bioptik technology, inc.¿新2019法說會_eng.pdf · organization chart. 4. bioptik technology,...
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BIOPTIK TECHNOLOGY, INC.
OUTLOOKDECEMBER 2019
LISTED NUMBER: 4161
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AGENDA
Performance
Product and Forecast
Corporate Introduction
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CORPORATE INTRODUCTION• Date of Establishment: June 1st, 1999• Entity: Incorporation• Listing• IPO: June, 2011• July, 2011 at emerging stock market • June, 2013 OTC-listed; list number: 4161• Product Category: Medical Device, Medical In Vitro
Diagnostic Device, Telehealth, Skin Care Products, Food Supplements, and Wound therapy products, Natural Astaxanthin 3
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ORGANIZATION CHART
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Bioptik Technology, Inc.
Biored Technology,
Inc.
Biowater Technology,
Inc.
Bioptik-Cayman Inc.
Guangdong Bioptik
Technology, Inc.
69.9% 100%
100%
100%
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QUALITY SYSTEM• ISO 13485• GMP(Good Manufacturing Practice in Taiwan)• Product: CE IVD(European Union), FDA(USA), SFDA(China)
approved, Health dept of Taiwan passed.
• ISO 9001; ISO 22716;ISO22000;HACCP ;ISO13485
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Hsinchu Science Park Branch Office
Headquarter
Tainan Office and subsidiary - BioredTechnology, Inc.
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HEADQUARTER MEDICAL DEVICE AND MEDICAL IN VITRO DIAGNOSTIC DEVICE
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G Blood Glucose Monitoring System
GU Blood Glucose/Uric Acid Dual-Function Monitoring
System
GC Blood Glucose/Cholesterol
Dual-Function Monitoring System
GCU Blood Glucose/Cholesterol /Uric Acid Monitoring System
ET-5661 EasyMate Plus Blood Glucose/Cholesterol/Uric Acid/Hemoglobin/Triglyceride Monitoring System
BPGC Blood Pressure /Glucose/Cholesterol
Multi-function Monitoring System
G Blood Glucose Monitoring System
GU Blood Glucose/Uric Acid Dual-Function Monitoring System
GC Blood Glucose/Cholesterol Dual-Function Monitoring System
GCU Blood Glucose/Cholesterol /Uric Acid Monitoring System
ET-5661 EasyMate Plus Blood Glucose/Cholesterol/Uric Acid/Hemoglobin/Triglyceride Monitoring System
BPGC Blood Pressure /Glucose/Cholesterol Multi-function Monitoring System
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HIGHLIGHTS – IOT APPLICATIONS
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Monitoring System Connects to Mobile
Device
Monitoring System Connects to Mobile
Device
Monitoring System Connects to Tablet
Monitoring System Connects to Tablet
Barcode Application Data Transmission POCT Health SystemData Management
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DEVELOPING PROJECTS WITH EXTERNAL COMPANIES
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Turn on the App
Home Glucose measurement
Bluetooth pairing
Measurement mode
Startmeasurement
Insert strip Apply sample Countdown Resurt
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HEADQUARTER FORECAST• IoT• Long-term Care Platform• Preventive Diagnostics and Precision Medicines
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Long-term Care System
Healthcare System
Social Work System
Professional Healthcare System
trans-disciplinary System
Vital Value System
Indicator Monitoring System
General Affairs System
Human Resource System
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Automatically uploading to system
Measurement
Using Wireless Monitoring Device
Clinical Operation Flow
*Blood Pressure Meter*Oximeter*Ear Thermometer*Blood Glucose Meter*Thermometer*Stadiometer*Weight Scale
Information Platform
1.ID Enter Patient’s ID2.ID Enter Operator’s ID3.Reading device Obtains Information
Using Wireless Monitoring Device
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Vital Information Measurement and Storage
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Equipped with wireless transmission technology in compliance to safety standard recognized worldwide
Vital information collected for both medical divisions as well as homecare patients. Devices are:NIBP/HR/BT/SpO2/BG/UA/CHOL/Scales
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Structure
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Information Appliances
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Customized Vital Signs Display
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★Data output*TPR output directly*Accelerate staff
handovers
★★ Data format*Basic data maintenance
*Nursing Information・Vital Signs・ Condition
records
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Mobile Home Healthcare and Care Platform
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Smart Homecare SchedulingPlatform
Enhance the benefits of hospitals and encourage action-based home care
Improve preventive care and medical tracking Constructing integrated massive data to provide treatment
decision analysis Route Planning Location Guide Check-in Tag Professional Medical Platform Digital Signature Validation
Method Mobile Application for Healthcare Professionals Download APP Daily information recording
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Long-term Care
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HSINCHU SCIENCE PARK BRANCH SKIN CARE PRODUCTS, FOOD SUPPLEMENTS, AND WOUND THERAPY PRODUCTS
Far Yea Product Series
Pharmacy Channels
ACUREAL Product Series
Medical Grade Scar
Gel
YU JIAN Dietary
Supplement Series
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Scar therapy gel
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HSINCHU SCIENCE PARK BRANCHFOOD SUPPLEMENTS
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DIETARY SUPPLEMENT –INFOMERCIAL –PSAC ASTAXANTHIN CAPSULE
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Infomercial PSAC astaxanthin capsule -Newly developed food supplement astaxanthin product targeting three hypers.
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DIETARY SUPPLEMENT –INFOMERCIAL –ACTION FREE
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Action Free capsule –Based on 20 years of research experience, hyaluronic acid based dietary supplement developed for joint health can effectively improve joint discomfort
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DIETARY SUPPLEMENT – PHYSICAL CHANNEL
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Currently sold at Great Tree Pharmacy and Tin Tin Drugstore, and will expand to major channels in Taiwan in 2020
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HSINCHU SCIENCE PARK BRANCH FORECAST
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• Southeast Asia Market Expansion
• Virtual Channel Development
• Foreign OEM Market Development
Skin Care Products
• Infomercial Product Development
• Physical Channel Expansion
• Functional Product Development
Food Supplements • Scar Care
• Wound Care• Pharmacy Market
Expansion
Wound therapy products
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HSINCHU SCIENCE PARK BRANCH OUTLOOK
2020 FUNCTIONAL PRODUCT DEVELOPMENT
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Supplement for Cartilage and
Bone
Advanced Action Free
Product
Allergy and intestinal health
productsProbiotics
AcurealHyaluronic
Acid Essence
Hyaluronic Acid Skin
Care Product
Bioptik Technology Inc.---
Expert on Guarding Your Health
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SUBSIDIARY BIORED NATURAL ASTAXANTHIN
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Feed/ ester-state astaxanthin (2%)
Food grade/ free-state astaxanthin (2%)
Medical grade/ free-state astaxanthin (98%)As a mega antioxidant, it slows down the oxidation reaction to eliminates the chain reaction of free radicals, hence to protect cells against oxidation.Highly purified medical grade free-state astaxanthin can be used as supplement to traditional therapy.Marketing: medical supplement, laboratory reference material
Protect cells against oxidation with antioxidant propertyWith the benefits of antioxidant property to eliminate free radical, it can serve as dietary supplement with compound substances for additive effect, such as promoting eye health and immunity, preventing of atherosclerosis cardiovascular diseases.Marketing: Dietary supplement additives
Egg yolk coloring and add antioxidant benefit as additive valueColoring on aquatic livestock to elevate marketing valuePromote gonadal gland health and increase conception rateIncrease cell membrane elasticity and resistanceMarketing: aquaculture and livestock feed additive
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Micronised Free Form AstaxanthinHomogenization Technology
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Publications
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• 1.Y.-Y. Chen, P.-C. Lee, Y.-L. Wu and L.-Y. Liu, In Vivo Effects of Free FormAstaxanthin Powder on Anti-Oxidation and Lipid Metabolism with High-Cholesterol Diet, PLoS One, 2015, 10(8), e0134733.
• 2.Wu, Y.J.; Wu, Y.C.; Chen, I.F.; Wu, Y.L.; Chuang, C.W.; Huang, H.H.; Kuo,S.M. Reparative Effects of Astaxanthin-Hyaluronan Nanoaggregates againstRetrorsine-CCl4-Induced Liver Fibrosis and Necrosis. Molecules 2018, 23, 726.
• 3.Wu, Y.C.; Huang, H.H.; Wu, Y.J.; Manousakas, I.; Yang, C.C.; Kuo, S.M.Therapeutic and Protective Effects of Liposomal Encapsulation of Astaxanthinin Mice with Alcoholic Liver Fibrosis. Int. J. Mol. Sci 2019, 20, 4057.
• 4.游離態蝦紅素處理方法 中華民國 發明專利申請案號:108108474. 案件申請日期:2019/03/13
• 5.蝦紅素粉固相均勻化之方法 中華民國 發明專利申請案號:108108475.案件申請日期:2019/03/13
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IN VIVO EFFECTS OF ASTAXANTHIN• In Vivo Effects of Free Form Astaxanthin Powder on Anti-Oxidation and Lipid Metabolism
with High-Cholesterol Diet PLoS One, 2015, 10(8), e0134733.
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Ethanol-induced severe liver fibrosis- alcohol-induced liver damage treat with Astaxanthin (I-Shou University/ Department of Biomedical Engineering)Therapeutic and Protective Effects of Liposomal Encapsulation of Astaxanthinin Mice with Alcoholic Liver Fibrosis. Int. J. Mol. Sci 2019, 20, 4057.
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Normal mouse liver
Normal liver dissection
Alcohol-induced liver damage
Oral Astaxanthintreatment
Intraperitoneal injection Astaxanthin treatment
Damaged liver dissection – liver fibrosis
* Alcohol-induced liver damage animal model shows the effectiveness of astaxanthin treatment according to the liver dissection. Injection method is superior than oral dosage treatment according to the experiment conducted.
Liver dissection after oral treatment
Liver dissection afterinjection treatment
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Reparative Effects of Astaxanthin-Hyaluronan Nanoaggregates against Retrorsine-CCl4-Induced Liver Fibrosis and Necrosis. Molecules 2018, 23, 726.
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Abstraction/ purification
Mechanofusion
Microencapsulation
Class 3 registration progress
Efficacy Evaluation Human Daily Dosage: 6mg/60kg B.W. Material Product1. Cholesterol induced fatty liver treatment evaluation ○ -2. Ethanol liver damage treatment evaluation ○ -3. Astaxanthin-hyaluronan nanocapsules repair carbon tetrachloride-induced liver fibrosis and necrosis ○ -
4. Tetrachloride-induced severe liver fibrosis - Chemical liver damage treatment evaluation ◎ ●
Safety Evaluation Human Daily Dosage: 80mg/60kg B.W. Material Product1. Salmonella reverse mutation test ● ●2. Micronuclei in peripheral blood of rodents ● ●3. Chromosomal aberration test with mammalian cells in culture ● ●4. Teratogenicity ● ●90-day feeding toxicity study: 120MOS; 1600 times of the dosage ● ●
Astaxanthin Stability Evaluation PTP (10 piece/ tablet) Material Product6 month accelerated test/ 24 months long term test/40℃,75%RH ◎ ●
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Product Performance Assessments
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Scores of liver fibrosis induced in rats: None (0, -)、Slight (1, +)、Mild (2, ++)、Moderate (3, +++)、Severe (4, ++++)
Pathological score 3.3±0.5 2.4±0.4
Product Biowater AstaxanthinCapsule (500mg/ Capsule)
Predicate (500mg/ Capsule)
Dosage in rate (mg/kg) Low Dosage High Dosage Low Dosage High Dosage
100 200 200 1,000
Dosage equivalence to human (mg/60kg)
1,000(2 Cap)
2,000(4 Cap)
2,000(4 Cap)
10,000(20 Cap)
ALT(GPT) Decrease (%) 47.0 54.3 29.3 39.6
AST(GOT)Decrease (%) 49.4 55.2 41.9 45.8
liver fibrosis pathological improvement
1.2±0.4 1.3±0.5 1.2±0.1 1.4±0.2
Source: TFDA Food Safety Abstract/M62-150400008001
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Industrial benefits/ Value-added
applications
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Safety, efficacy, stability testing and formulation development completed
Astaxanthin HealthSupplement Launch to Market
Class 3 Health Supplement Registration
The new plant was officially opened; raw material extraction, purification and application development were completed; ahead of other raw material competitors.
expecting to increase turnover substantially, add 30 new employees, launch 3 now products, and apply for 2 new patents
Completed the first track case review for liver protection in health food certificate third category. Product can label its efficacy.
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FINANCIAL HIGHLIGHTS• Consolidated Statement Unit: Thousand Dollar
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Year 2015 2016 2017 2018 2019Q3
Revenue 452,640 477,330 476,395 519,550 397,489
Margin 162,863 140,581 114,907 126,310 115,127
Operating Profit 55,731 17,726 4,953 2,153 1,348
Net Income before tax 40,270 9,480 (40,133) 31,487 12,745
EPS 0.56 0.16 (0.68) 0.53 0.26
Gross Profit Margin 35.98% 29.45% 24.12% 24.31% 28.96%
Operating Profit Margin 12.31% 3.71% 1.04% 0.41% 0.34%
Net Profit Margin 8.90% 1.99% -8.42% 6.06% 3.21%
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Sales Breakdown by Region
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50%
60%
70%
80%
90%
100%
2015 2016 2017 2018 2019Q3
88% 87% 87% 85% 84%
12% 13% 13% 15% 16%
Other
Taiwan
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Sales Breakdown by Product
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50%
60%
70%
80%
90%
100%
2015 2016 2017 2018 2019Q3
96% 95% 95% 93%85%
4% 5% 5% 7%15%
0% 0% 0% 0% 0%
其他
保養品
醫療檢測產品
otherCare productsMedical testing products
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Dividend Policy
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Year 2013 2014 2015 2016 2017 2018
EPS 2.19 0.66 0.56 0.16 (0.68) 0.53
Cash DPS 0 1 0.51 1 0 0.5
Stock DPS 1.5 0 0 0 0.5 0
DividendPayout Ratio
68.49%151.52% 91.07%625.00% -73.53% 94.34%
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Q & A37
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AN INDUSTRY THAT CREATES HEALTHY, BEAUTIFUL AND ENVIRONMENTAL FRIENDLY PRODUCTBIOPTIK TECHNOLOGY, INC.
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Thank you for listening~
BiOPTiK TECHNOLOGY, INC.AgendaCorporate IntroductionOrganization ChartQuality System投影片編號 6Headquarter Medical Device and Medical In Vitro Diagnostic DeviceHighlights – IoT ApplicationsDeveloping projects with external companiesHeadquarter Forecast投影片編號 11投影片編號 12投影片編號 13投影片編號 14投影片編號 15投影片編號 16Hsinchu Science Park Branch �Skin Care Products, Food Supplements, and Wound therapy productsHsinchu Science Park Branch�Food SupplementsDietary Supplement –Infomercial –PSAC astaxanthin capsuleDietary Supplement –Infomercial –Action FreeDietary Supplement – Physical ChannelHsinchu Science Park Branch ForecastHsinchu Science Park Branch Outlook�2020 Functional Product DevelopmentSubsidiary BIORED Natural Astaxanthin投影片編號 25投影片編號 26In Vivo Effects of Astaxanthin投影片編號 28投影片編號 29投影片編號 30投影片編號 31投影片編號 32Financial Highlights投影片編號 34投影片編號 35投影片編號 36投影片編號 37An industry that creates healthy, beautiful and environmental friendly product