stedim (Shanghai) Trading Co. Ltd3rd Floor, North Wing, Tower 1No. 4560 Jinke RoadZhangjiang Hi-Tech Park Pudong DistrictShanghai 201210, China

Phone +86.21.68782300Fax +86.21.68782332 | 68782882

Sartorius Stedim Biotech (Beijing) Co. Ltd.Guangzhou Representative OfficeUnit K, Building 23Huihua Commerce & Trade BuildingNo. 80 Xianlie Middle RoadGuangzhou 510070

Phone +86.20.37618687 | 37618651Fax +86.20.37619051

IndiaSartorius Stedim India Pvt. Ltd.#69/2-69/3, NH 48, JakkasandraNelamangala Tq562 123 Bangalore, India

Phone +91.80.4350.5250Fax +91.80.4350.5253

JapanSartorius Stedim Japan K.K.4th Fl., Daiwa Shinagawa North Bldg.8-11, Kita-Shinagawa 1-chomeShinagawa-ku, Tokyo, 140-0001 Japan

Phone +81.3.4331.4300Fax +81.3.4331.4301

MalaysiaSartorius Stedim Malaysia Sdn. Bhd.Lot L3-E-3B, Enterprise 4Technology Park MalaysiaBukit Jalil57000 Kuala Lumpur, Malaysia

Phone +60.3.8996.0622Fax +60.3.8996.0755

SingaporeSartorius Stedim Singapore Pte. Ltd.1 Science Park Road, The Capricorn, #05-08A,Singapore Science Park IISingapore 117528

Phone +65.6872.3966Fax +65.6778.2494

South KoreaSartorius Korea Biotech Co., Ltd.8th Floor, Solid Space B/D, PanGyoYeok-Ro 220, BunDang-GuSeongNam-Si, GyeongGi-Do, 463-400

Phone +82.31.622.5700Fax +82.31.622.5799

www.sartorius-stedim.com